Result of FASTA (omim) for
pFN21AB6571
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6571, 375 aa
1>>>pF1KB6571 375 - 375 aa - 375 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2229+/-0.000335; mu= 17.1759+/- 0.021
mean_var=70.0617+/-14.121, 0's: 0 Z-trim(114.6): 70 B-trim: 0 in 0/53
Lambda= 0.153227
statistics sampled from 24517 (24590) to 24517 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.288), width: 16
Scan time: 7.000
The best scores are: opt bits E(85289)
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 2589 581.4 1.1e-165
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 1383 314.8 2.2e-85
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 1383 314.8 2.2e-85
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 313 78.4 4.2e-14
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 306 76.8 1.1e-13
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 301 75.7 2.4e-13
NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 298 75.0 3.5e-13
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 298 75.0 3.6e-13
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 295 74.2 3.6e-13
NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 298 75.0 3.7e-13
NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 297 74.8 4.1e-13
NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 297 74.8 4.1e-13
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 295 74.3 5.4e-13
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 74.2 7.6e-13
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 294 74.2 7.6e-13
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 294 74.2 7.6e-13
XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 292 73.6 8.4e-13
NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 290 73.2 1.1e-12
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 289 73.0 1.3e-12
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 289 73.0 1.4e-12
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 282 71.3 2.6e-12
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 282 71.5 4.4e-12
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 274 69.6 1.2e-11
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 274 69.6 1.2e-11
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 274 69.7 1.4e-11
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 274 69.7 1.4e-11
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 274 69.7 1.4e-11
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 274 69.7 1.4e-11
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 272 69.2 1.8e-11
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 272 69.3 1.9e-11
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 269 68.6 3.3e-11
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 256 65.7 2.5e-10
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 250 64.4 5.7e-10
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 233 60.4 4.4e-09
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 233 60.6 6.5e-09
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 231 60.2 9.7e-09
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 223 58.4 3e-08
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 206 54.5 3.4e-07
NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 207 54.9 4e-07
NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 206 54.6 4.2e-07
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 54.6 4.2e-07
NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 206 54.6 4.2e-07
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 54.6 4.2e-07
NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 206 54.6 4.2e-07
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 206 54.6 4.2e-07
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 206 54.6 4.2e-07
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 54.6 4.2e-07
XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 206 54.6 4.2e-07
NP_005251 (OMIM: 601918) growth/differentiation fa ( 454) 206 54.7 5e-07
XP_011541610 (OMIM: 601918) PREDICTED: growth/diff ( 454) 206 54.7 5e-07
>>NP_005250 (OMIM: 601788,614160) growth/differentiation (375 aa)
initn: 2589 init1: 2589 opt: 2589 Z-score: 3095.3 bits: 581.4 E(85289): 1.1e-165
Smith-Waterman score: 2589; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375)
10 20 30 40 50 60
pF1KB6 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII
310 320 330 340 350 360
370
pF1KB6 YGKIPAMVVDRCGCS
:::::::::::::::
NP_005 YGKIPAMVVDRCGCS
370
>>XP_006719257 (OMIM: 603936) PREDICTED: growth/differen (407 aa)
initn: 1349 init1: 1088 opt: 1383 Z-score: 1654.0 bits: 314.8 E(85289): 2.2e-85
Smith-Waterman score: 1645; 65.1% identity (84.9% similar) in 352 aa overlap (34-375:58-407)
10 20 30 40 50 60
pF1KB6 LQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSK
: .: : .:.:::... :.:.:: :::::
XP_006 PAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDG-CPVCVWRQHSRELRLESIKSQILSK
30 40 50 60 70 80
70 80 90 100 110 120
pF1KB6 LRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDD-SSDGSLEDDDYHATTETIITMP
:::. :::::..:..:::::::::....: .: : : . . ::.:.:::::::.:.:
XP_006 LRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMA
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB6 TESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKD
:.: .:.::.: :: :.:: :....::.:::::.::::: :.::..::::: ::.
XP_006 QETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRL-KPLTG
150 160 170 180 190 200
190 200 210 220 230
pF1KB6 ---------GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN
: :. :::::.... .: ::::: : ::..:..::.:: ::::.:.: .
XP_006 EGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPS
210 220 230 240 250 260
240 250 260 270 280 290
pF1KB6 GHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAF
: ::::: ::: .::.::.:..: .. :::::..::::::::.::::::::::::::::
XP_006 GTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAF
270 280 290 300 310 320
300 310 320 330 340 350
pF1KB6 GWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYF
::::::::::::::::::.::..:.:::::::::.:::::::::::::::::::::::::
XP_006 GWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYF
330 340 350 360 370 380
360 370
pF1KB6 NGKEQIIYGKIPAMVVDRCGCS
: :.::::::::.:::::::::
XP_006 NDKQQIIYGKIPGMVVDRCGCS
390 400
>>NP_005802 (OMIM: 603936) growth/differentiation factor (407 aa)
initn: 1349 init1: 1088 opt: 1383 Z-score: 1654.0 bits: 314.8 E(85289): 2.2e-85
Smith-Waterman score: 1645; 65.1% identity (84.9% similar) in 352 aa overlap (34-375:58-407)
10 20 30 40 50 60
pF1KB6 LQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSK
: .: : .:.:::... :.:.:: :::::
NP_005 PAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDG-CPVCVWRQHSRELRLESIKSQILSK
30 40 50 60 70 80
70 80 90 100 110 120
pF1KB6 LRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDD-SSDGSLEDDDYHATTETIITMP
:::. :::::..:..:::::::::....: .: : : . . ::.:.:::::::.:.:
NP_005 LRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMA
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB6 TESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKD
:.: .:.::.: :: :.:: :....::.:::::.::::: :.::..::::: ::.
NP_005 QETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRL-KPLTG
150 160 170 180 190 200
190 200 210 220 230
pF1KB6 ---------GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN
: :. :::::.... .: ::::: : ::..:..::.:: ::::.:.: .
NP_005 EGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPS
210 220 230 240 250 260
240 250 260 270 280 290
pF1KB6 GHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAF
: ::::: ::: .::.::.:..: .. :::::..::::::::.::::::::::::::::
NP_005 GTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAF
270 280 290 300 310 320
300 310 320 330 340 350
pF1KB6 GWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYF
::::::::::::::::::.::..:.:::::::::.:::::::::::::::::::::::::
NP_005 GWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYF
330 340 350 360 370 380
360 370
pF1KB6 NGKEQIIYGKIPAMVVDRCGCS
: :.::::::::.:::::::::
NP_005 NDKQQIIYGKIPGMVVDRCGCS
390 400
>>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa)
initn: 279 init1: 168 opt: 313 Z-score: 374.2 bits: 78.4 E(85289): 4.2e-14
Smith-Waterman score: 351; 30.1% identity (53.6% similar) in 276 aa overlap (140-374:238-512)
110 120 130 140 150 160
pF1KB6 DYHATTETIITMPTESDFLMQVDGKPKCCFFKFS-SKIQYNKVVKA-QLWIYLRPVETP-
:::. :.: ..:: : .. :: :
NP_001 FLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSF
210 220 230 240 250 260
170 180 190 200 210 220
pF1KB6 --TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLG
: ...: .... . . . .. : : .:. .. . :. :. :.:
NP_001 KNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMG
270 280 290 300 310 320
230 240 250 260
pF1KB6 IEIKALDENG---HDLAVTFPG-PGEDGLNPFL-------EVKVTDT---------PKRS
...... ..: : :. . : : .::. ::.: : .:.
NP_001 LQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRN
330 340 350 360 370 380
270 280 290 300 310
pF1KB6 RRDFGLDC-------DEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECE
: . : : .:.: . : .. : :.:. .:: ::::::: : ::::.:::
NP_001 RSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECS
390 400 410 420 430 440
320 330 340 350 360
pF1KB6 FVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMV
: . .. :. ::: ::. :::.:::.. :..:::. . ..: : ::
NP_001 FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMV
450 460 470 480 490 500
370
pF1KB6 VDRCGCS
: :::
NP_001 VRACGCH
510
>>NP_878248 (OMIM: 604651) growth/differentiation factor (450 aa)
initn: 259 init1: 154 opt: 306 Z-score: 366.6 bits: 76.8 E(85289): 1.1e-13
Smith-Waterman score: 308; 29.8% identity (55.3% similar) in 228 aa overlap (166-374:226-449)
140 150 160 170 180 190
pF1KB6 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIK-PMKDGTRYTGIRSLKL
: .: .:: . :. . ..: : .
NP_878 YSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSPL---ALRRLGF
200 210 220 230 240 250
200 210 220 230 240 250
pF1KB6 DMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN-GHDLAVT-FPGPGEDGLNPF
: : . :... .. :: : ::.: . : :: .: :: .:
NP_878 GWPGGGGSAAEERAVLVVSSRTQRKES-LFREIRAQARALGAALASEPLPDPGTGTASPR
260 270 280 290 300 310
260 270 280 290 300
pF1KB6 LEV------KVTDTPKRSRRDFGLDCDE-HSTE--SRCCRYPLTVDFEAFGWD-WIIAPK
. ... . :. . : . :. . ::: : :: :::. .::: :::::
NP_878 AVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPL
320 330 340 350 360 370
310 320 330 340 350
pF1KB6 RYKANYCSGECEFVFLQKY-PHTH-----LVHQANPRGSAGPCCTPTKMSPINMLYFNGK
:.: .: : :.: . .. : .: :... : .. . ::.:...:::..::...
NP_878 DYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAA
380 390 400 410 420 430
360 370
pF1KB6 EQIIYGKIPAMVVDRCGCS
....: . :::. :::
NP_878 NNVVYKQYEDMVVEACGCR
440 450
>>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa)
initn: 213 init1: 147 opt: 301 Z-score: 360.6 bits: 75.7 E(85289): 2.4e-13
Smith-Waterman score: 315; 36.2% identity (63.1% similar) in 149 aa overlap (240-374:312-454)
210 220 230 240 250 260
pF1KB6 TVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGP-GEDGLNPFLEVKVTDTPKRSRRDF
..: : : :.: .: : ::
NP_001 TRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLP-----SPGRRRRRT
290 300 310 320 330
270 280 290 300 310 320
pF1KB6 GLDC---DEHSTESR--CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKY-
.. .:. .:: : . :: :.:. .::: ::::: .:.: .: : :.: . ..
NP_001 AFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLE
340 350 360 370 380 390
330 340 350 360 370
pF1KB6 PHTH-----LVHQANPRGSAGP-CCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
: .: :... .: ::. : ::.:::..::..::... ....: . :::. :::
NP_001 PTNHAIIQTLMNSMDP-GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR
400 410 420 430 440 450
>>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa)
initn: 360 init1: 113 opt: 298 Z-score: 357.6 bits: 75.0 E(85289): 3.5e-13
Smith-Waterman score: 376; 24.9% identity (51.6% similar) in 397 aa overlap (39-375:24-414)
10 20 30 40 50 60
pF1KB6 YIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLET
:.. : .. :::::. ::::::.: .
NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQILSKLKLTS
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 APNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPT--
:. ..: ... :.:... .: . . :..:.: : ::
NP_003 PPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFF
60 70 80 90 100 110
130 140 150 160 170
pF1KB6 -ESDFLMQVDGKPKCCFFKFS-SKIQYN--KVVKAQLWIY--LRPVETPTTVFVQILRLI
. . . .: . .:. : .. : ..:::.. .. : ... ...
NP_003 PSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQIL
120 130 140 150 160 170
180 190 200 210 220
pF1KB6 KPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIK-----
: :: : :: . .: . : : :.:: ....::.. . :::..:.
NP_003 KS-KDLTSPTQRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPC
180 190 200 210 220
230 240 250
pF1KB6 ---------ALDENGHDLAVTFPG--------PGED-----------GLNPFL-------
. .....: . : : :.. : .: :
NP_003 CTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPS
230 240 250 260 270 280
260 270 280 290 300 310
pF1KB6 -EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSG
... .: .:..: . ..... :: :: .::. .:: :: :: :.::.:.:
NP_003 YRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAG
290 300 310 320 330 340
320 330 340 350 360
pF1KB6 ECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMV
: ... . :.. : . ::..::.:::. . :...::. :: : .. :.
NP_003 ACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMI
350 360 370 380 390 400
370
pF1KB6 VDRCGCS
: : ::
NP_003 VKSCKCS
410
>>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa)
initn: 307 init1: 136 opt: 298 Z-score: 357.4 bits: 75.0 E(85289): 3.6e-13
Smith-Waterman score: 298; 35.4% identity (57.6% similar) in 158 aa overlap (226-374:278-423)
200 210 220 230 240 250
pF1KB6 MNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFP-GPGEDGLNPFLE
.. ::. : : .: ::::..: .
NP_055 KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLD---SFSSGPGEEALLQMRS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB6 VKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGEC
. :. : ::. . . : : :: .::. .::: ::::: :.: : : :
NP_055 NIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVC
310 320 330 340 350
320 330 340 350 360
pF1KB6 EFVFLQKY-PHTH-----LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYG-KIPA
.. . .. : : ::: : . .. ::.:::. ::..::.. : . : : .
NP_055 NYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLD-KGVVTYKFKYEG
360 370 380 390 400 410
370
pF1KB6 MVVDRCGCS
:.:..:::
NP_055 MAVSECGCR
420
>>XP_011527625 (OMIM: 112261,112600,235200) PREDICTED: b (240 aa)
initn: 290 init1: 134 opt: 295 Z-score: 357.4 bits: 74.2 E(85289): 3.6e-13
Smith-Waterman score: 341; 30.5% identity (57.1% similar) in 226 aa overlap (171-374:15-239)
150 160 170 180 190
pF1KB6 KFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDM-NPG
..: ..::: .... : : . : .
XP_011 MQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQN
10 20 30 40
200 210 220 230 240
pF1KB6 TGIWQSIDVKTVLQNWLKQPESNLG--IEIKALDE----NGHDLAVTFPGPGEDG----L
.. :.:.:: ... : : ..: : .:. :.: . . . .. .. .
XP_011 ASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQI
50 60 70 80 90 100
250 260 270 280 290 300
pF1KB6 NPFL-----EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGW-DWIIAPKR
:.: . : :: .:. . ... .: : :.:: ::: :: :::.::
XP_011 RPLLVTFGHDGKGHPLHKREKRQ-AKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPG
110 120 130 140 150 160
310 320 330 340 350
pF1KB6 YKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP--CCTPTKMSPINMLYFNGKEQ
:.: :: ::: : . .. : : . :. : .: : ::.::..: :.:::.. .:.
XP_011 YHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEK
170 180 190 200 210 220
360 370
pF1KB6 IIYGKIPAMVVDRCGCS
.. . :::. :::
XP_011 VVLKNYQDMVVEGCGCR
230 240
>>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa)
initn: 360 init1: 113 opt: 298 Z-score: 357.2 bits: 75.0 E(85289): 3.7e-13
Smith-Waterman score: 338; 23.8% identity (49.8% similar) in 412 aa overlap (52-375:36-442)
30 40 50 60 70
pF1KB6 DLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNI---SKDVIR
:::::. ::::::.: . :. ..:
NP_001 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP
10 20 30 40 50 60
80 90 100 110 120
pF1KB6 QLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHAT------------TETI---ITMPT
... :.:... .: . . :..:.: .::. .: :.
NP_001 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPS
70 80 90 100 110 120
130 140 150 160
pF1KB6 ---------ESDFLM-QVDGKPKCCFFKFSSKIQYN---------KVVKAQLWIY--LRP
.:. : .:. : . . .... ..:::.. .. :
NP_001 GSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNP
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 VETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQ
... ...: :: : :: . .: . : : :.:: ....::..
NP_001 KARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHH
190 200 210 220 230 240
220 230 240
pF1KB6 PESNLGIEIK--------------ALDENGHDLAVTFPG--------PGED---------
. :::..:. . .....: . : : :..
NP_001 KDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKK
250 260 270 280 290 300
250 260 270 280 290
pF1KB6 --GLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWD
: .: : ... .: .:..: . ..... :: :: .::. .::
NP_001 NSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK
310 320 330 340 350 360
300 310 320 330 340 350
pF1KB6 WIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYF
:: :: :.::.:.: : ... . :.. : . ::..::.:::. . :...::.
NP_001 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY
370 380 390 400 410 420
360 370
pF1KB6 NGKEQIIYGKIPAMVVDRCGCS
:: : .. :.: : ::
NP_001 IGKTPKIE-QLSNMIVKSCKCS
430 440
375 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 16:58:13 2016 done: Sat Nov 5 16:58:14 2016
Total Scan time: 7.000 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]