Result of FASTA (omim) for
pFN21AB5967
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5967, 518 aa
1>>>pF1KB5967 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2245+/-0.000346; mu= 5.2427+/- 0.022
mean_var=156.3607+/-31.432, 0's: 0 Z-trim(119.7): 95 B-trim: 0 in 0/53
Lambda= 0.102568
statistics sampled from 33879 (33974) to 33879 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.398), width: 16
Scan time: 8.680
The best scores are: opt bits E(85289)
NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 3605 545.3 1.7e-154
NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 3605 545.3 1.7e-154
XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 3605 545.3 1.7e-154
NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 3260 494.2 3.6e-139
NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 1720 266.3 1.6e-70
XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 1720 266.4 1.8e-70
NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 1710 264.9 4.5e-70
XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 1710 264.9 4.9e-70
XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 1425 222.6 1.8e-57
NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 867 140.2 2e-32
NP_005983 (OMIM: 187500,188400,192430,217095,60205 ( 372) 827 134.1 7e-31
NP_001071121 (OMIM: 606061,611363) T-box transcrip ( 447) 828 134.3 7.4e-31
XP_006724375 (OMIM: 187500,188400,192430,217095,60 ( 495) 825 133.9 1.1e-30
NP_542378 (OMIM: 187500,188400,192430,217095,60205 ( 495) 825 133.9 1.1e-30
XP_016884415 (OMIM: 187500,188400,192430,217095,60 ( 495) 825 133.9 1.1e-30
XP_016884414 (OMIM: 187500,188400,192430,217095,60 ( 545) 825 133.9 1.2e-30
NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 822 133.5 2e-30
NP_542377 (OMIM: 187500,188400,192430,217095,60205 ( 398) 816 132.5 2.3e-30
XP_016884417 (OMIM: 187500,188400,192430,217095,60 ( 448) 816 132.5 2.5e-30
XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 808 131.3 5.6e-30
XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 808 131.3 5.6e-30
NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 808 131.3 5.6e-30
XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 808 131.3 5.6e-30
NP_001159692 (OMIM: 606061,611363) T-box transcrip ( 297) 799 129.9 1e-29
NP_001317606 (OMIM: 260660,604127) T-box transcrip ( 602) 790 128.7 4.7e-29
NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 785 127.9 5.3e-29
XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 785 127.9 5.9e-29
NP_689593 (OMIM: 260660,604127) T-box transcriptio ( 496) 783 127.7 8.1e-29
XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 766 125.1 3.6e-28
XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 766 125.1 3.6e-28
XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 766 125.1 3.7e-28
XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 766 125.1 3.7e-28
XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 766 125.1 3.7e-28
NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 766 125.2 5.5e-28
XP_005271218 (OMIM: 260660,604127) PREDICTED: T-bo ( 635) 752 123.1 2.4e-27
NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 721 118.5 4.2e-26
XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 719 118.2 5.2e-26
XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 696 114.8 6.4e-25
NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 695 114.7 7e-25
NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 695 114.7 7e-25
XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 683 112.8 1.7e-24
NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 685 113.2 2e-24
NP_005433 (OMIM: 604615) eomesodermin homolog isof ( 686) 681 112.6 3.7e-24
NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 676 111.8 3.8e-24
XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 686 113.6 4.2e-24
XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 686 113.6 4.4e-24
XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 686 113.6 6e-24
NP_001074010 (OMIM: 616061) MAX gene-associated pr (2856) 686 113.7 7.4e-24
XP_005254310 (OMIM: 616061) PREDICTED: MAX gene-as (2906) 686 113.7 7.5e-24
XP_005254309 (OMIM: 616061) PREDICTED: MAX gene-as (2956) 686 113.7 7.7e-24
>>NP_852259 (OMIM: 142900,601620) T-box transcription fa (518 aa)
initn: 3605 init1: 3605 opt: 3605 Z-score: 2894.9 bits: 545.3 E(85289): 1.7e-154
Smith-Waterman score: 3605; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG
430 440 450 460 470 480
490 500 510
pF1KB5 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
::::::::::::::::::::::::::::::::::::::
NP_852 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
490 500 510
>>NP_000183 (OMIM: 142900,601620) T-box transcription fa (518 aa)
initn: 3605 init1: 3605 opt: 3605 Z-score: 2894.9 bits: 545.3 E(85289): 1.7e-154
Smith-Waterman score: 3605; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPG
430 440 450 460 470 480
490 500 510
pF1KB5 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
::::::::::::::::::::::::::::::::::::::
NP_000 TLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
490 500 510
>>XP_016875401 (OMIM: 142900,601620) PREDICTED: T-box tr (534 aa)
initn: 3605 init1: 3605 opt: 3605 Z-score: 2894.7 bits: 545.3 E(85289): 1.7e-154
Smith-Waterman score: 3605; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:17-534)
10 20 30 40
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQA
::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDGEQNLARAQGPGRTMADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 AFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 DIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNH
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 LDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQ
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 LKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTS
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 SNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYME
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 TSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSM
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 PSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQ
430 440 450 460 470 480
470 480 490 500 510
pF1KB5 PVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
490 500 510 520 530
>>NP_542448 (OMIM: 142900,601620) T-box transcription fa (468 aa)
initn: 3260 init1: 3260 opt: 3260 Z-score: 2619.6 bits: 494.2 E(85289): 3.6e-139
Smith-Waterman score: 3260; 100.0% identity (100.0% similar) in 468 aa overlap (51-518:1-468)
30 40 50 60 70 80
pF1KB5 DLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAG
::::::::::::::::::::::::::::::
NP_542 MEGIKVFLHERELWLKFHEVGTEMIITKAG
10 20 30
90 100 110 120 130 140
pF1KB5 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB5 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB5 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB5 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLPQEHSQI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB5 YHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 YHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQACMY
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB5 ASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 ASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLA
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB5 GMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_542 GMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPH
400 410 420 430 440 450
510
pF1KB5 QYHSVHGVGMVPEWSDNS
::::::::::::::::::
NP_542 QYHSVHGVGMVPEWSDNS
460
>>NP_001308049 (OMIM: 147891,601719) T-box transcription (546 aa)
initn: 1484 init1: 1322 opt: 1720 Z-score: 1387.0 bits: 266.3 E(85289): 1.6e-70
Smith-Waterman score: 1772; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:7-545)
10 20 30 40
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q
.....:.: ..: : . . :: ::.::. :: .:
NP_001 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL
:: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.:::::::::
NP_001 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB5 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
.:::::::::::: :::: :.:::::::::::::::::::::::::::::::::::::::
NP_001 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT
:::::::::::::::::::::::::::::.::::::::::::::::.::.::::::::::
NP_001 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST
:::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . :
NP_001 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK
. . ..:: :::. . ::: : . .: .. : .::: ::. . : : :.
NP_001 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKR
300 310 320 330 340 350
350 360 370 380 390
pF1KB5 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI-
:.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:.
NP_001 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB5 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE
::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :.
NP_001 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN
420 430 440 450 460
460 470 480 490
pF1KB5 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSHGVPRTL-
. :. .... : ::. :: . :: . .:: :::::. .
NP_001 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE
470 480 490 500 510 520
500 510
pF1KB5 SPHQYHSVHGVGMVPEWSDNS
: :::: :.: : .:.:
NP_001 SSLQYHS--GMGTVENWTDG
530 540
>>XP_011523792 (OMIM: 147891,601719) PREDICTED: T-box tr (609 aa)
initn: 1484 init1: 1322 opt: 1720 Z-score: 1386.3 bits: 266.4 E(85289): 1.8e-70
Smith-Waterman score: 1772; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:70-608)
10 20 30
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPES
.....:.: ..: : . . ::
XP_011 LNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAF---RAP-GPALGEASAANAPEP
40 50 60 70 80 90
40 50 60 70
pF1KB5 ALGAPS------KSPSSP-----QAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKA
::.::. :: .: :: ..: .:.::: :::.::: ::::.:::::::::
XP_011 ALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKA
100 110 120 130 140 150
80 90 100 110 120 130
pF1KB5 GRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHP
::::::::::::::.:::::::::.:::::::::::: :::: :.:::::::::::::::
XP_011 GRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHP
160 170 180 190 200 210
140 150 160 170 180 190
pF1KB5 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNT
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_011 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNT
220 230 240 250 260 270
200 210 220 230 240 250
pF1KB5 AFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVP
::::::::::.::.:::::::::::::::::::::::::::: .: :..:.:::::::.
XP_011 AFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVIS
280 290 300 310 320 330
260 270 280 290 300 310
pF1KB5 RSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQE
.: .::.. : . . . : . . ..:: :::. . ::: : . .: ..
XP_011 KSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRD
340 350 360 370 380 390
320 330 340 350 360 370
pF1KB5 HSQIYHCTKRKEEECSTTDHPYKKPYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESA
: .::: ::. . : : :. :.: .:: :: ..:: : .:: :. :: .: .
XP_011 SSLFYHCLKRRADGTRHLDLPCKRSYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVT
400 410 420 430 440 450
380 390 400 410 420
pF1KB5 QRQACMYASSAPPSEPVPSLEDI-----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSA
:.::::..:.: : ...:. ::: : :. :.: .:: :. .::: : .
XP_011 PREACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPT
460 470 480 490 500
430 440 450 460 470 480
pF1KB5 HFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGP------QTGLQSPGTL
:::. ..::: .. ..: :.. :. .... : ::. :: . :: .
XP_011 HFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCER
510 520 530 540 550 560
490 500 510
pF1KB5 QPP--------EFLYSHGVPRTL-SPHQYHSVHGVGMVPEWSDNS
.:: :::::. . : :::: :.: : .:.:
XP_011 KPPSPHLNAANEFLYSQTFSLSRESSLQYHS--GMGTVENWTDG
570 580 590 600
>>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa)
initn: 1586 init1: 1297 opt: 1710 Z-score: 1379.1 bits: 264.9 E(85289): 4.5e-70
Smith-Waterman score: 1761; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:7-544)
10 20 30 40
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q
.....:.: ..: : . . :: ::.::. :: .:
NP_060 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL
:: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.:::::::::
NP_060 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB5 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
.:::::::::::: :::: :.:::::::::::::::::::::::::::::::::::::::
NP_060 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT
:::::::::::::::::::::::::::::.::::::::::::::::.::.::::::::::
NP_060 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST
:::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . :
NP_060 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK
. . ..:: :::. . ::: : . .: .. : .::: ::.. : : :.
NP_060 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT-RHLDLPCKR
300 310 320 330 340 350
350 360 370 380 390
pF1KB5 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI-
:.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:.
NP_060 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB5 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE
::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :.
NP_060 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN
420 430 440 450 460
460 470 480 490
pF1KB5 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSHGVPRTL-
. :. .... : ::. :: . :: . .:: :::::. .
NP_060 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE
470 480 490 500 510 520
500 510
pF1KB5 SPHQYHSVHGVGMVPEWSDNS
: :::: :.: : .:.:
NP_060 SSLQYHS--GMGTVENWTDG
530 540
>>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa)
initn: 1586 init1: 1297 opt: 1710 Z-score: 1378.3 bits: 264.9 E(85289): 4.9e-70
Smith-Waterman score: 1761; 53.9% identity (71.2% similar) in 553 aa overlap (1-516:70-607)
10 20 30
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPES
.....:.: ..: : . . ::
XP_011 LNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAF---RAP-GPALGEASAANAPEP
40 50 60 70 80 90
40 50 60 70
pF1KB5 ALGAPS------KSPSSP-----QAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKA
::.::. :: .: :: ..: .:.::: :::.::: ::::.:::::::::
XP_011 ALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKA
100 110 120 130 140 150
80 90 100 110 120 130
pF1KB5 GRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHP
::::::::::::::.:::::::::.:::::::::::: :::: :.:::::::::::::::
XP_011 GRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHP
160 170 180 190 200 210
140 150 160 170 180 190
pF1KB5 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNT
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_011 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNT
220 230 240 250 260 270
200 210 220 230 240 250
pF1KB5 AFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVP
::::::::::.::.:::::::::::::::::::::::::::: .: :..:.:::::::.
XP_011 AFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVIS
280 290 300 310 320 330
260 270 280 290 300 310
pF1KB5 RSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQE
.: .::.. : . . . : . . ..:: :::. . ::: : . .: ..
XP_011 KSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRD
340 350 360 370 380 390
320 330 340 350 360 370
pF1KB5 HSQIYHCTKRKEEECSTTDHPYKKPYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESA
: .::: ::.. : : :. :.: .:: :: ..:: : .:: :. :: .: .
XP_011 SSLFYHCLKRRDGT-RHLDLPCKRSYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVT
400 410 420 430 440 450
380 390 400 410 420
pF1KB5 QRQACMYASSAPPSEPVPSLEDI-----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSA
:.::::..:.: : ...:. ::: : :. :.: .:: :. .::: : .
XP_011 PREACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPT
460 470 480 490 500
430 440 450 460 470 480
pF1KB5 HFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGP------QTGLQSPGTL
:::. ..::: .. ..: :.. :. .... : ::. :: . :: .
XP_011 HFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCER
510 520 530 540 550 560
490 500 510
pF1KB5 QPP--------EFLYSHGVPRTL-SPHQYHSVHGVGMVPEWSDNS
.:: :::::. . : :::: :.: : .:.:
XP_011 KPPSPHLNAANEFLYSQTFSLSRESSLQYHS--GMGTVENWTDG
570 580 590 600
>>XP_011523797 (OMIM: 147891,601719) PREDICTED: T-box tr (417 aa)
initn: 1433 init1: 1278 opt: 1425 Z-score: 1152.9 bits: 222.6 E(85289): 1.8e-57
Smith-Waterman score: 1427; 65.7% identity (80.1% similar) in 341 aa overlap (1-327:70-403)
10 20 30
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPES
.....:.: ..: : . . ::
XP_011 LNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAF---RAP-GPALGEASAANAPEP
40 50 60 70 80 90
40 50 60 70
pF1KB5 ALGAPS------KSPSSP-----QAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKA
::.::. :: .: :: ..: .:.::: :::.::: ::::.:::::::::
XP_011 ALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKA
100 110 120 130 140 150
80 90 100 110 120 130
pF1KB5 GRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHP
::::::::::::::.:::::::::.:::::::::::: :::: :.:::::::::::::::
XP_011 GRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHP
160 170 180 190 200 210
140 150 160 170 180 190
pF1KB5 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNT
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_011 DSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNT
220 230 240 250 260 270
200 210 220 230 240 250
pF1KB5 AFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVP
::::::::::.::.:::::::::::::::::::::::::::: .: :..:.:::::::.
XP_011 AFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVIS
280 290 300 310 320 330
260 270 280 290 300 310
pF1KB5 RSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQE
.: .::.. : . . . : . . ..:: :::. . ::: : . .: ..
XP_011 KSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRD
340 350 360 370 380 390
320 330 340 350 360 370
pF1KB5 HSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQ
: .::: ::.
XP_011 SSLFYHCLKRRGCLRLLSWYNGRVS
400 410
>>NP_005987 (OMIM: 181450,601621) T-box transcription fa (723 aa)
initn: 833 init1: 634 opt: 867 Z-score: 703.0 bits: 140.2 E(85289): 2e-32
Smith-Waterman score: 867; 37.7% identity (60.7% similar) in 448 aa overlap (28-462:77-506)
10 20 30 40 50
pF1KB5 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVF
: :.:: .. .. . ::
NP_005 PPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEEVEDDPKVH
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB5 LHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFA
:. .::: .::. ::::.:::.:::::: .::. .::. :.::::::::. ::: ::::
NP_005 LEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYKFH
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB5 DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMH
...: :.:::.: :: :.:.:::::::: .:: ..:.:.::::::: : : ::::::
NP_005 NSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMH
170 180 190 200 210 220
180 190 200 210 220 230
pF1KB5 KYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFR
:::::.:::.: :. . ..: :..:::: :::::.::: :::::::.:::::::::
NP_005 KYQPRFHIVRA--NDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFR
230 240 250 260 270 280
240 250 260 270 280 290
pF1KB5 GSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGV
. . . .. ... . . : . ... .:..: :::. :.. .. .: :.
NP_005 DTGNGRREKRKQLTLQSMRVFDERHKKENGTSDES--SSEQAAFNCFAQASSPAASTVGT
290 300 310 320 330 340
300 310 320 330 340
pF1KB5 SGPSQDLLPPPNPYPLPQEHSQIYH----C------TKRKEEECSTTDHPYKKPYMETSP
:. .:: : . : :. : : : .:: : : : .. ..
NP_005 SN-LKDLCPSEGESDAEAE-SKEEHGPEACDAAKISTTTSEEPCRDKGSPAVKAHLFAAE
350 360 370 380 390 400
350 360 370 380 390 400
pF1KB5 SEEDS-FYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPS
.:: .. :... :. :. : .: : . . . :. .
NP_005 RPRDSGRLDKASPDSRHSPATIS--SSTRGLGAEERRSPVREGTAPAKVEEARALPGKEA
410 420 430 440 450
410 420 430 440 450 460
pF1KB5 YSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQL--GEGMFQHQTSVAHQ
.. :: : . .::...::: : :. . .. :. :. .: : .. :
NP_005 FAPLTVQT---------DAAAAHLAQGPL-PGLGFAPGLAGQQFFNGHPLFLHPSQFAMG
460 470 480 490 500
470 480 490 500 510
pF1KB5 PVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPHQYHSVHGVGMVPEWSDNS
NP_005 GAFSSMAAAGMGPLLATVSGASTGVSGLDSTAMASAAAAQGLSGASAATLPFHLQQHVLA
510 520 530 540 550 560
518 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:47:51 2016 done: Sat Nov 5 10:47:52 2016
Total Scan time: 8.680 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]