FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5347, 435 aa 1>>>pF1KB5347 435 - 435 aa - 435 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5566+/-0.000446; mu= 15.5854+/- 0.028 mean_var=62.2545+/-12.411, 0's: 0 Z-trim(109.8): 59 B-trim: 233 in 1/49 Lambda= 0.162551 statistics sampled from 17955 (18014) to 17955 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.211), width: 16 Scan time: 8.520 The best scores are: opt bits E(85289) NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 2880 684.4 1.5e-196 XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 2711 644.8 1.2e-184 XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 1600 384.2 3.2e-106 NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 1600 384.2 3.4e-106 NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 1351 325.9 1.3e-88 NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 1327 320.2 6.3e-87 NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 1078 261.8 2.4e-69 NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 1072 260.4 6.5e-69 NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 1014 246.8 8.5e-65 NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 409 105.0 4.3e-22 XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 394 101.4 4.6e-21 XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 394 101.4 5e-21 XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 394 101.4 5e-21 NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 316 83.1 1.3e-15 XP_016868468 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 282 75.1 2.7e-13 XP_016868467 (OMIM: 610469) PREDICTED: AP-3 comple ( 303) 282 75.1 2.7e-13 XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 279 74.4 5.6e-13 NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 273 73.1 1.6e-12 NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 273 73.1 1.6e-12 NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 273 73.1 1.6e-12 NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 273 73.1 1.6e-12 XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 269 72.1 2.1e-12 NP_006794 (OMIM: 610469) AP-3 complex subunit mu-2 ( 418) 262 70.5 9.5e-12 NP_001127768 (OMIM: 610469) AP-3 complex subunit m ( 418) 262 70.5 9.5e-12 XP_016868466 (OMIM: 610469) PREDICTED: AP-3 comple ( 418) 262 70.5 9.5e-12 XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 205 57.0 5.8e-08 NP_006864 (OMIM: 605357) stonin-1 [Homo sapiens] ( 735) 180 51.3 9.7e-06 NP_001185524 (OMIM: 605357) stonin-1 [Homo sapiens ( 735) 180 51.3 9.7e-06 XP_006720342 (OMIM: 608467) PREDICTED: stonin-2 is ( 898) 145 43.1 0.0034 NP_149095 (OMIM: 608467) stonin-2 isoform 1 [Homo ( 905) 145 43.1 0.0035 NP_001243359 (OMIM: 608467) stonin-2 isoform 2 [Ho ( 920) 145 43.1 0.0035 XP_011535544 (OMIM: 608467) PREDICTED: stonin-2 is ( 955) 145 43.1 0.0036 XP_011535543 (OMIM: 608467) PREDICTED: stonin-2 is ( 962) 145 43.1 0.0037 XP_011535542 (OMIM: 608467) PREDICTED: stonin-2 is ( 977) 145 43.2 0.0037 XP_005271599 (OMIM: 600820,617164) PREDICTED: coat ( 417) 136 40.9 0.0074 NP_001646 (OMIM: 600820,617164) coatomer subunit d ( 511) 136 41.0 0.0089 >>NP_001123996 (OMIM: 603535) AP-1 complex subunit mu-1 (435 aa) initn: 2880 init1: 2880 opt: 2880 Z-score: 3649.7 bits: 684.4 E(85289): 1.5e-196 Smith-Waterman score: 2880; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 370 380 390 400 410 420 430 pF1KB5 VRYITQNGDYQLRTQ ::::::::::::::: NP_001 VRYITQNGDYQLRTQ 430 >>XP_016882909 (OMIM: 603535) PREDICTED: AP-1 complex su (409 aa) initn: 2711 init1: 2711 opt: 2711 Z-score: 3435.9 bits: 644.8 E(85289): 1.2e-184 Smith-Waterman score: 2711; 100.0% identity (100.0% similar) in 409 aa overlap (27-435:1-409) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI :::::::::::::::::::::::::::::::::: XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 340 350 360 370 380 390 430 pF1KB5 VRYITQNGDYQLRTQ ::::::::::::::: XP_016 VRYITQNGDYQLRTQ 400 >>XP_016882910 (OMIM: 603535) PREDICTED: AP-1 complex su (397 aa) initn: 2601 init1: 1600 opt: 1600 Z-score: 2028.1 bits: 384.2 E(85289): 3.2e-106 Smith-Waterman score: 2581; 97.1% identity (97.1% similar) in 409 aa overlap (27-435:1-397) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI :::::::::::::::::::::::::::::::::: XP_016 MSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS :: :::::::::::::::::::::::::::::::::::::::::::::: XP_016 LL------------VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 160 170 180 190 200 250 260 270 280 290 300 pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 330 340 350 360 370 380 430 pF1KB5 VRYITQNGDYQLRTQ ::::::::::::::: XP_016 VRYITQNGDYQLRTQ 390 >>NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 iso (423 aa) initn: 2770 init1: 1600 opt: 1600 Z-score: 2027.6 bits: 384.2 E(85289): 3.4e-106 Smith-Waterman score: 2750; 97.2% identity (97.2% similar) in 435 aa overlap (1-435:1-423) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS :: :::::::::::::::::::::::::::::::::::::::::::::: NP_115 LL------------VSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS 190 200 210 220 250 260 270 280 290 300 pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW 350 360 370 380 390 400 430 pF1KB5 VRYITQNGDYQLRTQ ::::::::::::::: NP_115 VRYITQNGDYQLRTQ 410 420 >>NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 iso (423 aa) initn: 1351 init1: 1351 opt: 1351 Z-score: 1712.0 bits: 325.9 E(85289): 1.3e-88 Smith-Waterman score: 2269; 77.6% identity (92.6% similar) in 434 aa overlap (1-434:1-422) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI ::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.:: NP_005 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: NP_005 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: NP_005 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKS :: :.:::.:: :::::.::..:::::::::::::::.:::. :::.:. NP_005 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKN 190 200 210 220 250 260 270 280 290 300 pF1KB5 KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSH :::::::::::::::::::.::::::::::::.::::::::.:.::::::::::::: :: NP_005 KSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSH 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 SRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSF ::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::::: NP_005 SRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSF 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 PGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW :::::::::::::::::: :. ::.:::.:::::::::.:::::::.::::::::::::: NP_005 PGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPW 350 360 370 380 390 400 430 pF1KB5 VRYITQNGDYQLRTQ ::::::.::::::: NP_005 VRYITQSGDYQLRTS 410 420 >>NP_001287816 (OMIM: 607309) AP-1 complex subunit mu-2 (425 aa) initn: 2070 init1: 1131 opt: 1327 Z-score: 1681.6 bits: 320.2 E(85289): 6.3e-87 Smith-Waterman score: 2245; 77.1% identity (92.0% similar) in 436 aa overlap (1-434:1-424) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI ::::::..::.::: :: :::.::: ::..:::::.:...:::: :.:.:.:: :.:.:: NP_001 MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF ::.:::::::..::: .:::.:::::...:: :::::::::::::::::.:::::::::: NP_001 KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVN :.:::::::::::::::...::::: : : :::::::::::::::.:::::.::::::: NP_001 GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 LLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG-- :: :.:::.:: :::::.::..:::::::::::::::.:::. :: . NP_001 LL------------VNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGLSGS 190 200 210 220 240 250 260 270 280 290 pF1KB5 KSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKH :.:::::::::::::::::::.::::::::::::.::::::::.:.::::::::::::: NP_001 KNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKF 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 SHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIK ::::.: :.:::.:::..:.::.::: .:::.:::::.:::.:::.:.::: . ..:::: NP_001 SHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIK 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 SFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQAL :::::::::::::::::::: :. ::.:::.:::::::::.:::::::.::::::::::: NP_001 SFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQAL 350 360 370 380 390 400 420 430 pF1KB5 PWVRYITQNGDYQLRTQ ::::::::.::::::: NP_001 PWVRYITQSGDYQLRTS 410 420 >>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa) initn: 1063 init1: 365 opt: 1078 Z-score: 1365.9 bits: 261.8 E(85289): 2.4e-69 Smith-Waterman score: 1078; 39.1% identity (71.3% similar) in 442 aa overlap (6-433:5-432) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI ... . ::.::: : :: :. . :. : ... ... . ::. . . :. . NP_001 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::.:::::::..:: NP_001 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 GYPQTTDSKILQEYITQEGHKLETGAPRPPAT--VTNAVSWRSEGIKYRKNEVFLDVIES ::::.... :. .:::.: : .: . : ::. ..:: ::::::.::.::::.:: NP_001 GYPQNSETGALKTFITQQGIKSQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLES 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 VNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRG :::: .: .:.:: ... : . :. .:::::: ..:.:::..... :.: NP_001 VNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKG 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 ------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIW :: .:. ..: ::::::::.:...:.::::::::::::: :: . . . NP_001 TADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFR 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 IESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPEN . .... .....: . ::.:: :...:..::.: .... . :..:. . NP_001 VIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASE 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 SEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKII . :::.:: . : :: . :.. : .. . : ..::::..::.: :. ::..:::::.. NP_001 NAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLKVF 350 360 370 380 390 400 420 430 pF1KB5 EK----SGYQALPWVRYITQNGDYQLRTQ : : .... ::::: ..: :. : NP_001 EPKLNYSDHDVIKWVRYIGRSGIYETRC 410 420 430 >>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa) initn: 953 init1: 545 opt: 1072 Z-score: 1358.2 bits: 260.4 E(85289): 6.5e-69 Smith-Waterman score: 1072; 38.5% identity (70.9% similar) in 444 aa overlap (6-433:5-434) 10 20 30 40 50 60 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWI ... . ::.::: : :: :. . :. : ... ... . ::. . . :. . NP_004 MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ-VRSPVTNIARTSFFHV 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 KHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF :..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::.:::::::..:: NP_004 KRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDF 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 GYPQTTDSKILQEYITQEG----HKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVI ::::.... :. .:::.: :. . . . ::. ..:: ::::::.::.::::. NP_004 GYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 ESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTG :::::: .: .:.:: ... : . :. .:::::: ..:.:::..... : NP_004 ESVNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG 180 190 200 210 220 240 250 260 270 280 pF1KB5 RG------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPL .: :: .:. ..: ::::::::.:...:.::::::::::::: :: . . NP_004 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILP 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 IWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVP . . .... .....: . ::.:: :...:..::.: .... . :..:. NP_004 FRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKA 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 ENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLK .. :::.:: . : :: . :.. : .. . : ..::::..::.: :. ::..::::: NP_004 SENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-FAPSGLKVRYLK 350 360 370 380 390 400 410 420 430 pF1KB5 IIEK----SGYQALPWVRYITQNGDYQLRTQ ..: : .... ::::: ..: :. : NP_004 VFEPKLNYSDHDVIKWVRYIGRSGIYETRC 410 420 430 >>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa) initn: 936 init1: 545 opt: 1014 Z-score: 1284.3 bits: 246.8 E(85289): 8.5e-65 Smith-Waterman score: 1014; 38.4% identity (70.5% similar) in 430 aa overlap (20-433:49-459) 10 20 30 40 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPI : :. :: .:. .. ... . ::. NP_001 VYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVN----VIHARQQ--VRSPV 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 LAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVI . . :. .:..:..:.:..:.:. ...:: ::::. .:.. :: .. ::.:..:::. NP_001 TNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVL 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 IYELLDELMDFGYPQTTDSKILQEYITQEG----HKLETGAPRPPATVTNAVSWRSEGIK :::::::..::::::.... :. .:::.: :. . . . ::. ..:: :::: NP_001 IYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIK 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 YRKNEVFLDVIESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGMPELRLG ::.::.::::.:::::: .: .:.:: ... : . :. .:::::: ..: NP_001 YRRNELFLDVLESVNLL------------MSPQGQVLSAHVSGRVVMKSYLSGMPECKFG 200 210 220 230 240 230 240 250 260 270 pF1KB5 LNDKVLFDNTGRG------KS--KSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELM .:::..... :.: :: .:. ..: ::::::::.:...:.::::::::::::: NP_001 MNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELM 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB5 SYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKF :: . . . . .... .....: . ::.:: :...:..::.: .... . NP_001 RYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQV 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 KTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYF :..:. .. :::.:: . : :: . :.. : .. . : ..::::..::.: : NP_001 ICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVP-F 370 380 390 400 410 400 410 420 430 pF1KB5 TTSGIQVRYLKIIEK----SGYQALPWVRYITQNGDYQLRTQ . ::..:::::..: : .... ::::: ..: :. : NP_001 APSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC 420 430 440 450 460 >>NP_004713 (OMIM: 602296,612936) AP-4 complex subunit m (453 aa) initn: 586 init1: 251 opt: 409 Z-score: 517.7 bits: 105.0 E(85289): 4.3e-22 Smith-Waterman score: 618; 28.1% identity (59.9% similar) in 466 aa overlap (4-433:3-452) 10 20 30 40 50 pF1KB5 MSASAVYVLDLKGKVLICRNYRGDVDMSEV-EHFMPILMEKEEEGMLSPI-LAHGGVRFM : ..:. :: :: ...::: .: : :. : : ::. . : : .:. NP_004 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGL--PGDESPVVMHHHGRHFI 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 WIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELM :.:..::::.:...:. .. .: ... ....: : : .: : ...::::::.. NP_004 HIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVL 60 70 80 90 100 110 120 130 140 150 pF1KB5 DFGYPQTTDSKILQEYITQE------------------GHKLETGAPRPPATVTNAV-SW :.:: :::....:...: : : . . . : .... : : NP_004 DYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 RSEGIKYRKNEVFLDVIESVNLLGKYPGVGWLGHTVSANGNVLRSEIVGSIKMRVFLSGM ::. . .::::::::.: ...: ...::..:. .. : :... :: . NP_004 RSD--QSQKNEVFLDVVERLSVL------------IASNGSLLKVDVQGEIRLKSFLPSG 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 PELRLGLNDKVLFDNTG-RGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMS :.:.::... .. :: . ......:.::. : :..::. : . . ::.::. .: NP_004 SEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMR 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB5 YRLNTHVK---PLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSP :.:. . :. . :: .. .:.. ..: . .. .: : ::..:.:.: . : NP_004 YQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSL 290 300 310 320 330 340 340 350 360 370 380 pF1KB5 KFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEG-----KP---- . . . : .. . :.. ::.. .. .:. . ..: .: NP_004 SQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLG 350 360 370 380 390 400 390 400 410 420 430 pF1KB5 PISVKFEIPYFTTSGIQVRYLKIIEKSGYQALP--WVRYITQNGDYQLRTQ : :..::.: : ::.:::.:.. . .: : :::..... : .: NP_004 PASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 410 420 430 440 450 435 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:38:32 2016 done: Mon Nov 7 04:38:33 2016 Total Scan time: 8.520 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]