Result of FASTA (omim) for
pFN21AB5947
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5947, 509 aa
1>>>pF1KB5947 509 - 509 aa - 509 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.6135+/-0.000633; mu= -0.4515+/- 0.038
mean_var=933.4217+/-215.649, 0's: 0 Z-trim(114.9): 1206 B-trim: 0 in 0/55
Lambda= 0.041979
statistics sampled from 23567 (24985) to 23567 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.293), width: 16
Scan time: 8.340
The best scores are: opt bits E(85289)
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 3500 229.0 2.6e-59
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 3500 229.0 2.6e-59
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 2276 154.8 5.4e-37
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 2276 154.8 5.4e-37
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 2276 154.8 5.4e-37
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 2276 154.8 5.4e-37
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 2276 154.9 5.5e-37
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 2276 154.9 5.5e-37
XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-pr ( 491) 2237 152.4 2.8e-36
NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 2237 152.4 2.8e-36
NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 2237 152.5 2.8e-36
XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-pr ( 682) 2237 152.7 3.2e-36
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 2124 145.6 3.2e-34
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 2081 142.9 1.8e-33
XP_011539755 (OMIM: 153390,615758) PREDICTED: tyro ( 516) 1992 137.6 8.3e-32
XP_011539756 (OMIM: 153390,615758) PREDICTED: tyro ( 516) 1992 137.6 8.3e-32
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1952 135.3 4.5e-31
XP_016866139 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1952 135.3 4.5e-31
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1952 135.3 4.5e-31
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 1952 135.3 4.5e-31
XP_016866142 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1952 135.3 4.5e-31
XP_016866143 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 1952 135.3 4.5e-31
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 1942 134.7 6.9e-31
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 1942 134.7 6.9e-31
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 1900 132.1 4e-30
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1900 132.1 4e-30
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 1900 132.1 4e-30
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 1895 131.8 4.9e-30
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 1895 131.8 4.9e-30
XP_016883515 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1886 131.3 7.2e-30
XP_016883516 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1886 131.3 7.2e-30
XP_016883514 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1886 131.3 7.2e-30
XP_016883513 (OMIM: 114500,190090,616937) PREDICTE ( 542) 1886 131.3 7.2e-30
XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1861 129.7 2e-29
XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 1861 129.7 2e-29
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 1861 129.7 2e-29
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 1861 129.7 2e-29
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 1861 129.7 2e-29
NP_001317397 (OMIM: 153390,615758) tyrosine-protei ( 458) 1645 116.5 1.7e-25
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 1512 108.6 4.6e-23
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 1512 108.6 4.6e-23
XP_011539313 (OMIM: 164940) PREDICTED: tyrosine-pr ( 460) 1485 106.8 1.4e-22
XP_005258196 (OMIM: 164880) PREDICTED: tyrosine-pr ( 499) 1380 100.5 1.2e-20
XP_016856163 (OMIM: 164940) PREDICTED: tyrosine-pr ( 325) 1365 99.3 1.8e-20
>>NP_001036236 (OMIM: 153390,615758) tyrosine-protein ki (509 aa)
initn: 3500 init1: 3500 opt: 3500 Z-score: 1185.7 bits: 229.0 E(85289): 2.6e-59
Smith-Waterman score: 3500; 100.0% identity (100.0% similar) in 509 aa overlap (1-509:1-509)
10 20 30 40 50 60
pF1KB5 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
430 440 450 460 470 480
490 500
pF1KB5 PEDRPTFDYLRSVLEDFFTATEGQYQPQP
:::::::::::::::::::::::::::::
NP_001 PEDRPTFDYLRSVLEDFFTATEGQYQPQP
490 500
>>NP_005347 (OMIM: 153390,615758) tyrosine-protein kinas (509 aa)
initn: 3500 init1: 3500 opt: 3500 Z-score: 1185.7 bits: 229.0 E(85289): 2.6e-59
Smith-Waterman score: 3500; 100.0% identity (100.0% similar) in 509 aa overlap (1-509:1-509)
10 20 30 40 50 60
pF1KB5 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
430 440 450 460 470 480
490 500
pF1KB5 PEDRPTFDYLRSVLEDFFTATEGQYQPQP
:::::::::::::::::::::::::::::
NP_005 PEDRPTFDYLRSVLEDFFTATEGQYQPQP
490 500
>>NP_001165602 (OMIM: 142370) tyrosine-protein kinase HC (504 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.1 bits: 154.8 E(85289): 5.4e-37
Smith-Waterman score: 2276; 65.8% identity (84.0% similar) in 511 aa overlap (1-509:1-504)
10 20 30 40 50
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPA
::: :. . . . . .. . : :. : .:. .:. . :::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREGS----
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 SPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAK
.: .:.::..:: : ::.:.::.:. .::.:::::::.::.: .::.:: :.::.
NP_001 ---EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVAR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV
..::: : ::::..:::::::::::::: :::.::.::.: ::.::::::.: ::..:
NP_001 VDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEW
::::::.::::::::::: :: :.::: :: ...:::: .:: ::...:::::: .: :
NP_001 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 EVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQ
:.:::.::: ..:::::::::::. :: :::::::..: :::: .:::::::.:: :::.
NP_001 EIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 RLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER
.::.:.::::.::::::::.: .:::.::::. : : . ::.:..:::::::::::.:
NP_001 KLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFT
::::::::::::::: .: ::::::::::.:::::::::::::::::::::::::.:.::
NP_001 NYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFT
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWK
:::::::::::: ::::.::::::::.:::::. ::::::: ::.:::::::..: :::
NP_001 IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWK
420 430 440 450 460 470
480 490 500
pF1KB5 ERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
.:::.::::.:..:::.::.::::.::: ::
NP_001 NRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165600 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.1 bits: 154.8 E(85289): 5.4e-37
Smith-Waterman score: 2276; 65.6% identity (83.9% similar) in 514 aa overlap (1-509:1-505)
10 20 30 40 50
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRD---PLVTYEGSN
::: :. . . . . .. . : :. : .: :. : . .. : . ::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTST--IKPGPNSHNSNTPGIREAGS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 PPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNF
.: .:.::..:: : ::.:.::.:. .::.:::::::.::.: .::.:: :.
NP_001 ------EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG
::...::: : ::::..:::::::::::::: :::.::.::.: ::.::::::.: ::
NP_001 VARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE
..:::::::.::::::::::: :: :.::: :: ...:::: .:: ::...:::::: .
NP_001 DTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL
: ::.:::.::: ..:::::::::::. :: :::::::..: :::: .:::::::.:: :
NP_001 DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 QHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI
::..::.:.::::.::::::::.: .:::.::::. : : . ::.:..::::::::::
NP_001 QHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG
:.:::::::::::::::: .: ::::::::::.:::::::::::::::::::::::::.:
NP_001 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL
.:::::::::::::: ::::.::::::::.:::::. ::::::: ::.:::::::..:
NP_001 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR
420 430 440 450 460 470
480 490 500
pF1KB5 CWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
:::.:::.::::.:..:::.::.::::.::: ::
NP_001 CWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165604 (OMIM: 142370) tyrosine-protein kinase HC (505 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.1 bits: 154.8 E(85289): 5.4e-37
Smith-Waterman score: 2276; 65.6% identity (83.9% similar) in 514 aa overlap (1-509:1-505)
10 20 30 40 50
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRD---PLVTYEGSN
::: :. . . . . .. . : :. : .: :. : . .. : . ::
NP_001 MGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTST--IKPGPNSHNSNTPGIREAGS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 PPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNF
.: .:.::..:: : ::.:.::.:. .::.:::::::.::.: .::.:: :.
NP_001 ------EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG
::...::: : ::::..:::::::::::::: :::.::.::.: ::.::::::.: ::
NP_001 VARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE
..:::::::.::::::::::: :: :.::: :: ...:::: .:: ::...:::::: .
NP_001 DTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL
: ::.:::.::: ..:::::::::::. :: :::::::..: :::: .:::::::.:: :
NP_001 DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 QHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI
::..::.:.::::.::::::::.: .:::.::::. : : . ::.:..::::::::::
NP_001 QHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG
:.:::::::::::::::: .: ::::::::::.:::::::::::::::::::::::::.:
NP_001 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL
.:::::::::::::: ::::.::::::::.:::::. ::::::: ::.:::::::..:
NP_001 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR
420 430 440 450 460 470
480 490 500
pF1KB5 CWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
:::.:::.::::.:..:::.::.::::.::: ::
NP_001 CWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165603 (OMIM: 142370) tyrosine-protein kinase HC (506 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.1 bits: 154.8 E(85289): 5.4e-37
Smith-Waterman score: 2276; 65.6% identity (83.9% similar) in 514 aa overlap (1-509:2-506)
10 20 30 40 50
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRD---PLVTYEGS
::: :. . . . . .. . : :. : .: :. : . .. : . ::
NP_001 MMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTST--IKPGPNSHNSNTPGIREAGS
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 NPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFN
.: .:.::..:: : ::.:.::.:. .::.:::::::.::.: .::.:: :
NP_001 -------EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ
.::...::: : ::::..:::::::::::::: :::.::.::.: ::.::::::.: :
NP_001 YVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW
:..:::::::.::::::::::: :: :.::: :: ...:::: .:: ::...::::::
NP_001 GDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQ
.: ::.:::.::: ..:::::::::::. :: :::::::..: :::: .:::::::.::
NP_001 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 LQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF
:::..::.:.::::.::::::::.: .:::.::::. : : . ::.:..:::::::::
NP_001 LQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 IEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINY
::.:::::::::::::::: .: ::::::::::.:::::::::::::::::::::::::.
NP_001 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 GTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR
:.:::::::::::::: ::::.::::::::.:::::. ::::::: ::.:::::::..:
NP_001 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM
420 430 440 450 460 470
480 490 500
pF1KB5 LCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
:::.:::.::::.:..:::.::.::::.::: ::
NP_001 RCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500
>>NP_001165601 (OMIM: 142370) tyrosine-protein kinase HC (525 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.0 bits: 154.9 E(85289): 5.5e-37
Smith-Waterman score: 2276; 65.8% identity (84.0% similar) in 511 aa overlap (1-509:22-525)
10 20 30
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLL
::: :. . . . . .. . : :. : .:.
NP_001 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 IRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEW
.:. . ::: .: .:.::..:: : ::.:.::.:. .::.::::
NP_001 PGPNSHNSNTPGIREGS-------EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEW
70 80 90 100 110
100 110 120 130 140 150
pF1KB5 WKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESE
:::.::.: .::.:: :.::...::: : ::::..:::::::::::::: :::.::.::
NP_001 WKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSE
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 STAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLC
.: ::.::::::.: ::..:::::::.::::::::::: :: :.::: :: ...::::
NP_001 TTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLC
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 TRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQ
.:: ::...:::::: .: ::.:::.::: ..:::::::::::. :: :::::::..:
NP_001 QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKP
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB5 GSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLT
:::: .:::::::.:: :::..::.:.::::.::::::::.: .:::.::::. : :
NP_001 GSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQP
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB5 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR
. ::.:..:::::::::::.:::::::::::::::: .: ::::::::::.:::::::::
NP_001 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB5 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGY
::::::::::::::::.:.:::::::::::::: ::::.::::::::.:::::. :::::
NP_001 EGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY
420 430 440 450 460 470
460 470 480 490 500
pF1KB5 RMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
:: ::.:::::::..: :::.:::.::::.:..:::.::.::::.::: ::
NP_001 RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500 510 520
>>NP_002101 (OMIM: 142370) tyrosine-protein kinase HCK i (526 aa)
initn: 2272 init1: 2272 opt: 2276 Z-score: 785.0 bits: 154.9 E(85289): 5.5e-37
Smith-Waterman score: 2276; 65.6% identity (83.9% similar) in 514 aa overlap (1-509:22-526)
10 20 30
pF1KB5 MGCGCSSHPE--DDWMENIDVCENCHYPIVPLDGKGTLL
::: :. . . . . .. . : :. : .:
NP_002 MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTST--
10 20 30 40 50
40 50 60 70 80 90
pF1KB5 IRNGSEVRD---PLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS
:. : . .. : . :: .: .:.::..:: : ::.:.::.:. .::.:
NP_002 IKPGPNSHNSNTPGIREAGS-------EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEES
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB5 GEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIR
::::::.::.: .::.:: :.::...::: : ::::..:::::::::::::: :::.::
NP_002 GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIR
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 ESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASD
.::.: ::.::::::.: ::..:::::::.::::::::::: :: :.::: :: ...:
NP_002 DSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGND
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 GLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKS
::: .:: ::...:::::: .: ::.:::.::: ..:::::::::::. :: :::::::.
NP_002 GLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKT
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB5 LKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGI
.: :::: .:::::::.:: :::..::.:.::::.::::::::.: .:::.::::. :
NP_002 MKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB5 KLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEY
: . ::.:..:::::::::::.:::::::::::::::: .: ::::::::::.::::::
NP_002 KQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEY
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB5 TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLE
:::::::::::::::::::.:.:::::::::::::: ::::.::::::::.:::::. ::
NP_002 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE
420 430 440 450 460 470
460 470 480 490 500
pF1KB5 RGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
::::: ::.:::::::..: :::.:::.::::.:..:::.::.::::.::: ::
NP_002 RGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
480 490 500 510 520
>>XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-protei (491 aa)
initn: 1228 init1: 1203 opt: 2237 Z-score: 772.4 bits: 152.4 E(85289): 2.8e-36
Smith-Waterman score: 2237; 70.4% identity (88.2% similar) in 449 aa overlap (62-509:43-491)
40 50 60 70 80 90
pF1KB5 GKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL
: ..:.::. :. : ::.:.:::....:
XP_016 SDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB5 EQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSF
:. ::::::.:: : .::::: :.::: :.:: : ::::...:::::::::::::. :.:
XP_016 EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAF
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB5 LIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTN
::::::. ::::::::::: .:.:.::::::.:::::.::::::::: . ....:: .
XP_016 LIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQK
140 150 160 170 180 190
220 230 240 250 260 270
pF1KB5 ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVA
.:::: :: . : . :::::: .: ::.:::..:::.::::::::::::::::. ::::
XP_016 QADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVA
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB5 VKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKT
::.:: :.:: .::: :::::: :::..::::::::: .:::::::::: .:::.::::.
XP_016 VKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKS
260 270 280 290 300 310
340 350 360 370 380 390
pF1KB5 PSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE
: :. . ::.:..::::::::.::..:::::::::::.:::..: ::::::::::.::
XP_016 DEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE
320 330 340 350 360 370
400 410 420 430 440 450
pF1KB5 DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVI
:::::::::::::::::::::::.: :::::::::::::: ::::.:.::::: :: .:.
XP_016 DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVM
380 390 400 410 420 430
460 470 480 490 500
pF1KB5 QNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
: .:::: : .:::.:::..:..::::. :.:::::::.:::.::.:::::::: ::
XP_016 TALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
440 450 460 470 480 490
>>NP_001104567 (OMIM: 165120) tyrosine-protein kinase Ly (491 aa)
initn: 1228 init1: 1203 opt: 2237 Z-score: 772.4 bits: 152.4 E(85289): 2.8e-36
Smith-Waterman score: 2237; 70.4% identity (88.2% similar) in 449 aa overlap (62-509:43-491)
40 50 60 70 80 90
pF1KB5 GKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL
: ..:.::. :. : ::.:.:::....:
NP_001 SDDGVDLKTQPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB5 EQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSF
:. ::::::.:: : .::::: :.::: :.:: : ::::...:::::::::::::. :.:
NP_001 EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAF
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB5 LIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTN
::::::. ::::::::::: .:.:.::::::.:::::.::::::::: . ....:: .
NP_001 LIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQK
140 150 160 170 180 190
220 230 240 250 260 270
pF1KB5 ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVA
.:::: :: . : . :::::: .: ::.:::..:::.::::::::::::::::. ::::
NP_001 QADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVA
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB5 VKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKT
::.:: :.:: .::: :::::: :::..::::::::: .:::::::::: .:::.::::.
NP_001 VKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKS
260 270 280 290 300 310
340 350 360 370 380 390
pF1KB5 PSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE
: :. . ::.:..::::::::.::..:::::::::::.:::..: ::::::::::.::
NP_001 DEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE
320 330 340 350 360 370
400 410 420 430 440 450
pF1KB5 DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVI
:::::::::::::::::::::::.: :::::::::::::: ::::.:.::::: :: .:.
NP_001 DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVM
380 390 400 410 420 430
460 470 480 490 500
pF1KB5 QNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
: .:::: : .:::.:::..:..::::. :.:::::::.:::.::.:::::::: ::
NP_001 TALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
440 450 460 470 480 490
509 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:40:15 2016 done: Sat Nov 5 15:40:16 2016
Total Scan time: 8.340 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]