FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9501, 487 aa 1>>>pF1KE9501 487 - 487 aa - 487 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2674+/-0.000452; mu= 13.9692+/- 0.029 mean_var=124.9537+/-28.171, 0's: 0 Z-trim(113.1): 521 B-trim: 2161 in 2/49 Lambda= 0.114736 statistics sampled from 21588 (22262) to 21588 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.261), width: 16 Scan time: 8.260 The best scores are: opt bits E(85289) NP_001091681 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158 NP_000852 (OMIM: 600167) histamine H1 receptor [Ho ( 487) 3291 556.7 5.5e-158 XP_011531954 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158 NP_001091683 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158 XP_011531955 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158 XP_016861773 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158 NP_001091682 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158 XP_016861772 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158 NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 464 88.7 4.3e-17 NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 464 88.7 4.3e-17 XP_011542345 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855644 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855645 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855651 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855649 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855643 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855646 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855647 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 NP_000731 (OMIM: 100100,118494) muscarinic acetylc ( 590) 454 87.1 1.5e-16 XP_016855642 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_011542346 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_011542343 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_011542347 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_011542348 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855648 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_005273089 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855652 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855641 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 XP_016855650 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16 NP_001006631 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_001006627 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_001006629 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_001006632 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_000730 (OMIM: 118493) muscarinic acetylcholine ( 466) 452 86.7 1.5e-16 NP_001006633 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 XP_011514071 (OMIM: 118493) PREDICTED: muscarinic ( 466) 452 86.7 1.5e-16 NP_001006628 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_001006630 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16 NP_000732 (OMIM: 118495) muscarinic acetylcholine ( 479) 450 86.4 2e-16 NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 443 85.2 4.3e-16 XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 443 85.2 4.3e-16 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 428 82.6 2e-15 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 428 82.6 2e-15 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 427 82.5 2.4e-15 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 412 80.0 1.4e-14 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 405 78.8 2.8e-14 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 405 78.8 2.8e-14 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 405 78.9 3e-14 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 78.9 3.2e-14 >>NP_001091681 (OMIM: 600167) histamine H1 receptor [Hom (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: NP_001 RILHIRS >>NP_000852 (OMIM: 600167) histamine H1 receptor [Homo s (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: NP_000 RILHIRS >>XP_011531954 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: XP_011 RILHIRS >>NP_001091683 (OMIM: 600167) histamine H1 receptor [Hom (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: NP_001 RILHIRS >>XP_011531955 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: XP_011 RILHIRS >>XP_016861773 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: XP_016 RILHIRS >>NP_001091682 (OMIM: 600167) histamine H1 receptor [Hom (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: NP_001 RILHIRS >>XP_016861772 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa) initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158 Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487) 10 20 30 40 50 60 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 430 440 450 460 470 480 pF1KE9 RILHIRS ::::::: XP_016 RILHIRS >>NP_001307846 (OMIM: 118496) muscarinic acetylcholine r (532 aa) initn: 701 init1: 398 opt: 464 Z-score: 427.9 bits: 88.7 E(85289): 4.3e-17 Smith-Waterman score: 688; 29.0% identity (58.8% similar) in 486 aa overlap (26-486:29-513) 10 20 30 40 50 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERK ... ...: ... :.:. :.::. . . . . NP_001 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 LHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFS :.::.: :..::. ::::.: : . :.::..:.:: : .::..:::::.::... NP_001 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 VFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRR .... .::: :. .:: : :: ::. : ::..:: ::. :: :.... . .: NP_001 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 EDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSE :.:. .: . . ::: ::.:. .: .: .::. .... . .. : . NP_001 -DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKA 190 200 210 220 230 240 250 260 270 280 pF1KE9 IKLRPEN----------PKGD-AKKPGKESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMK : .: . :. :.. ... : .:. . .: : .:: . : . NP_001 EKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 SPVVFSQEDDREVDKLYCFP-LDIVHMQAAAEGSSRDYVA--VNRSHGQLKTDEQGLNTH . : .... :: : :..:. . . :. .... : .... . .:... .: NP_001 LTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTP 300 310 320 330 340 350 350 360 370 380 390 pF1KE9 G------ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLR . :.. ..: . . .: . :: : :.. . . : : NP_001 NYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE9 ---SHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMF ::. . . . .:::::. :. :. :::. : :: :. .: .:: .: : . NP_001 PNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHL 420 430 440 450 460 470 460 470 480 pF1KE9 TIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS :: :.:::.::. : :::..:.:::: .: : NP_001 GYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 480 490 500 510 520 530 >>NP_036257 (OMIM: 118496) muscarinic acetylcholine rece (532 aa) initn: 701 init1: 398 opt: 464 Z-score: 427.9 bits: 88.7 E(85289): 4.3e-17 Smith-Waterman score: 688; 29.0% identity (58.8% similar) in 486 aa overlap (26-486:29-513) 10 20 30 40 50 pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERK ... ...: ... :.:. :.::. . . . . NP_036 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 LHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFS :.::.: :..::. ::::.: : . :.::..:.:: : .::..:::::.::... NP_036 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 VFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRR .... .::: :. .:: : :: ::. : ::..:: ::. :: :.... . .: NP_036 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 EDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSE :.:. .: . . ::: ::.:. .: .: .::. .... . .. : . NP_036 -DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKA 190 200 210 220 230 240 250 260 270 280 pF1KE9 IKLRPEN----------PKGD-AKKPGKESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMK : .: . :. :.. ... : .:. . .: : .:: . : . NP_036 EKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 SPVVFSQEDDREVDKLYCFP-LDIVHMQAAAEGSSRDYVA--VNRSHGQLKTDEQGLNTH . : .... :: : :..:. . . :. .... : .... . .:... .: NP_036 LTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTP 300 310 320 330 340 350 350 360 370 380 390 pF1KE9 G------ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLR . :.. ..: . . .: . :: : :.. . . : : NP_036 NYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE9 ---SHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMF ::. . . . .:::::. :. :. :::. : :: :. .: .:: .: : . NP_036 PNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHL 420 430 440 450 460 470 460 470 480 pF1KE9 TIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS :: :.:::.::. : :::..:.:::: .: : NP_036 GYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 480 490 500 510 520 530 487 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:49:19 2016 done: Mon Nov 7 03:49:20 2016 Total Scan time: 8.260 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]