Result of FASTA (omim) for
pFN21AB6620
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6620, 435 aa
1>>>pF1KB6620 435 - 435 aa - 435 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0811+/-0.000343; mu= 2.5063+/- 0.021
mean_var=294.6581+/-60.279, 0's: 0 Z-trim(124.1): 67 B-trim: 808 in 1/61
Lambda= 0.074716
statistics sampled from 44920 (45005) to 44920 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.825), E-opt: 0.2 (0.528), width: 16
Scan time: 9.570
The best scores are: opt bits E(85289)
NP_002333 (OMIM: 600979) tumor necrosis factor rec ( 435) 3169 354.7 2.8e-97
NP_001257916 (OMIM: 600979) tumor necrosis factor ( 416) 2956 331.7 2.2e-90
XP_005253745 (OMIM: 600979) PREDICTED: tumor necro ( 399) 1668 192.8 1.3e-48
XP_006719046 (OMIM: 600979) PREDICTED: tumor necro ( 255) 1650 190.7 3.8e-48
NP_001057 (OMIM: 191191) tumor necrosis factor rec ( 461) 451 61.7 4.5e-09
XP_011540365 (OMIM: 191191) PREDICTED: tumor necro ( 462) 451 61.7 4.5e-09
XP_011540362 (OMIM: 191191) PREDICTED: tumor necro ( 484) 451 61.7 4.7e-09
XP_016857700 (OMIM: 191191) PREDICTED: tumor necro ( 491) 451 61.7 4.7e-09
NP_003814 (OMIM: 603361) tumor necrosis factor rec ( 300) 417 57.8 4.3e-08
XP_016883626 (OMIM: 109535,606843) PREDICTED: tumo ( 222) 412 57.2 5.1e-08
NP_001241 (OMIM: 109535,606843) tumor necrosis fac ( 277) 412 57.3 5.9e-08
NP_001309350 (OMIM: 109535,606843) tumor necrosis ( 281) 412 57.3 6e-08
NP_001257878 (OMIM: 174810,602080,603499,612301) t ( 263) 405 56.5 9.6e-08
NP_001289682 (OMIM: 109535,606843) tumor necrosis ( 237) 403 56.2 1e-07
XP_016883624 (OMIM: 109535,606843) PREDICTED: tumo ( 323) 403 56.4 1.3e-07
NP_001257879 (OMIM: 174810,602080,603499,612301) t ( 337) 403 56.4 1.3e-07
NP_003830 (OMIM: 174810,602080,603499,612301) tumo ( 616) 405 56.9 1.7e-07
NP_001257880 (OMIM: 174810,602080,603499,612301) t ( 299) 386 54.5 4.3e-07
XP_011524546 (OMIM: 174810,602080,603499,612301) P ( 621) 386 54.8 7.1e-07
XP_016857702 (OMIM: 191191) PREDICTED: tumor necro ( 440) 377 53.7 1.1e-06
XP_016857701 (OMIM: 191191) PREDICTED: tumor necro ( 440) 377 53.7 1.1e-06
NP_690593 (OMIM: 109535,606843) tumor necrosis fac ( 203) 357 51.2 2.9e-06
XP_016883625 (OMIM: 109535,606843) PREDICTED: tumo ( 289) 357 51.4 3.7e-06
NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 350 50.6 6.2e-06
NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401) 339 49.6 1.8e-05
XP_016866233 (OMIM: 605732) PREDICTED: tumor necro ( 444) 337 49.4 2.2e-05
XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 329 48.2 2.3e-05
NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 328 48.0 2.4e-05
NP_055267 (OMIM: 605732) tumor necrosis factor rec ( 655) 337 49.6 2.9e-05
NP_001056 (OMIM: 142680,191190,614810) tumor necro ( 455) 329 48.6 4.1e-05
XP_016881554 (OMIM: 174810,602080,603499,612301) P ( 566) 312 46.8 0.00017
XP_011540743 (OMIM: 153243) PREDICTED: tumor necro ( 594) 304 46.0 0.00032
NP_001234 (OMIM: 153243) tumor necrosis factor rec ( 595) 304 46.0 0.00032
XP_011527411 (OMIM: 109535,606843) PREDICTED: tumo ( 166) 267 41.4 0.0021
NP_001309351 (OMIM: 109535,606843) tumor necrosis ( 225) 267 41.5 0.0026
XP_005260676 (OMIM: 109535,606843) PREDICTED: tumo ( 229) 267 41.6 0.0026
NP_001265197 (OMIM: 174810,602080,603499,612301) t ( 602) 266 41.9 0.0055
NP_690610 (OMIM: 134637,601859) tumor necrosis fac ( 314) 257 40.6 0.0069
XP_011538067 (OMIM: 134637,601859) PREDICTED: tumo ( 368) 257 40.7 0.0077
NP_001307548 (OMIM: 134637,601859) tumor necrosis ( 197) 251 39.8 0.0079
NP_690611 (OMIM: 134637,601859) tumor necrosis fac ( 220) 251 39.8 0.0085
>>NP_002333 (OMIM: 600979) tumor necrosis factor recepto (435 aa)
initn: 3169 init1: 3169 opt: 3169 Z-score: 1867.5 bits: 354.7 E(85289): 2.8e-97
Smith-Waterman score: 3169; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
370 380 390 400 410 420
430
pF1KB6 TPSNRGPRNQFITHD
:::::::::::::::
NP_002 TPSNRGPRNQFITHD
430
>>NP_001257916 (OMIM: 600979) tumor necrosis factor rece (416 aa)
initn: 2948 init1: 2948 opt: 2956 Z-score: 1743.7 bits: 331.7 E(85289): 2.2e-90
Smith-Waterman score: 2956; 98.5% identity (99.0% similar) in 413 aa overlap (23-435:5-416)
10 20 30 40 50 60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
:. ::: . ::::::::::::::::::::::::::::
NP_001 MEATGISLASQLK-VPPYASENQTCRDQEKEYYEPQHRICCS
10 20 30 40
70 80 90 100 110 120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
350 360 370 380 390 400
430
pF1KB6 TPSNRGPRNQFITHD
:::::::::::::::
NP_001 TPSNRGPRNQFITHD
410
>>XP_005253745 (OMIM: 600979) PREDICTED: tumor necrosis (399 aa)
initn: 1734 init1: 1668 opt: 1668 Z-score: 993.6 bits: 192.8 E(85289): 1.3e-48
Smith-Waterman score: 2846; 91.7% identity (91.7% similar) in 435 aa overlap (1-435:1-399)
10 20 30 40 50 60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
:::::::::::::::::::::::::::::::::::::::::::
XP_005 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSG-----------------
190 200 210 220
250 260 270 280 290 300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
:::::::::::::::::::::::::::::::::::::::::
XP_005 -------------------SLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
230 240 250 260
310 320 330 340 350 360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
270 280 290 300 310 320
370 380 390 400 410 420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
330 340 350 360 370 380
430
pF1KB6 TPSNRGPRNQFITHD
:::::::::::::::
XP_005 TPSNRGPRNQFITHD
390
>>XP_006719046 (OMIM: 600979) PREDICTED: tumor necrosis (255 aa)
initn: 1650 init1: 1650 opt: 1650 Z-score: 985.4 bits: 190.7 E(85289): 3.8e-48
Smith-Waterman score: 1650; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222)
10 20 30 40 50 60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
::::::::::::::::::::::::::::::::::::::::::
XP_006 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSEPALSKGVENLQALLYQA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
XP_006 ATGSSEASFPTLSPL
250
>>NP_001057 (OMIM: 191191) tumor necrosis factor recepto (461 aa)
initn: 341 init1: 199 opt: 451 Z-score: 283.8 bits: 61.7 E(85289): 4.5e-09
Smith-Waterman score: 472; 29.8% identity (53.3% similar) in 392 aa overlap (9-376:2-352)
10 20 30 40 50
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
:: .:. :..:: : ::.. : : ::: : ..::: .:::.
NP_001 MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
..:::.: :: .... :.. :::: .: ...:.. ::.. : : : : : :
NP_001 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
60 70 80 90 100
120 130 140 150 160 170
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
:: ... : :.:: .:: : : : : : :: . . . .. : ::
NP_001 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
: :.::.: . :.:: :. : : ::.:. :..: . : . . : : :
NP_001 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
170 180 190 200 210
230 240 250 260 270 280
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
: :: ..: . . .:: . . :: :.: .: :. ::
NP_001 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
220 230 240 250
290 300 310 320 330 340
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
:.. ::.. :. .. :: :.. . : ..:: : :: :.: :..... ..
NP_001 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
260 270 280 290 300 310
350 360 370 380 390
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP
: . :. ...:. ... .:. . : .::
NP_001 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSP
320 330 340 350 360 370
400 410 420 430
pF1KB6 PGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
NP_001 GGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRS
380 390 400 410 420 430
>>XP_011540365 (OMIM: 191191) PREDICTED: tumor necrosis (462 aa)
initn: 341 init1: 199 opt: 451 Z-score: 283.8 bits: 61.7 E(85289): 4.5e-09
Smith-Waterman score: 476; 29.2% identity (52.6% similar) in 418 aa overlap (9-401:2-378)
10 20 30 40 50
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
:: .:. :..:: : ::.. : : ::: : ..::: .:::.
XP_011 MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
..:::.: :: .... :.. :::: .: ...:.. ::.. : : : : : :
XP_011 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
60 70 80 90 100
120 130 140 150 160 170
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
:: ... : :.:: .:: : : : : : :: . . . .. : ::
XP_011 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
: :.::.: . :.:: :. : : ::.:. :..: . : . . : : :
XP_011 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
170 180 190 200 210
230 240 250 260 270 280
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
: :: ..: . . .:: . . :: :.: .: :. ::
XP_011 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
220 230 240 250
290 300 310 320 330 340
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
:.. ::.. :. .. :: :.. . : ..:: : :: :.: :..... ..
XP_011 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
260 270 280 290 300 310
350 360 370 380 390
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPG-DLPATPEPPYPIPEEGDPG
: . :. ...:. ... .:. . : .:: . .. : .: .
XP_011 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSADSS
320 330 340 350 360 370
400 410 420 430
pF1KB6 PPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
: : .:
XP_011 PGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFR
380 390 400 410 420 430
>>XP_011540362 (OMIM: 191191) PREDICTED: tumor necrosis (484 aa)
initn: 341 init1: 199 opt: 451 Z-score: 283.6 bits: 61.7 E(85289): 4.7e-09
Smith-Waterman score: 482; 29.1% identity (51.9% similar) in 443 aa overlap (9-427:2-395)
10 20 30 40 50
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
:: .:. :..:: : ::.. : : ::: : ..::: .:::.
XP_011 MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
..:::.: :: .... :.. :::: .: ...:.. ::.. : : : : : :
XP_011 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
60 70 80 90 100
120 130 140 150 160 170
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
:: ... : :.:: .:: : : : : : :: . . . .. : ::
XP_011 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
: :.::.: . :.:: :. : : ::.:. :..: . : . . : : :
XP_011 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
170 180 190 200 210
230 240 250 260 270 280
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
: :: ..: . . .:: . . :: :.: .: :. ::
XP_011 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
220 230 240 250
290 300 310 320 330 340
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
:.. ::.. :. .. :: :.. . : ..:: : :: :.: :..... ..
XP_011 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
260 270 280 290 300 310
350 360 370 380 390
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP
: . :. ...:. ... .:. . : .:: : ... :
XP_011 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPG-----VEASGAGEARASTGS
320 330 340 350 360
400 410 420 430
pF1KB6 PGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD
::: . . :. : :: ::.. .:
XP_011 SGLSDCMYR--HCLLLSPTPGCG-TPADSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQA
370 380 390 400 410 420
XP_011 SSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
430 440 450 460 470 480
>>XP_016857700 (OMIM: 191191) PREDICTED: tumor necrosis (491 aa)
initn: 341 init1: 199 opt: 451 Z-score: 283.5 bits: 61.7 E(85289): 4.7e-09
Smith-Waterman score: 451; 35.1% identity (57.2% similar) in 222 aa overlap (9-219:2-211)
10 20 30 40 50
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
:: .:. :..:: : ::.. : : ::: : ..::: .:::.
XP_016 MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
..:::.: :: .... :.. :::: .: ...:.. ::.. : : : : : :
XP_016 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
60 70 80 90 100
120 130 140 150 160 170
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
:: ... : :.:: .:: : : : : : :: . . . .. : ::
XP_016 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
: :.::.: . :.:: :. : : ::.:. :..: . : . . :
XP_016 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVS
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB6 VLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPD
XP_016 TRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNC
230 240 250 260 270 280
>>NP_003814 (OMIM: 603361) tumor necrosis factor recepto (300 aa)
initn: 366 init1: 182 opt: 417 Z-score: 266.3 bits: 57.8 E(85289): 4.3e-08
Smith-Waterman score: 434; 32.1% identity (53.6% similar) in 274 aa overlap (6-276:3-249)
10 20 30 40 50 60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
: .:::. :::.: .:: . ..: .:. : .. : : :. :.
NP_003 MRALEGPGLSLLCLVLALPALLPVPAVRGV----AETPTYPWRDAETGE---RLVCA
10 20 30 40 50
70 80 90 100 110
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGL--EEIAPCTS
.:::::.:. : : :.:. : :.. :::: . :: :. . : :: : .
NP_003 QCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYL---ERCRYCNVLCGEREEEARACHA
60 70 80 90 100
120 130 140 150 160 170
pF1KB6 KRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNT
.. :::. :.: : : ..::::. . . . . :..: :: : :. .
NP_003 THNRACRCRTGFFAHA-----GFCLEHASCPPGAGV-IAPGTPSQNTQCQPCPPGTFSAS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 SSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLE-PLPPEMSGTMLMLAVLLPLAFF
:: : .:::: : ::. .::... :: : . :: .. :. ... .. :
NP_003 SSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB6 LLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPI
. : : : : .: . :.: ::.: ::
NP_003 QDI---------SIKRLQRLLQAL--EAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDG
230 240 250 260 270
300 310 320 330 340 350
pF1KB6 SGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTI
NP_003 ALLVRLLQALRVARMPGLERSVRERFLPVH
280 290 300
>>XP_016883626 (OMIM: 109535,606843) PREDICTED: tumor ne (222 aa)
initn: 330 init1: 173 opt: 412 Z-score: 265.0 bits: 57.2 E(85289): 5.1e-08
Smith-Waterman score: 441; 33.0% identity (57.4% similar) in 230 aa overlap (16-244:5-214)
10 20 30 40 50
pF1KB6 MLLPWATSAPGLAWGPLVLGLFG-LLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICC
:: :.: ::.: .:. :: : :: ::.: .. ::
XP_016 MVRLPLQCVLWGCLLTAVHPE--PPTA-----CR--EKQYLINSQ--CC
10 20 30
60 70 80 90 100 110
pF1KB6 SRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSK
: : :: . . :... .: : :.:. . . :: : :. . ::: .::. ::.
XP_016 SLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB6 RKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTS
: : :. : :.. : : : : .: :: .. . .: ... : :: .: :.:.:
XP_016 TDTICTCEEGWHCTSEA--CESCVLHRSCSPGFGVK-QIATGVSDTICEPCPVGFFSNVS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB6 SPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLL
: .:.: : ::.. :: :: ..:..: : . ..... ... . : .:
XP_016 SAFEKCHPWTSCETKDLVVQQAGTNKTDVVCG------PQDRLRALVVIPIIFGILFAIL
160 170 180 190 200
240 250 260 270 280 290
pF1KB6 LATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISG
:. ::
XP_016 LVLVFISGQEANQ
210 220
435 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:08:46 2016 done: Sat Nov 5 11:08:47 2016
Total Scan time: 9.570 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]