Result of FASTA (omim) for
pFN21AB6635
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6635, 418 aa
1>>>pF1KB6635 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5877+/-0.000351; mu= 17.4947+/- 0.022
mean_var=99.4985+/-19.650, 0's: 0 Z-trim(116.0): 67 B-trim: 579 in 3/53
Lambda= 0.128578
statistics sampled from 26697 (26766) to 26697 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.314), width: 16
Scan time: 9.200
The best scores are: opt bits E(85289)
NP_689419 (OMIM: 606098) sorting nexin-6 isoform b ( 418) 2711 513.3 4.5e-145
XP_006720287 (OMIM: 606098) PREDICTED: sorting nex ( 381) 2032 387.3 3.5e-107
NP_067072 (OMIM: 606098) sorting nexin-6 isoform a ( 290) 1848 353.1 5.4e-97
NP_689413 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 1772 339.1 1.2e-92
NP_055241 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 1772 339.1 1.2e-92
NP_001269383 (OMIM: 605937) sorting nexin-5 isofor ( 299) 1315 254.2 3.2e-67
NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402) 219 51.0 6.2e-06
NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519) 219 51.1 7.5e-06
NP_683758 (OMIM: 601272) sorting nexin-1 isoform b ( 457) 188 45.3 0.00037
XP_005254668 (OMIM: 601272) PREDICTED: sorting nex ( 399) 187 45.1 0.00038
NP_001229862 (OMIM: 601272) sorting nexin-1 isofor ( 557) 188 45.4 0.00043
NP_003090 (OMIM: 601272) sorting nexin-1 isoform a ( 522) 185 44.8 0.0006
>>NP_689419 (OMIM: 606098) sorting nexin-6 isoform b [Ho (418 aa)
initn: 2711 init1: 2711 opt: 2711 Z-score: 2725.5 bits: 513.3 E(85289): 4.5e-145
Smith-Waterman score: 2711; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
310 320 330 340 350 360
370 380 390 400 410
pF1KB6 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
370 380 390 400 410
>>XP_006720287 (OMIM: 606098) PREDICTED: sorting nexin-6 (381 aa)
initn: 2442 init1: 2032 opt: 2032 Z-score: 2045.3 bits: 387.3 E(85289): 3.5e-107
Smith-Waterman score: 2372; 91.1% identity (91.1% similar) in 418 aa overlap (1-418:1-381)
10 20 30 40 50 60
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
::::: ::::::::::::::::::
XP_006 TVHTK-------------------------------------IPPAPPRPDFDASREKLQ
70 80
130 140 150 160 170 180
pF1KB6 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB6 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB6 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
210 220 230 240 250 260
310 320 330 340 350 360
pF1KB6 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
270 280 290 300 310 320
370 380 390 400 410
pF1KB6 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
330 340 350 360 370 380
>>NP_067072 (OMIM: 606098) sorting nexin-6 isoform a [Ho (290 aa)
initn: 1848 init1: 1848 opt: 1848 Z-score: 1862.4 bits: 353.1 E(85289): 5.4e-97
Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 290 aa overlap (129-418:1-290)
100 110 120 130 140 150
pF1KB6 AGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEV
::::::::::::::::::::::::::::::
NP_067 MTKEEFTKMKQELEAEYLAIFKKTVAMHEV
10 20 30
160 170 180 190 200 210
pF1KB6 FLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 FLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB6 DDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKF
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB6 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB6 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
220 230 240 250 260 270
400 410
pF1KB6 HAKGNLQLLQNCLAVLNGDT
::::::::::::::::::::
NP_067 HAKGNLQLLQNCLAVLNGDT
280 290
>>NP_689413 (OMIM: 605937) sorting nexin-5 isoform a [Ho (404 aa)
initn: 1767 init1: 1739 opt: 1772 Z-score: 1784.3 bits: 339.1 E(85289): 1.2e-92
Smith-Waterman score: 1772; 64.5% identity (90.0% similar) in 400 aa overlap (21-417:5-404)
10 20 30 40 50
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLS--EEDRG-LKAINVDLQSDAALQVDISDALSERDK
:..:. ::::. :....:::. : .::.:: ::::::::
NP_689 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
10 20 30 40
60 70 80 90 100 110
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
::::::::..::.:.. ::::.::::.:.::::...:. :::: :::::: .::::. ::
NP_689 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
:.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
NP_689 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
::::.:::::: :: :: . :::..::::: :. .:::.::::::.:..::..:.::.:
NP_689 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB6 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
:. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
NP_689 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB6 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
.::::::..::.::. . .:::::::::...:.::::.:::::::: :.::: ::. ::
NP_689 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB6 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
NP_689 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
350 360 370 380 390 400
pF1KB6 T
>>NP_055241 (OMIM: 605937) sorting nexin-5 isoform a [Ho (404 aa)
initn: 1767 init1: 1739 opt: 1772 Z-score: 1784.3 bits: 339.1 E(85289): 1.2e-92
Smith-Waterman score: 1772; 64.5% identity (90.0% similar) in 400 aa overlap (21-417:5-404)
10 20 30 40 50
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLS--EEDRG-LKAINVDLQSDAALQVDISDALSERDK
:..:. ::::. :....:::. : .::.:: ::::::::
NP_055 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
10 20 30 40
60 70 80 90 100 110
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
::::::::..::.:.. ::::.::::.:.::::...:. :::: :::::: .::::. ::
NP_055 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
:.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
NP_055 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
::::.:::::: :: :: . :::..::::: :. .:::.::::::.:..::..:.::.:
NP_055 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB6 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
:. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
NP_055 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB6 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
.::::::..::.::. . .:::::::::...:.::::.:::::::: :.::: ::. ::
NP_055 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB6 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
NP_055 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
350 360 370 380 390 400
pF1KB6 T
>>NP_001269383 (OMIM: 605937) sorting nexin-5 isoform b (299 aa)
initn: 1312 init1: 1312 opt: 1315 Z-score: 1327.9 bits: 254.2 E(85289): 3.2e-67
Smith-Waterman score: 1315; 64.5% identity (90.3% similar) in 299 aa overlap (119-417:1-299)
90 100 110 120 130 140
pF1KB6 HDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAI
.:::::::::::::::.::::::::::::.
NP_001 MQKLGEGEGSMTKEEFAKMKQELEAEYLAV
10 20 30
150 160 170 180 190 200
pF1KB6 FKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSAD
:::::. ::::: :...::.: .: ::::::::.:::::: :: :: . :::..:::::
NP_001 FKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSAD
40 50 60 70 80 90
210 220 230 240 250 260
pF1KB6 GVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG
:. .:::.::::::.:..::..:.::.::. .:.:.::::::..:::: . .. :..:.
NP_001 EVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLA
100 110 120 130 140 150
270 280 290 300 310 320
pF1KB6 TQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRS
.. : : :..:::.:::.: ::.:.:::.::::::..::.::. . .:::::::::...
NP_001 LEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKA
160 170 180 190 200 210
330 340 350 360 370 380
pF1KB6 LVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKN
:.::::.:::::::: :.::: ::. :: ::::::..:::::.:::.:: .::::::::
NP_001 LIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKN
220 230 240 250 260 270
390 400 410
pF1KB6 LVELAELELKHAKGNLQLLQNCLAVLNGDT
:.:..:::.:::..:..:::.:. .....
NP_001 LIEMSELEIKHARNNVSLLQSCIDLFKNN
280 290
>>NP_001265128 (OMIM: 605929) sorting nexin-2 isoform 2 (402 aa)
initn: 280 init1: 151 opt: 219 Z-score: 227.5 bits: 51.0 E(85289): 6.2e-06
Smith-Waterman score: 297; 24.0% identity (57.0% similar) in 391 aa overlap (28-394:8-378)
10 20 30 40 50
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDA-ALQVDISDALSERDKVK
::. . :. . ..: ... .:: . : ..
NP_001 MSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMN
10 20 30 40
60 70 80 90 100 110
pF1KB6 ----FTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDAS
. : ::.:: :...:::: :. .:. ::.... . ..:::.:::: . .
NP_001 AYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 REKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNF
. :. :. ..: : ::.. :. .:. : .: :.. :: : .: ..
NP_001 KVKV---GKEDSSST--EFVE-------------KRRAAL-ERYLQRTVKHPTLLQDPDL
110 120 130 140
180 190 200 210 220 230
pF1KB6 HVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYH
. ::: ...: ... . ... . :.::.: .: . : .::... . .
NP_001 RQFLE-SSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLD
150 160 170 180 190 200
240 250 260 270 280 290
pF1KB6 NRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKTRKI
.... .. . .. .: . . ...: :: ..: : . . . ...:. .: ..
NP_001 QQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQL
210 220 230 240 250 260
300 310 320 330 340
pF1KB6 EARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKAR---AK----
. . . . .:.::. :.: :.: .. .: . .:.:. .: : : ::
NP_001 HQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVA
270 280 290 300 310 320
350 360 370 380 390
pF1KB6 NKD--VLQA-------ETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELE
:: . :: :.. : . ::.::.. ..:. :. .:: :. ... :
NP_001 NKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESL
330 340 350 360 370 380
400 410
pF1KB6 LKHAKGNLQLLQNCLAVLNGDT
NP_001 VQTQQQLIKYWEAFLPEAKAIA
390 400
>>NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 [Ho (519 aa)
initn: 253 init1: 151 opt: 219 Z-score: 226.0 bits: 51.1 E(85289): 7.5e-06
Smith-Waterman score: 297; 24.0% identity (57.0% similar) in 391 aa overlap (28-394:125-495)
10 20 30 40 50
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDA-ALQVDISDALSERD
::. . :. . ..: ... .:: . :
NP_003 EPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGD
100 110 120 130 140 150
60 70 80 90 100 110
pF1KB6 KVK----FTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDF
.. . : ::.:: :...:::: :. .:. ::.... . ..:::.:::: .
NP_003 GMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIV
160 170 180 190 200 210
120 130 140 150 160 170
pF1KB6 DASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRD
.. :. :. ..: : ::.. :. .:. : .: :.. :: : .:
NP_003 GMTKVKV---GKEDSSST--EFVE-------------KRRAAL-ERYLQRTVKHPTLLQD
220 230 240 250
180 190 200 210 220 230
pF1KB6 LNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLL
... ::: ...: ... . ... . :.::.: .: . : .::... .
NP_003 PDLRQFLE-SSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFE
260 270 280 290 300 310
240 250 260 270 280
pF1KB6 EYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKT
. .... .. . .. .: . . ...: :: ..: : . . . ...:. .:
NP_003 NLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKI
320 330 340 350 360 370
290 300 310 320 330 340
pF1KB6 RKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKAR---AK-
... . . . .:.::. :.: :.: .. .: . .:.:. .: : : ::
NP_003 DQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKM
380 390 400 410 420 430
350 360 370 380 390
pF1KB6 ---NKD--VLQA-------ETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELA
:: . :: :.. : . ::.::.. ..:. :. .:: :. ...
NP_003 MVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYL
440 450 460 470 480 490
400 410
pF1KB6 ELELKHAKGNLQLLQNCLAVLNGDT
:
NP_003 ESLVQTQQQLIKYWEAFLPEAKAIA
500 510
>>NP_683758 (OMIM: 601272) sorting nexin-1 isoform b [Ho (457 aa)
initn: 116 init1: 65 opt: 188 Z-score: 195.7 bits: 45.3 E(85289): 0.00037
Smith-Waterman score: 298; 22.1% identity (55.8% similar) in 389 aa overlap (28-397:69-436)
10 20 30 40 50
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDK
. : : .. ..: : :. . .
NP_683 SDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQ-DLFAGDGMNAY
40 50 60 70 80 90
60 70 80 90 100 110
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
: . : :..::: :....:.: :. .:. :.... :... :.:.:: : . . ..
NP_683 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKV
100 110 120 130 140 150
120 130 140 150 160 170
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
:. : : : . ::.: :. .:. : .: :.. :: . .: . .
NP_683 KVGK----EDSSS------------AEFLE--KRRAAL-ERYLQRIVNHPTMLQDPDVRE
160 170 180 190
180 190 200 210 220 230
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYHNR
::: ...: .. . ..: . :..:.: .: . : .::.. . ..:
NP_683 FLE-KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB6 VKDASAKSDRMTRSHKSAADDYNRIGSSLYALGT-QDSTDICKFFLKVSELFDKTRKIEA
.. : . .. .: : . ....:: ::. .:.: . . . ...:. .: ....
NP_683 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQ
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB6 RVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAET
. . .. . :..::. :.: .. . .: .. ...:. .:.: : . .: :.
NP_683 EQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANK
320 330 340 350 360 370
360 370 380 390
pF1KB6 SQQLCCQK----------------FEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
..: : ::.:: ...:.: :. .. :...... : :
NP_683 PDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLY
380 390 400 410 420 430
400 410
pF1KB6 HAKGNLQLLQNCLAVLNGDT
NP_683 SQQQLAKYWEAFLPEAKAIS
440 450
>>XP_005254668 (OMIM: 601272) PREDICTED: sorting nexin-1 (399 aa)
initn: 116 init1: 65 opt: 187 Z-score: 195.4 bits: 45.1 E(85289): 0.00038
Smith-Waterman score: 297; 22.6% identity (56.8% similar) in 359 aa overlap (58-397:5-343)
30 40 50 60 70 80
pF1KB6 DRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIW
: . : :..::: :....:.: :. .:.
XP_005 MNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLG
10 20 30
90 100 110 120 130 140
pF1KB6 LHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLA
:.... :... :.:.:: : . . .. :. : : : . ::.:
XP_005 LYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGK----EDSSS------------AEFLE
40 50 60 70
150 160 170 180 190 200
pF1KB6 IFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSA
:. .:. : .: :.. :: . .: . . ::: ...: .. . ..: . :..
XP_005 --KRRAAL-ERYLQRIVNHPTMLQDPDVREFLE-KEELPRAVGTQTLSGAGLLKMFNKAT
80 90 100 110 120 130
210 220 230 240 250 260
pF1KB6 DGVIVSGVK--DVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLY
:.: .: . : .::.. . ..:.. : . .. .: : . ....::
XP_005 DAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLA
140 150 160 170 180 190
270 280 290 300 310 320
pF1KB6 ALGT-QDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYR
::. .:.: . . . ...:. .: .... . . .. . :..::. :.: .. . .
XP_005 MLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQ
200 210 220 230 240 250
330 340 350 360
pF1KB6 RSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQK----------------FEKISE
: .. ...:. .:.: : . .: :. ..: : ::.::
XP_005 RMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERIST
260 270 280 290 300 310
370 380 390 400 410
pF1KB6 SAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
...:.: :. .. :...... : :
XP_005 VVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQAGEQLGIRSGILLTKKLPRYSKFFST
320 330 340 350 360 370
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:11:37 2016 done: Sat Nov 5 11:11:39 2016
Total Scan time: 9.200 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]