Result of FASTA (omim) for
pFN21AB7937
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7937, 376 aa
1>>>pF1KB7937 376 - 376 aa - 376 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.7131+/-0.000436; mu= -6.8019+/- 0.027
mean_var=342.5732+/-72.708, 0's: 0 Z-trim(121.2): 108 B-trim: 349 in 1/56
Lambda= 0.069294
statistics sampled from 37302 (37421) to 37302 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.439), width: 16
Scan time: 8.080
The best scores are: opt bits E(85289)
NP_056943 (OMIM: 600520) transcription initiation ( 376) 2492 262.6 1.1e-69
NP_963889 (OMIM: 600520) transcription initiation ( 337) 2246 238.0 2.5e-62
NP_001265869 (OMIM: 600520) transcription initiati ( 326) 2173 230.6 3.9e-60
NP_001180416 (OMIM: 605358) TFIIA-alpha and beta-l ( 444) 412 54.7 4.8e-07
NP_006863 (OMIM: 605358) TFIIA-alpha and beta-like ( 478) 412 54.7 5.1e-07
>>NP_056943 (OMIM: 600520) transcription initiation fact (376 aa)
initn: 2492 init1: 2492 opt: 2492 Z-score: 1372.2 bits: 262.6 E(85289): 1.1e-69
Smith-Waterman score: 2492; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376)
10 20 30 40 50 60
pF1KB7 MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 PDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 SVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 AAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 KDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNL
310 320 330 340 350 360
370
pF1KB7 NGRDYIFSKAIGDAEW
::::::::::::::::
NP_056 NGRDYIFSKAIGDAEW
370
>>NP_963889 (OMIM: 600520) transcription initiation fact (337 aa)
initn: 2246 init1: 2246 opt: 2246 Z-score: 1239.9 bits: 238.0 E(85289): 2.5e-62
Smith-Waterman score: 2246; 100.0% identity (100.0% similar) in 337 aa overlap (40-376:1-337)
10 20 30 40 50 60
pF1KB7 VPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQ
::::::::::::::::::::::::::::::
NP_963 MELKTLWENKLMQSRAVDGFHSEEQQLLLQ
10 20 30
70 80 90 100 110 120
pF1KB7 VQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 VQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHM
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB7 NASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVI
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB7 PQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 PQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQ
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB7 ITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 ITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQV
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB7 EEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSK
280 290 300 310 320 330
370
pF1KB7 AIGDAEW
:::::::
NP_963 AIGDAEW
>>NP_001265869 (OMIM: 600520) transcription initiation f (326 aa)
initn: 2173 init1: 2173 opt: 2173 Z-score: 1200.6 bits: 230.6 E(85289): 3.9e-60
Smith-Waterman score: 2173; 100.0% identity (100.0% similar) in 326 aa overlap (51-376:1-326)
30 40 50 60 70 80
pF1KB7 VINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQ
::::::::::::::::::::::::::::::
NP_001 MQSRAVDGFHSEEQQLLLQVQQQHQPQQQQ
10 20 30
90 100 110 120 130 140
pF1KB7 HHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB7 ATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB7 VIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQA
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB7 QPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDV
220 230 240 250 260 270
330 340 350 360 370
pF1KB7 SDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW
280 290 300 310 320
>>NP_001180416 (OMIM: 605358) TFIIA-alpha and beta-like (444 aa)
initn: 501 init1: 403 opt: 412 Z-score: 247.4 bits: 54.7 E(85289): 4.8e-07
Smith-Waterman score: 451; 34.6% identity (58.4% similar) in 332 aa overlap (97-376:120-444)
70 80 90 100 110 120
pF1KB7 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLI
: : ::. :. :...:: . : : :
NP_001 TLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQ-LNPWS-LQ
90 100 110 120 130 140
130 140 150 160 170
pF1KB7 QHMNASNMSAAATAATLALPAGVTPVQQ---------ILTNSGQLLQVVRAA-----NGA
. :. .. ::.: ::.. ::.. :. ..: : ...
NP_001 ATTEKSQRIETVLQQPAILPSG--PVDRKHLENATSDILVSPGNEHKIVPEALLCHQESS
150 160 170 180 190 200
180 190 200 210 220
pF1KB7 QYIFQPQQSVVLQQQV------IPQMQPGGVQAP--VIQQVLAPLPGGISPQ--TGVIIQ
.:: : .::.. :: . .. :... . .. :. : : : : . ..
NP_001 HYISLP--GVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLH
210 220 230 240 250 260
230 240 250 260 270 280
pF1KB7 PQQILFTGNKTQVIPTTVAAPT--PAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTS
. . : . : .. :. :.. . ...: . . . .. . ..::::.::::
NP_001 ILKNRMYGCDSVKQPRNIEEPSNIPVSEK-DSNSQVDLSIRVTDDDIGEIIQVDGSGDTS
270 280 290 300 310 320
290 300 310
pF1KB7 SEE------DEDEEE-----DYDD----DEEEDK--EKDGA------EDGQV---EEEPL
:.: : ::.: : : .:: :. ..:.: :: :: ::.::
NP_001 SNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPL
330 340 350 360 370 380
320 330 340 350 360 370
pF1KB7 NSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDA
:: ::::... .::::.::.::::::::::::::::.::::.: ..::::.:.::::::
NP_001 NSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDA
390 400 410 420 430 440
pF1KB7 EW
::
NP_001 EW
>>NP_006863 (OMIM: 605358) TFIIA-alpha and beta-like fac (478 aa)
initn: 653 init1: 403 opt: 412 Z-score: 247.0 bits: 54.7 E(85289): 5.1e-07
Smith-Waterman score: 451; 34.6% identity (58.4% similar) in 332 aa overlap (97-376:154-478)
70 80 90 100 110 120
pF1KB7 LLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLI
: : ::. :. :...:: . : : :
NP_006 TLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQ-LNPWS-LQ
130 140 150 160 170 180
130 140 150 160 170
pF1KB7 QHMNASNMSAAATAATLALPAGVTPVQQ---------ILTNSGQLLQVVRAA-----NGA
. :. .. ::.: ::.. ::.. :. ..: : ...
NP_006 ATTEKSQRIETVLQQPAILPSG--PVDRKHLENATSDILVSPGNEHKIVPEALLCHQESS
190 200 210 220 230
180 190 200 210 220
pF1KB7 QYIFQPQQSVVLQQQV------IPQMQPGGVQAP--VIQQVLAPLPGGISPQ--TGVIIQ
.:: : .::.. :: . .. :... . .. :. : : : : . ..
NP_006 HYISLP--GVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLH
240 250 260 270 280 290
230 240 250 260 270 280
pF1KB7 PQQILFTGNKTQVIPTTVAAPT--PAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTS
. . : . : .. :. :.. . ...: . . . .. . ..::::.::::
NP_006 ILKNRMYGCDSVKQPRNIEEPSNIPVSEK-DSNSQVDLSIRVTDDDIGEIIQVDGSGDTS
300 310 320 330 340 350
290 300 310
pF1KB7 SEE------DEDEEE-----DYDD----DEEEDK--EKDGA------EDGQV---EEEPL
:.: : ::.: : : .:: :. ..:.: :: :: ::.::
NP_006 SNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPL
360 370 380 390 400 410
320 330 340 350 360 370
pF1KB7 NSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDA
:: ::::... .::::.::.::::::::::::::::.::::.: ..::::.:.::::::
NP_006 NSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDA
420 430 440 450 460 470
pF1KB7 EW
::
NP_006 EW
376 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 14:40:47 2016 done: Sat Nov 5 14:40:49 2016
Total Scan time: 8.080 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]