FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA1417, 1353 aa 1>>>pF1KA1417 1353 - 1353 aa - 1353 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7260+/-0.000537; mu= 11.5990+/- 0.033 mean_var=231.1872+/-48.548, 0's: 0 Z-trim(112.5): 208 B-trim: 313 in 1/55 Lambda= 0.084351 statistics sampled from 21267 (21485) to 21267 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.252), width: 16 Scan time: 13.930 The best scores are: opt bits E(85289) NP_056340 (OMIM: 606457) inhibitor of Bruton tyros (1353) 9010 1111.9 0 XP_006715516 (OMIM: 606457) PREDICTED: inhibitor o (1394) 8255 1020.0 0 NP_001287835 (OMIM: 606457) inhibitor of Bruton ty (1338) 6752 837.1 0 XP_006715517 (OMIM: 606457) PREDICTED: inhibitor o (1379) 6752 837.1 0 XP_016878186 (OMIM: 176270,227220,605837,615516) P (2556) 317 54.3 1.3e-05 XP_016878187 (OMIM: 176270,227220,605837,615516) P (2556) 317 54.3 1.3e-05 XP_011520435 (OMIM: 176270,227220,605837,615516) P (3749) 317 54.5 1.7e-05 XP_011520433 (OMIM: 176270,227220,605837,615516) P (4673) 317 54.6 1.9e-05 XP_006720790 (OMIM: 176270,227220,605837,615516) P (4748) 317 54.6 1.9e-05 XP_016878184 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05 XP_016878185 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05 XP_005268333 (OMIM: 176270,227220,605837,615516) P (4796) 317 54.6 2e-05 XP_006720789 (OMIM: 176270,227220,605837,615516) P (4829) 317 54.7 2e-05 NP_004658 (OMIM: 176270,227220,605837,615516) E3 u (4834) 317 54.7 2e-05 XP_011537899 (OMIM: 609248) PREDICTED: probable E3 ( 960) 302 52.0 2.4e-05 XP_011537897 (OMIM: 609248) PREDICTED: probable E3 (1011) 302 52.0 2.5e-05 XP_011537896 (OMIM: 609248) PREDICTED: probable E3 (1011) 302 52.0 2.5e-05 XP_011537895 (OMIM: 609248) PREDICTED: probable E3 (1073) 302 52.1 2.6e-05 XP_011537894 (OMIM: 609248) PREDICTED: probable E3 (1081) 302 52.1 2.6e-05 XP_016878195 (OMIM: 605109,617011) PREDICTED: prob (2792) 297 51.9 7.4e-05 NP_036271 (OMIM: 606051) secretion-regulating guan ( 458) 282 49.2 8.1e-05 XP_016871530 (OMIM: 609248) PREDICTED: probable E3 ( 936) 285 49.9 0.0001 NP_001265114 (OMIM: 609248) probable E3 ubiquitin- ( 979) 285 50.0 0.0001 XP_011537898 (OMIM: 609248) PREDICTED: probable E3 ( 987) 285 50.0 0.0001 NP_056416 (OMIM: 609248) probable E3 ubiquitin-pro (1049) 285 50.0 0.00011 NP_071362 (OMIM: 609248) probable E3 ubiquitin-pro (1057) 285 50.0 0.00011 NP_057407 (OMIM: 608242) E3 ISG15--protein ligase (1024) 283 49.7 0.00013 XP_011530324 (OMIM: 608242) PREDICTED: E3 ISG15--p (1100) 283 49.8 0.00013 NP_061185 (OMIM: 609587) protein RCC2 [Homo sapien ( 522) 276 48.5 0.00015 NP_001129676 (OMIM: 609587) protein RCC2 [Homo sap ( 522) 276 48.5 0.00015 NP_003913 (OMIM: 605109,617011) probable E3 ubiqui (4861) 275 49.5 0.00068 XP_016878194 (OMIM: 605109,617011) PREDICTED: prob (4883) 275 49.5 0.00069 XP_016878193 (OMIM: 605109,617011) PREDICTED: prob (4885) 275 49.5 0.00069 XP_016878192 (OMIM: 605109,617011) PREDICTED: prob (4891) 275 49.5 0.00069 XP_016878191 (OMIM: 605109,617011) PREDICTED: prob (4892) 275 49.5 0.00069 XP_016878190 (OMIM: 605109,617011) PREDICTED: prob (4892) 275 49.5 0.00069 XP_016878189 (OMIM: 605109,617011) PREDICTED: prob (4897) 275 49.5 0.00069 XP_016878188 (OMIM: 605109,617011) PREDICTED: prob (4909) 275 49.5 0.00069 NP_001305434 (OMIM: 605200) probable E3 ubiquitin- ( 368) 253 45.6 0.00081 XP_005263389 (OMIM: 605200) PREDICTED: probable E3 ( 896) 253 46.0 0.0015 XP_005263388 (OMIM: 605200) PREDICTED: probable E3 ( 903) 253 46.0 0.0015 XP_016864296 (OMIM: 605200) PREDICTED: probable E3 ( 924) 253 46.0 0.0015 NP_001258531 (OMIM: 605200) probable E3 ubiquitin- ( 932) 253 46.0 0.0015 XP_005263387 (OMIM: 605200) PREDICTED: probable E3 ( 993) 253 46.1 0.0016 XP_005263386 (OMIM: 605200) PREDICTED: probable E3 (1042) 253 46.1 0.0016 XP_016864295 (OMIM: 605200) PREDICTED: probable E3 (1042) 253 46.1 0.0016 XP_005263384 (OMIM: 605200) PREDICTED: probable E3 (1050) 253 46.1 0.0016 NP_055421 (OMIM: 605200) probable E3 ubiquitin-pro (1050) 253 46.1 0.0016 XP_016875866 (OMIM: 603524) PREDICTED: RCC1 and BT ( 285) 236 43.4 0.0029 NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 233 43.4 0.0061 >>NP_056340 (OMIM: 606457) inhibitor of Bruton tyrosine (1353 aa) initn: 9010 init1: 9010 opt: 9010 Z-score: 5942.2 bits: 1111.9 E(85289): 0 Smith-Waterman score: 9010; 100.0% identity (100.0% similar) in 1353 aa overlap (1-1353:1-1353) 10 20 30 40 50 60 pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA1 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL 1270 1280 1290 1300 1310 1320 1330 1340 1350 pF1KA1 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC ::::::::::::::::::::::::::::::::: NP_056 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC 1330 1340 1350 >>XP_006715516 (OMIM: 606457) PREDICTED: inhibitor of Br (1394 aa) initn: 8255 init1: 8255 opt: 8255 Z-score: 5445.5 bits: 1020.0 E(85289): 0 Smith-Waterman score: 8837; 97.0% identity (97.0% similar) in 1385 aa overlap (1-1344:1-1385) 10 20 30 40 50 60 pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVR------------------ :::::::::::::::::::::::::::::::::::::::::: XP_006 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSS 1210 1220 1230 1240 1250 1260 1250 1260 1270 pF1KA1 -----------------------CSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV ::::::::::::::::::::::::::::::::::::: XP_006 PQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KA1 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP 1330 1340 1350 1360 1370 1380 1340 1350 pF1KA1 QGPLAVPMWNKHGC ::::: XP_006 QGPLAVPMWNKHGC 1390 >>NP_001287835 (OMIM: 606457) inhibitor of Bruton tyrosi (1338 aa) initn: 6752 init1: 6752 opt: 6752 Z-score: 4457.2 bits: 837.1 E(85289): 0 Smith-Waterman score: 8879; 98.9% identity (98.9% similar) in 1353 aa overlap (1-1353:1-1338) 10 20 30 40 50 60 pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSST------------ 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---ELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 1250 1260 pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP 1190 1200 1210 1220 1230 1240 1270 1280 1290 1300 1310 1320 pF1KA1 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL 1250 1260 1270 1280 1290 1300 1330 1340 1350 pF1KA1 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC ::::::::::::::::::::::::::::::::: NP_001 VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC 1310 1320 1330 >>XP_006715517 (OMIM: 606457) PREDICTED: inhibitor of Br (1379 aa) initn: 7500 init1: 6752 opt: 6752 Z-score: 4457.1 bits: 837.1 E(85289): 0 Smith-Waterman score: 8787; 96.0% identity (96.0% similar) in 1394 aa overlap (1-1353:1-1379) 10 20 30 40 50 60 pF1KA1 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA1 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA1 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA1 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA1 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA1 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA1 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA1 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA1 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA1 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA1 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA1 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA1 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA1 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA1 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA1 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA1 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSST------------ 970 980 990 1000 1030 1040 1050 1060 1070 1080 pF1KA1 SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ---ELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW 1010 1020 1030 1040 1050 1060 1090 1100 1110 1120 1130 1140 pF1KA1 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK 1070 1080 1090 1100 1110 1120 1150 1160 1170 1180 1190 1200 pF1KA1 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS 1130 1140 1150 1160 1170 1180 1210 1220 1230 1240 pF1KA1 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVR------------------ :::::::::::::::::::::::::::::::::::::::::: XP_006 SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSS 1190 1200 1210 1220 1230 1240 1250 1260 1270 pF1KA1 -----------------------CSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV ::::::::::::::::::::::::::::::::::::: XP_006 PQPLPPGFKRFSCLRHPSSWDYRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMV 1250 1260 1270 1280 1290 1300 1280 1290 1300 1310 1320 1330 pF1KA1 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTP 1310 1320 1330 1340 1350 1360 1340 1350 pF1KA1 QGPLAVPMWNKHGC :::::::::::::: XP_006 QGPLAVPMWNKHGC 1370 >>XP_016878186 (OMIM: 176270,227220,605837,615516) PREDI (2556 aa) initn: 212 init1: 212 opt: 317 Z-score: 221.7 bits: 54.3 E(85289): 1.3e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:1781-2009) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 1760 1770 1780 1790 1800 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 1810 1820 1830 1840 1850 1860 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 1870 1880 1890 1900 1910 1920 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 1930 1940 1950 1960 1970 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 1980 1990 2000 2010 2020 2030 >-- initn: 260 init1: 217 opt: 286 Z-score: 201.4 bits: 50.6 E(85289): 0.00018 Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:790-1050) 120 130 140 150 160 170 pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS :..::.. . ::: :. . .:.:.. .. XP_016 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK 760 770 780 790 800 810 180 190 200 210 220 230 pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ . :.... . ::. :...:..:: : : :::::::. : : :..:. : :: : XP_016 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 820 830 840 850 860 870 240 250 260 270 280 290 pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA :: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . . XP_016 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC 880 890 900 910 920 930 300 310 320 330 340 350 pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG : .: .: .:.: : .: . : ... : :. : .:. : : : .. : XP_016 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG 940 950 960 970 980 360 370 380 390 400 pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI : : :: :..: .: . ... . .: : .::.: .: :::: XP_016 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI 990 1000 1010 1020 1030 410 420 430 440 450 460 pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE .: :... : .:. XP_016 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA 1040 1050 1060 1070 1080 1090 >>XP_016878187 (OMIM: 176270,227220,605837,615516) PREDI (2556 aa) initn: 212 init1: 212 opt: 317 Z-score: 221.7 bits: 54.3 E(85289): 1.3e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:1781-2009) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 1760 1770 1780 1790 1800 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 1810 1820 1830 1840 1850 1860 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 1870 1880 1890 1900 1910 1920 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 1930 1940 1950 1960 1970 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 1980 1990 2000 2010 2020 2030 >-- initn: 260 init1: 217 opt: 286 Z-score: 201.4 bits: 50.6 E(85289): 0.00018 Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:790-1050) 120 130 140 150 160 170 pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS :..::.. . ::: :. . .:.:.. .. XP_016 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK 760 770 780 790 800 810 180 190 200 210 220 230 pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ . :.... . ::. :...:..:: : : :::::::. : : :..:. : :: : XP_016 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 820 830 840 850 860 870 240 250 260 270 280 290 pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA :: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . . XP_016 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC 880 890 900 910 920 930 300 310 320 330 340 350 pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG : .: .: .:.: : .: . : ... : :. : .:. : : : .. : XP_016 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG 940 950 960 970 980 360 370 380 390 400 pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI : : :: :..: .: . ... . .: : .::.: .: :::: XP_016 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI 990 1000 1010 1020 1030 410 420 430 440 450 460 pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE .: :... : .:. XP_016 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA 1040 1050 1060 1070 1080 1090 >>XP_011520435 (OMIM: 176270,227220,605837,615516) PREDI (3749 aa) initn: 212 init1: 212 opt: 317 Z-score: 219.8 bits: 54.5 E(85289): 1.7e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:2974-3202) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_011 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 2950 2960 2970 2980 2990 3000 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_011 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 3010 3020 3030 3040 3050 3060 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_011 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 3070 3080 3090 3100 3110 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_011 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 3120 3130 3140 3150 3160 3170 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_011 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 3180 3190 3200 3210 3220 3230 >-- initn: 260 init1: 217 opt: 286 Z-score: 199.4 bits: 50.8 E(85289): 0.00023 Smith-Waterman score: 335; 30.6% identity (59.4% similar) in 288 aa overlap (144-424:1983-2243) 120 130 140 150 160 170 pF1KA1 IQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFS :..::.. . ::: :. . .:.:.. .. XP_011 QITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK 1960 1970 1980 1990 2000 2010 180 190 200 210 220 230 pF1KA1 RSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQ . :.... . ::. :...:..:: : : :::::::. : : :..:. : :: : XP_011 TK--RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQ 2020 2030 2040 2050 2060 2070 240 250 260 270 280 290 pF1KA1 VA-AAKD-HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAA :: ...: .:..::..: :...: . : .:: .::.:..:. :.:. . . XP_011 VACGSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIE--RLNGQGVCQIEC 2080 2090 2100 2110 2120 300 310 320 330 340 350 pF1KA1 G-RFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDG : .: .: .:.: : .: . : ... : :. : .:. : : : .. : XP_011 GAQFSLALTKSGVVWTWG-KGDYFR--LGHGSDVHVRKPQVVEGLRGKKI----VHVAVG 2130 2140 2150 2160 2170 2180 360 370 380 390 400 pF1KA1 ATVC--VTTRGDIYLLADYQCKKMA--SKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKI : : :: :..: .: . ... . .: : .::.: .: :::: XP_011 ALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG--LE------------GQKI 2190 2200 2210 2220 410 420 430 440 450 460 pF1KA1 CILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFE .: :... : .:. XP_011 TRVAC-GSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGA 2230 2240 2250 2260 2270 2280 >>XP_011520433 (OMIM: 176270,227220,605837,615516) PREDI (4673 aa) initn: 212 init1: 212 opt: 317 Z-score: 218.7 bits: 54.6 E(85289): 1.9e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:3898-4126) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_011 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 3870 3880 3890 3900 3910 3920 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_011 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 3930 3940 3950 3960 3970 3980 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_011 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 3990 4000 4010 4020 4030 4040 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_011 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 4050 4060 4070 4080 4090 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_011 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4100 4110 4120 4130 4140 4150 >>XP_006720790 (OMIM: 176270,227220,605837,615516) PREDI (4748 aa) initn: 212 init1: 212 opt: 317 Z-score: 218.6 bits: 54.6 E(85289): 1.9e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:3973-4201) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_006 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 3950 3960 3970 3980 3990 4000 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_006 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 4010 4020 4030 4040 4050 4060 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_006 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 4070 4080 4090 4100 4110 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_006 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 4120 4130 4140 4150 4160 4170 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_006 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4180 4190 4200 4210 4220 4230 >>XP_016878184 (OMIM: 176270,227220,605837,615516) PREDI (4796 aa) initn: 212 init1: 212 opt: 317 Z-score: 218.5 bits: 54.6 E(85289): 2e-05 Smith-Waterman score: 353; 31.7% identity (60.4% similar) in 240 aa overlap (143-378:4021-4249) 120 130 140 150 160 170 pF1KA1 YIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLF .::.::. . ::::... .:.... XP_016 TLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIE-- 4000 4010 4020 4030 4040 180 190 200 210 220 230 pF1KA1 SRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCS : :: . .:. ::. .. :..:: :.: :::::.: . : :.:::.:.:: XP_016 SLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVV 4050 4060 4070 4080 4090 4100 240 250 260 270 280 290 pF1KA1 QVAAAKD--HTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVA ..: .. .:. ::.: :...: . . .:: ..:.:: .:.. : : .. : XP_016 DIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDS--LTGLGVVKVE 4110 4120 4130 4140 4150 4160 300 310 320 330 340 pF1KA1 AG-RFHTVLWTREAVYTMGLNG-GQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAAS : .: ..: :::: : . .:: : . : ::::..:. : . .:.. XP_016 CGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDH----VRRPRQVQGLQGKKVIA--IATG 4170 4180 4190 4200 4210 350 360 370 380 390 400 pF1KA1 DGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICI . :: : :..: .: . .... : XP_016 SLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWS 4220 4230 4240 4250 4260 4270 1353 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 14:37:23 2016 done: Mon Nov 7 14:37:25 2016 Total Scan time: 13.930 Total Display time: 0.540 Function used was FASTA [36.3.4 Apr, 2011]