FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1354, 617 aa 1>>>pF1KA1354 617 - 617 aa - 617 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4142+/-0.000391; mu= 18.4952+/- 0.024 mean_var=77.4564+/-16.174, 0's: 0 Z-trim(110.7): 412 B-trim: 12 in 1/57 Lambda= 0.145729 statistics sampled from 18719 (19167) to 18719 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.225), width: 16 Scan time: 9.740 The best scores are: opt bits E(85289) NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 4192 891.7 0 NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 3911 832.6 0 NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 3911 832.6 0 XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 3911 832.6 0 NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 3911 832.6 0 NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 3911 832.6 0 NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 3911 832.6 0 XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 3911 832.6 0 NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 3911 832.6 0 XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 3911 832.6 0 XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 3911 832.6 0 XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1324 288.7 4.2e-77 NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 1324 288.7 4.2e-77 XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 1324 288.7 4.2e-77 NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 1180 258.4 5.4e-68 XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60 XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60 XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 1058 232.8 3.4e-60 NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 1051 231.3 8.6e-60 NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 1051 231.3 9e-60 XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1051 231.4 9.3e-60 XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 1051 231.4 9.4e-60 NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 1049 230.8 9.7e-60 XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59 XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59 XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 1050 231.2 1.1e-59 NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 968 213.9 1.5e-54 NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 933 206.5 2.6e-52 NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 933 206.5 2.6e-52 XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 926 205.0 5.9e-52 NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 926 205.1 7.3e-52 NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 909 201.4 7.3e-51 NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 909 201.4 7.3e-51 XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 905 200.6 1.2e-50 XP_006724581 (OMIM: 300980,300982) PREDICTED: kelc ( 604) 898 199.1 3.7e-50 NP_085127 (OMIM: 300980,300982) kelch-like protein ( 604) 898 199.1 3.7e-50 NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 894 198.3 6.4e-50 XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 892 197.9 9.1e-50 NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 891 197.6 9.7e-50 NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 891 197.6 1e-49 XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 891 197.7 1e-49 NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 887 196.8 1.7e-49 NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 878 194.9 7.5e-49 XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 869 193.0 2.2e-48 NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 868 192.8 2.9e-48 NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 868 192.8 2.9e-48 NP_569713 (OMIM: 614214) kelch-like protein 6 [Hom ( 621) 796 177.7 1.1e-43 NP_001290038 (OMIM: 614522) kelch-like protein 12 ( 467) 781 174.4 7.6e-43 XP_011508139 (OMIM: 614522) PREDICTED: kelch-like ( 522) 781 174.5 8.3e-43 NP_001244124 (OMIM: 605775,614495) kelch-like prot ( 505) 771 172.4 3.5e-42 >>NP_061335 (OMIM: 611201) kelch-like protein 9 [Homo sa (617 aa) initn: 4192 init1: 4192 opt: 4192 Z-score: 4764.2 bits: 891.7 E(85289): 0 Smith-Waterman score: 4192; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617) 10 20 30 40 50 60 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 550 560 570 580 590 600 610 pF1KA1 PGSPSRESPLSAPSDHS ::::::::::::::::: NP_061 PGSPSRESPLSAPSDHS 610 >>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4445.0 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:1-613) 10 20 30 40 50 60 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD ::.:::..:::.:.::: ::: ::.::::::::::::::::::.:::::::::.::: : NP_001 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD . :::::.::::::::::::::::::::::::::::::.::::.:::::::::::::::: NP_001 DAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN :::::::::::::::::::::::::::::.:::::::::::::::: :::::::.:.::: NP_001 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI ::::::::::::::::::::::::::::::::::::::.:::::::.::::.:::::::: NP_001 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::.::: NP_001 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT ::::::::::::::::::::::.:.::.:::::::::::::::::::::::::::::::: NP_001 VTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN :::::::::::::::::::::::::::::::::::::::.:::::::.::::: :::::: NP_001 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT :: :::.:::::::::::::::::::.:::::::::::::.::::::::::::.:::::: NP_001 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV ::::::::::::..:::::::::::::::::::::::::: ::::::::::::::::::: NP_001 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::. NP_001 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 550 560 570 580 590 600 610 pF1KA1 PGSPSRESPLSAPSDHS ::::::::::: NP_001 TPSPSRESPLSAP 610 >>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS ::.:::..:::.:.::: ::: ::.:::::::: NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK ::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::::::: NP_001 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC ::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE :::::::::::: :::::::.:.::::::::::::::::::::::::::::::::::::: NP_001 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS ::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::::::: NP_001 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD ::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:::::: NP_001 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI :::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::::::: NP_001 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS ::::::.::::::::::::.::::::::::::::::::..:::::::::::::::::::: NP_001 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW :::::: ::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 550 560 570 580 590 600 580 590 600 610 pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::. ::::::::::: NP_001 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 >>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS ::.:::..:::.:.::: ::: ::.:::::::: XP_016 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK ::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::::::: XP_016 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC ::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.:::: XP_016 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE :::::::::::: :::::::.:.::::::::::::::::::::::::::::::::::::: XP_016 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS ::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::::::: XP_016 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD ::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:::::: XP_016 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI :::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::::::: XP_016 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS ::::::.::::::::::::.::::::::::::::::::..:::::::::::::::::::: XP_016 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW :::::: ::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_016 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 550 560 570 580 590 600 580 590 600 610 pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::. ::::::::::: XP_016 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 >>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.7 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:27-639) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSS ::.:::..:::.:.::: ::: ::.:::::::: NP_001 MDHLHRGELVAAILRNRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSS 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA1 VVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIK ::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::::::: NP_001 VVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA1 LHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNC ::::.::::.:::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 LHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA1 VEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE :::::::::::: :::::::.:.::::::::::::::::::::::::::::::::::::: NP_001 VEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELE 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA1 LFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEAS ::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::::::: NP_001 LFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA1 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMD ::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:::::: NP_001 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA1 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA1 SALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGI :::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::::::: NP_001 SALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGI 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 THDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS ::::::.::::::::::::.::::::::::::::::::..:::::::::::::::::::: NP_001 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW :::::: ::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 550 560 570 580 590 600 580 590 600 610 pF1KA1 HKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::. ::::::::::: NP_001 HKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 >>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:37-649) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN ::.:::..:::.:.::: ::: ::.:::: NP_001 HLYCCSSKEDCSEDDKCILSRSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 10 20 30 40 50 60 40 50 60 70 80 90 pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL ::::::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::: NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS ::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::. NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 130 140 150 160 170 180 160 170 180 190 200 210 pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::: :::::::.:.::::::::::::::::::::::::::::::::: NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 190 200 210 220 230 240 220 230 240 250 260 270 pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL ::::::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::: NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 250 260 270 280 290 300 280 290 300 310 320 330 pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL ::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:: NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 310 320 330 340 350 360 340 350 360 370 380 390 pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 370 380 390 400 410 420 400 410 420 430 440 450 pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI :::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::: NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 430 440 450 460 470 480 460 470 480 490 500 510 pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD ::::::::::.::::::::::::.::::::::::::::::::..:::::::::::::::: NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 490 500 510 520 530 540 520 530 540 550 560 570 pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 550 560 570 580 590 600 580 590 600 610 pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::::::. ::::::::::: NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 610 620 630 640 >>NP_277030 (OMIM: 300655) kelch-like protein 13 isoform (655 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:43-655) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN ::.:::..:::.:.::: ::: ::.:::: NP_277 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL ::::::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::: NP_277 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS ::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::. NP_277 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::: :::::::.:.::::::::::::::::::::::::::::::::: NP_277 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL ::::::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::: NP_277 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL ::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:: NP_277 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_277 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI :::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::: NP_277 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 440 450 460 470 480 490 460 470 480 490 500 510 pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD ::::::::::.::::::::::::.::::::::::::::::::..:::::::::::::::: NP_277 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 500 510 520 530 540 550 520 530 540 550 560 570 pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::. NP_277 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 560 570 580 590 600 610 580 590 600 610 pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::::::. ::::::::::: NP_277 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 620 630 640 650 >>XP_011529713 (OMIM: 300655) PREDICTED: kelch-like prot (655 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:43-655) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN ::.:::..:::.:.::: ::: ::.:::: XP_011 WKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL ::::::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::: XP_011 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS ::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::. XP_011 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::: :::::::.:.::::::::::::::::::::::::::::::::: XP_011 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL ::::::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::: XP_011 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL ::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:: XP_011 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI :::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::: XP_011 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 440 450 460 470 480 490 460 470 480 490 500 510 pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD ::::::::::.::::::::::::.::::::::::::::::::..:::::::::::::::: XP_011 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 500 510 520 530 540 550 520 530 540 550 560 570 pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 560 570 580 590 600 610 580 590 600 610 pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::::::. ::::::::::: XP_011 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 620 630 640 650 >>NP_001161771 (OMIM: 300655) kelch-like protein 13 isof (658 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.6 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:46-658) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN ::.:::..:::.:.::: ::: ::.:::: NP_001 RRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL ::::::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::: NP_001 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS ::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::. NP_001 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::: :::::::.:.::::::::::::::::::::::::::::::::: NP_001 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL ::::::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::: NP_001 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL ::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:: NP_001 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI :::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::: NP_001 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 440 450 460 470 480 490 460 470 480 490 500 510 pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD ::::::::::.::::::::::::.::::::::::::::::::..:::::::::::::::: NP_001 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 500 510 520 530 540 550 520 530 540 550 560 570 pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 560 570 580 590 600 610 580 590 600 610 pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::::::. ::::::::::: NP_001 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 620 630 640 650 >>XP_011529711 (OMIM: 300655) PREDICTED: kelch-like prot (661 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 4444.5 bits: 832.6 E(85289): 0 Smith-Waterman score: 3911; 92.8% identity (98.2% similar) in 613 aa overlap (1-613:49-661) 10 20 30 pF1KA1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSN ::.:::..:::.:.::: ::: ::.:::: XP_011 RRQLSLKQADFKDIFKKSTSGSLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSN 20 30 40 50 60 70 40 50 60 70 80 90 pF1KA1 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDL ::::::::::::::.:::::::::.::: :. :::::.:::::::::::::::::::::: XP_011 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KA1 MCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVS ::::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::. XP_011 MCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVT 140 150 160 170 180 190 160 170 180 190 200 210 pF1KA1 LDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC :::::::::::::::: :::::::.:.::::::::::::::::::::::::::::::::: XP_011 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHC 200 210 220 230 240 250 220 230 240 250 260 270 pF1KA1 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL ::::::::.:::::::.::::.::::::::::::::::.::::::::::::::::::::: XP_011 TELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KA1 LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSL ::::::::::::::::::::::::::.:::::::::::::::::::::::::.:.::.:: XP_011 LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSL 320 330 340 350 360 370 340 350 360 370 380 390 pF1KA1 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT 380 390 400 410 420 430 400 410 420 430 440 450 pF1KA1 FFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYI :::::::::.:::::::.::::: :::::::: :::.:::::::::::::::::::.::: XP_011 FFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYI 440 450 460 470 480 490 460 470 480 490 500 510 pF1KA1 SGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYD ::::::::::.::::::::::::.::::::::::::::::::..:::::::::::::::: XP_011 SGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYD 500 510 520 530 540 550 520 530 540 550 560 570 pF1KA1 DVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPE :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::. XP_011 DVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPD 560 570 580 590 600 610 580 590 600 610 pF1KA1 KDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS :::::::::::::::::::::::::::::. ::::::::::: XP_011 KDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 620 630 640 650 660 617 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:50:31 2016 done: Sun Nov 6 06:50:33 2016 Total Scan time: 9.740 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]