Result of FASTA (omim) for
pFN21AE0230
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0230, 177 aa
1>>>pF1KE0230 177 - 177 aa - 177 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9949+/-0.000555; mu= 9.8427+/- 0.035
mean_var=343.1269+/-67.134, 0's: 0 Z-trim(119.0): 164 B-trim: 133 in 1/49
Lambda= 0.069238
statistics sampled from 32462 (32634) to 32462 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.383), width: 16
Scan time: 4.920
The best scores are: opt bits E(85289)
NP_001005922 (OMIM: 148022) keratin-associated pro ( 278) 850 97.8 1.5e-20
NP_005544 (OMIM: 148021) keratin-associated protei ( 169) 724 84.8 7.4e-17
NP_114163 (OMIM: 608822) keratin-associated protei ( 174) 336 46.1 3.5e-05
NP_112228 (OMIM: 608820) keratin-associated protei ( 167) 303 42.8 0.00033
NP_112229 (OMIM: 608819) keratin-associated protei ( 177) 270 39.5 0.0034
NP_000418 (OMIM: 152445,604117) loricrin [Homo sap ( 312) 271 40.0 0.0041
XP_016878164 (OMIM: 612454) PREDICTED: multiple ep ( 854) 275 41.2 0.0051
XP_016878163 (OMIM: 612454) PREDICTED: multiple ep ( 854) 275 41.2 0.0051
XP_016878162 (OMIM: 612454) PREDICTED: multiple ep (1021) 275 41.3 0.0056
XP_016878161 (OMIM: 612454) PREDICTED: multiple ep (1044) 275 41.3 0.0056
NP_115821 (OMIM: 612454) multiple epidermal growth (1044) 275 41.3 0.0056
XP_016878160 (OMIM: 612454) PREDICTED: multiple ep (1092) 275 41.4 0.0058
XP_016878159 (OMIM: 612454) PREDICTED: multiple ep (1097) 275 41.4 0.0058
>>NP_001005922 (OMIM: 148022) keratin-associated protein (278 aa)
initn: 1474 init1: 457 opt: 850 Z-score: 489.8 bits: 97.8 E(85289): 1.5e-20
Smith-Waterman score: 902; 64.1% identity (72.8% similar) in 184 aa overlap (1-175:1-170)
10 20 30 40 50 60
pF1KE0 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
::::::: :::::::::::::::::::: ::::::::: .::: : :::
NP_001 MGCCGCS-------GGCGSSCGGCGSGCGGCGSGCGGCGSGCGGSGSSC--C-----VPV
10 20 30 40
70 80 90 100 110
pF1KE0 CCCKPVCSWVPACSCTSCG-----SCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQ
::::::: ::.:::.::: : :::::::::::: :::::::::::::::::: :.
NP_001 CCCKPVCCRVPTCSCSSCGKGGCGSSGGSKGGCGSCGGCKGGCGSCGGSKGGCGSCGGSK
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 SSCCKPCCCSSGCGSSC--CQSSCCKP-CCCQS-SCCVPVCCQSSCCKPCCCQSNCCVPV
..: . ..::::.: : :::: : :::. ::::.: ::: : : . .: .
NP_001 GGCGSCGGSKGGCGSGCGGCGSSCCVPVCCCKPMCCCVPACSCSSCGKGGCGSCGCSKGA
110 120 130 140 150 160
pF1KE0 CCQCKI
: .:
NP_001 CGSCGGSKGGCGSCGGCKGGCGSCGGSKGGCGSGCGGCGSGCGVPVCCCSCSSCGSCAGS
170 180 190 200 210 220
>--
initn: 746 init1: 365 opt: 569 Z-score: 338.1 bits: 69.7 E(85289): 4.3e-12
Smith-Waterman score: 692; 61.1% identity (69.1% similar) in 149 aa overlap (11-159:171-277)
10 20 30 40
pF1KE0 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGS
:.. ::::: :::: .:::.::...:::::
NP_001 CCCVPACSCSSCGKGGCGSCGCSKGACGSCGGSKGGCGS-CGGCKGGCGSCGGSKGGCGS
150 160 170 180 190
50 60 70 80 90 100
pF1KE0 GCGGCSSSCGGCGSRCYVPVCCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGS
:::::.:.:: :::::: ::.:::::.::::::::
NP_001 GCGGCGSGCG-------VPVCCC----------SCSSCGSCAGSKGGCGS----------
200 210 220 230
110 120 130 140 150 160
pF1KE0 CGGSKGGCGSCGCSQSSCCKPCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKP
.::: :::::::::::::::::::::::::: ::::::::::: ::
NP_001 -----------SCSQCSCCKPCCCSSGCGSSCCQSSCCKPCCSQSSCCVPVCCQ---CKI
240 250 260 270
170
pF1KE0 CCCQSNCCVPVCCQCKI
>>NP_005544 (OMIM: 148021) keratin-associated protein 5- (169 aa)
initn: 2062 init1: 475 opt: 724 Z-score: 423.7 bits: 84.8 E(85289): 7.4e-17
Smith-Waterman score: 899; 62.8% identity (68.6% similar) in 191 aa overlap (1-177:1-169)
10 20 30 40 50 60
pF1KE0 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV
::::::: ::::.:::: ::::.::::: ::: :: : .::
NP_005 MGCCGCSGGCGSSCGGCDSSCGSCGSGCRGCGP--------------SC------C-APV
10 20 30
70 80 90 100
pF1KE0 CCCKPVCSWVPACSCTSCG-----SCGGSKGGCGSCGGSKGGC-------GSCGGSKGGC
:::::: ::::::.::: ::::::::::::: :. .: ..::.: :
NP_005 YCCKPVCCCVPACSCSSCGKRGCGSCGGSKGGCGSCGCSQCSCCKPCCCSSGCGSSCCQC
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE0 GSCG--CSQSSCCKPCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSN
. : ::: ::::::: ::: :::::::::::::: .:: : ::::::::::: ::
NP_005 SCCKPYCSQCSCCKPCCSSSGRGSSCCQSSCCKPCC-SSSGCGSSCCQSSCCKPCCSQSR
100 110 120 130 140 150
170
pF1KE0 CCVPVCCQCKI
:::::: ::::
NP_005 CCVPVCYQCKI
160
>>NP_114163 (OMIM: 608822) keratin-associated protein 1- (174 aa)
initn: 464 init1: 259 opt: 336 Z-score: 214.1 bits: 46.1 E(85289): 3.5e-05
Smith-Waterman score: 336; 45.6% identity (65.6% similar) in 90 aa overlap (91-172:9-95)
70 80 90 100 110
pF1KE0 CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCG-GSKGGCGSCGGSKGGCGSCGCSQSSCC
:: : . :.::.: : . .: ..:::
NP_114 MTCCQTSFCGYPSFSISGTCGSS---CCQPSCCETSCC
10 20 30
120 130 140 150 160 170
pF1KE0 KP-CCCSSGCG------SSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVC
.: : .: :: :. :.::::.: ::..::: : ::..:::.: ::: . : :
NP_114 QPRSCQTSFCGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCETSCCQPSCCQISSCGTGC
40 50 60 70 80 90
pF1KE0 CQCKI
NP_114 GIGGGISYGQEGSSGAVSTRIRWCRPDSRVEGTYLPPCCVVSCTPPSCCQLHHAQASCCR
100 110 120 130 140 150
>>NP_112228 (OMIM: 608820) keratin-associated protein 1- (167 aa)
initn: 675 init1: 200 opt: 303 Z-score: 196.4 bits: 42.8 E(85289): 0.00033
Smith-Waterman score: 329; 50.6% identity (63.6% similar) in 77 aa overlap (110-174:2-77)
80 90 100 110 120 130
pF1KE0 SCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCCSSG-CGSSCCQSSCC
.: :. : : : : .:: ::::::: :::
NP_112 MTC-CQTSFCGYPSCSTSGTCGSSCCQPSCC
10 20 30
140 150 160 170
pF1KE0 KPCCCQSSCC-VPVC----------CQSSCCKPCCCQSNCCVPVCCQCKI
. ::: ::: . : :.::::.: ::...:: : :::
NP_112 ETSCCQPSCCQTSFCGFPSFSTSGTCSSSCCQPSCCETSCCQPSCCQTSSCGTGCGIGGG
40 50 60 70 80 90
NP_112 IGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAEASCCRPSYCG
100 110 120 130 140 150
>>NP_112229 (OMIM: 608819) keratin-associated protein 1- (177 aa)
initn: 544 init1: 217 opt: 270 Z-score: 178.4 bits: 39.5 E(85289): 0.0034
Smith-Waterman score: 342; 47.3% identity (62.6% similar) in 91 aa overlap (91-174:4-87)
70 80 90 100 110 120
pF1KE0 CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCK
: : : ::. : :.:: ::::.
NP_112 MACCQTSFCGFPSCSTS----GTCG---SSCCQ
10 20
130 140 150 160 170
pF1KE0 PCCC-SSGCGSSCCQSSCCKPCCCQSSCC-VPV-----CCQSSCCKPCCCQSNCCVPVCC
: :: .:.: ::..:::.: :::.: : : :.::::.: ::...:: : :
NP_112 PSCCETSSCQPRCCETSCCQPSCCQTSFCGFPSFSTGGTCDSSCCQPSCCETSCCQPSCY
30 40 50 60 70 80
pF1KE0 QCKI
:
NP_112 QTSSCGTGCGIGGGIGYGQEGSSGAVSTRIRWCRPDCRVEGTCLPPCCVVSCTPPSCCQL
90 100 110 120 130 140
>>NP_000418 (OMIM: 152445,604117) loricrin [Homo sapiens (312 aa)
initn: 435 init1: 186 opt: 271 Z-score: 176.8 bits: 40.0 E(85289): 0.0041
Smith-Waterman score: 271; 41.6% identity (53.0% similar) in 149 aa overlap (5-141:94-240)
10 20
pF1KE0 MGCCGCSRGCGSGC---GGCGSSC---GGCGSGC
: : : :::: :: ::.: :: ::.
NP_000 CGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSG
70 80 90 100 110 120
30 40 50 60 70 80
pF1KE0 GGCG---SGRGGCGSGCGGCSSSCGGCGSRCYVPVCCCKPVCSWVPACSCTSCGSCGGSK
:: : :: :: ..: .:: :: :: : : : : . . ..: : ::
NP_000 GGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGG--
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE0 GGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCKPCCC---SSGCGSSCCQSSCCKPCC
:: . :: : :: : :::.:: :: :... . : : : ::: .: . :
NP_000 GGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCF
190 200 210 220 230 240
150 160 170
pF1KE0 CQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
NP_000 SSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQT
250 260 270 280 290 300
>>XP_016878164 (OMIM: 612454) PREDICTED: multiple epider (854 aa)
initn: 194 init1: 118 opt: 275 Z-score: 175.1 bits: 41.2 E(85289): 0.0051
Smith-Waterman score: 287; 32.2% identity (50.3% similar) in 199 aa overlap (2-174:81-270)
10 20
pF1KE0 MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
: : :. : :: :. :: : :.::
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
60 70 80 90 100
30 40 50 60 70 80
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
: :. : : :::. . : : : : : : :: . :::.. :.:.
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
110 120 130 140 150 160
90 100 110 120 130
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
:.: : .: : : .:. : .:. :: :.... :.: : :. : :..:
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
170 180 190 200 210 220
140 150 160 170
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
: . .: . : : ... : :: . :: : . .:. :.
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVT--GHCC--CLAGWTGNLPLLCHHPGIRCDSTCP
230 240 250 260 270 280
XP_016 PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVH
290 300 310 320 330 340
>>XP_016878163 (OMIM: 612454) PREDICTED: multiple epider (854 aa)
initn: 194 init1: 118 opt: 275 Z-score: 175.1 bits: 41.2 E(85289): 0.0051
Smith-Waterman score: 287; 32.2% identity (50.3% similar) in 199 aa overlap (2-174:81-270)
10 20
pF1KE0 MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
: : :. : :: :. :: : :.::
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
60 70 80 90 100
30 40 50 60 70 80
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
: :. : : :::. . : : : : : : :: . :::.. :.:.
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
110 120 130 140 150 160
90 100 110 120 130
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
:.: : .: : : .:. : .:. :: :.... :.: : :. : :..:
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
170 180 190 200 210 220
140 150 160 170
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
: . .: . : : ... : :: . :: : . .:. :.
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVT--GHCC--CLAGWTGNLPLLCHHPGIRCDSTCP
230 240 250 260 270 280
XP_016 PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVH
290 300 310 320 330 340
>>XP_016878162 (OMIM: 612454) PREDICTED: multiple epider (1021 aa)
initn: 166 init1: 118 opt: 275 Z-score: 174.5 bits: 41.3 E(85289): 0.0056
Smith-Waterman score: 296; 32.2% identity (47.9% similar) in 211 aa overlap (2-174:377-582)
10 20
pF1KE0 MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
: : :. : :: :. :: : :.::
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
350 360 370 380 390 400
30 40 50 60 70 80
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
: :. : : :::. . : : : : : : :: . :::.. :.:.
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
410 420 430 440 450 460
90 100 110 120 130
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
:.: : .: : : .:. : .:. :: :.... :.: : :. : :..:
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
470 480 490 500 510 520
140 150 160 170
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPV----CCQS--------SCCKPCCCQSNCCVPVCC
: . .: . : : ... : :: :: . : : : :: : :
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSC
530 540 550 560 570 580
pF1KE0 QCKI
.
XP_016 ENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICEC
590 600 610 620 630 640
>>XP_016878161 (OMIM: 612454) PREDICTED: multiple epider (1044 aa)
initn: 166 init1: 118 opt: 275 Z-score: 174.4 bits: 41.3 E(85289): 0.0056
Smith-Waterman score: 296; 32.2% identity (47.9% similar) in 211 aa overlap (2-174:377-582)
10 20
pF1KE0 MGCCGCSRGCGSGCGGCGSSC--GGCGSGCG
: : :. : :: :. :: : :.::
XP_016 RLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPG-WSG-HHCNESCPVGYYGDGCQ
350 360 370 380 390 400
30 40 50 60 70 80
pF1KE0 -GCGSGRGG-CGSGCGGCSSSCGGCGSRCYVPVCCCK---PVCSWVPACSCTSCGSCGGS
: :. : : :::. . : : : : : : :: . :::.. :.:.
XP_016 LPCTCQNGADCHSITGGCTCAPGFMGEVCAVS-CAAGTYGPNCSSI--CSCNNGGTCSPV
410 420 430 440 450 460
90 100 110 120 130
pF1KE0 KGGCGSCGGSKG-GCG-SC-GGSKG-GCG-SCGCSQSSCCKP----CCCSSG-CGSSC--
:.: : .: : : .:. : .:. :: :.... :.: : :. : :..:
XP_016 DGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCEL
470 480 490 500 510 520
140 150 160 170
pF1KE0 -CQS-----SCCKPC-CCQSSCCVPV----CCQS--------SCCKPCCCQSNCCVPVCC
: . .: . : : ... : :: :: . : : : :: : :
XP_016 PCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSC
530 540 550 560 570 580
pF1KE0 QCKI
.
XP_016 ENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICEC
590 600 610 620 630 640
177 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:22:23 2016 done: Thu Nov 3 20:22:24 2016
Total Scan time: 4.920 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]