Result of FASTA (omim) for
pFN21AB5316
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5316, 450 aa
1>>>pF1KB5316 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0805+/-0.000469; mu= 14.9605+/- 0.030
mean_var=97.2154+/-19.172, 0's: 0 Z-trim(110.8): 52 B-trim: 163 in 2/51
Lambda= 0.130079
statistics sampled from 19245 (19289) to 19245 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.226), width: 16
Scan time: 7.820
The best scores are: opt bits E(85289)
NP_001137359 (OMIM: 604508) COP9 signalosome compl ( 450) 2944 563.3 4.6e-160
NP_004227 (OMIM: 604508) COP9 signalosome complex ( 443) 2867 548.9 1e-155
NP_002806 (OMIM: 604449) 26S proteasome non-ATPase ( 422) 386 83.2 1.4e-15
NP_001257411 (OMIM: 604449) 26S proteasome non-ATP ( 422) 386 83.2 1.4e-15
>>NP_001137359 (OMIM: 604508) COP9 signalosome complex s (450 aa)
initn: 2944 init1: 2944 opt: 2944 Z-score: 2994.6 bits: 563.3 E(85289): 4.6e-160
Smith-Waterman score: 2944; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KB5 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
370 380 390 400 410 420
430 440 450
pF1KB5 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
::::::::::::::::::::::::::::::
NP_001 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
430 440 450
>>NP_004227 (OMIM: 604508) COP9 signalosome complex subu (443 aa)
initn: 2089 init1: 2089 opt: 2867 Z-score: 2916.6 bits: 548.9 E(85289): 1e-155
Smith-Waterman score: 2867; 98.4% identity (98.4% similar) in 450 aa overlap (1-450:1-443)
10 20 30 40 50 60
pF1KB5 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYIS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TSKQNSDFLCQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
:::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TSKQ-------MDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILR
130 140 150 160 170
190 200 210 220 230 240
pF1KB5 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLI
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRN
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDH
360 370 380 390 400 410
430 440 450
pF1KB5 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
::::::::::::::::::::::::::::::
NP_004 QKRGGARYTALDKWTNQLNSLNQAVVSKLA
420 430 440
>>NP_002806 (OMIM: 604449) 26S proteasome non-ATPase reg (422 aa)
initn: 302 init1: 229 opt: 386 Z-score: 400.6 bits: 83.2 E(85289): 1.4e-15
Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (49-411:4-380)
20 30 40 50 60 70
pF1KB5 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI
::. ::.. : . : .. :....:
NP_002 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR
10 20 30
80 90 100 110 120 130
pF1KB5 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ--
... : : .. .: . . : .... . ....: :. : :: .. : .
NP_002 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL
40 50 60 70 80 90
140 150 160 170 180
pF1KB5 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ
.::. .. : :: .. ::... : ...: .::.. ..: . .. :
NP_002 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ
100 110 120 130 140 150
190 200 210 220 230
pF1KB5 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL
: . . : . . :.:. :: . : : .: : .: .. .:: : :
NP_002 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK
160 170 180 190 200
240 250 260 270 280 290
pF1KB5 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI
..... .: .: .: ... :.. :.:::..:: ::. : :::..: ......
NP_002 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT--
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB5 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH
: : : : . :. ...: .: ....::: : .... :::.: :
NP_002 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB5 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN
. .: :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .::
NP_002 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE
330 340 350 360 370 380
420 430 440 450
pF1KB5 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
NP_002 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
390 400 410 420
>>NP_001257411 (OMIM: 604449) 26S proteasome non-ATPase (422 aa)
initn: 302 init1: 229 opt: 386 Z-score: 400.6 bits: 83.2 E(85289): 1.4e-15
Smith-Waterman score: 396; 26.5% identity (57.7% similar) in 388 aa overlap (49-411:4-380)
20 30 40 50 60 70
pF1KB5 EYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKI
::. ::.. : . : .. :....:
NP_001 MAAAAVVEFQRAQSLLSTDREASIDILHSIVKR
10 20 30
80 90 100 110 120 130
pF1KB5 NFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI-----STSKQNSDFLCQ--
... : : .. .: . . : .... . ....: :. : :: .. : .
NP_001 DIQ-ENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSL
40 50 60 70 80 90
140 150 160 170 180
pF1KB5 MDLLQEF-------YETTLEALKDAKNDRLWF---KTNTKLGKLYLEREEYGKLQKILRQ
.::. .. : :: .. ::... : ...: .::.. ..: . .. :
NP_001 LDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQ
100 110 120 130 140 150
190 200 210 220 230
pF1KB5 LHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAI--PHPL
: . . : . . :.:. :: . : : .: : .: .. .:: : :
NP_001 LLRELKKMDDK------ALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCP-PK
160 170 180 190 200
240 250 260 270 280 290
pF1KB5 IMGVIRECGGKMHL-REGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGI
..... .: .: .: ... :.. :.:::..:: ::. : :::..: ......
NP_001 LQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNT--
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB5 NPFDSQEAKPYK-----NDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREH
: : : : . :. ...: .: ....::: : .... :::.: :
NP_001 -PEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTH
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB5 IEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVN
. .: :. : ::..:.:..:..: ::. .... :::: : : :::. .:: .::
NP_001 LAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGE
330 340 350 360 370 380
420 430 440 450
pF1KB5 QLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
NP_001 GVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
390 400 410 420
450 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 00:57:44 2016 done: Sat Nov 5 00:57:45 2016
Total Scan time: 7.820 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]