FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9259, 1210 aa 1>>>pF1KE9259 1210 - 1210 aa - 1210 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4619+/-0.000477; mu= -9.8166+/- 0.030 mean_var=483.1301+/-96.831, 0's: 0 Z-trim(123.0): 557 B-trim: 0 in 0/59 Lambda= 0.058350 statistics sampled from 41469 (42131) to 41469 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.494), width: 16 Scan time: 17.300 The best scores are: opt bits E(85289) NP_006700 (OMIM: 604599) histone-lysine N-methyltr (1210) 8278 712.6 3.9e-204 XP_006715039 (OMIM: 604599) PREDICTED: histone-lys (1217) 8254 710.5 1.6e-203 XP_005248881 (OMIM: 604599) PREDICTED: histone-lys (1267) 8205 706.4 2.9e-202 XP_006715037 (OMIM: 604599) PREDICTED: histone-lys (1274) 8181 704.4 1.2e-201 NP_001305762 (OMIM: 604599) histone-lysine N-methy (1008) 6869 593.9 1.7e-168 NP_079532 (OMIM: 604599) histone-lysine N-methyltr (1176) 5613 488.2 1.3e-136 NP_001276342 (OMIM: 604599) histone-lysine N-methy (1233) 5613 488.2 1.4e-136 XP_016865691 (OMIM: 604599) PREDICTED: histone-lys (1183) 5589 486.2 5.3e-136 XP_006715038 (OMIM: 604599) PREDICTED: histone-lys (1240) 5589 486.2 5.5e-136 XP_016870625 (OMIM: 607001,610253) PREDICTED: hist (1265) 3780 333.9 3.9e-90 XP_016870627 (OMIM: 607001,610253) PREDICTED: hist (1260) 3764 332.6 9.9e-90 XP_016870626 (OMIM: 607001,610253) PREDICTED: hist (1260) 3764 332.6 9.9e-90 XP_011517327 (OMIM: 607001,610253) PREDICTED: hist (1267) 3764 332.6 9.9e-90 XP_005266167 (OMIM: 607001,610253) PREDICTED: hist (1267) 3764 332.6 9.9e-90 XP_016870624 (OMIM: 607001,610253) PREDICTED: hist (1291) 3764 332.6 1e-89 XP_006717351 (OMIM: 607001,610253) PREDICTED: hist (1292) 3764 332.6 1e-89 XP_016870623 (OMIM: 607001,610253) PREDICTED: hist (1293) 3764 332.6 1e-89 XP_011517325 (OMIM: 607001,610253) PREDICTED: hist (1294) 3764 332.6 1e-89 XP_005266162 (OMIM: 607001,610253) PREDICTED: hist (1295) 3764 332.6 1e-89 NP_079033 (OMIM: 607001,610253) histone-lysine N-m (1298) 3764 332.6 1e-89 XP_011517324 (OMIM: 607001,610253) PREDICTED: hist (1300) 3764 332.6 1e-89 XP_011517323 (OMIM: 607001,610253) PREDICTED: hist (1301) 3764 332.6 1e-89 XP_011517326 (OMIM: 607001,610253) PREDICTED: hist (1275) 3754 331.7 1.8e-89 XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 3450 306.0 6.3e-82 XP_011517335 (OMIM: 607001,610253) PREDICTED: hist (1246) 3129 279.1 1.2e-73 XP_011517328 (OMIM: 607001,610253) PREDICTED: hist (1253) 3111 277.6 3.5e-73 XP_011517332 (OMIM: 607001,610253) PREDICTED: hist ( 559) 2483 224.4 1.6e-57 XP_011517333 (OMIM: 607001,610253) PREDICTED: hist ( 488) 2410 218.2 1e-55 XP_011517329 (OMIM: 607001,610253) PREDICTED: hist ( 930) 1748 162.8 9.7e-39 NP_001138999 (OMIM: 607001,610253) histone-lysine ( 808) 1207 117.2 4.5e-25 XP_011517330 (OMIM: 607001,610253) PREDICTED: hist ( 811) 1207 117.2 4.5e-25 XP_006717566 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08 NP_001180354 (OMIM: 606503) histone-lysine N-methy ( 350) 535 60.3 2.6e-08 XP_011517964 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08 XP_016872126 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08 NP_078946 (OMIM: 606503) histone-lysine N-methyltr ( 350) 535 60.3 2.6e-08 NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 535 60.3 2.9e-08 NP_003164 (OMIM: 300254) histone-lysine N-methyltr ( 412) 531 60.0 3.7e-08 NP_001269095 (OMIM: 300254) histone-lysine N-methy ( 423) 531 60.0 3.8e-08 NP_001263254 (OMIM: 609834) histone-lysine N-methy ( 365) 399 48.8 7.5e-05 NP_055757 (OMIM: 610583) ankyrin repeat domain-con ( 722) 400 49.2 0.00012 NP_001229740 (OMIM: 610583) ankyrin repeat domain- ( 727) 400 49.2 0.00012 XP_005248738 (OMIM: 610583) PREDICTED: ankyrin rep ( 727) 400 49.2 0.00012 NP_001229738 (OMIM: 610583) ankyrin repeat domain- ( 727) 400 49.2 0.00012 NP_006506 (OMIM: 609834) histone-lysine N-methyltr ( 684) 399 49.1 0.00012 XP_016865987 (OMIM: 610583) PREDICTED: ankyrin rep ( 687) 389 48.2 0.00021 NP_001229742 (OMIM: 610583) ankyrin repeat domain- ( 692) 389 48.2 0.00022 NP_001305310 (OMIM: 243305,602088) inversin isofor ( 969) 381 47.7 0.00044 XP_011533901 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 376 47.1 0.00046 NP_055240 (OMIM: 243305,602088) inversin isoform a (1065) 381 47.7 0.00047 >>NP_006700 (OMIM: 604599) histone-lysine N-methyltransf (1210 aa) initn: 8278 init1: 8278 opt: 8278 Z-score: 3785.8 bits: 712.6 E(85289): 3.9e-204 Smith-Waterman score: 8278; 100.0% identity (100.0% similar) in 1210 aa overlap (1-1210:1-1210) 10 20 30 40 50 60 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE9 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE9 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE9 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE9 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1150 1160 1170 1180 1190 1200 1210 pF1KE9 ELGSLPPVNT :::::::::: NP_006 ELGSLPPVNT 1210 >>XP_006715039 (OMIM: 604599) PREDICTED: histone-lysine (1217 aa) initn: 8264 init1: 5490 opt: 8254 Z-score: 3774.9 bits: 710.5 E(85289): 1.6e-203 Smith-Waterman score: 8254; 99.4% identity (99.4% similar) in 1217 aa overlap (1-1210:1-1217) 10 20 30 40 50 60 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 730 740 750 760 770 780 790 800 810 820 830 pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAAI :::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_006 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAI 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE9 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE9 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE9 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE9 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE9 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE9 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD 1150 1160 1170 1180 1190 1200 1200 1210 pF1KE9 PHPELLPELGSLPPVNT ::::::::::::::::: XP_006 PHPELLPELGSLPPVNT 1210 >>XP_005248881 (OMIM: 604599) PREDICTED: histone-lysine (1267 aa) initn: 8205 init1: 8205 opt: 8205 Z-score: 3752.4 bits: 706.4 E(85289): 2.9e-202 Smith-Waterman score: 8205; 99.8% identity (100.0% similar) in 1198 aa overlap (13-1210:70-1267) 10 20 30 40 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG ..:::::::::::::::::::::::::::: XP_005 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA 460 470 480 490 500 510 470 480 490 500 510 520 pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA 520 530 540 550 560 570 530 540 550 560 570 580 pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS 580 590 600 610 620 630 590 600 610 620 630 640 pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE 640 650 660 670 680 690 650 660 670 680 690 700 pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 700 710 720 730 740 750 710 720 730 740 750 760 pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 760 770 780 790 800 810 770 780 790 800 810 820 pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL 820 830 840 850 860 870 830 840 850 860 870 880 pF1KE9 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 880 890 900 910 920 930 890 900 910 920 930 940 pF1KE9 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD 940 950 960 970 980 990 950 960 970 980 990 1000 pF1KE9 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL 1000 1010 1020 1030 1040 1050 1010 1020 1030 1040 1050 1060 pF1KE9 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT 1060 1070 1080 1090 1100 1110 1070 1080 1090 1100 1110 1120 pF1KE9 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV 1120 1130 1140 1150 1160 1170 1130 1140 1150 1160 1170 1180 pF1KE9 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI 1180 1190 1200 1210 1220 1230 1190 1200 1210 pF1KE9 ALEQSRLARLDPHPELLPELGSLPPVNT :::::::::::::::::::::::::::: XP_005 ALEQSRLARLDPHPELLPELGSLPPVNT 1240 1250 1260 >>XP_006715037 (OMIM: 604599) PREDICTED: histone-lysine (1274 aa) initn: 8191 init1: 5417 opt: 8181 Z-score: 3741.4 bits: 704.4 E(85289): 1.2e-201 Smith-Waterman score: 8181; 99.3% identity (99.4% similar) in 1205 aa overlap (13-1210:70-1274) 10 20 30 40 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG ..:::::::::::::::::::::::::::: XP_006 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA 460 470 480 490 500 510 470 480 490 500 510 520 pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA 520 530 540 550 560 570 530 540 550 560 570 580 pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS 580 590 600 610 620 630 590 600 610 620 630 640 pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE 640 650 660 670 680 690 650 660 670 680 690 700 pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 700 710 720 730 740 750 710 720 730 740 750 760 pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 760 770 780 790 800 810 770 780 790 800 810 pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLV 820 830 840 850 860 870 820 830 840 850 860 870 pF1KE9 -EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 880 890 900 910 920 930 880 890 900 910 920 930 pF1KE9 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI 940 950 960 970 980 990 940 950 960 970 980 990 pF1KE9 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW 1000 1010 1020 1030 1040 1050 1000 1010 1020 1030 1040 1050 pF1KE9 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL 1060 1070 1080 1090 1100 1110 1060 1070 1080 1090 1100 1110 pF1KE9 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC 1120 1130 1140 1150 1160 1170 1120 1130 1140 1150 1160 1170 pF1KE9 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC 1180 1190 1200 1210 1220 1230 1180 1190 1200 1210 pF1KE9 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT ::::::::::::::::::::::::::::::::::: XP_006 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT 1240 1250 1260 1270 >>NP_001305762 (OMIM: 604599) histone-lysine N-methyltra (1008 aa) initn: 6879 init1: 4105 opt: 6869 Z-score: 3145.8 bits: 593.9 E(85289): 1.7e-168 Smith-Waterman score: 6869; 99.3% identity (99.3% similar) in 1008 aa overlap (210-1210:1-1008) 180 190 200 210 220 230 pF1KE9 VHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEE :::::::::::::::::::::::::::::: NP_001 MSDDVHSLGKVTSDLAKRRKLNSGGGLSEE 10 20 30 240 250 260 270 280 290 pF1KE9 LGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLS 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE9 RKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERG 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE9 FEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMV 220 230 240 250 260 270 480 490 500 510 520 530 pF1KE9 LCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED 280 290 300 310 320 330 540 550 560 570 580 590 pF1KE9 ASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPL 340 350 360 370 380 390 600 610 620 630 640 650 pF1KE9 ADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVK 400 410 420 430 440 450 660 670 680 690 700 710 pF1KE9 QGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR 460 470 480 490 500 510 720 730 740 750 760 770 pF1KE9 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 520 530 540 550 560 570 780 790 800 810 820 830 pF1KE9 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAA ::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAA 580 590 600 610 620 630 840 850 860 870 880 890 pF1KE9 IAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP 640 650 660 670 680 690 900 910 920 930 940 950 pF1KE9 ERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKY 700 710 720 730 740 750 960 970 980 990 1000 1010 pF1KE9 ISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPP 760 770 780 790 800 810 1020 1030 1040 1050 1060 1070 pF1KE9 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI 820 830 840 850 860 870 1080 1090 1100 1110 1120 1130 pF1KE9 SDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLR 880 890 900 910 920 930 1140 1150 1160 1170 1180 1190 pF1KE9 FPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARL 940 950 960 970 980 990 1200 1210 pF1KE9 DPHPELLPELGSLPPVNT :::::::::::::::::: NP_001 DPHPELLPELGSLPPVNT 1000 >>NP_079532 (OMIM: 604599) histone-lysine N-methyltransf (1176 aa) initn: 5613 init1: 5613 opt: 5613 Z-score: 2573.5 bits: 488.2 E(85289): 1.3e-136 Smith-Waterman score: 7974; 97.2% identity (97.2% similar) in 1210 aa overlap (1-1210:1-1176) 10 20 30 40 50 60 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF ::::::::::::: ::::::::::::: NP_079 KREPPRAKEPRGV----------------------------------SNDTSSLETERGF 370 380 430 440 450 460 470 480 pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 690 700 710 720 730 740 790 800 810 820 830 840 pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA 750 760 770 780 790 800 850 860 870 880 890 900 pF1KE9 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA 810 820 830 840 850 860 910 920 930 940 950 960 pF1KE9 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS 870 880 890 900 910 920 970 980 990 1000 1010 1020 pF1KE9 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA 930 940 950 960 970 980 1030 1040 1050 1060 1070 1080 pF1KE9 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR 990 1000 1010 1020 1030 1040 1090 1100 1110 1120 1130 1140 pF1KE9 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS 1050 1060 1070 1080 1090 1100 1150 1160 1170 1180 1190 1200 pF1KE9 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP 1110 1120 1130 1140 1150 1160 1210 pF1KE9 ELGSLPPVNT :::::::::: NP_079 ELGSLPPVNT 1170 >>NP_001276342 (OMIM: 604599) histone-lysine N-methyltra (1233 aa) initn: 5613 init1: 5613 opt: 5613 Z-score: 2573.3 bits: 488.2 E(85289): 1.4e-136 Smith-Waterman score: 7901; 97.0% identity (97.2% similar) in 1198 aa overlap (13-1210:70-1233) 10 20 30 40 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG ..:::::::::::::::::::::::::::: NP_001 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP ::::::::::::::::::::::::::::::: NP_001 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGV----------------------------- 400 410 420 430 410 420 430 440 450 460 pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----SNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA 440 450 460 470 480 470 480 490 500 510 520 pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE9 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE9 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KE9 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KE9 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KE9 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KE9 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI 1150 1160 1170 1180 1190 1200 1190 1200 1210 pF1KE9 ALEQSRLARLDPHPELLPELGSLPPVNT :::::::::::::::::::::::::::: NP_001 ALEQSRLARLDPHPELLPELGSLPPVNT 1210 1220 1230 >>XP_016865691 (OMIM: 604599) PREDICTED: histone-lysine (1183 aa) initn: 5599 init1: 2825 opt: 5589 Z-score: 2562.6 bits: 486.2 E(85289): 5.3e-136 Smith-Waterman score: 7950; 96.6% identity (96.6% similar) in 1217 aa overlap (1-1210:1-1183) 10 20 30 40 50 60 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF ::::::::::::: ::::::::::::: XP_016 KREPPRAKEPRGV----------------------------------SNDTSSLETERGF 370 380 430 440 450 460 470 480 pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 630 640 650 660 670 680 730 740 750 760 770 780 pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA 690 700 710 720 730 740 790 800 810 820 830 pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAAI :::::::::::::::::::::::::::::::::::: ::::::::::::::::: XP_016 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAI 750 760 770 780 790 800 840 850 860 870 880 890 pF1KE9 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE 810 820 830 840 850 860 900 910 920 930 940 950 pF1KE9 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI 870 880 890 900 910 920 960 970 980 990 1000 1010 pF1KE9 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL 930 940 950 960 970 980 1020 1030 1040 1050 1060 1070 pF1KE9 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS 990 1000 1010 1020 1030 1040 1080 1090 1100 1110 1120 1130 pF1KE9 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF 1050 1060 1070 1080 1090 1100 1140 1150 1160 1170 1180 1190 pF1KE9 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD 1110 1120 1130 1140 1150 1160 1200 1210 pF1KE9 PHPELLPELGSLPPVNT ::::::::::::::::: XP_016 PHPELLPELGSLPPVNT 1170 1180 >>XP_006715038 (OMIM: 604599) PREDICTED: histone-lysine (1240 aa) initn: 5599 init1: 2825 opt: 5589 Z-score: 2562.3 bits: 486.2 E(85289): 5.5e-136 Smith-Waterman score: 7877; 96.4% identity (96.6% similar) in 1205 aa overlap (13-1210:70-1240) 10 20 30 40 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG ..:::::::::::::::::::::::::::: XP_006 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP ::::::::::::::::::::::::::::::: XP_006 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGV----------------------------- 400 410 420 430 410 420 430 440 450 460 pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 -----SNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA 440 450 460 470 480 470 480 490 500 510 520 pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 730 740 750 760 770 780 770 780 790 800 810 pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLV 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE9 -EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE9 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE9 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE9 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE9 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE9 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 pF1KE9 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT ::::::::::::::::::::::::::::::::::: XP_006 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT 1210 1220 1230 1240 >>XP_016870625 (OMIM: 607001,610253) PREDICTED: histone- (1265 aa) initn: 4011 init1: 2862 opt: 3780 Z-score: 1739.2 bits: 333.9 E(85289): 3.9e-90 Smith-Waterman score: 3825; 48.2% identity (72.8% similar) in 1261 aa overlap (1-1204:32-1258) 10 20 30 pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKET ::: :.: :.: :.:.: . :: XP_016 AAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGE----AHMAA---DGET 10 20 30 40 50 40 50 60 70 80 pF1KE9 RGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGA---DTPVGATP :. : .: :. . : : :: . ..:.. ... . ....:. :. .. XP_016 NGSCENSDAS------SHANAAKHTQDSAR-VNPQDGTNTLTRIAENGVSERDSEAAKQN 60 70 80 90 100 90 100 110 120 130 140 pF1KE9 LI-GDESENLEGDGDLRGGRILLGHATKSFP--SSPSKGGSCPSRAKMSMTG-AGKS-PP . .:. . :. .: :: : .. : .. . ..: :..: .. : :::. : XP_016 HVTADDFVQTSVIGS--NGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTP 110 120 130 140 150 160 150 160 170 180 190 200 pF1KE9 SVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRP : .. . . :.. : ..: .: .: .. ::::::::: : : . : : XP_016 S--AFPQTPAAPPATLGEGSADTEDRK-LPAPGADVKVHRARKTMPKSVVGLH-AASKDP 170 180 190 200 210 220 210 220 230 240 pF1KE9 PEIQHFR-MSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSA------------------ :... : .. . ..: ::..... : .: . : . XP_016 REVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTAAAVSRK 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE9 --RRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSY-SVDERVDSDSKSEVEALTEQLSE :: : .:. .. . .::. :. ... : :. . :. .:.. . ... XP_016 KKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDS 290 300 310 320 330 340 310 320 330 340 pF1KE9 EEEEEEEEEEEEEEEEEE------EEEEEDEESGNQSDRSGSSGRRKAKKKWRK-----D .:.. :: ::.. . :. :. . ..:: ...::. .:.. . :::. : : XP_016 DEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKSSESSIKKKFLKRKGKTD 350 360 370 380 390 400 350 360 370 380 390 pF1KE9 SPWVKPSRKRRKREPPRAKEPRGVNGV----GSSGPSE---------YMEVPLGSLELPS :::.::.::::.: :.: :. : .:.: .: :::: : ::.: XP_016 SPWIKPARKRRRRS---RKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRV 410 420 430 440 450 400 410 420 430 440 450 pF1KE9 EGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGEL .: :: . :..: . :::. :..:.::::::::.:: .:. :...:::::::: :: XP_016 KGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMATESVDHEL 460 470 480 490 500 510 460 470 480 490 500 510 pF1KE9 SGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVA . :. ...: : ::::... :.:::: ::.:::::.::::::::::::.:.::.:. .. XP_016 GRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSIS 520 530 540 550 560 570 520 530 540 550 560 570 pF1KE9 HRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PPLSQDVPGR ::::: :.:..:. .::::::..:.:.:::: ..: .. :..:.: .. . :: XP_016 HRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQEKGSALEGR 580 590 600 610 620 630 580 590 600 610 620 630 pF1KE9 ADTSQPSARMRGHGEPRRPPCDPLADTIDS--SGPSLTLPNGGCLSAVGLPLGPGREALE :::. :: : : : : . . : . : : : . :: :::.:.:: XP_016 ADTTTGSA----AGPPLSED-DKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLE 640 650 660 670 680 640 650 660 670 680 690 pF1KE9 KALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAA .::. .::. :::::::.:::.:..:::::::.:::.:..::::. ..:.::.:::::: XP_016 SALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAA 690 700 710 720 730 740 700 710 720 730 740 750 pF1KE9 QKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST . : :.:::.:.::::::.. ...::::::::. :::::...:... :. : :. .::: XP_016 EAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGST 750 760 770 780 790 800 760 770 780 790 800 810 pF1KE9 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL ::: ::: :. :.:. :::.::.::: ::.:::::.:::.:.::......::..:.:... XP_016 CLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINI 810 820 830 840 850 860 820 830 840 850 860 870 pF1KE9 TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR :::::::::::.:.: . :::.:: :.::::::: :::.::::::::. .:::.::::: XP_016 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 870 880 890 900 910 920 880 890 900 910 920 930 pF1KE9 GANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENV .. :.::::.: . . :.:: :::... :. .. .: .:.:. ::.::::: . XP_016 DSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERI 930 940 950 960 970 980 940 950 960 970 980 990 pF1KE9 PIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIR ::::::.::.:::: .:::.:.:: :: :::::::::::.:.:.::::::::.:::::.: XP_016 PIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMR 990 1000 1010 1020 1030 1040 1000 1010 1020 1030 1040 1050 pF1KE9 CWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVR :::::::::: ::: :::::::::.::::::::.:::::.:...::::::: :::::: XP_016 CWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVR 1050 1060 1070 1080 1090 1100 1060 1070 1080 1090 1100 1110 pF1KE9 ALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINH .:: :: :::.::::::::::.::::::.::::::::::::::::::::.:::.:::::: XP_016 SLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINH 1110 1120 1130 1140 1150 1160 1120 1130 1140 1150 1160 1170 pF1KE9 LCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSE :.::..:::::: :::::::::::::.: :..::.::::::.::::::.: :.:.::: XP_016 HCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSP 1170 1180 1190 1200 1210 1220 1180 1190 1200 1210 pF1KE9 KCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT ::.::. :.: .:. :. . . . ::. .: XP_016 KCRHSSAALAQRQASAAQ-EAQEDGLPDTSSAAAADPL 1230 1240 1250 1260 1210 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:22:13 2016 done: Sat Nov 5 22:22:16 2016 Total Scan time: 17.300 Total Display time: 0.520 Function used was FASTA [36.3.4 Apr, 2011]