FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1177, 684 aa 1>>>pF1KE1177 684 - 684 aa - 684 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1470+/-0.000368; mu= 16.5620+/- 0.023 mean_var=102.0621+/-20.381, 0's: 0 Z-trim(115.6): 196 B-trim: 50 in 1/54 Lambda= 0.126953 statistics sampled from 25961 (26192) to 25961 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.307), width: 16 Scan time: 10.970 The best scores are: opt bits E(85289) NP_006506 (OMIM: 609834) histone-lysine N-methyltr ( 684) 4769 884.5 0 XP_016862521 (OMIM: 609834) PREDICTED: histone-lys ( 479) 3285 612.5 1.1e-174 NP_001230652 (OMIM: 609834) histone-lysine N-methy ( 545) 2640 494.4 4.6e-139 NP_001307605 (OMIM: 609834) histone-lysine N-methy ( 406) 2625 491.6 2.4e-138 XP_006713355 (OMIM: 609834) PREDICTED: histone-lys ( 448) 2625 491.6 2.6e-138 NP_001307606 (OMIM: 609834) histone-lysine N-methy ( 428) 2591 485.4 1.9e-136 XP_006713357 (OMIM: 609834) PREDICTED: histone-lys ( 428) 2591 485.4 1.9e-136 NP_001263254 (OMIM: 609834) histone-lysine N-methy ( 365) 2423 454.6 3.1e-127 NP_001307607 (OMIM: 609834) histone-lysine N-methy ( 396) 2397 449.8 8.9e-126 XP_011544282 (OMIM: 605847) PREDICTED: B-cell CLL/ ( 293) 527 107.2 8.9e-23 XP_011517964 (OMIM: 606503) PREDICTED: histone-lys ( 350) 483 99.2 2.7e-20 NP_001180354 (OMIM: 606503) histone-lysine N-methy ( 350) 483 99.2 2.7e-20 XP_006717566 (OMIM: 606503) PREDICTED: histone-lys ( 350) 483 99.2 2.7e-20 XP_016872126 (OMIM: 606503) PREDICTED: histone-lys ( 350) 483 99.2 2.7e-20 NP_078946 (OMIM: 606503) histone-lysine N-methyltr ( 350) 483 99.2 2.7e-20 NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 483 99.3 3.1e-20 NP_003164 (OMIM: 300254) histone-lysine N-methyltr ( 412) 467 96.4 2.4e-19 NP_001269095 (OMIM: 300254) histone-lysine N-methy ( 423) 467 96.4 2.4e-19 NP_001305762 (OMIM: 604599) histone-lysine N-methy (1008) 399 84.2 2.7e-15 NP_079532 (OMIM: 604599) histone-lysine N-methyltr (1176) 399 84.2 3e-15 XP_016865691 (OMIM: 604599) PREDICTED: histone-lys (1183) 399 84.2 3e-15 NP_006700 (OMIM: 604599) histone-lysine N-methyltr (1210) 399 84.2 3.1e-15 XP_006715039 (OMIM: 604599) PREDICTED: histone-lys (1217) 399 84.2 3.1e-15 NP_001276342 (OMIM: 604599) histone-lysine N-methy (1233) 399 84.3 3.1e-15 XP_006715038 (OMIM: 604599) PREDICTED: histone-lys (1240) 399 84.3 3.1e-15 XP_005248881 (OMIM: 604599) PREDICTED: histone-lys (1267) 399 84.3 3.2e-15 XP_006715037 (OMIM: 604599) PREDICTED: histone-lys (1274) 399 84.3 3.2e-15 XP_011517333 (OMIM: 607001,610253) PREDICTED: hist ( 488) 392 82.7 3.7e-15 XP_011517332 (OMIM: 607001,610253) PREDICTED: hist ( 559) 392 82.7 4.1e-15 XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 392 82.8 5.3e-15 XP_011517335 (OMIM: 607001,610253) PREDICTED: hist (1246) 392 83.0 7.6e-15 XP_011517328 (OMIM: 607001,610253) PREDICTED: hist (1253) 392 83.0 7.7e-15 XP_016870626 (OMIM: 607001,610253) PREDICTED: hist (1260) 392 83.0 7.7e-15 XP_016870627 (OMIM: 607001,610253) PREDICTED: hist (1260) 392 83.0 7.7e-15 XP_016870625 (OMIM: 607001,610253) PREDICTED: hist (1265) 392 83.0 7.7e-15 XP_005266167 (OMIM: 607001,610253) PREDICTED: hist (1267) 392 83.0 7.7e-15 XP_011517327 (OMIM: 607001,610253) PREDICTED: hist (1267) 392 83.0 7.7e-15 XP_011517326 (OMIM: 607001,610253) PREDICTED: hist (1275) 392 83.0 7.8e-15 XP_016870624 (OMIM: 607001,610253) PREDICTED: hist (1291) 392 83.0 7.9e-15 XP_006717351 (OMIM: 607001,610253) PREDICTED: hist (1292) 392 83.0 7.9e-15 XP_016870623 (OMIM: 607001,610253) PREDICTED: hist (1293) 392 83.0 7.9e-15 XP_011517325 (OMIM: 607001,610253) PREDICTED: hist (1294) 392 83.0 7.9e-15 XP_005266162 (OMIM: 607001,610253) PREDICTED: hist (1295) 392 83.0 7.9e-15 NP_079033 (OMIM: 607001,610253) histone-lysine N-m (1298) 392 83.0 7.9e-15 XP_011517324 (OMIM: 607001,610253) PREDICTED: hist (1300) 392 83.0 7.9e-15 XP_011517323 (OMIM: 607001,610253) PREDICTED: hist (1301) 392 83.0 7.9e-15 XP_011508072 (OMIM: 607999) PREDICTED: histone-lys (1244) 310 68.0 2.5e-10 XP_016857277 (OMIM: 607999) PREDICTED: histone-lys (1244) 310 68.0 2.5e-10 XP_016857275 (OMIM: 607999) PREDICTED: histone-lys (2663) 310 68.2 4.6e-10 XP_006711515 (OMIM: 607999) PREDICTED: histone-lys (2904) 310 68.2 4.9e-10 >>NP_006506 (OMIM: 609834) histone-lysine N-methyltransf (684 aa) initn: 4769 init1: 4769 opt: 4769 Z-score: 4723.7 bits: 884.5 E(85289): 0 Smith-Waterman score: 4769; 100.0% identity (100.0% similar) in 684 aa overlap (1-684:1-684) 10 20 30 40 50 60 pF1KE1 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 IEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 LRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 GLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 KLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDF 610 620 630 640 650 660 670 680 pF1KE1 YATGINQLISRWQKCVDCNGSYFD :::::::::::::::::::::::: NP_006 YATGINQLISRWQKCVDCNGSYFD 670 680 >>XP_016862521 (OMIM: 609834) PREDICTED: histone-lysine (479 aa) initn: 3285 init1: 3285 opt: 3285 Z-score: 3256.9 bits: 612.5 E(85289): 1.1e-174 Smith-Waterman score: 3285; 100.0% identity (100.0% similar) in 479 aa overlap (206-684:1-479) 180 190 200 210 220 230 pF1KE1 SEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPV :::::::::::::::::::::::::::::: XP_016 METFVDPTYIGNIGRFLNHSCEPNLLMIPV 10 20 30 240 250 260 270 280 290 pF1KE1 RIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCT 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE1 AFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIF 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE1 LFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDND 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE1 QLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEV 220 230 240 250 260 270 480 490 500 510 520 530 pF1KE1 SSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTI 280 290 300 310 320 330 540 550 560 570 580 590 pF1KE1 WWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVA 340 350 360 370 380 390 600 610 620 630 640 650 pF1KE1 QPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVES 400 410 420 430 440 450 660 670 680 pF1KE1 QSTDFYATGINQLISRWQKCVDCNGSYFD ::::::::::::::::::::::::::::: XP_016 QSTDFYATGINQLISRWQKCVDCNGSYFD 460 470 >>NP_001230652 (OMIM: 609834) histone-lysine N-methyltra (545 aa) initn: 3812 init1: 2625 opt: 2640 Z-score: 2617.7 bits: 494.4 E(85289): 4.6e-139 Smith-Waterman score: 3538; 79.7% identity (79.7% similar) in 684 aa overlap (1-684:1-545) 10 20 30 40 50 60 pF1KE1 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR :::::::::::::::::::::::::::::::::::::::::: NP_001 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKG------------------ 130 140 150 160 190 200 210 220 230 240 pF1KE1 RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE1 VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE1 DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -SSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK 170 180 190 200 210 220 370 380 390 400 410 420 pF1KE1 MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI 230 240 250 260 270 280 430 440 450 460 470 480 pF1KE1 IEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLI 290 300 310 320 330 340 490 500 510 520 530 540 pF1KE1 LRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAA 350 360 370 380 390 400 550 560 570 580 590 600 pF1KE1 GLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQ 410 420 430 440 450 460 610 620 630 640 650 660 pF1KE1 KLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDF 470 480 490 500 510 520 670 680 pF1KE1 YATGINQLISRWQKCVDCNGSYFD :::::::::::::::::::::::: NP_001 YATGINQLISRWQKCVDCNGSYFD 530 540 >>NP_001307605 (OMIM: 609834) histone-lysine N-methyltra (406 aa) initn: 2625 init1: 2625 opt: 2625 Z-score: 2604.6 bits: 491.6 E(85289): 2.4e-138 Smith-Waterman score: 2625; 100.0% identity (100.0% similar) in 383 aa overlap (302-684:24-406) 280 290 300 310 320 330 pF1KE1 SEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVF :::::::::::::::::::::::::::::: NP_001 MSRAARKTCRWARGPRGPRRRPSSSLYCPVEKSNISCGNEKEPSMCGSAPSVF 10 20 30 40 50 340 350 360 370 380 390 pF1KE1 PSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFK 60 70 80 90 100 110 400 410 420 430 440 450 pF1KE1 KFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIG 120 130 140 150 160 170 460 470 480 490 500 510 pF1KE1 KVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQW 180 190 200 210 220 230 520 530 540 550 560 570 pF1KE1 LDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQ 240 250 260 270 280 290 580 590 600 610 620 630 pF1KE1 RLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLN 300 310 320 330 340 350 640 650 660 670 680 pF1KE1 NFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD 360 370 380 390 400 >>XP_006713355 (OMIM: 609834) PREDICTED: histone-lysine (448 aa) initn: 2625 init1: 2625 opt: 2625 Z-score: 2604.0 bits: 491.6 E(85289): 2.6e-138 Smith-Waterman score: 2625; 100.0% identity (100.0% similar) in 383 aa overlap (302-684:66-448) 280 290 300 310 320 330 pF1KE1 SEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVF :::::::::::::::::::::::::::::: XP_006 NLAFCPVLSSELKEASRGESFTSLVSGVSHSSLYCPVEKSNISCGNEKEPSMCGSAPSVF 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE1 PSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFK 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE1 KFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIG 160 170 180 190 200 210 460 470 480 490 500 510 pF1KE1 KVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQW 220 230 240 250 260 270 520 530 540 550 560 570 pF1KE1 LDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQ 280 290 300 310 320 330 580 590 600 610 620 630 pF1KE1 RLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLN 340 350 360 370 380 390 640 650 660 670 680 pF1KE1 NFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD 400 410 420 430 440 >>NP_001307606 (OMIM: 609834) histone-lysine N-methyltra (428 aa) initn: 2580 init1: 2580 opt: 2591 Z-score: 2570.6 bits: 485.4 E(85289): 1.9e-136 Smith-Waterman score: 2591; 96.0% identity (97.0% similar) in 398 aa overlap (287-684:33-428) 260 270 280 290 300 310 pF1KE1 ELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCG : :. :.:.. :: :::::::: NP_001 SLFLNAMSCADAVTTAETEWSRKVYSSTSKCSRRIKKAGDFVPWN--LYRKEEKSNISCG 10 20 30 40 50 60 320 330 340 350 360 370 pF1KE1 NEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAF 70 80 90 100 110 120 380 390 400 410 420 430 pF1KE1 GPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEEL 130 140 150 160 170 180 440 450 460 470 480 490 pF1KE1 NVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCD 190 200 210 220 230 240 500 510 520 530 540 550 pF1KE1 EKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITS 250 260 270 280 290 300 560 570 580 590 600 610 pF1KE1 EKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYS 310 320 330 340 350 360 620 630 640 650 660 670 pF1KE1 PDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCV 370 380 390 400 410 420 680 pF1KE1 DCNGSYFD :::::::: NP_001 DCNGSYFD >>XP_006713357 (OMIM: 609834) PREDICTED: histone-lysine (428 aa) initn: 2580 init1: 2580 opt: 2591 Z-score: 2570.6 bits: 485.4 E(85289): 1.9e-136 Smith-Waterman score: 2591; 96.0% identity (97.0% similar) in 398 aa overlap (287-684:33-428) 260 270 280 290 300 310 pF1KE1 ELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCG : :. :.:.. :: :::::::: XP_006 SLFLNAMSCADAVTTAETEWSRKVYSSTSKCSRRIKKAGDFVPWN--LYRKEEKSNISCG 10 20 30 40 50 60 320 330 340 350 360 370 pF1KE1 NEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAF 70 80 90 100 110 120 380 390 400 410 420 430 pF1KE1 GPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEEL 130 140 150 160 170 180 440 450 460 470 480 490 pF1KE1 NVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NVNHSTVVRHLKQIGKVKKLDKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCD 190 200 210 220 230 240 500 510 520 530 540 550 pF1KE1 EKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKWILYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITS 250 260 270 280 290 300 560 570 580 590 600 610 pF1KE1 EKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYS 310 320 330 340 350 360 620 630 640 650 660 670 pF1KE1 PDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PDLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCV 370 380 390 400 410 420 680 pF1KE1 DCNGSYFD :::::::: XP_006 DCNGSYFD >>NP_001263254 (OMIM: 609834) histone-lysine N-methyltra (365 aa) initn: 2418 init1: 2418 opt: 2423 Z-score: 2405.3 bits: 454.6 E(85289): 3.1e-127 Smith-Waterman score: 2423; 98.0% identity (99.4% similar) in 349 aa overlap (1-349:1-348) 10 20 30 40 50 60 pF1KE1 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLPVGAWPPGAAPAPFQYTPDHVVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGADIDPTQITFPGCICVKTPCLPGTCSCLRHGENYDDNSCLRDIGSGGKYAEPVFECNV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIHLQTKSDSNYIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFLPF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLETMKMMLDKKQIRAIFLFEFK :::::::::::::::::::::::::::::::::::::::: .... ::. NP_001 DSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLTLE-VSLFSDKQLAPPYSGRQWL 310 320 330 340 350 370 380 390 400 410 420 pF1KE1 MGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDESLEDEERSGRPSEVDNDQLRAI NP_001 ASFTSA 360 >>NP_001307607 (OMIM: 609834) histone-lysine N-methyltra (396 aa) initn: 2354 init1: 2354 opt: 2397 Z-score: 2379.1 bits: 449.8 E(85289): 8.9e-126 Smith-Waterman score: 2397; 93.4% identity (96.3% similar) in 378 aa overlap (307-684:24-396) 280 290 300 310 320 330 pF1KE1 RLDHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKR :.:. ...::.:. : :. : :. NP_001 MFAEAAKTTRPCGMAEFKEKPEAPTEQLDVACGQENLP--VGAWP---PGAAP 10 20 30 40 340 350 360 370 380 390 pF1KE1 LTLETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKG ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APFQTMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKG 50 60 70 80 90 100 400 410 420 430 440 450 pF1KE1 DESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DESLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKL 110 120 130 140 150 160 460 470 480 490 500 510 pF1KE1 DKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKWVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEE 170 180 190 200 210 220 520 530 540 550 560 570 pF1KE1 APKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLA 230 240 250 260 270 280 580 590 600 610 620 630 pF1KE1 LVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVNRKGPILLHDNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNYHVFKHLNNFLQG 290 300 310 320 330 340 640 650 660 670 680 pF1KE1 KRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRFHNQQDAENAFQEFVESQSTDFYATGINQLISRWQKCVDCNGSYFD 350 360 370 380 390 >>XP_011544282 (OMIM: 605847) PREDICTED: B-cell CLL/lymp (293 aa) initn: 511 init1: 511 opt: 527 Z-score: 529.9 bits: 107.2 E(85289): 8.9e-23 Smith-Waterman score: 527; 65.1% identity (82.9% similar) in 129 aa overlap (309-437:148-273) 280 290 300 310 320 330 pF1KE1 DHGKLRKPCYCGAKSCTAFLPFDSSLYCPVEKSNISCGNEKEPSMCGSAPSVFPSCKRLT . ..:. :. :: : . : : . : XP_011 TPQPSRPVSPAGPPEGVPEEAQPPRLGQERDPGGITAGSTDEPPMLTKEEPV-P--ELLE 120 130 140 150 160 170 340 350 360 370 380 390 pF1KE1 LETMKMMLDKKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGDE :::.::::::::.::::::.:::.::.:: :::::..:::::::. :::::::::: :. XP_011 AETMEMMLDKKQIQAIFLFELKMGHKAVETLRNINNTLGPGTANEHIVQWWFKKFCKEDK 180 190 200 210 220 230 400 410 420 430 440 450 pF1KE1 SLEDEERSGRPSEVDNDQLRAIIEADPLTTTREVAEELNVNHSTVVRHLKQIGKVKKLDK :::::..: :::::::::.:.:::::. ::.:::.::: XP_011 SLEDEKHSVWPSEVDNDQLKALIEADPVKTTQEVAQELNHRPFYGRLAFEANWKGEKAQ 240 250 260 270 280 290 460 470 480 490 500 510 pF1KE1 WVPHELTENQKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAP 684 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:58:06 2016 done: Mon Nov 7 03:58:08 2016 Total Scan time: 10.970 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]