Result of FASTA (omim) for
pFN21AB0413
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0413, 467 aa
1>>>pF1KB0413 467 - 467 aa - 467 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0852+/-0.000322; mu= 19.7167+/- 0.020
mean_var=83.9551+/-16.795, 0's: 0 Z-trim(118.1): 62 B-trim: 932 in 1/53
Lambda= 0.139975
statistics sampled from 30533 (30630) to 30533 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.359), width: 16
Scan time: 9.660
The best scores are: opt bits E(85289)
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 3459 708.3 1.1e-203
XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440) 2710 557.0 3.7e-158
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 2638 542.4 7.8e-154
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 2638 542.4 7.8e-154
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 2474 509.3 7.9e-144
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 2245 463.1 6.9e-130
XP_006715125 (OMIM: 606749) PREDICTED: tubulointer ( 458) 1525 317.7 4.2e-86
NP_055279 (OMIM: 606749) tubulointerstitial nephri ( 476) 1525 317.7 4.3e-86
XP_016866235 (OMIM: 606749) PREDICTED: tubulointer ( 401) 1345 281.3 3.3e-75
XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438) 1293 270.8 5.2e-72
XP_011512799 (OMIM: 606749) PREDICTED: tubulointer ( 426) 1160 244.0 6.1e-64
XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 1157 243.2 7.4e-64
XP_016866236 (OMIM: 606749) PREDICTED: tubulointer ( 351) 1157 243.3 8.2e-64
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 412 92.8 1.5e-18
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 412 92.8 1.5e-18
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 412 92.8 1.5e-18
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 412 92.8 1.5e-18
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 412 92.8 1.5e-18
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 412 92.8 1.5e-18
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 336 77.3 5.1e-14
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 277 65.7 3.1e-10
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 237 57.3 4.9e-08
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 208 51.6 3.9e-06
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 208 51.6 3.9e-06
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 203 50.6 7.7e-06
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 196 49.2 2.1e-05
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 196 49.2 2.1e-05
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 196 49.2 2.1e-05
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 196 49.2 2.1e-05
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 196 49.2 2.1e-05
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 190 47.7 2.7e-05
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 160 41.8 0.0028
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 160 41.8 0.0028
NP_001326 (OMIM: 602364) cathepsin W preproprotein ( 376) 158 41.6 0.0046
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201) 151 39.9 0.0078
>>NP_071447 (OMIM: 616064) tubulointerstitial nephritis (467 aa)
initn: 3459 init1: 3459 opt: 3459 Z-score: 3777.4 bits: 708.3 E(85289): 1.1e-203
Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 467 aa overlap (1-467:1-467)
10 20 30 40 50 60
pF1KB0 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY
370 380 390 400 410 420
430 440 450 460
pF1KB0 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
:::::::::::::::::::::::::::::::::::::::::::::::
NP_071 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
430 440 450 460
>>XP_005271163 (OMIM: 616064) PREDICTED: tubulointerstit (440 aa)
initn: 2738 init1: 2710 opt: 2710 Z-score: 2960.3 bits: 557.0 E(85289): 3.7e-158
Smith-Waterman score: 2710; 100.0% identity (100.0% similar) in 364 aa overlap (1-364:1-364)
10 20 30 40 50 60
pF1KB0 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY
::::
XP_005 GPVQDGERRRCQMEGRSNTGLRPTPGAQPGARGATSASCAASMSATSRASCWASGAAWAW
370 380 390 400 410 420
>>XP_005271164 (OMIM: 616064) PREDICTED: tubulointerstit (362 aa)
initn: 2638 init1: 2638 opt: 2638 Z-score: 2882.8 bits: 542.4 E(85289): 7.8e-154
Smith-Waterman score: 2638; 100.0% identity (100.0% similar) in 362 aa overlap (106-467:1-362)
80 90 100 110 120 130
pF1KB0 FCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQC
::::::::::::::::::::::::::::::
XP_005 MHGGRIYPVLGTYWDNCNRCTCQENRQWQC
10 20 30
140 150 160 170 180 190
pF1KB0 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB0 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB0 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB0 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB0 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG
280 290 300 310 320 330
440 450 460
pF1KB0 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
::::::::::::::::::::::::::::::::
XP_005 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
340 350 360
>>NP_001191344 (OMIM: 616064) tubulointerstitial nephrit (362 aa)
initn: 2638 init1: 2638 opt: 2638 Z-score: 2882.8 bits: 542.4 E(85289): 7.8e-154
Smith-Waterman score: 2638; 100.0% identity (100.0% similar) in 362 aa overlap (106-467:1-362)
80 90 100 110 120 130
pF1KB0 FCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQC
::::::::::::::::::::::::::::::
NP_001 MHGGRIYPVLGTYWDNCNRCTCQENRQWQC
10 20 30
140 150 160 170 180 190
pF1KB0 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYT
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB0 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLS
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB0 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRA
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB0 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFL
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB0 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERG
280 290 300 310 320 330
440 450 460
pF1KB0 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
::::::::::::::::::::::::::::::::
NP_001 HFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
340 350 360
>>XP_011540248 (OMIM: 616064) PREDICTED: tubulointerstit (408 aa)
initn: 2474 init1: 2474 opt: 2474 Z-score: 2703.2 bits: 509.3 E(85289): 7.9e-144
Smith-Waterman score: 2474; 100.0% identity (100.0% similar) in 342 aa overlap (126-467:67-408)
100 110 120 130 140 150
pF1KB0 PPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNY
::::::::::::::::::::::::::::::
XP_011 PLLTLSVRRSQSQEAEARGPAWAPAHTFTSTCQENRQWQCDQEPCLVDPDMIKAINQGNY
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB0 GWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB0 LIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRL
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB0 DGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNN
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB0 DIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYR
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB0 RHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGV
340 350 360 370 380 390
460
pF1KB0 WGRVGMEDMGHH
::::::::::::
XP_011 WGRVGMEDMGHH
400
>>NP_001191343 (OMIM: 616064) tubulointerstitial nephrit (436 aa)
initn: 2237 init1: 2237 opt: 2245 Z-score: 2452.9 bits: 463.1 E(85289): 6.9e-130
Smith-Waterman score: 3147; 93.4% identity (93.4% similar) in 467 aa overlap (1-467:1-436)
10 20 30 40 50 60
pF1KB0 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRAD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 NCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGT
::::: ::::::::::::::::::::::::
NP_001 NCNRC-------------------------------WQAGNHSAFWGMTLDEGIRYRLGT
130 140
190 200 210 220 230 240
pF1KB0 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASD
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB0 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRER
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB0 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMEN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB0 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKY
330 340 350 360 370 380
430 440 450 460
pF1KB0 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
390 400 410 420 430
>>XP_006715125 (OMIM: 606749) PREDICTED: tubulointerstit (458 aa)
initn: 1451 init1: 664 opt: 1525 Z-score: 1666.8 bits: 317.7 E(85289): 4.2e-86
Smith-Waterman score: 1525; 49.4% identity (73.5% similar) in 427 aa overlap (45-463:36-456)
20 30 40 50 60 70
pF1KB0 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY
:.::.. ::. : : :. . .: .::
XP_006 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY
10 20 30 40 50 60
80 90 100 110 120
pF1KB0 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT
:: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: ::
XP_006 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS
:. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. ::
XP_006 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS
...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.:
XP_006 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA
:..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. .
XP_006 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPL---FKDQNATN
250 260 270 280 290
310 320 330 340 350 360
pF1KB0 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL
: : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.
XP_006 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB0 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS
:.:.:::: :: ::: :. . . :.::. ::.::.:::: .:. :.: ::::
XP_006 MQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANS
360 370 380 390 400 410
430 440 450 460
pF1KB0 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
:: .::: :.:::.::::: :::......::.. :
XP_006 WGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
420 430 440 450
>>NP_055279 (OMIM: 606749) tubulointerstitial nephritis (476 aa)
initn: 1451 init1: 664 opt: 1525 Z-score: 1666.6 bits: 317.7 E(85289): 4.3e-86
Smith-Waterman score: 1525; 49.4% identity (73.5% similar) in 427 aa overlap (45-463:54-474)
20 30 40 50 60 70
pF1KB0 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY
:.::.. ::. : : :. . .: .::
NP_055 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY
30 40 50 60 70 80
80 90 100 110 120
pF1KB0 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT
:: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: ::
NP_055 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB0 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS
:. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. ::
NP_055 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM
150 160 170 180 190 200
190 200 210 220 230 240
pF1KB0 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS
...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.:
NP_055 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
210 220 230 240 250 260
250 260 270 280 290 300
pF1KB0 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA
:..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. .
NP_055 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPL---FKDQNATN
270 280 290 300 310
310 320 330 340 350 360
pF1KB0 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL
: : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.
NP_055 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI
320 330 340 350 360 370
370 380 390 400 410 420
pF1KB0 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS
:.:.:::: :: ::: :. . . :.::. ::.::.:::: .:. :.: ::::
NP_055 MQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANS
380 390 400 410 420 430
430 440 450 460
pF1KB0 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
:: .::: :.:::.::::: :::......::.. :
NP_055 WGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
440 450 460 470
>>XP_016866235 (OMIM: 606749) PREDICTED: tubulointerstit (401 aa)
initn: 1321 init1: 664 opt: 1345 Z-score: 1471.1 bits: 281.3 E(85289): 3.3e-75
Smith-Waterman score: 1345; 50.8% identity (76.0% similar) in 362 aa overlap (102-463:42-399)
80 90 100 110 120 130
pF1KB0 YCDLFCNRTVSDCCPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCTCQENR
.:::.. :. : .. .::: :::. ..
XP_016 YLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGCFKDGQHYEEGSVIKENCNSCTCS-GQ
20 30 40 50 60 70
140 150 160 170 180 190
pF1KB0 QWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMH
::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. :: ...:.
XP_016 QWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPMLLSMN
80 90 100 110 120 130
200 210 220 230 240 250
pF1KB0 EIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMT
:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.: :..:
XP_016 EMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYT
140 150 160 170 180 190
260 270 280 290 300 310
pF1KB0 PVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMM
::::::.:: .....:: .: .: :::.::.::.:: :::. .:. . : :
XP_016 ANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPL---FKDQNATNNGCAM
200 210 220 230 240
320 330 340 350 360 370
pF1KB0 HSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHE
::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.:.:.:
XP_016 ASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVRE
250 260 270 280 290 300
380 390 400 410 420 430
pF1KB0 DFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAW
::: :: ::: :. . . :.::. ::.::.:::: .:. :.: :::::: .:
XP_016 DFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSW
310 320 330 340 350 360
440 450 460
pF1KB0 GERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
:: :.:::.::::: :::......::.. :
XP_016 GENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
370 380 390 400
>>XP_016866234 (OMIM: 606749) PREDICTED: tubulointerstit (438 aa)
initn: 1239 init1: 664 opt: 1293 Z-score: 1413.9 bits: 270.8 E(85289): 5.2e-72
Smith-Waterman score: 1293; 49.2% identity (73.2% similar) in 370 aa overlap (45-406:54-417)
20 30 40 50 60 70
pF1KB0 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY
:.::.. ::. : : :. . .: .::
XP_016 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY
30 40 50 60 70 80
80 90 100 110 120
pF1KB0 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT
:: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: ::
XP_016 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB0 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS
:. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. ::
XP_016 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM
150 160 170 180 190 200
190 200 210 220 230 240
pF1KB0 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS
...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.:
XP_016 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
210 220 230 240 250 260
250 260 270 280 290 300
pF1KB0 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA
:..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. .
XP_016 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATN
270 280 290 300 310
310 320 330 340 350 360
pF1KB0 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL
: : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.
XP_016 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI
320 330 340 350 360 370
370 380 390 400 410 420
pF1KB0 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS
:.:.:::: :: ::: :. . . :.::. ::.::.::
XP_016 MQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGLLPIPGESHGERMAISGFFE
380 390 400 410 420 430
430 440 450 460
pF1KB0 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
XP_016 E
467 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:52:02 2016 done: Sat Nov 5 11:52:03 2016
Total Scan time: 9.660 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]