Result of FASTA (omim) for
pFN21AB6688
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6688, 458 aa
1>>>pF1KB6688 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9420+/-0.000424; mu= 19.9821+/- 0.027
mean_var=100.2974+/-24.247, 0's: 0 Z-trim(110.9): 628 B-trim: 1891 in 2/48
Lambda= 0.128065
statistics sampled from 18525 (19307) to 18525 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.226), width: 16
Scan time: 7.560
The best scores are: opt bits E(85289)
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 3011 567.7 2.3e-161
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 3011 567.7 2.3e-161
NP_001243690 (OMIM: 312861) 5-hydroxytryptamine re ( 248) 988 193.6 5.1e-49
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 939 184.9 4.1e-46
NP_001307687 (OMIM: 601122) 5-hydroxytryptamine re ( 439) 790 157.3 7.6e-38
XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 456) 790 157.3 7.8e-38
NP_000858 (OMIM: 601122) 5-hydroxytryptamine recep ( 481) 790 157.4 8.1e-38
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 677 136.4 1.4e-31
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 623 126.4 1.3e-28
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 600 122.3 3.3e-27
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 574 117.3 7.3e-26
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 544 111.8 3.5e-24
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 531 109.3 1.6e-23
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 531 109.3 1.6e-23
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 531 109.4 1.7e-23
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 531 109.4 1.8e-23
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 531 109.4 1.8e-23
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 532 109.7 1.9e-23
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 531 109.6 2.2e-23
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 519 107.1 8e-23
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 519 107.1 8e-23
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 519 107.1 8e-23
XP_005246577 (OMIM: 601122) PREDICTED: 5-hydroxytr ( 362) 508 105.1 3.3e-22
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 487 101.3 5.2e-21
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 487 101.3 5.4e-21
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 487 101.3 5.4e-21
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 467 97.6 7.1e-20
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 462 96.7 1.4e-19
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 457 95.8 2.7e-19
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 450 94.3 4.9e-19
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 450 94.3 5e-19
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 450 94.3 5.1e-19
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 450 94.4 5.3e-19
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 450 94.4 5.5e-19
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 450 94.4 5.6e-19
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 450 94.5 6.1e-19
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 450 94.5 6.1e-19
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 450 94.5 6.3e-19
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 450 94.5 6.4e-19
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 450 94.5 6.5e-19
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 450 94.5 6.5e-19
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 450 94.5 6.5e-19
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 450 94.5 6.5e-19
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400) 431 90.9 6.6e-18
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400) 431 90.9 6.6e-18
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400) 431 90.9 6.6e-18
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400) 431 90.9 6.6e-18
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 419 88.8 3.3e-17
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 410 87.0 9.1e-17
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 410 87.0 9.2e-17
>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa)
initn: 3011 init1: 3011 opt: 3011 Z-score: 3017.9 bits: 567.7 E(85289): 2.3e-161
Smith-Waterman score: 3011; 99.8% identity (99.8% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_000 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
370 380 390 400 410 420
430 440 450
pF1KB6 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
::::::::::::::::::::::::::::::::::::::
NP_000 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
430 440 450
>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa)
initn: 3011 init1: 3011 opt: 3011 Z-score: 3017.9 bits: 567.7 E(85289): 2.3e-161
Smith-Waterman score: 3011; 99.8% identity (99.8% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
370 380 390 400 410 420
430 440 450
pF1KB6 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
::::::::::::::::::::::::::::::::::::::
NP_001 EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
430 440 450
>>NP_001243690 (OMIM: 312861) 5-hydroxytryptamine recept (248 aa)
initn: 988 init1: 988 opt: 988 Z-score: 1001.0 bits: 193.6 E(85289): 5.1e-49
Smith-Waterman score: 988; 97.4% identity (98.7% similar) in 155 aa overlap (1-155:1-155)
10 20 30 40 50 60
pF1KB6 MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
:::::::::::::::::::::::::::::::: ..
NP_001 PLPRYLCPVWISLDVLFSTASIMHLCAISLDRCISSYPCDWTEGRRKGVREQHDVRAQRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
NP_001 KFRSYWVLRSFLHTADDYGDYVLPDHLRSAPTSFDVTARPHRGTAWTKSGFPEVLQEEYG
190 200 210 220 230 240
>>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa)
initn: 1240 init1: 769 opt: 939 Z-score: 948.9 bits: 184.9 E(85289): 4.1e-46
Smith-Waterman score: 1413; 55.0% identity (78.0% similar) in 409 aa overlap (53-458:74-471)
30 40 50 60 70 80
pF1KB6 SDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEK
.:: :: ...::.::.::::::::::.::
NP_000 NWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEK
50 60 70 80 90 100
90 100 110 120 130 140
pF1KB6 KLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASI
::.::::::::::::::::.:.::::.:.:.::: : :::: :: ::: ::::::::::
NP_000 KLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASI
110 120 130 140 150 160
150 160 170 180 190 200
pF1KB6 MHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFV
::::::::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. :::
NP_000 MHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-
170 180 190 200 210 220
210 220 230 240 250 260
pF1KB6 NNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLD
.. .:.: : :::::::::.:::::::::::: ::: :...: . . . :..
NP_000 KEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFS
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB6 FLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLI
:: . . .. . : . .:. : :::.:.::.:: ::::::::.:..
NP_000 FLP--------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVV
290 300 310 320 330
330 340 350 360 370 380
pF1KB6 MWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNY
::::::::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: :
NP_000 MWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRY
340 350 360 370 380 390
390 400 410 420 430
pF1KB6 LRCNYKVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVE
..:.:: .::: . . . : : .. .:... ..... . :..::. .. . .
NP_000 IQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQH
400 410 420 430 440 450
440 450
pF1KB6 NLELPVNPSSVVSERISSV
. : . :. :.:..: :
NP_000 SEEASKDNSDGVNEKVSCV
460 470
>>NP_001307687 (OMIM: 601122) 5-hydroxytryptamine recept (439 aa)
initn: 1236 init1: 640 opt: 790 Z-score: 800.4 bits: 157.3 E(85289): 7.6e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:13-361)
30 40 50 60 70 80
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
.: :: :...:: ::::: :::.:::.:::
NP_001 MKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
10 20 30 40
90 100 110 120 130 140
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
:. ::::::::::.::.::::.:::..::.:... .:::: :::.:. :::::::::::
NP_001 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. . :
NP_001 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
: ::::. .:.:.::..::: ::.::..:: :::..:...: .. . .. :.
NP_001 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
170 180 190 200 210 220
270 280 290 300
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
. : : . . . ....: ::. :.. :: . . ..:.:.::..
NP_001 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
230 240 250 260 270
310 320 330 340 350 360
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
::::::::::.::.:::::::::: :::. :::: .. ::..::::::: ::.:::::
NP_001 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
::::: .: ::. :. :::.. :
NP_001 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
340 350 360 370 380 390
>>XP_006712545 (OMIM: 601122) PREDICTED: 5-hydroxytrypta (456 aa)
initn: 1236 init1: 640 opt: 790 Z-score: 800.2 bits: 157.3 E(85289): 7.8e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:30-378)
30 40 50 60 70 80
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
.: :: :...:: ::::: :::.:::.:::
XP_006 MLSKITTKPETESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
10 20 30 40 50
90 100 110 120 130 140
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
:. ::::::::::.::.::::.:::..::.:... .:::: :::.:. :::::::::::
XP_006 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. . :
XP_006 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
120 130 140 150 160 170
210 220 230 240 250 260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
: ::::. .:.:.::..::: ::.::..:: :::..:...: .. . .. :.
XP_006 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
180 190 200 210 220 230
270 280 290 300
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
. : : . . . ....: ::. :.. :: . . ..:.:.::..
XP_006 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
::::::::::.::.:::::::::: :::. :::: .. ::..::::::: ::.:::::
XP_006 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
::::: .: ::. :. :::.. :
XP_006 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
360 370 380 390 400 410
>>NP_000858 (OMIM: 601122) 5-hydroxytryptamine receptor (481 aa)
initn: 1236 init1: 640 opt: 790 Z-score: 800.0 bits: 157.4 E(85289): 8.1e-38
Smith-Waterman score: 1208; 52.4% identity (78.5% similar) in 353 aa overlap (54-391:55-403)
30 40 50 60 70 80
pF1KB6 DISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKK
.: :: :...:: ::::: :::.:::.:::
NP_000 HVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKK
30 40 50 60 70 80
90 100 110 120 130 140
pF1KB6 LHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIM
:. ::::::::::.::.::::.:::..::.:... .:::: :::.:. :::::::::::
NP_000 LQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIM
90 100 110 120 130 140
150 160 170 180 190 200
pF1KB6 HLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVN
::::::.:::.::..::. ...:::. :..::..:: ::::...:.:. :.. . :
NP_000 HLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDN-PN
150 160 170 180 190 200
210 220 230 240 250 260
pF1KB6 NTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLS
: ::::. .:.:.::..::: ::.::..:: :::..:...: .. . .. :.
NP_000 NITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLT
210 220 230 240 250 260
270 280 290 300
pF1KB6 L------DFLKCCKRNTAE-----EENSANPNQ-DQNARRRKKKERRPRGTMQAINNERK
. : : . . . ....: ::. :.. :: . . ..:.:.::..
NP_000 VSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTI--GKKSVQTISNEQR
270 280 290 300 310 320
310 320 330 340 350 360
pF1KB6 ASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVY
::::::::::.::.:::::::::: :::. :::: .. ::..::::::: ::.:::::
NP_000 ASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQTTLQMLLEIFVWIGYVSSGVNPLVY
330 340 350 360 370 380
370 380 390 400 410 420
pF1KB6 TLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKAS
::::: .: ::. :. :::.. :
NP_000 TLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPA
390 400 410 420 430 440
>>NP_001159419 (OMIM: 103780,164230,181500,182135,606788 (387 aa)
initn: 931 init1: 485 opt: 677 Z-score: 688.2 bits: 136.4 E(85289): 1.4e-31
Smith-Waterman score: 1104; 51.5% identity (75.0% similar) in 344 aa overlap (118-458:55-387)
90 100 110 120 130 140
pF1KB6 TNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCA
: :::: :: ::: :::::::::::::::
NP_001 GTLHQFNYCERCSESQNNKCISCVDPEDKWYRWPLPSKLCAVWIYLDVLFSTASIMHLCA
30 40 50 60 70 80
150 160 170 180 190 200
pF1KB6 ISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC
:::::::::.:::.::::::::::..:: ::.::.:.:.::::.::.:. ::: .. .:
NP_001 ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVF-KEGSC
90 100 110 120 130 140
210 220 230 240 250 260
pF1KB6 VLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCC
.: : :::::::::.:::::::::::: ::: :...: . . . :..::
NP_001 LLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLP--
150 160 170 180 190 200
270 280 290 300 310 320
pF1KB6 KRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPF
. . .. . : . .:. : :::.:.::.:: ::::::::.:..:::::
NP_001 ------QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPF
210 220 230 240 250
330 340 350 360 370 380
pF1KB6 FITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNY
:::::..:.:..:::. .. ::::::::::. :..:::::::::: :: ::: :..:.:
NP_001 FITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQY
260 270 280 290 300 310
390 400 410 420 430 440
pF1KB6 KVEKKP-PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEM--QVENLELP
: .::: . . . : : .. .:... ..... . :..::. .. . .. :
NP_001 KENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDA--KTTDNDCSMVALGKQHSEEAS
320 330 340 350 360 370
450
pF1KB6 VNPSSVVSERISSV
. :. :.:..: :
NP_001 KDNSDGVNEKVSCV
380
>>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor (377 aa)
initn: 562 init1: 228 opt: 623 Z-score: 634.4 bits: 126.4 E(85289): 1.3e-28
Smith-Waterman score: 623; 33.2% identity (64.7% similar) in 334 aa overlap (57-379:42-367)
30 40 50 60 70 80
pF1KB6 VSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHN
:. . .: . :. .: .:. .. . .:::.
NP_000 PQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHT
20 30 40 50 60 70
90 100 110 120 130 140
pF1KB6 ATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLC
.::.. ::: .:.::..::::.:. : ..: . . :: .:.: :. ::::.:::
NP_000 PANYLIGSLATTDLLVSILVMPISI-AYTITHTWNFGQILCDIWLSSDITCCTASILHLC
80 90 100 110 120 130
150 160 170 180 190 200
pF1KB6 AISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTT
.:.:::: :: . .:.:. . .: ::::::::: .:.: :. . . :. . .
NP_000 VIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIP-PL--FWRQAKAQEEMSD
140 150 160 170 180
210 220 230 240 250 260
pF1KB6 CVLNDP--NFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALM---LLHGHTEEPPGLSL
:..: .... .. ::.:: ....: : :: :. .. :.:. :
NP_000 CLVNTSQISYTIYSTCGAFYIPSVLLIILYG-RIYRAARNRILNPPSLYGKRFTTAHLIT
190 200 210 220 230 240
270 280 290 300 310
pF1KB6 DFL--KCCKRNTAEEE----NSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGI
. :. :.. .: ....: .... . : ..: ::::.:.:::
NP_000 GSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAAR-ERKATKILGI
250 260 270 280 290 300
320 330 340 350 360 370
pF1KB6 VFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIY
.. .:.: : :::..... .:. :: . :.. :.:.::. : :::..::.::. .
NP_000 ILGAFIICWLPFFVVSLVLPICRDSC--WIHPALFDFFTWLGYLNSLINPIIYTVFNEEF
310 320 330 340 350 360
380 390 400 410 420 430
pF1KB6 RRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIE
:.::
NP_000 RQAFQKIVPFRKAS
370
>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa)
initn: 490 init1: 207 opt: 600 Z-score: 609.4 bits: 122.3 E(85289): 3.3e-27
Smith-Waterman score: 603; 29.3% identity (64.0% similar) in 389 aa overlap (60-444:103-470)
30 40 50 60 70 80
pF1KB6 VAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATN
.. .:.:...::.:::..:. ...:...::
NP_000 GSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTN
80 90 100 110 120 130
90 100 110 120 130 140
pF1KB6 YFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAIS
::...::.::.:.. :.:.: . . : . : .: :: ..::: ::::. ::.::
NP_000 YFIVNLAVADLLLSATVLPFSATMEVLGF-WAFGRAFCDVWAAVDVLCCTASILSLCTIS
140 150 160 170 180 190
150 160 170 180 190 200
pF1KB6 LDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTC-V
.::::..:. ... . .. :: .:..:.... ::: :..: . : : .. : .
NP_000 VDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVG-PLLGWK--EPVPPDERFCGI
200 210 220 230 240
210 220 230 240 250 260
pF1KB6 LNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDF-LKCC
.. ......: .:..:....:. :: .::. :.. :.. ... : . . :.
NP_000 TEEAGYAVFSSVCSFYLPMAVIVVMYC-RVYVVARSTTRSLEAGVKRERGKASEVVLRIH
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB6 KRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAI--NNERKASKVLGIVFFVFLIMWC
:..: ..:. . : : . : ... . . :.::.:.:.:: ::.. :
NP_000 CRGAATGADGAH-----GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWF
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB6 PFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC
:::.. :. : . : : ...:. :.:: : .:::.: .. ..::: :::
NP_000 PFFFVLPLGSLFPQ---LKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRC
370 380 390 400 410
390 400 410 420 430 440
pF1KB6 NYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPV
. . ... : . :: . . ... :. : ...: :: . . : :
NP_000 QCRRRRRR--RPLWRVYGHHWRA---STSGLRQDCAP---SSGDAPPGAPLALTALPDPD
420 430 440 450 460 470
450
pF1KB6 NPSSVVSERISSV
NP_000 PEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEA
480 490 500 510 520 530
458 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:48:08 2016 done: Sat Nov 5 18:48:09 2016
Total Scan time: 7.560 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]