FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5056, 557 aa 1>>>pF1KB5056 557 - 557 aa - 557 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3031+/-0.000345; mu= 16.3309+/- 0.022 mean_var=148.3007+/-31.337, 0's: 0 Z-trim(119.2): 104 B-trim: 1562 in 1/57 Lambda= 0.105318 statistics sampled from 32772 (32900) to 32772 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.386), width: 16 Scan time: 11.300 The best scores are: opt bits E(85289) XP_005270326 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 557) 3853 597.3 4e-170 NP_004201 (OMIM: 603804) E3 ubiquitin-protein liga ( 574) 3786 587.2 4.8e-167 XP_011538635 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 556) 3784 586.9 5.7e-167 XP_016872398 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 580) 3781 586.4 8.1e-167 XP_011538634 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 594) 3781 586.4 8.2e-167 XP_011538633 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 612) 3781 586.5 8.4e-167 XP_005270327 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 499) 3432 533.3 6.7e-151 XP_011538637 (OMIM: 603804) PREDICTED: E3 ubiquiti ( 290) 1317 211.7 2.6e-54 NP_001136123 (OMIM: 615893) E3 ubiquitin-protein l ( 555) 962 158.1 6.8e-38 NP_001295106 (OMIM: 615893) E3 ubiquitin-protein l ( 373) 913 150.4 9.1e-36 NP_001295107 (OMIM: 615893) E3 ubiquitin-protein l ( 315) 591 101.4 4.4e-21 XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 339) 194 41.1 0.0066 >>XP_005270326 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (557 aa) initn: 3853 init1: 3853 opt: 3853 Z-score: 3175.2 bits: 597.3 E(85289): 4e-170 Smith-Waterman score: 3853; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 HGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 VDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 GTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 APNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACC 490 500 510 520 530 540 550 pF1KB5 PICRRPIKDIIKTYRSS ::::::::::::::::: XP_005 PICRRPIKDIIKTYRSS 550 >>NP_004201 (OMIM: 603804) E3 ubiquitin-protein ligase N (574 aa) initn: 3786 init1: 3786 opt: 3786 Z-score: 3120.1 bits: 587.2 E(85289): 4.8e-167 Smith-Waterman score: 3786; 99.8% identity (100.0% similar) in 548 aa overlap (10-557:27-574) 10 20 30 40 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPA :.:::::::::::::::::::::::::::::::: NP_004 MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 TPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 LRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFH 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 RINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLR 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 READDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 READDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 AGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTC 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB5 DPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGM 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB5 QLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDP 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB5 LLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMC 490 500 510 520 530 540 530 540 550 pF1KB5 LCYACGLRLKKALHACCPICRRPIKDIIKTYRSS :::::::::::::::::::::::::::::::::: NP_004 LCYACGLRLKKALHACCPICRRPIKDIIKTYRSS 550 560 570 >>XP_011538635 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (556 aa) initn: 3781 init1: 3781 opt: 3784 Z-score: 3118.6 bits: 586.9 E(85289): 5.7e-167 Smith-Waterman score: 3784; 98.7% identity (99.1% similar) in 556 aa overlap (5-557:1-556) 10 20 30 40 50 pF1KB5 MGGQITRSTLH---DSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQI .. : :: :::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNTSFLHLQPDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQI 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIH 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 RTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCD 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 LNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 RVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSP 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 EALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLF 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 GLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSA 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 GGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALH 480 490 500 510 520 530 540 550 pF1KB5 ACCPICRRPIKDIIKTYRSS :::::::::::::::::::: XP_011 ACCPICRRPIKDIIKTYRSS 540 550 >>XP_016872398 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (580 aa) initn: 3781 init1: 3781 opt: 3781 Z-score: 3115.9 bits: 586.4 E(85289): 8.1e-167 Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 546 aa overlap (12-557:35-580) 10 20 30 40 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL :::::::::::::::::::::::::::::: XP_016 HLYQTNIKRTGAVLLGSFPSARRVGLGSRADSIGGPFPVTSHRCHHKQKHCPAVLPSGGL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB5 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB5 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB5 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH 490 500 510 520 530 540 530 540 550 pF1KB5 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS :::::::::::::::::::::::::::::::::::: XP_016 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS 550 560 570 580 >>XP_011538634 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (594 aa) initn: 3781 init1: 3781 opt: 3781 Z-score: 3115.8 bits: 586.4 E(85289): 8.2e-167 Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 546 aa overlap (12-557:49-594) 10 20 30 40 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL :::::::::::::::::::::::::::::: XP_011 CDSPWKMLLESGHNSDPKRGFLDLMQEKIWDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB5 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT 320 330 340 350 360 370 350 360 370 380 390 400 pF1KB5 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB5 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB5 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH 500 510 520 530 540 550 530 540 550 pF1KB5 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS :::::::::::::::::::::::::::::::::::: XP_011 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS 560 570 580 590 >>XP_011538633 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (612 aa) initn: 3781 init1: 3781 opt: 3781 Z-score: 3115.6 bits: 586.5 E(85289): 8.4e-167 Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 546 aa overlap (12-557:67-612) 10 20 30 40 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL :::::::::::::::::::::::::::::: XP_011 CDSPWKMLLESGHNSDPKRGFLDLMQEKIWDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB5 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB5 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 160 170 180 190 200 210 170 180 190 200 210 220 pF1KB5 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KB5 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHA 280 290 300 310 320 330 290 300 310 320 330 340 pF1KB5 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVT 340 350 360 370 380 390 350 360 370 380 390 400 pF1KB5 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAA 400 410 420 430 440 450 410 420 430 440 450 460 pF1KB5 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLS 460 470 480 490 500 510 470 480 490 500 510 520 pF1KB5 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGH 520 530 540 550 560 570 530 540 550 pF1KB5 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS :::::::::::::::::::::::::::::::::::: XP_011 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS 580 590 600 610 >>XP_005270327 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (499 aa) initn: 3432 init1: 3432 opt: 3432 Z-score: 2830.1 bits: 533.3 E(85289): 6.7e-151 Smith-Waterman score: 3432; 100.0% identity (100.0% similar) in 499 aa overlap (59-557:1-499) 30 40 50 60 70 80 pF1KB5 QKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQ :::::::::::::::::::::::::::::: XP_005 MDLSHKAVKRQASFCNAITFSNRPVLIYEQ 10 20 30 90 100 110 120 130 140 pF1KB5 VRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB5 NIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDC 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB5 LRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRA 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB5 LPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRS 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB5 GGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNA 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB5 DGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPAS 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB5 TPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICY 400 410 420 430 440 450 510 520 530 540 550 pF1KB5 EHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS 460 470 480 490 >>XP_011538637 (OMIM: 603804) PREDICTED: E3 ubiquitin-pr (290 aa) initn: 1316 init1: 1316 opt: 1317 Z-score: 1096.1 bits: 211.7 E(85289): 2.6e-54 Smith-Waterman score: 1317; 90.6% identity (94.4% similar) in 213 aa overlap (12-218:67-279) 10 20 30 40 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL :::::::::::::::::::::::::::::: XP_011 CDSPWKMLLESGHNSDPKRGFLDLMQEKIWDSIGGPFPVTSHRCHHKQKHCPAVLPSGGL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB5 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB5 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRV 160 170 180 190 200 210 170 180 190 200 210 pF1KB5 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLL--DSELV---LPDC-LRPRSFT :::::::::::::::::::::::::::::::::::::: :.. :.: .. :.. XP_011 FHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLGLDTRQERGQWPSCAFQSRAYK 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB5 ALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDG . : XP_011 SSRHQGSTAHVGHR 280 290 >>NP_001136123 (OMIM: 615893) E3 ubiquitin-protein ligas (555 aa) initn: 1374 init1: 588 opt: 962 Z-score: 801.3 bits: 158.1 E(85289): 6.8e-38 Smith-Waterman score: 1493; 43.6% identity (67.5% similar) in 567 aa overlap (8-555:3-554) 10 20 30 40 50 pF1KB5 MGGQITRSTLHDSIGGPFPVTSHRCHHKQKHC-PAVLPSGGLPATPLLFHPHTKGSQILM .:.: .. : : . : . : :. : .: :: ..::... . NP_001 MGNTVHRTLPDPSPPA--RLLATRPCCGPGPERRPVLGEAPR-FHAQAKGKNVRL 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPD : . . :. ::::..::..::. .::::::... . ::::::.:::..::: . . NP_001 DGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFTAHDPSLMSAQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 SLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRT ..:::::::::.. :.:::::::..: . ...:.:.:..::::. .::. .:: :: . NP_001 DIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVNDGEPVLFHCGVAV 120 130 140 150 160 170 180 190 200 210 220 pF1KB5 ADPLWALVDVYGLTRGVQLLDS---ELVLPDCLRPRSFTALRRPSLR-------READDA . :::::.::::.: ::::.: . . : : :.: :: . : .. NP_001 GGPLWALIDVYGITDEVQLLESAFADTLTPARLSQARFSACLPPSSHDAANFDNNELENN 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 RLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVR .. ..: : . : : : ::. :: . . . . :: :..:::::: : : : NP_001 QVVAKLGHLALGRAPGPPPADAAAAAIPCGPRERPRPASSPALLEADLRFHATR-GPDVS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 ILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLR . .. :: . . :.:::. ::.: .:..::.: : : : ::::.::.:.::::.:: NP_001 LSADRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGVLR 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 PADLPFSPEALVDRKEFWAVCRVPGPLHSG-DILGLVVNADGELHLSHNGAAAGMQLCVD : .:: .:.::.::::.:.: :. ::. :: : :.... :.. :. :: : :::: NP_001 PNELPADPDALLDRKEYWVVARA-GPVPSGGDALSFTLRPGGDVLLGINGRPRGRLLCVD 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 ASQPLWMLFGLHGTIT-QIRILGSTILAERGIPSLPCSPASTPTSPSALGSRL---SDPL ..: :: .:...: .. :.:.::. : :::.: : : ::. :: NP_001 TTQALWAFFAVRGGVAGQLRLLGT----------LQSSPATTTPSGSLSGSQDDSDSDMT 420 430 440 450 460 470 480 490 500 510 520 pF1KB5 LSTCSSGPLGSSAGGTAPNSPVSLPESPV-TPG--LGQWSDECTICYEHAVDTVIYTCGH .:. .:. . :. :::.::.: : ::: .: : . :::.:.. :::::::::: NP_001 FSVNQSSSASESSLVTAPSSPLSPPVSPVFSPPEPAGIKNGECTVCFDGEVDTVIYTCGH 470 480 490 500 510 520 530 540 550 pF1KB5 MCLCYACGLRLKKALHACCPICRRPIKDIIKTYRSS ::::..::::::. .::::::::::::.:: :: NP_001 MCLCHSCGLRLKRQARACCPICRRPIKDVIKIYRP 530 540 550 >>NP_001295106 (OMIM: 615893) E3 ubiquitin-protein ligas (373 aa) initn: 852 init1: 406 opt: 913 Z-score: 763.1 bits: 150.4 E(85289): 9.1e-36 Smith-Waterman score: 929; 44.7% identity (66.3% similar) in 356 aa overlap (208-555:31-372) 180 190 200 210 220 230 pF1KB5 RTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCD :: : : : . : .. .. ..: NP_001 MGNTVHRTLPESAFADTLTPARLSQARFSACLPPSSHDAANFDN--NELENNQVVAKLGH 10 20 30 40 50 240 250 260 270 280 290 pF1KB5 LNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVA : . : : : ::. :: . . . . :: :..:::::: : : : . .. :: NP_001 LALGRAPGPPPADAAAAAIPCGPRERPRPASSPALLEADLRFHATR-GPDVSLSADRKVA 60 70 80 90 100 110 300 310 320 330 340 350 pF1KB5 RVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSP . . :.:::. ::.: .:..::.: : : : ::::.::.:.::::.::: .:: .: NP_001 CAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAAPGALAFGITSCDPGVLRPNELPADP 120 130 140 150 160 170 360 370 380 390 400 410 pF1KB5 EALVDRKEFWAVCRVPGPLHSG-DILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWML .::.::::.:.: :. ::. :: : :.... :.. :. :: : ::::..: :: . NP_001 DALLDRKEYWVVARA-GPVPSGGDALSFTLRPGGDVLLGINGRPRGRLLCVDTTQALWAF 180 190 200 210 220 230 420 430 440 450 460 470 pF1KB5 FGLHGTIT-QIRILGSTILAERGIPSLPCSPASTPTSPSALGSRL---SDPLLSTCSSGP :...: .. :.:.::. : :::.: : : ::. :: .:. .:. NP_001 FAVRGGVAGQLRLLGT----------LQSSPATTTPSGSLSGSQDDSDSDMTFSVNQSSS 240 250 260 270 280 480 490 500 510 520 pF1KB5 LGSSAGGTAPNSPVSLPESPV-TPG--LGQWSDECTICYEHAVDTVIYTCGHMCLCYACG . :. :::.::.: : ::: .: : . :::.:.. ::::::::::::::..:: NP_001 ASESSLVTAPSSPLSPPVSPVFSPPEPAGIKNGECTVCFDGEVDTVIYTCGHMCLCHSCG 290 300 310 320 330 340 530 540 550 pF1KB5 LRLKKALHACCPICRRPIKDIIKTYRSS ::::. .::::::::::::.:: :: NP_001 LRLKRQARACCPICRRPIKDVIKIYRP 350 360 370 557 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:04:27 2016 done: Mon Nov 7 04:04:28 2016 Total Scan time: 11.300 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]