Result of FASTA (omim) for
pFN21AB5832
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5832, 481 aa
1>>>pF1KB5832 481 - 481 aa - 481 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.8232+/-0.000415; mu= -16.4884+/- 0.025
mean_var=496.4965+/-106.239, 0's: 0 Z-trim(123.9): 34 B-trim: 799 in 1/61
Lambda= 0.057559
statistics sampled from 44390 (44451) to 44390 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.521), width: 16
Scan time: 11.880
The best scores are: opt bits E(85289)
NP_006067 (OMIM: 604019) arf-GAP domain and FG rep ( 481) 3303 288.7 2.5e-77
XP_016867601 (OMIM: 604019) PREDICTED: arf-GAP dom ( 394) 2691 237.8 4.3e-62
XP_005250363 (OMIM: 604019) PREDICTED: arf-GAP dom ( 492) 2076 186.8 1.2e-46
XP_016867602 (OMIM: 604019) PREDICTED: arf-GAP dom ( 295) 1995 179.9 8.7e-45
XP_016867603 (OMIM: 604019) PREDICTED: arf-GAP dom ( 247) 1336 125.1 2.3e-28
NP_001128659 (OMIM: 600862) arf-GAP domain and FG ( 584) 929 91.6 6.4e-18
XP_005246573 (OMIM: 600862) PREDICTED: arf-GAP dom ( 586) 929 91.6 6.4e-18
XP_006712542 (OMIM: 600862) PREDICTED: arf-GAP dom ( 600) 929 91.6 6.5e-18
XP_006712541 (OMIM: 600862) PREDICTED: arf-GAP dom ( 602) 929 91.6 6.5e-18
NP_001128660 (OMIM: 600862) arf-GAP domain and FG ( 560) 908 89.8 2.1e-17
NP_004495 (OMIM: 600862) arf-GAP domain and FG rep ( 562) 908 89.8 2.1e-17
XP_006712543 (OMIM: 600862) PREDICTED: arf-GAP dom ( 578) 908 89.9 2.1e-17
NP_001128661 (OMIM: 600862) arf-GAP domain and FG ( 522) 896 88.8 3.9e-17
>>NP_006067 (OMIM: 604019) arf-GAP domain and FG repeat- (481 aa)
initn: 3303 init1: 3303 opt: 3303 Z-score: 1509.3 bits: 288.7 E(85289): 2.5e-77
Smith-Waterman score: 3303; 100.0% identity (100.0% similar) in 481 aa overlap (1-481:1-481)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
430 440 450 460 470 480
pF1KB5 L
:
NP_006 L
>>XP_016867601 (OMIM: 604019) PREDICTED: arf-GAP domain (394 aa)
initn: 2691 init1: 2691 opt: 2691 Z-score: 1235.8 bits: 237.8 E(85289): 4.3e-62
Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 394 aa overlap (88-481:1-394)
60 70 80 90 100 110
pF1KB5 VDITVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDA
::::::::::::::::::::::::::::::
XP_016 MTTFTEPEVVFLQSRGNEVCRKIWLGLFDA
10 20 30
120 130 140 150 160 170
pF1KB5 RTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRT
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAP
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB5 QMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQG
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB5 TPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSST
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB5 GLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSF
280 290 300 310 320 330
420 430 440 450 460 470
pF1KB5 PAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTT
340 350 360 370 380 390
480
pF1KB5 NPFL
::::
XP_016 NPFL
>>XP_005250363 (OMIM: 604019) PREDICTED: arf-GAP domain (492 aa)
initn: 2070 init1: 2000 opt: 2076 Z-score: 958.5 bits: 186.8 E(85289): 1.2e-46
Smith-Waterman score: 3271; 97.8% identity (97.8% similar) in 492 aa overlap (1-481:1-492)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
190 200 210 220 230 240
250 260 270 280 290
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPA--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAASRMLTES
250 260 270 280 290 300
300 310 320 330 340
pF1KB5 ---GSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSFGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 GGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPP
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 TGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSP
430 440 450 460 470 480
470 480
pF1KB5 FASKPPTTNPFL
::::::::::::
XP_005 FASKPPTTNPFL
490
>>XP_016867602 (OMIM: 604019) PREDICTED: arf-GAP domain (295 aa)
initn: 1995 init1: 1995 opt: 1995 Z-score: 925.1 bits: 179.9 E(85289): 8.7e-45
Smith-Waterman score: 1995; 100.0% identity (100.0% similar) in 292 aa overlap (1-292:1-292)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAVGC
250 260 270 280 290
310 320 330 340 350 360
pF1KB5 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
>>XP_016867603 (OMIM: 604019) PREDICTED: arf-GAP domain (247 aa)
initn: 1308 init1: 1308 opt: 1336 Z-score: 630.4 bits: 125.1 E(85289): 2.3e-28
Smith-Waterman score: 1564; 95.5% identity (95.5% similar) in 242 aa overlap (251-481:6-247)
230 240 250 260 270 280
pF1KB5 ASTDLLADIGGDPFAAPQMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPA
::::::::::::::::::::::::::::::
XP_016 MRRRDGQTPSQGGFANFDAFSSGPSSSVFGSLPPA
10 20 30
290 300 310 320
pF1KB5 GQASFQAQPTPA-----------GSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAG
:::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 GQASFQAQPTPAASRMLTESYSFGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAG
40 50 60 70 80 90
330 340 350 360 370 380
pF1KB5 VPSSLFGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSSLFGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLA
100 110 120 130 140 150
390 400 410 420 430 440
pF1KB5 PGPGFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPGFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRP
160 170 180 190 200 210
450 460 470 480
pF1KB5 LSQPAGISTNPFMTGPSSSPFASKPPTTNPFL
::::::::::::::::::::::::::::::::
XP_016 LSQPAGISTNPFMTGPSSSPFASKPPTTNPFL
220 230 240
>>NP_001128659 (OMIM: 600862) arf-GAP domain and FG repe (584 aa)
initn: 1009 init1: 635 opt: 929 Z-score: 442.7 bits: 91.6 E(85289): 6.4e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
. .:.. : . ::.::.: ::: :::..
NP_001 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
10 20 30 40
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
NP_001 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
.:: :::::::::::::::::::::::.:.: . ...: .:. .: :: :::..
NP_001 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
:::: ::.: . .: :: :: . ::... . : . :::.:.:.: :::
NP_001 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
170 180 190 200 210
240 250 260 270 280
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
: . : : :: : . ..:. ... :::::::... .:: ::..: :... :: :
NP_001 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
: .. : : .: :: :.. .: :.:.. .. . : .. :. :: .
NP_001 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
:... . . ::. : .. ..: : . . :.. .: : ::: .. .:
NP_001 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
330 340 350 360 370 380
410 420 430 440 450
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
: .:: .. .:. : : .. . . ..: : .. .: .: :. .:
NP_001 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
390 400 410 420 430 440
460 470 480
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL
::. :. :: . ::..:: :. :. ::::
NP_001 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTP
450 460 470 480 490 500
NP_001 APYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGFAAFGQTKPVVTPFGQVAAAGVSS
510 520 530 540 550 560
>>XP_005246573 (OMIM: 600862) PREDICTED: arf-GAP domain (586 aa)
initn: 1048 init1: 635 opt: 929 Z-score: 442.7 bits: 91.6 E(85289): 6.4e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
. .:.. : . ::.::.: ::: :::..
XP_005 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
10 20 30 40
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_005 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
.:: :::::::::::::::::::::::.:.: . ...: .:. .: :: :::..
XP_005 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
:::: ::.: . .: :: :: . ::... . : . :::.:.:.: :::
XP_005 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
170 180 190 200 210
240 250 260 270 280
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
: . : : :: : . ..:. ... :::::::... .:: ::..: :... :: :
XP_005 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
: .. : : .: :: :.. .: :.:.. .. . : .. :. :: .
XP_005 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
:... . . ::. : .. ..: : . . :.. .: : ::: .. .:
XP_005 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
330 340 350 360 370 380
410 420 430 440 450
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
: .:: .. .:. : : .. . . ..: : .. .: .: :. .:
XP_005 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
390 400 410 420 430 440
460 470 480
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL
::. :. :: . ::..:: :. :. ::::
XP_005 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTP
450 460 470 480 490 500
XP_005 APYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQTKPVVTPFGQVAAAGV
510 520 530 540 550 560
>>XP_006712542 (OMIM: 600862) PREDICTED: arf-GAP domain (600 aa)
initn: 1009 init1: 635 opt: 929 Z-score: 442.6 bits: 91.6 E(85289): 6.5e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
. .:.. : . ::.::.: ::: :::..
XP_006 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
10 20 30 40
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_006 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
.:: :::::::::::::::::::::::.:.: . ...: .:. .: :: :::..
XP_006 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
:::: ::.: . .: :: :: . ::... . : . :::.:.:.: :::
XP_006 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
170 180 190 200 210
240 250 260 270 280
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
: . : : :: : . ..:. ... :::::::... .:: ::..: :... :: :
XP_006 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
: .. : : .: :: :.. .: :.:.. .. . : .. :. :: .
XP_006 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
:... . . ::. : .. ..: : . . :.. .: : ::: .. .:
XP_006 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
330 340 350 360 370 380
410 420 430 440 450
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
: .:: .. .:. : : .. . . ..: : .. .: .: :. .:
XP_006 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
390 400 410 420 430 440
460 470 480
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL
::. :. :: . ::..:: :. :. ::::
XP_006 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATGLSGAMHSQVFPHAHFAA
450 460 470 480 490 500
XP_006 TFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGFAAFGQTK
510 520 530 540 550 560
>>XP_006712541 (OMIM: 600862) PREDICTED: arf-GAP domain (602 aa)
initn: 1048 init1: 635 opt: 929 Z-score: 442.6 bits: 91.6 E(85289): 6.5e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
. .:.. : . ::.::.: ::: :::..
XP_006 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
10 20 30 40
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_006 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
.:: :::::::::::::::::::::::.:.: . ...: .:. .: :: :::..
XP_006 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
:::: ::.: . .: :: :: . ::... . : . :::.:.:.: :::
XP_006 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
170 180 190 200 210
240 250 260 270 280
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
: . : : :: : . ..:. ... :::::::... .:: ::..: :... :: :
XP_006 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
: .. : : .: :: :.. .: :.:.. .. . : .. :. :: .
XP_006 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
280 290 300 310 320
350 360 370 380 390 400
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
:... . . ::. : .. ..: : . . :.. .: : ::: .. .:
XP_006 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
330 340 350 360 370 380
410 420 430 440 450
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
: .:: .. .:. : : .. . . ..: : .. .: .: :. .:
XP_006 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
390 400 410 420 430 440
460 470 480
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL
::. :. :: . ::..:: :. :. ::::
XP_006 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATGLSGAMHSQVFPHAHFAA
450 460 470 480 490 500
XP_006 TFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQ
510 520 530 540 550 560
>>NP_001128660 (OMIM: 600862) arf-GAP domain and FG repe (560 aa)
initn: 988 init1: 635 opt: 908 Z-score: 433.6 bits: 89.8 E(85289): 2.1e-17
Smith-Waterman score: 930; 40.8% identity (62.8% similar) in 478 aa overlap (31-480:15-451)
10 20 30 40 50 60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
. .:.. : . ::.::.: ::: :::..
NP_001 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
10 20 30 40
70 80 90 100 110 120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
NP_001 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
50 60 70 80 90 100
130 140 150 160 170
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
.:: :::::::::::::::::::::::.:.: . ...: .:. .: :: :::..
NP_001 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
:::: ::.: . .: :: :: . ::... . : . :::.:.:.: :::
NP_001 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
170 180 190 200 210
240 250 260 270 280
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
: . : : :: : . ..:. ... :::::::... .:: ::..: :... :: :
NP_001 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB5 TP-AGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVT
: ...: .. :. : : : :: :.: :. :. : . :..
NP_001 TGGSAASVNANFAHFDNFPKS---SSADFGTF---------NTSQSHQTASAVSKV-STN
280 290 300 310
350 360 370 380 390 400
pF1KB5 MGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-GFPQAV
.: .. :.. . : :.: .: : ::: .. .: : .:
NP_001 KAGLQTADKYAALANLDNIFSAG--------------QGGDQGSGFGTTGKAPVGSVVSV
320 330 340 350 360
410 420 430 440 450
pF1KB5 PPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQPAGIST
: .. .:. : : .. . . ..: : .. .: .: :. .:::. :.
NP_001 PSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQPASSSV
370 380 390 400 410 420
460 470 480
pF1KB5 -NPFMTGPSSSPF-ASKPPT----TNPFL
:: . ::..:: :. :. ::::
NP_001 PAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTPAPYSLP
430 440 450 460 470 480
481 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:05:20 2016 done: Sat Nov 5 15:05:21 2016
Total Scan time: 11.880 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]