Result of FASTA (omim) for
pFN21AF0068
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KF0068, 1191 aa
1>>>pF1KF0068 1191 - 1191 aa - 1191 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.0452+/-0.000361; mu= 10.3901+/- 0.023
mean_var=175.4140+/-35.812, 0's: 0 Z-trim(119.4): 176 B-trim: 286 in 1/58
Lambda= 0.096837
statistics sampled from 33103 (33305) to 33103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.39), width: 16
Scan time: 17.660
The best scores are: opt bits E(85289)
XP_011521290 (OMIM: 609526) PREDICTED: puratrophin (1191) 8084 1142.6 0
XP_011521287 (OMIM: 609526) PREDICTED: puratrophin (1191) 8084 1142.6 0
XP_011521288 (OMIM: 609526) PREDICTED: puratrophin (1191) 8084 1142.6 0
NP_001123201 (OMIM: 609526) puratrophin-1 isoform (1191) 8084 1142.6 0
NP_001123199 (OMIM: 609526) puratrophin-1 isoform (1191) 8084 1142.6 0
NP_001123200 (OMIM: 609526) puratrophin-1 isoform (1191) 8084 1142.6 0
XP_011521289 (OMIM: 609526) PREDICTED: puratrophin (1191) 8084 1142.6 0
NP_001123203 (OMIM: 609526) puratrophin-1 isoform (1110) 6740 954.8 0
XP_016876923 (OMIM: 610018) PREDICTED: rho guanine (1331) 1180 178.1 3.3e-43
NP_060541 (OMIM: 610018) rho guanine nucleotide ex (1519) 1180 178.1 3.6e-43
XP_011535239 (OMIM: 610018) PREDICTED: rho guanine (1523) 1180 178.1 3.7e-43
XP_005267901 (OMIM: 610018) PREDICTED: rho guanine (1471) 1133 171.6 3.4e-41
NP_001265458 (OMIM: 610018) rho guanine nucleotide ( 805) 969 148.5 1.7e-34
XP_016876924 (OMIM: 610018) PREDICTED: rho guanine ( 809) 969 148.5 1.7e-34
XP_016876925 (OMIM: 610018) PREDICTED: rho guanine ( 809) 969 148.5 1.7e-34
XP_016876926 (OMIM: 610018) PREDICTED: rho guanine ( 757) 922 141.9 1.5e-32
NP_001265459 (OMIM: 610018) rho guanine nucleotide ( 757) 922 141.9 1.5e-32
XP_016865292 (OMIM: 601893,617061) PREDICTED: trip (2612) 654 104.8 7.4e-21
XP_016865291 (OMIM: 601893,617061) PREDICTED: trip (2880) 654 104.9 7.9e-21
XP_011512412 (OMIM: 601893,617061) PREDICTED: trip (3038) 654 104.9 8.3e-21
XP_011512411 (OMIM: 601893,617061) PREDICTED: trip (3048) 654 104.9 8.3e-21
XP_011512410 (OMIM: 601893,617061) PREDICTED: trip (3058) 654 104.9 8.3e-21
XP_011512409 (OMIM: 601893,617061) PREDICTED: trip (3076) 654 104.9 8.3e-21
XP_016865290 (OMIM: 601893,617061) PREDICTED: trip (3093) 654 104.9 8.4e-21
NP_009049 (OMIM: 601893,617061) triple functional (3097) 654 104.9 8.4e-21
NP_001309930 (OMIM: 604605,608901) kalirin isoform ( 667) 632 101.3 2.1e-20
NP_001309929 (OMIM: 604605,608901) kalirin isoform ( 668) 632 101.3 2.1e-20
NP_001309928 (OMIM: 604605,608901) kalirin isoform ( 668) 632 101.3 2.1e-20
NP_001309927 (OMIM: 604605,608901) kalirin isoform ( 669) 632 101.3 2.1e-20
NP_001309926 (OMIM: 604605,608901) kalirin isoform ( 699) 630 101.1 2.7e-20
NP_001309925 (OMIM: 604605,608901) kalirin isoform ( 700) 630 101.1 2.7e-20
NP_001309924 (OMIM: 604605,608901) kalirin isoform ( 701) 630 101.1 2.7e-20
NP_001309922 (OMIM: 604605,608901) kalirin isoform (1288) 630 101.3 4.3e-20
NP_008995 (OMIM: 604605,608901) kalirin isoform 3 (1289) 630 101.3 4.3e-20
NP_001309921 (OMIM: 604605,608901) kalirin isoform (1613) 608 98.3 4.3e-19
NP_001309920 (OMIM: 604605,608901) kalirin isoform (1641) 608 98.3 4.4e-19
XP_016862924 (OMIM: 604605,608901) PREDICTED: kali (1643) 608 98.3 4.4e-19
NP_001309919 (OMIM: 604605,608901) kalirin isoform (1650) 608 98.3 4.4e-19
XP_016862923 (OMIM: 604605,608901) PREDICTED: kali (1652) 608 98.3 4.4e-19
NP_001309918 (OMIM: 604605,608901) kalirin isoform (1654) 608 98.3 4.4e-19
XP_016862922 (OMIM: 604605,608901) PREDICTED: kali (1656) 608 98.3 4.4e-19
NP_003938 (OMIM: 604605,608901) kalirin isoform 2 (1663) 608 98.3 4.4e-19
XP_006713878 (OMIM: 604605,608901) PREDICTED: kali (1665) 608 98.3 4.5e-19
XP_016862921 (OMIM: 604605,608901) PREDICTED: kali (2366) 601 97.4 1.2e-18
XP_011511587 (OMIM: 604605,608901) PREDICTED: kali (2367) 601 97.4 1.2e-18
NP_001309917 (OMIM: 604605,608901) kalirin isoform (2396) 601 97.4 1.2e-18
XP_016862920 (OMIM: 604605,608901) PREDICTED: kali (2398) 601 97.4 1.2e-18
XP_011511585 (OMIM: 604605,608901) PREDICTED: kali (2401) 601 97.4 1.2e-18
XP_016862919 (OMIM: 604605,608901) PREDICTED: kali (2955) 601 97.5 1.4e-18
XP_006713877 (OMIM: 604605,608901) PREDICTED: kali (2956) 601 97.5 1.4e-18
>>XP_011521290 (OMIM: 609526) PREDICTED: puratrophin-1 i (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>XP_011521287 (OMIM: 609526) PREDICTED: puratrophin-1 i (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>XP_011521288 (OMIM: 609526) PREDICTED: puratrophin-1 i (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>NP_001123201 (OMIM: 609526) puratrophin-1 isoform 1 [H (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>NP_001123199 (OMIM: 609526) puratrophin-1 isoform 1 [H (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>NP_001123200 (OMIM: 609526) puratrophin-1 isoform 1 [H (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>XP_011521289 (OMIM: 609526) PREDICTED: puratrophin-1 i (1191 aa)
initn: 8084 init1: 8084 opt: 8084 Z-score: 6110.2 bits: 1142.6 E(85289): 0
Smith-Waterman score: 8084; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1150 1160 1170 1180 1190
>>NP_001123203 (OMIM: 609526) puratrophin-1 isoform 2 [H (1110 aa)
initn: 6716 init1: 6716 opt: 6740 Z-score: 5095.8 bits: 954.8 E(85289): 0
Smith-Waterman score: 7355; 93.2% identity (93.2% similar) in 1191 aa overlap (1-1191:1-1110)
10 20 30 40 50 60
pF1KF0 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KF0 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG--
70 80 90 100 110
130 140 150 160 170 180
pF1KF0 DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KF0 LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
:::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------TRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
120 130 140 150
250 260 270 280 290 300
pF1KF0 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
160 170 180 190 200 210
310 320 330 340 350 360
pF1KF0 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
220 230 240 250 260 270
370 380 390 400 410 420
pF1KF0 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
280 290 300 310 320 330
430 440 450 460 470 480
pF1KF0 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
340 350 360 370 380 390
490 500 510 520 530 540
pF1KF0 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KF0 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
460 470 480 490 500 510
610 620 630 640 650 660
pF1KF0 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
520 530 540 550 560 570
670 680 690 700 710 720
pF1KF0 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
580 590 600 610 620 630
730 740 750 760 770 780
pF1KF0 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
640 650 660 670 680 690
790 800 810 820 830 840
pF1KF0 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
700 710 720 730 740 750
850 860 870 880 890 900
pF1KF0 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
760 770 780 790 800 810
910 920 930 940 950 960
pF1KF0 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
820 830 840 850 860 870
970 980 990 1000 1010 1020
pF1KF0 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
880 890 900 910 920 930
1030 1040 1050 1060 1070 1080
pF1KF0 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
940 950 960 970 980 990
1090 1100 1110 1120 1130 1140
pF1KF0 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
1000 1010 1020 1030 1040 1050
1150 1160 1170 1180 1190
pF1KF0 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
1060 1070 1080 1090 1100 1110
>>XP_016876923 (OMIM: 610018) PREDICTED: rho guanine nuc (1331 aa)
initn: 1054 init1: 627 opt: 1180 Z-score: 896.7 bits: 178.1 E(85289): 3.3e-43
Smith-Waterman score: 1461; 31.8% identity (56.6% similar) in 1218 aa overlap (46-1187:177-1326)
20 30 40 50 60 70
pF1KF0 GHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPA-GATQDEELQG-SPLSRKFQLP
:: :: . : . .. : . ::: .
XP_016 EAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSA
150 160 170 180 190 200
80 90 100 110 120 130
pF1KF0 PAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG--ESDTPGVGLVGDP
: . :: . .. . .:.. :.:: . : . .. ..: ::. . .:.
XP_016 PLSP--GDKEDAS--HQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK
210 220 230 240 250 260
140 150 160 170
pF1KF0 GPSRAMPSGLSP-GALDSDPVGLG-----------DPLSEI-SKLLEAAPSGSGLPKPAD
:. . : . :: . . : : :::. . ::.. :.: : .
XP_016 EPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEE
270 280 290 300 310 320
180 190 200 210 220 230
pF1KF0 CLLAQ-----DLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLL
: .. :. :.:.:::. : : : .:::.: . : . : . : :
XP_016 ALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLH
330 340 350 360 370 380
240 250 260 270 280 290
pF1KF0 YLRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEV
::.:. ::..:.:::.::.: : : .:. .:::::... . : ::. . ..
XP_016 YLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDL
390 400 410 420 430
300 310 320 330 340
pF1KF0 PS---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAAC
:. :.: .. :.. : .. : ::: . :....... : . ::..
XP_016 PTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVL
440 450 460 470 480 490
350 360 370 380 390 400
pF1KF0 ALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEV
. .. ::: .... .: : :: . . .:.:: .: :. :: .:: : :..
XP_016 GSVRQAIEELEGAAEPEEEEAVG--MPKP---LQKVLADPRLTALQRDGGAILMRLRS--
500 510 520 530 540 550
410 420 430 440 450 460
pF1KF0 PEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVW
.:. . . ::..:: .:::. :: ..: : : :. :.:. :
XP_016 -----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQW
560 570 580 590 600
470 480 490 500 510 520
pF1KF0 LQQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP
:. : : . : .:. : ... :. . .::.. :... : : : .
XP_016 LSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENA
610 620 630 640 650
530 540 550 560 570 580
pF1KF0 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPG-
. . : . : . : : . : : :: ..:..: :..:: .:.: ::
XP_016 TSQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGR
660 670 680 690 700
590 600 610 620 630 640
pF1KF0 -VVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL-
.:: : :. : :. . :..: ::: ::: : .: ::::. ..:..
XP_016 EAVLAALALR--RAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVG
710 720 730 740 750 760
650 660 670 680
pF1KF0 -EASLKL-----------------P--PVGSTASLCVSQVPA---APAHPPLRKAYSFDR
::: . : : : .:: . . :. ::.: : .
XP_016 EEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYE
770 780 790 800 810 820
690 700 710 720
pF1KF0 NLGQSLSEPACHCHHAATIA-------------ACRRPEA---GGGALPQASPTVPPPGS
. : :. : :.. .: : : . :.. : :
XP_016 EEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRM
830 840 850 860 870 880
730 740 750 760 770 780
pF1KF0 SDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEK
::.. : ...:..: :..:: .: . ::: .:. ::: : .. :.
XP_016 ERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAALSARER
890 900 910 920 930 940
790 800 810 820 830 840
pF1KF0 LRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFK
::.:: :::::..:. :: :.. :::: ::..:: : :.. . . ... . . :
XP_016 LRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS-PLSK
950 960 970 980 990
850 860 870 880 890 900
pF1KF0 DKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP--TQELSALREAQSLVHFQL
...: : .: : : .:.... .:. ::.:: : .:: ..: :: : .:.. :
XP_016 GSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLRE-AGPELSSECRALGAAVQLLREQE
1000 1010 1020 1030 1040 1050
910 920 930 940 950 960
pF1KF0 RHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGP
.: ::::..:..::...:::::::...: :.: ::.: .:..::::.:::::: . ::
XP_016 ARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLK-GP
1060 1070 1080 1090 1100 1110
970 980 990 1000 1010 1020
pF1KF0 TG-VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTAD
: . :.::..:: ::.:::: :.:.: ::.:::::.::....:::.: :: ::..
XP_016 EGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSS
1120 1130 1140 1150 1160 1170
1030 1040 1050 1060 1070 1080
pF1KF0 ISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASI
:..::::::.::::.:. .:::::.::: : :: .:...::.. .: : .:.:::.
XP_016 IAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTRASV
1180 1190 1200 1210 1220 1230
1090 1100 1110 1120 1130
pF1KF0 AVAPFDHDSLYLGASNSLPG-DPASCSVLGSLNLHLYR-DPALLGLRCPLYPSFPEEAAL
::. :.: :. :::: .:..::. . .. . . : ..: : : ::
XP_016 AVSSFEH------AGPSLPGLSPGACSLPARVEEEAWDLDVKQISLASP---SAPETLDS
1240 1250 1260 1270 1280
1140 1150 1160 1170 1180 1190
pF1KF0 EAEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV
... : . : . . . .:. :. . : : . .: :. .:.: :
XP_016 SGDVSPGPRNSPSLQPPHPGSSTPTLA-SRGILG--LSRQSHARALSDPTTPL
1290 1300 1310 1320 1330
>>NP_060541 (OMIM: 610018) rho guanine nucleotide exchan (1519 aa)
initn: 1054 init1: 627 opt: 1180 Z-score: 895.9 bits: 178.1 E(85289): 3.6e-43
Smith-Waterman score: 1452; 32.5% identity (57.0% similar) in 1138 aa overlap (46-1108:369-1444)
20 30 40 50 60 70
pF1KF0 GHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPA-GATQDEELQG-SPLSRKFQLP
:: :: . : . .. : . ::: .
NP_060 EAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSA
340 350 360 370 380 390
80 90 100 110 120 130
pF1KF0 PAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQG--ESDTPGVGLVGDP
: . :: . .. . . :.. :.:: . : . .. ..: ::. . .:.
NP_060 PLS--PGDKEDASHQEA--LGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK
400 410 420 430 440 450
140 150 160 170
pF1KF0 GPSRAMPSGLSP-GALDSDPVGLG-----------DPLSEI-SKLLEAAPSGSGLPKPAD
:. . : . :: . . : : :::. . ::.. :.: : .
NP_060 EPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEE
460 470 480 490 500 510
180 190 200 210 220 230
pF1KF0 CLLAQ-----DLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLL
: .. :. :.:.:::. : : : .:::.: . : . : . : :
NP_060 ALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLH
520 530 540 550 560 570
240 250 260 270 280 290
pF1KF0 YLRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEV
::.:. ::..:.:::.::.: : : .:. .:::::... . : ::. . ..
NP_060 YLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDL
580 590 600 610 620 630
300 310 320 330 340
pF1KF0 PS---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAAC
:. :.: .. :.. : .. : ::: . :....... : . ::..
NP_060 PTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVL
640 650 660 670 680 690
350 360 370 380 390 400
pF1KF0 ALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEV
. .. ::: .... .: : :: . . .:.:: .: :. :: .:: : :..
NP_060 GSVRQAIEELEGAAEPEEEEAVG--MPKP---LQKVLADPRLTALQRDGGAILMRLRS--
700 710 720 730 740
410 420 430 440 450 460
pF1KF0 PEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVW
.:. . . ::..:: .:::. :: ..: : : :. :.:. :
NP_060 -----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQW
750 760 770 780 790
470 480 490 500 510 520
pF1KF0 LQQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDP
:. : : . : .:. : ... :. . .::.. :... : : : .
NP_060 LSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENA
800 810 820 830 840
530 540 550 560 570 580
pF1KF0 PGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPG-
. . : . : . : : . : : :: ..:..: :..:: .:.: ::
NP_060 TSQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGR
850 860 870 880 890
590 600 610 620 630 640
pF1KF0 -VVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL-
.:: : :. : :. . :..: ::: ::: : .: ::::. ..:..
NP_060 EAVLAALALR--RAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVG
900 910 920 930 940 950
650 660 670 680
pF1KF0 -EASLKL-----------------P--PVGSTASLCVSQVPA---APAHPPLRKAYSFDR
::: . : : : .:: . . :. ::.: : .
NP_060 EEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYE
960 970 980 990 1000 1010
690 700 710 720
pF1KF0 NLGQSLSEPACHCHHAATIA-------------ACRRPEA---GGGALPQASPTVPPPGS
. : :. : :.. .: : : . :.. : :
NP_060 EEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRM
1020 1030 1040 1050 1060 1070
730 740 750 760 770 780
pF1KF0 SDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEK
::.. : ...:..: :..:: .: . ::: .:. ::: : .. :.
NP_060 ERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAALSARER
1080 1090 1100 1110 1120 1130
790 800 810 820 830 840
pF1KF0 LRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFK
::.:: :::::..:. :: :.. :::: ::..:: : :.. . . ... . . :
NP_060 LRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS-PLSK
1140 1150 1160 1170 1180 1190
850 860 870 880 890 900
pF1KF0 DKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP--TQELSALREAQSLVHFQL
...: : .: : : .:.... .:. ::.:: : .:: ..: :: : .:.. :
NP_060 GSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLRE-AGPELSSECRALGAAVQLLREQE
1200 1210 1220 1230 1240
910 920 930 940 950 960
pF1KF0 RHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGP
.: ::::..:..::...:::::::...: :.: ::.: .:..::::.:::::: . ::
NP_060 ARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLK-GP
1250 1260 1270 1280 1290 1300
970 980 990 1000 1010 1020
pF1KF0 TG-VDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTAD
: . :.::..:: ::.:::: :.:.: ::.:::::.::....:::.: :: ::..
NP_060 EGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSS
1310 1320 1330 1340 1350 1360
1030 1040 1050 1060 1070 1080
pF1KF0 ISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASI
:..::::::.::::.:. .:::::.::: : :: .:...::.. .: : .:.:::.
NP_060 IAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTRASV
1370 1380 1390 1400 1410 1420
1090 1100 1110 1120 1130 1140
pF1KF0 AVAPFDHDSLYLGASNSLPG-DPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
::. :.: :. :::: .:..::.
NP_060 AVSSFEH------AGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPG
1430 1440 1450 1460 1470
1191 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:06:23 2016 done: Fri Nov 4 20:06:25 2016
Total Scan time: 17.660 Total Display time: 0.570
Function used was FASTA [36.3.4 Apr, 2011]