FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9421, 348 aa 1>>>pF1KE9421 348 - 348 aa - 348 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7452+/-0.000512; mu= 19.9423+/- 0.032 mean_var=137.4852+/-35.893, 0's: 0 Z-trim(110.2): 576 B-trim: 1233 in 1/50 Lambda= 0.109382 statistics sampled from 17700 (18471) to 17700 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.567), E-opt: 0.2 (0.217), width: 16 Scan time: 5.980 The best scores are: opt bits E(85289) NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 2320 378.5 1.2e-104 NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 1690 279.1 1e-74 NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 1625 268.8 1.2e-71 NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 1052 178.4 2e-44 NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 983 167.5 3.8e-41 NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 886 152.2 1.6e-36 NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 849 146.3 8.4e-35 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 434 81.0 5.1e-15 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 421 78.9 2e-14 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 421 78.9 2e-14 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 421 78.9 2e-14 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 421 78.9 2e-14 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 421 78.9 2.1e-14 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 421 79.0 2.1e-14 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 409 76.9 6.7e-14 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 409 76.9 6.8e-14 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 409 76.9 6.9e-14 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 409 76.9 7.1e-14 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 409 77.0 7.4e-14 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 409 77.0 7.4e-14 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 409 77.1 7.9e-14 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 409 77.1 7.9e-14 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 409 77.1 8.2e-14 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 409 77.1 8.3e-14 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 409 77.1 8.3e-14 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 409 77.2 8.4e-14 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 409 77.2 8.4e-14 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 409 77.2 8.4e-14 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 409 77.2 8.4e-14 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 408 77.0 9.2e-14 NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 407 76.8 1e-13 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 405 76.3 1.1e-13 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 405 76.3 1.1e-13 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 405 76.4 1.2e-13 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 76.4 1.2e-13 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 76.4 1.2e-13 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 76.4 1.2e-13 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 76.4 1.2e-13 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 76.4 1.2e-13 NP_001265426 (OMIM: 102776) adenosine receptor A2a ( 412) 401 75.8 1.9e-13 NP_000666 (OMIM: 102776) adenosine receptor A2a [H ( 412) 401 75.8 1.9e-13 NP_001265428 (OMIM: 102776) adenosine receptor A2a ( 412) 401 75.8 1.9e-13 NP_001265427 (OMIM: 102776) adenosine receptor A2a ( 412) 401 75.8 1.9e-13 NP_001265429 (OMIM: 102776) adenosine receptor A2a ( 412) 401 75.8 1.9e-13 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 386 73.4 9.4e-13 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 366 70.4 9.3e-12 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 366 70.4 9.8e-12 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 364 70.0 1.1e-11 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 360 69.3 1.6e-11 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 357 68.7 2e-11 >>NP_778227 (OMIM: 608282) trace amine-associated recept (348 aa) initn: 2320 init1: 2320 opt: 2320 Z-score: 1999.8 bits: 378.5 E(85289): 1.2e-104 Smith-Waterman score: 2320; 100.0% identity (100.0% similar) in 348 aa overlap (1-348:1-348) 10 20 30 40 50 60 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_778 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_778 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_778 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 VVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_778 VVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 SSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_778 SSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV 250 260 270 280 290 300 310 320 330 340 pF1KE9 YYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD :::::::::::::::::::::::::::::::::::::::::::::::: NP_778 YYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD 310 320 330 340 >>NP_778237 (OMIM: 608923) trace amine-associated recept (345 aa) initn: 1711 init1: 1682 opt: 1690 Z-score: 1462.6 bits: 279.1 E(85289): 1e-74 Smith-Waterman score: 1690; 69.0% identity (89.0% similar) in 345 aa overlap (1-345:1-345) 10 20 30 40 50 60 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF : .: : ::.::: ::: ::.: :.::: : ::: :.:::::::.::::::::.:::: NP_778 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL ::::.:::::.:::::::::::::::::: ::.:::::::: :.: :::: :..::..:: NP_778 KQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL :::: ::.::::::::::.:::::::::::::: .::.. . :: ..::::. ..:.::: NP_778 FHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEEL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 VVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQS ::.:.::::. .:::::: :: ::::. :...:..:::::..::.:::.:.:...: NP_778 SDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKTES 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 SSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV :::::: :::.::::::::::....::..::::: .:..:::.:.:::: .::: ::. NP_778 SSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCWCA 250 260 270 280 290 300 310 320 330 340 pF1KE9 YYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD ::::::::::::.:: :: ::::.::.:.::...:.: :::::.. NP_778 YYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI 310 320 330 340 >>NP_444508 (OMIM: 606927) trace amine-associated recept (342 aa) initn: 1657 init1: 1596 opt: 1625 Z-score: 1407.2 bits: 268.8 E(85289): 1.2e-71 Smith-Waterman score: 1625; 67.6% identity (89.8% similar) in 343 aa overlap (1-343:1-342) 10 20 30 40 50 60 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF :..:::: .:.:::..:: :::.:::::: : :::....::..::.::::::: ..::: NP_444 MTSNFSQP-VVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHF 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL ::::.::::::::::::::::::::: :: ::.:::::::: ..: .:.: :..::..:. NP_444 KQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL .::: : .::::.:::::.: :::::::::::: .::.. .::: ..::::.:..:.::: NP_444 LHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEEL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 VVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQS : ::.:::::: ..:.:::. :::::::...:...::::::.::.:: :::.:.:...: NP_444 VSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVES 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 SSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV :::::: ::::::::::::::... ::..::::: :: .:::.:.:.:: :.::: : . NP_444 SSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSA 240 250 260 270 280 290 310 320 330 340 pF1KE9 YYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD ::::::::::::.:: :: ::::::.:: ::...::: .:: : NP_444 YYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 300 310 320 330 340 >>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa) initn: 1100 init1: 690 opt: 1052 Z-score: 918.6 bits: 178.4 E(85289): 2e-44 Smith-Waterman score: 1052; 46.2% identity (75.5% similar) in 331 aa overlap (13-343:16-337) 10 20 30 40 50 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAI .::. :: :: .: .. : . ..: . . : .. ..::..: .:. NP_003 MRAVFIQGAEEHPAAFCYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 LHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCF .:: ::::::::. ::: ::...:. :.:.::.:::::::.::: :..:: .:: ::. NP_003 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGI .:.:::: ::.::. :. ::: ::.:::: :. :. .: ..:. ..:: . : . NP_003 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 EELVVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQ . . . :::.:: ::. : : : :::.: . :. .: :::.:: .::..: .: :. NP_003 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQI-TTLSK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 AQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV . ... ::.:::::::::::.. .:. :::. .:...:. ..::::: :..:.. NP_003 SLAGA-------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD : .:.::: ::.::.: :::: ::.:: .: ::. .. :..:..: NP_003 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE 300 310 320 330 >>NP_612200 (OMIM: 609333) trace amine-associated recept (339 aa) initn: 981 init1: 512 opt: 983 Z-score: 859.7 bits: 167.5 E(85289): 3.8e-41 Smith-Waterman score: 983; 42.8% identity (73.1% similar) in 334 aa overlap (13-343:4-336) 10 20 30 40 50 60 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF .:.. .: ::.:. .: :. ::... . . . :::.:...: :: NP_612 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHF 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL ::::::::.:: :.: .:::.: :::.: :::.: :::::. .::.:: : . ::. NP_612 KQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASI 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL ::: ::.::: :: ::: : .:... : . : .:: ....:.... : .: ::. NP_612 FHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEI 120 130 140 150 160 170 190 200 210 220 230 pF1KE9 VVA-LTCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTASQA . : :::.. ... .: :. :.::. :. .: .:.:.::.::: : : :.: NP_612 YYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLI-SDANQK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 QSSSESYKERVAK-RERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV . . .:. ... .::::.:::::.:..::. : :... .:.: ....: :: . ..:. NP_612 LQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLI 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD : : ::..::..::::: :: ::.:... ::... ::: .:: : NP_612 WFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS 300 310 320 330 >>NP_001028252 (OMIM: 604849) trace amine-associated rec (351 aa) initn: 882 init1: 551 opt: 886 Z-score: 776.8 bits: 152.2 E(85289): 1.6e-36 Smith-Waterman score: 886; 40.2% identity (70.1% similar) in 321 aa overlap (14-333:25-337) 10 20 30 40 pF1KE9 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFG : . :.:: .. : : : .:. .. . .. :: NP_001 MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHT :: ..:.: .:::::::::::: :.: .:::.: :.::.: .::::.::::: ..::.. NP_001 NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 CFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFY :: . ..:.:::: ...::. :. :: : ::.:. : ..: : ...:.. . NP_001 SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 TGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQA . : .::: . ..: ..: . .:. : :. :: :. :: ::.::: :....: NP_001 SEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 RKIESTASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFIT . :.. :. ...: :...::::::::....::. :.: . ..: ..:: : NP_001 HAINNL-------RENQNNQV-KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFST 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 PPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD : ... :.: :.::. :::::.::: :: .:.: :. ::.. . NP_001 PVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE 300 310 320 330 340 350 >>NP_055441 (OMIM: 604849) trace amine-associated recept (306 aa) initn: 843 init1: 512 opt: 849 Z-score: 745.8 bits: 146.3 E(85289): 8.4e-35 Smith-Waterman score: 849; 40.7% identity (71.3% similar) in 300 aa overlap (35-333:1-292) 10 20 30 40 50 60 pF1KE9 FSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLH .:. .. . .. :::: ..:.: .::::: NP_055 MYSFMAGSIFITIFGNLAMIISISYFKQLH 10 20 30 70 80 90 100 110 120 pF1KE9 TPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLFHLC ::::::: :.: .:::.: :.::.: .::::.::::: ..::.. :: . ..:.:::: NP_055 TPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLC 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE9 CISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEELVVAL ...::. :. :: : ::.:. : ..: : ...:.. .. : .::: . . NP_055 SVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE9 TCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQSSSE .: ..: . .:. : :. :: :. :: ::.::: :....:. :.. : NP_055 ACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNL-------RE 160 170 180 190 200 250 260 270 280 290 300 pF1KE9 SYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCVYYN . ...: :...::::::::....::. :.: . ..: ..:: :: ... :.: :.: NP_055 NQNNQV-KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFN 210 220 230 240 250 260 310 320 330 340 pF1KE9 SAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD :. :::::.::: :: .:.: :. ::.. . NP_055 STCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE 270 280 290 300 >>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa) initn: 548 init1: 328 opt: 434 Z-score: 390.7 bits: 81.0 E(85289): 5.1e-15 Smith-Waterman score: 566; 34.9% identity (66.4% similar) in 298 aa overlap (38-311:33-326) 10 20 30 40 50 60 pF1KE9 AEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLA------AFGNLLVMIAILHFK :.:.: :.. .:::.::. :: .:. NP_000 QPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 QLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLF .:.: ::..:.::::::...:..:.::.... . . : ::. .:.: : .:. ::. NP_000 RLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIE 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 HLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSI----FYTGANEEGI :: :.::::.:.:.:. : . .: . . . :.. :. : :: .: ....:.: NP_000 TLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 EELVVALTCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTAS . . :: :. :: ... .. :..: : :::.::..: ::.: .::... . NP_000 N-CYANETC---CDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEG 190 200 210 220 230 240 250 260 270 280 pF1KE9 Q--AQSSSESYKE--------RVAK---RERKAAKTLGIAMAAFLVSWLPYLVDAVIDAY . .:. :. .. : .: .:.:: ::::: :..: . :::... .. . NP_000 RFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 MNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSE .. . :: .: : : ::..::::: NP_000 QDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNG 300 310 320 330 340 350 >>NP_001035262 (OMIM: 602164) 5-hydroxytryptamine recept (360 aa) initn: 556 init1: 249 opt: 421 Z-score: 380.1 bits: 78.9 E(85289): 2e-14 Smith-Waterman score: 612; 34.2% identity (65.8% similar) in 310 aa overlap (32-326:19-327) 10 20 30 40 50 60 pF1KE9 VNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFK . .: . :. ..: .::::::.:. . NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDR 10 20 30 40 70 80 90 100 110 120 pF1KE9 QLHT-PTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL ::. ::..:.::: ::.::.: ::::.... :.. : .:. .: .: .:. . ::. NP_001 QLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASI 50 60 70 80 90 100 130 140 150 160 170 pF1KE9 FHLCCISVDRYIAVT-DPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEE :::::::.::: :. .::.: .:.: .. . : . . :: .. : :. :: . NP_001 FHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIID 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 LVVAL-----TCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIE- :. . : .:. ... : .. :.:: . ::. : .:...::..:..:. NP_001 LIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQM 170 180 190 200 210 220 240 250 260 270 280 pF1KE9 ------STASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNF :. :. ::... .:. . : :::::: : :. : . : :..: ..: .... NP_001 LQRAGASSESRPQSADQHSTHRM-RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 ITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVE .: :. ..: : ::..::..:::. . : .:. .:. NP_001 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS 290 300 310 320 330 340 pF1KE9 TD NP_001 TTTINGSTHVLRF 350 360 >>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa) initn: 556 init1: 249 opt: 421 Z-score: 380.0 bits: 78.9 E(85289): 2e-14 Smith-Waterman score: 612; 34.2% identity (65.8% similar) in 310 aa overlap (32-326:19-327) 10 20 30 40 50 60 pF1KE9 VNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFK . .: . :. ..: .::::::.:. . NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDR 10 20 30 40 70 80 90 100 110 120 pF1KE9 QLHT-PTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL ::. ::..:.::: ::.::.: ::::.... :.. : .:. .: .: .:. . ::. NP_955 QLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASI 50 60 70 80 90 100 130 140 150 160 170 pF1KE9 FHLCCISVDRYIAVT-DPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEE :::::::.::: :. .::.: .:.: .. . : . . :: .. : :. :: . NP_955 FHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIID 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 LVVAL-----TCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIE- :. . : .:. ... : .. :.:: . ::. : .:...::..:..:. NP_955 LIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQM 170 180 190 200 210 220 240 250 260 270 280 pF1KE9 ------STASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNF :. :. ::... .:. . : :::::: : :. : . : :..: ..: .... NP_955 LQRAGASSESRPQSADQHSTHRM-RTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 ITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVE .: :. ..: : ::..::..:::. . : .:. .:. NP_955 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS 290 300 310 320 330 340 pF1KE9 TD NP_955 TTTINGSTHVLSGCSPVSSFLLLFCNRPVPV 350 360 370 348 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:52:56 2016 done: Mon Nov 7 03:52:57 2016 Total Scan time: 5.980 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]