Result of FASTA (omim) for
pFN21AB7183
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7183, 503 aa
1>>>pF1KB7183 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9619+/-0.000407; mu= 20.2867+/- 0.025
mean_var=64.5927+/-13.440, 0's: 0 Z-trim(111.3): 173 B-trim: 1026 in 1/49
Lambda= 0.159582
statistics sampled from 19678 (19869) to 19678 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.233), width: 16
Scan time: 9.550
The best scores are: opt bits E(85289)
NP_000489 (OMIM: 124080,203400,610600) cytochrome ( 503) 3385 788.4 0
NP_000488 (OMIM: 103900,202010,610613) cytochrome ( 503) 3144 732.9 5e-211
NP_001021384 (OMIM: 103900,202010,610613) cytochro ( 437) 2507 586.2 6.2e-167
XP_011515176 (OMIM: 103900,202010,610613) PREDICTE ( 529) 2305 539.8 7.3e-153
XP_011515177 (OMIM: 103900,202010,610613) PREDICTE ( 528) 1497 353.8 7.2e-97
NP_000772 (OMIM: 118485,613743) cholesterol side-c ( 521) 1198 284.9 3.8e-76
XP_016868635 (OMIM: 103900,202010,610613) PREDICTE ( 282) 944 226.3 9.3e-59
NP_001093243 (OMIM: 118485,613743) cholesterol sid ( 363) 872 209.8 1.1e-53
NP_000776 (OMIM: 264700,609506) 25-hydroxyvitamin ( 508) 746 180.9 7.8e-45
XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 736 178.6 3.9e-44
XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 736 178.6 3.9e-44
NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvita ( 514) 736 178.6 3.9e-44
XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 736 178.6 3.9e-44
NP_000775 (OMIM: 213700,606530) sterol 26-hydroxyl ( 531) 683 166.4 1.9e-40
XP_016858977 (OMIM: 213700,606530) PREDICTED: ster ( 391) 587 144.2 6.7e-34
XP_016883182 (OMIM: 126065,143880) PREDICTED: 1,25 ( 448) 541 133.6 1.1e-30
NP_001122387 (OMIM: 126065,143880) 1,25-dihydroxyv ( 448) 541 133.6 1.1e-30
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 361 92.1 3.1e-18
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 361 92.1 3.1e-18
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 361 92.1 3.1e-18
NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 362 92.4 3.1e-18
NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 362 92.4 3.2e-18
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 342 87.8 7.8e-17
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 341 87.6 9.1e-17
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 337 86.6 1.2e-16
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 337 86.7 1.7e-16
NP_000766 (OMIM: 601258) cytochrome P450 2J2 [Homo ( 502) 336 86.5 2e-16
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 333 85.8 3.3e-16
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 327 84.3 7e-16
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 327 84.4 8.8e-16
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 322 83.2 1.6e-15
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 322 83.2 1.6e-15
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 317 82.1 4.2e-15
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 316 81.9 5.1e-15
XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 313 81.0 5.7e-15
XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 313 81.1 6e-15
XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 313 81.1 6e-15
XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 313 81.1 6e-15
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 313 81.1 6.3e-15
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 313 81.1 6.3e-15
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 313 81.1 6.3e-15
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 313 81.2 8.2e-15
NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494) 311 80.7 1.1e-14
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 310 80.5 1.3e-14
NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501) 307 79.8 2.1e-14
NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500) 306 79.6 2.4e-14
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 304 79.0 2.7e-14
NP_000753 (OMIM: 122700,122720,188890,211980) cyto ( 494) 304 79.1 3.3e-14
NP_000762 (OMIM: 122700,601130) cytochrome P450 2C ( 490) 302 78.6 4.5e-14
XP_016871247 (OMIM: 122700,601130) PREDICTED: cyto ( 490) 302 78.6 4.5e-14
>>NP_000489 (OMIM: 124080,203400,610600) cytochrome P450 (503 aa)
initn: 3385 init1: 3385 opt: 3385 Z-score: 4209.5 bits: 788.4 E(85289): 0
Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
430 440 450 460 470 480
490 500
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
:::::::::::::::::::::::
NP_000 IKMVYSFILRPGTSPLLTFRAIN
490 500
>>NP_000488 (OMIM: 103900,202010,610613) cytochrome P450 (503 aa)
initn: 3144 init1: 3144 opt: 3144 Z-score: 3909.6 bits: 732.9 E(85289): 5e-211
Smith-Waterman score: 3144; 93.2% identity (97.6% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
NP_000 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
:: ::::.:::::::::::::.::: ::::::::::::::::::::: :: ::::::::
NP_000 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
::::::::::::::::::::::::::.::::.::::::::::::::::::::::::::::
NP_000 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
::::::: ::::::::::::::::::::::::::::::::.:::.::.:::::::.::::
NP_000 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
.:::::::::::::::::.::::::::::::::.::: :::::::::::::::::::::
NP_000 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
:::::::::::::::::::::::::.:::::::::::::::::.::::::::: ::::::
NP_000 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
::::::::::::::::::.:::::::::::::::::::::::::::::::. ::::::::
NP_000 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
430 440 450 460 470 480
490 500
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
:::::::::::. :::::::::
NP_000 IKMVYSFILRPSMFPLLTFRAIN
490 500
>>NP_001021384 (OMIM: 103900,202010,610613) cytochrome P (437 aa)
initn: 2506 init1: 2506 opt: 2507 Z-score: 3117.9 bits: 586.2 E(85289): 6.2e-167
Smith-Waterman score: 2555; 80.7% identity (84.7% similar) in 503 aa overlap (1-503:1-437)
10 20 30 40 50 60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
NP_001 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
:: ::::.:::::::::::::.::: ::::::::::::::::::::: :: ::::::::
NP_001 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
::::::::::::::::::::::::::.::::.::::::::::::::::::::::::::::
NP_001 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
::::::: ::::::::::::::::::::::::::::::::.:::.::.:::::::.::::
NP_001 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
.:::::::::::::::::.::::::::::::::.::: :::::::::::::::::::::
NP_001 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
:::::::::::::::::::::::::.::::::::::::::
NP_001 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG--------------------
370 380 390 400
430 440 450 460 470 480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
::::. ::::::::
NP_001 ----------------------------------------------VLKHLQVETLTQED
410
490 500
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
:::::::::::. :::::::::
NP_001 IKMVYSFILRPSMFPLLTFRAIN
420 430
>>XP_011515176 (OMIM: 103900,202010,610613) PREDICTED: c (529 aa)
initn: 2305 init1: 2305 opt: 2305 Z-score: 2865.4 bits: 539.8 E(85289): 7.3e-153
Smith-Waterman score: 3082; 88.7% identity (92.8% similar) in 529 aa overlap (1-503:1-529)
10 20 30 40 50 60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
XP_011 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
:: ::::.:::::::::::::.::: ::::::::::::::::::::: :: ::::::::
XP_011 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
70 80 90 100 110 120
130 140 150
pF1KB7 QHRGHKCGVFLLN--------------------------GPEWRFNRLRLNPDVLSPKAV
::::::::::::: :::::::::::::.::::.::
XP_011 QHRGHKCGVFLLNVADRGNSSPPFPGGIHGAPTHSGCRNGPEWRFNRLRLNPEVLSPNAV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB7 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGH
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB7 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKI
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKI
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB7 YQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP
::::::.:::.::.:::::::.:::: .:::::::::::::::::.::::::::::::::
XP_011 YQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB7 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN
.::: ::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_011 NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQN
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB7 YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRR
:::::::::.::::::::: ::::::::::::::::::::::::.:::::::::::::::
XP_011 YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRR
430 440 450 460 470 480
460 470 480 490 500
pF1KB7 LAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
::::::::::::::::. :::::::::::::::::::. :::::::::
XP_011 LAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
490 500 510 520
>>XP_011515177 (OMIM: 103900,202010,610613) PREDICTED: c (528 aa)
initn: 1523 init1: 1497 opt: 1497 Z-score: 1860.1 bits: 353.8 E(85289): 7.2e-97
Smith-Waterman score: 2305; 80.1% identity (84.7% similar) in 457 aa overlap (88-495:1-454)
60 70 80 90 100 110
pF1KB7 EQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWV
::::::::::::::::::::: :: :::::
XP_011 MVCVMLPEDVEKLQQVDSLHPHRMSLEPWV
10 20 30
120 130 140 150
pF1KB7 AYRQHRGHKCGVFLLN--------------------------GPEWRFNRLRLNPDVLSP
:::::::::::::::: :::::::::::::.::::
XP_011 AYRQHRGHKCGVFLLNVADRGNSSPPFPGGIHGAPTHSGCRNGPEWRFNRLRLNPEVLSP
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB7 KAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB7 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCI
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_011 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCI
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB7 QKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELA
:::::::::.:::.::.:::::::.:::: .:::::::::::::::::.:::::::::::
XP_011 QKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELA
220 230 240 250 260 270
340 350 360 370
pF1KB7 RNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR-----------------
:::.::: :::::::::::::::::::::::::::::::::::
XP_011 RNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRKGAESTGSPIQLRTLSM
280 290 300 310 320 330
380 390 400 410 420
pF1KB7 ------LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW
:::::::::::.:::::::::::::::::.::::::::: ::::::::::::::
XP_011 DAPTSRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB7 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI
::::::::::.::::::::::::::::::::::::::: : : . . .. :...
XP_011 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH---HNLCNFEGLRRLHHVHGLR
400 410 420 430 440
490 500
pF1KB7 LRPGTSPLLTFRAIN
.: .:
XP_011 TKPDGNPASVLGAETPPGGDTNPRGHKDGLQLHIEAQHVPPPHLQSHQLITSLHPGSQPG
450 460 470 480 490 500
>>NP_000772 (OMIM: 118485,613743) cholesterol side-chain (521 aa)
initn: 1173 init1: 618 opt: 1198 Z-score: 1488.1 bits: 284.9 E(85289): 3.8e-76
Smith-Waterman score: 1198; 38.9% identity (69.0% similar) in 496 aa overlap (11-503:20-515)
10 20 30 40 50
pF1KB7 MALRAKAEVCVAAPWLSLQRARA-LGTRAARAPRTVLPFEAMPQHPGNRWL
..:: .: : :. : :. . :. ::. .:. : ::
NP_000 MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCR
: ..::: : ...::. :.::. :::.: .::. . : :. :::: : . .. .: :
NP_000 NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 MILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQ
... :::::.:. . ::.: .. :. .:. :: .:..:.:.. :::..:::.::: .
NP_000 FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 ALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVM
.:.... . . :. . :.. ..:....:. . ..:::: :.. . . . :. :. :
NP_000 VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
190 200 210 220 230 240
240 250 260 270 280
pF1KB7 FKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH--YTG
:...: .. .: .: : . :.::.: ::: ::. .: :..: :: . : : :
NP_000 FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB7 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA
:. .:: ...:.: :::: :. ::.::::.. : :.:.::: ::..:: : :::
NP_000 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB7 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY
. . .:::.:..::::::.:... :.: . .::::..: ::: ::::: .:
NP_000 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB7 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL
.:::. ..: :: ..: :::. . :... ::.:.:::::::.:: :: ..: ..:
NP_000 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
430 440 450 460 470 480
470 480 490 500
pF1KB7 KHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
..: :: :. ....:: : .:: .:
NP_000 ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
490 500 510 520
>>XP_016868635 (OMIM: 103900,202010,610613) PREDICTED: c (282 aa)
initn: 962 init1: 936 opt: 944 Z-score: 1175.9 bits: 226.3 E(85289): 9.3e-59
Smith-Waterman score: 944; 82.5% identity (90.4% similar) in 177 aa overlap (319-495:35-208)
290 300 310 320 330 340
pF1KB7 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA
:.::::::::::::::.::: :::::::::
XP_016 TPHREVVLGGVSRGLSPPVQGLTLQLCLLQTVFPLLMTLFELARNPNVQQALRQESLAAA
10 20 30 40 50 60
350 360 370 380 390 400
pF1KB7 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY
:::::::::::::::::::::::::::::::::::::.:::::::::::::::::.::::
XP_016 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY
70 80 90 100 110 120
410 420 430 440 450 460
pF1KB7 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL
::::: ::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH--
130 140 150 160 170 180
470 480 490 500
pF1KB7 KHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
: : . . .. :... .: .:
XP_016 -HNLCNFEGLRRLHHVHGLRTKPDGNPASVLGAETPPGGDTNPRGHKDGLQLHIEAQHVP
190 200 210 220 230 240
>>NP_001093243 (OMIM: 118485,613743) cholesterol side-ch (363 aa)
initn: 868 init1: 569 opt: 872 Z-score: 1084.7 bits: 209.8 E(85289): 1.1e-53
Smith-Waterman score: 872; 39.2% identity (69.7% similar) in 357 aa overlap (149-503:1-357)
120 130 140 150 160 170
pF1KB7 YRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ
..:.:.. :::..:::.::: ..:.... .
NP_001 MAPEATKNFLPLLDAVSRDFVSVLHRRIKK
10 20 30
180 190 200 210 220 230
pF1KB7 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM
. :. . :.. ..:....:. . ..:::: :.. . . . :. :. ::...: ..
NP_001 AGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPML
40 50 60 70 80 90
240 250 260 270 280 290
pF1KB7 FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH--YTGIVAELLLK
.: .: : . :.::.: ::: ::. .: :..: :: . : : ::. .::
NP_001 NLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD
100 110 120 130 140 150
300 310 320 330 340 350
pF1KB7 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ
...:.: :::: :. ::.::::.. : :.:.::: ::..:: : ::: . .
NP_001 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA
160 170 180 190 200 210
360 370 380 390 400 410
pF1KB7 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAAL
.:::.:..::::::.:... :.: . .::::..: ::: ::::: .:.:::. ..
NP_001 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF
220 230 240 250 260 270
420 430 440 450 460 470
pF1KB7 FPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL
: :: ..: :::. . :... ::.:.:::::::.:: :: ..: ..:..: ::
NP_001 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ
280 290 300 310 320 330
480 490 500
pF1KB7 TQEDIKMVYSFILRPGTSPLLTFRAIN
:. ....:: : .:: .:
NP_001 HLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
340 350 360
>>NP_000776 (OMIM: 264700,609506) 25-hydroxyvitamin D-1 (508 aa)
initn: 729 init1: 333 opt: 746 Z-score: 925.9 bits: 180.9 E(85289): 7.8e-45
Smith-Waterman score: 755; 32.5% identity (60.6% similar) in 464 aa overlap (23-474:24-479)
10 20 30 40 50
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQ
.:: : .. : : :. :. : ... .
NP_000 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPS----FLAELFCKG
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 GYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY
: .:: . : ..::.. ..: : : : : ::.: . .. .: : . ::. .
NP_000 GLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 RQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQN
:. : . ::.. .: ::. : : : .: :.:. :. .. :. :. . :.. :
NP_000 RRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRR---QR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 ARGS----LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTV
.::. :. :: .... .:. .:.: ::: . . . .:..:. .: ::.
NP_000 GRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTL
180 190 200 210 220 230
240 250 260 270 280
pF1KB7 QLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---NRPQH--YTGI-
: ::. : : . : : . . :: .: ... ... : :. ..:.. .:
NP_000 LTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAH
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB7 VAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA
....:.. :: ..: .: :: ..:::.. : .:.::.:.:.:: :..: :: .
NP_000 LTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALS
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB7 SISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFL
: .:: ..::::.:..::.:::::: :: ..:. . .: :: .::: .
NP_000 PGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCH
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB7 YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV
:. .:. : ::.:. . : ::: . . : .::::: :.:.:::::: :. . : ..
NP_000 YATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQI
420 430 440 450 460 470
470 480 490 500
pF1KB7 LKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
: :: :.
NP_000 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
480 490 500
>>XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25-dih (514 aa)
initn: 688 init1: 339 opt: 736 Z-score: 913.3 bits: 178.6 E(85289): 3.9e-44
Smith-Waterman score: 736; 29.5% identity (62.6% similar) in 441 aa overlap (52-491:70-503)
30 40 50 60 70 80
pF1KB7 RALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRY
:::: . : .. : . . .. : :::.
XP_016 EVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRM
40 50 60 70 80 90
90 100 110 120 130 140
pF1KB7 NLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNR
.::. . : . : .: : ...: .: :. ..:: :::..: . :...:.: .:. :
XP_016 KLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVR
100 110 120 130 140 150
150 160 170 180 190 200
pF1KB7 LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN
.. ...: :... .. : :: . . : . :: . :. . ....:.
XP_016 SAFQKKLMKPGEVMKLDNKINEVLADFMGRIDE--LCDERGHVE-DLYSELNKWSFESIC
160 170 180 190 200 210
210 220 230 240 250 260
pF1KB7 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWD
:.:. .:.::. .. .. ..::. :...:... ..: : : . .. :::..: :::
XP_016 LVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWD
220 230 240 250 260 270
270 280 290 300 310 320
pF1KB7 CIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAF
::. ::.. .. . : . .. .. . .:: . . : :: ..:.:::
XP_016 TIFKSVKACIDNRLEKYS---QQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTAN
280 290 300 310 320 330
330 340 350 360 370 380
pF1KB7 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQ-KATTELPLLRAALKETLRLYPVGL
:. :..:.:::.::: : .: . .. .. :. . ..: :.: :::..:: :
XP_016 SLMWILYNLSRNPQVQQKLLKE-IQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB7 FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH
: :.... :: .: .: ::.... :: . : .. :.:::. . . : :
XP_016 FTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAH
400 410 420 430 440 450
450 460 470 480 490 500
pF1KB7 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR
.::: : :.:.:::::: .. : : ..... ... .: ..:..: : :
XP_016 LPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFC
460 470 480 490 500 510
pF1KB7 AIN
XP_016 QR
503 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:27:41 2016 done: Fri Nov 4 20:27:42 2016
Total Scan time: 9.550 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]