Result of FASTA (omim) for
pFN21AB9747
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9747, 545 aa
1>>>pF1KB9747 545 - 545 aa - 545 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5982+/-0.00034; mu= 9.3101+/- 0.021
mean_var=142.7692+/-28.910, 0's: 0 Z-trim(120.1): 76 B-trim: 809 in 2/53
Lambda= 0.107339
statistics sampled from 34911 (34987) to 34911 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.41), width: 16
Scan time: 10.000
The best scores are: opt bits E(85289)
NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 3739 590.5 4.6e-168
XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 3739 590.5 5e-168
NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 3727 588.6 1.7e-167
XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 3727 588.6 1.8e-167
XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 2298 367.2 5.5e-101
XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 1711 276.4 1.6e-73
NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 1710 276.2 1.7e-73
NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 1710 276.2 1.7e-73
NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 1677 271.1 5.4e-72
XP_006724375 (OMIM: 187500,188400,192430,217095,60 ( 495) 897 150.3 1.3e-35
NP_542378 (OMIM: 187500,188400,192430,217095,60205 ( 495) 897 150.3 1.3e-35
XP_016884415 (OMIM: 187500,188400,192430,217095,60 ( 495) 897 150.3 1.3e-35
XP_016884414 (OMIM: 187500,188400,192430,217095,60 ( 545) 897 150.3 1.4e-35
NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 899 150.7 1.4e-35
NP_542377 (OMIM: 187500,188400,192430,217095,60205 ( 398) 874 146.7 1.3e-34
XP_016884417 (OMIM: 187500,188400,192430,217095,60 ( 448) 874 146.7 1.4e-34
NP_005983 (OMIM: 187500,188400,192430,217095,60205 ( 372) 866 145.4 2.8e-34
NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 843 142.1 5.8e-33
NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 824 139.0 2.7e-32
XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 824 139.0 2.9e-32
XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 819 138.2 5e-32
XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 819 138.2 5e-32
NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 819 138.2 5e-32
XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 819 138.2 5e-32
NP_001071121 (OMIM: 606061,611363) T-box transcrip ( 447) 804 135.9 2.6e-31
NP_001159692 (OMIM: 606061,611363) T-box transcrip ( 297) 800 135.2 2.8e-31
XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 790 133.7 9.9e-31
XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 787 133.2 1.4e-30
XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 785 132.9 1.7e-30
XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 785 132.9 1.7e-30
XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 785 132.9 1.7e-30
NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 786 133.2 2.3e-30
NP_001317606 (OMIM: 260660,604127) T-box transcrip ( 602) 775 131.5 7.4e-30
NP_689593 (OMIM: 260660,604127) T-box transcriptio ( 496) 767 130.2 1.5e-29
XP_005271218 (OMIM: 260660,604127) PREDICTED: T-bo ( 635) 763 129.6 2.8e-29
XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 723 123.3 1.3e-27
NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 724 123.5 1.6e-27
NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 724 123.5 1.6e-27
XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 723 123.4 1.7e-27
NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 713 121.9 5.2e-27
XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 695 119.0 3e-26
NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 689 118.1 5.8e-26
NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 674 115.7 2.6e-25
XP_016866961 (OMIM: 143100,143400,604613) PREDICTE ( 449) 674 115.8 3e-25
XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 682 117.3 3.2e-25
XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 682 117.3 3.4e-25
XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 682 117.4 4.6e-25
NP_001074010 (OMIM: 616061) MAX gene-associated pr (2856) 682 117.5 5.7e-25
XP_005254310 (OMIM: 616061) PREDICTED: MAX gene-as (2906) 682 117.5 5.7e-25
XP_005254309 (OMIM: 616061) PREDICTED: MAX gene-as (2956) 682 117.5 5.8e-25
>>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa)
initn: 3739 init1: 3739 opt: 3739 Z-score: 3138.3 bits: 590.5 E(85289): 4.6e-168
Smith-Waterman score: 3739; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:1-545)
10 20 30 40 50 60
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 VGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNMW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 TSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 TSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 QVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTVE
490 500 510 520 530 540
pF1KB9 NWTDG
:::::
NP_060 NWTDG
>>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa)
initn: 3739 init1: 3739 opt: 3739 Z-score: 3137.6 bits: 590.5 E(85289): 5e-168
Smith-Waterman score: 3739; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:64-608)
10 20 30
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAP
::::::::::::::::::::::::::::::
XP_011 PGMRRPLNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB9 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB9 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB9 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB9 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB9 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB9 SLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPRE
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB9 ACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTATT
460 470 480 490 500 510
460 470 480 490 500 510
pF1KB9 MMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPQGCERKPPSPHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPQGCERKPPSPHL
520 530 540 550 560 570
520 530 540
pF1KB9 NAANEFLYSQTFSLSRESSLQYHSGMGTVENWTDG
:::::::::::::::::::::::::::::::::::
XP_011 NAANEFLYSQTFSLSRESSLQYHSGMGTVENWTDG
580 590 600
>>NP_001308049 (OMIM: 147891,601719) T-box transcription (546 aa)
initn: 2294 init1: 2294 opt: 3727 Z-score: 3128.3 bits: 588.6 E(85289): 1.7e-167
Smith-Waterman score: 3727; 99.8% identity (99.8% similar) in 546 aa overlap (1-545:1-546)
10 20 30 40 50 60
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVAAAAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILLIDIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKITQLKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENNPFAKGFRGSDDSDLRVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLGTHQAL
250 260 270 280 290 300
310 320 330 340 350
pF1KB9 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRR-DGTRHLDLPCKRSYLEAPS
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_001 QHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYHCLKRRADGTRHLDLPCKRSYLEAPS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB9 SVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLPPPPLSCNM
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB9 WTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTSVSPYTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB9 SQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRESSLQYHSGMGTV
490 500 510 520 530 540
540
pF1KB9 ENWTDG
::::::
NP_001 ENWTDG
>>XP_011523792 (OMIM: 147891,601719) PREDICTED: T-box tr (609 aa)
initn: 2294 init1: 2294 opt: 3727 Z-score: 3127.6 bits: 588.6 E(85289): 1.8e-167
Smith-Waterman score: 3727; 99.8% identity (99.8% similar) in 546 aa overlap (1-545:64-609)
10 20 30
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAP
::::::::::::::::::::::::::::::
XP_011 PGMRRPLNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB9 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB9 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB9 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB9 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB9 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
340 350 360 370 380 390
340 350 360 370 380
pF1KB9 SLFYHCLKRR-DGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPR
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFYHCLKRRADGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPR
400 410 420 430 440 450
390 400 410 420 430 440
pF1KB9 EACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFPTHFTAT
460 470 480 490 500 510
450 460 470 480 490 500
pF1KB9 TMMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPQGCERKPPSPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMMPRLPTLSAQSSQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPQGCERKPPSPH
520 530 540 550 560 570
510 520 530 540
pF1KB9 LNAANEFLYSQTFSLSRESSLQYHSGMGTVENWTDG
::::::::::::::::::::::::::::::::::::
XP_011 LNAANEFLYSQTFSLSRESSLQYHSGMGTVENWTDG
580 590 600
>>XP_011523797 (OMIM: 147891,601719) PREDICTED: T-box tr (417 aa)
initn: 2294 init1: 2294 opt: 2298 Z-score: 1934.0 bits: 367.2 E(85289): 5.5e-101
Smith-Waterman score: 2298; 98.8% identity (98.8% similar) in 346 aa overlap (1-346:64-409)
10 20 30
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAP
::::::::::::::::::::::::::::::
XP_011 PGMRRPLNKMGERPEPGDAPGGPGESGKKEMLQDKGLSESEEAFRAPGPALGEASAANAP
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB9 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB9 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB9 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB9 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVI
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB9 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKSIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDS
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB9 SLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPRE
:::::::::: : :
XP_011 SLFYHCLKRRGCLRLLSWYNGRVS
400 410
>>XP_016875401 (OMIM: 142900,601620) PREDICTED: T-box tr (534 aa)
initn: 1586 init1: 1297 opt: 1711 Z-score: 1441.2 bits: 276.4 E(85289): 1.6e-73
Smith-Waterman score: 1762; 53.8% identity (71.4% similar) in 556 aa overlap (5-544:15-532)
10 20 30 40
pF1KB9 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGS
. .....:.: ..: : . . :: ::.::. :
XP_016 MDGEQNLARAQGPGRTMADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KS
10 20 30 40 50
50 60 70 80 90 100
pF1KB9 PPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTG
: .: :: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::
XP_016 PSSP-----QAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTG
60 70 80 90 100
110 120 130 140 150 160
pF1KB9 MNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLV
.:::::::::.:::::::::::: :::: :.:::::::::::::::::::::::::::::
XP_016 LNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLV
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 SFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFIS
:::::::::::::::::::::::::::::::::::::::.::::::::::::::::.::.
XP_016 SFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIA
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB9 VTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLS
:::::::::::::::::::::::::::: .: :..:.:::::::. .: .::.. : .
XP_016 VTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSP
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 ATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT
. . : . . ..:: :::. . ::: : . .: .. : .::: ::..
XP_016 FSSESRALSTSSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEE
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 -RHLDLPCKRSYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEI
: : :. :.: .:: :: ..:: : .:: :. :: .: . :.::::..:.:
XP_016 CSTTDHPYKKPYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPS
350 360 370 380 390 400
410 420 430 440 450
pF1KB9 AGVSGVDDLPPPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTL
: ...:. ::: : :. :.: .:: :. .::: : .:::. ..::: .
XP_016 EPVPSLEDI-----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGM
410 420 430 440 450
460 470 480 490 500 510
pF1KB9 SAQSSQPPGNAHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFL
. ..: :.. :. .... : ::. :: . :: . .:: :::
XP_016 ANHGSPQLGEGMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFL
460 470 480 490 500
520 530 540
pF1KB9 YSQTFSLSRE-SSLQYHS--GMGTVENWTDG
::. .. : : :::: :.: : .:.:
XP_016 YSH--GVPRTLSPHQYHSVHGVGMVPEWSDNS
510 520 530
>>NP_852259 (OMIM: 142900,601620) T-box transcription fa (518 aa)
initn: 1586 init1: 1297 opt: 1710 Z-score: 1440.5 bits: 276.2 E(85289): 1.7e-73
Smith-Waterman score: 1761; 54.0% identity (71.5% similar) in 554 aa overlap (7-544:1-516)
10 20 30 40 50
pF1KB9 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA
.....:.: ..: : . . :: ::.::. :: .:
NP_852 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q
10 20 30 40
60 70 80 90 100 110
pF1KB9 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL
:: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.:::::::::
NP_852 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB9 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
.:::::::::::: :::: :.:::::::::::::::::::::::::::::::::::::::
NP_852 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB9 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT
:::::::::::::::::::::::::::::.::::::::::::::::.::.::::::::::
NP_852 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB9 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG
:::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . :
NP_852 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT-RHLDLPCKR
. . ..:: :::. . ::: : . .: .. : .::: ::.. : : :.
NP_852 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB9 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP
:.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:.
NP_852 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI-
350 360 370 380 390
420 430 440 450 460
pF1KB9 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN
::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :.
NP_852 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE
400 410 420 430 440 450
470 480 490 500 510 520
pF1KB9 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE
. :. .... : ::. :: . :: . .:: :::::. .. :
NP_852 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSH--GVPRT
460 470 480 490
530 540
pF1KB9 -SSLQYHS--GMGTVENWTDG
: :::: :.: : .:.:
NP_852 LSPHQYHSVHGVGMVPEWSDNS
500 510
>>NP_000183 (OMIM: 142900,601620) T-box transcription fa (518 aa)
initn: 1586 init1: 1297 opt: 1710 Z-score: 1440.5 bits: 276.2 E(85289): 1.7e-73
Smith-Waterman score: 1761; 54.0% identity (71.5% similar) in 554 aa overlap (7-544:1-516)
10 20 30 40 50
pF1KB9 MLQDKGLSESEEAF---RAP-GPALGEASAANAPEPALAAPGLSGAALGSPPGPGADVVA
.....:.: ..: : . . :: ::.::. :: .:
NP_000 MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPS------KSPSSP-----Q
10 20 30 40
60 70 80 90 100 110
pF1KB9 AAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYKVKVTGMNPKTKYILL
:: ..: .:.::: :::.::: ::::.:::::::::::::::::::::::.:::::::::
NP_000 AAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB9 IDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
.:::::::::::: :::: :.:::::::::::::::::::::::::::::::::::::::
NP_000 MDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB9 HLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTAFCTHVFPETSFISVTSYQNHKIT
:::::::::::::::::::::::::::::.::::::::::::::::.::.::::::::::
NP_000 HLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKIT
170 180 190 200 210 220
240 250 260 270 280 290
pF1KB9 QLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIMRQRLISPQLSATPDVGPLLG
:::::::::::::::::: .: :..:.:::::::. .: .::.. : . . . :
NP_000 QLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPRSTVRQKVASNHSPFSSESRALST
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 THQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDSSLFYHCLKRRDGT-RHLDLPCKR
. . ..:: :::. . ::: : . .: .. : .::: ::.. : : :.
NP_000 SSNLGSQYQCENGVSGP---SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB9 SYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYSGSGPEIAGVSGVDDLP
:.: .:: :: ..:: : .:: :. :: .: . :.::::..:.: : ...:.
NP_000 PYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDI-
350 360 370 380 390
420 430 440 450 460
pF1KB9 PPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGN
::: : :. :.: .:: :. .::: : .:::. ..::: .. ..: :.
NP_000 ----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGE
400 410 420 430 440 450
470 480 490 500 510 520
pF1KB9 AHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERKPPSPHLNAANEFLYSQTFSLSRE
. :. .... : ::. :: . :: . .:: :::::. .. :
NP_000 GMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQPP--------EFLYSH--GVPRT
460 470 480 490
530 540
pF1KB9 -SSLQYHS--GMGTVENWTDG
: :::: :.: : .:.:
NP_000 LSPHQYHSVHGVGMVPEWSDNS
500 510
>>NP_542448 (OMIM: 142900,601620) T-box transcription fa (468 aa)
initn: 1564 init1: 1275 opt: 1677 Z-score: 1413.6 bits: 271.1 E(85289): 5.4e-72
Smith-Waterman score: 1726; 57.3% identity (73.8% similar) in 492 aa overlap (64-544:1-466)
40 50 60 70 80 90
pF1KB9 LAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAG
.:.::: :::.::: ::::.::::::::::
NP_542 MEGIKVFLHERELWLKFHEVGTEMIITKAG
10 20 30
100 110 120 130 140 150
pF1KB9 RRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPD
:::::::::::::.:::::::::.:::::::::::: :::: :.::::::::::::::::
NP_542 RRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPD
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB9 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTA
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_542 SPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB9 FCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISK
:::::::::.::.:::::::::::::::::::::::::::: .: :..:.:::::::. .
NP_542 FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRMQSKEYPVVPR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB9 SIMRQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDL--PLSTFPTQRDS
: .::.. : . . . : . . ..:: :::. . ::: : . .: ..
NP_542 STVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSG---PSQDLLPPPNPYPLPQEH
220 230 240 250 260
340 350 360 370 380
pF1KB9 SLFYHCLKRRDGT-RHLDLPCKRSYLE-APSSVGEDHYFRSPPPYDQQMLSPSYCSEVTP
: .::: ::.. : : :. :.: .:: :: ..:: : .:: :. :: .: .
NP_542 SQIYHCTKRKEEECSTTDHPYKKPYMETSPSE--EDSFYRSSYP-QQQGLGASYRTESAQ
270 280 290 300 310 320
390 400 410 420 430 440
pF1KB9 REACMYSGSGPEIAGVSGVDDLPPPPLSCNMWTSVSPYTS---YSVQTMETVPYQPFPTH
:.::::..:.: : ...:. ::: : :. :.: .:: :. .::: : .:
NP_542 RQACMYASSAPPSEPVPSLEDI-----SCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAH
330 340 350 360 370
450 460 470 480 490 500
pF1KB9 FTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLS-QSQVRERGPSASFPRERGLPQGCERK
::. ..::: .. ..: :.. :. .... : ::. :: . :: . .
NP_542 FTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGP------QTGLQSPGTLQ
380 390 400 410 420 430
510 520 530 540
pF1KB9 PPSPHLNAANEFLYSQTFSLSRESSLQYHS--GMGTVENWTDG
:: :::::. . : :::: :.: : .:.:
NP_542 PP--------EFLYSHGVPRTL-SPHQYHSVHGVGMVPEWSDNS
440 450 460
>>XP_006724375 (OMIM: 187500,188400,192430,217095,602054 (495 aa)
initn: 924 init1: 392 opt: 897 Z-score: 760.4 bits: 150.3 E(85289): 1.3e-35
Smith-Waterman score: 897; 47.6% identity (69.8% similar) in 315 aa overlap (16-320:60-362)
10 20 30 40
pF1KB9 MLQDKGLSESEEAFRAPGPALGEASAANAPEPALAAPGLSGAALG
:::: . :: : : . .: .
XP_006 AASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAP-----AAGAATSAAA
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB9 SPPGPGADVVAAAAA----EQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMFPSYK
: ::::. .::: : . . ...: :. : :: .:.. :::::.:::::::::...
XP_006 EPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQ
90 100 110 120 130 140
110 120 130 140 150
pF1KB9 VKVTGMNPKTKYILLIDIVPADDHRYK--FCDNKWMVAGKAEPAMPGRLYVHPDSPATGA
::. ::.: . :.::.:.::.::.::. : ...:.:::::.:: :::.. :::::: ::
XP_006 VKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB9 HWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKAD---ENNAFGSKNTAFCT
.::.:.:::.::::::: :: :::::::::.::::.:.: .: ... .. .: : :
XP_006 QWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEEN--FKT
210 220 230 240 250 260
220 230 240 250 260 270
pF1KB9 HVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDL-RVARLQSKEYPVISKSIM
:: :: : .::.::::.:::::: .:::::::: : : : : :..: ..
XP_006 FVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHR--PGALPLMS-AFA
270 280 290 300 310
280 290 300 310 320 330
pF1KB9 RQRLISPQLSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQDLPLSTFPTQRDSSLFYH
:.: .: : : : . .: ...:.. :. . :..: :
XP_006 RSR--NPVASPTQPSGTEKDAAEARREFQRDAGGPAVLGDPAHPPQLLARVLSPSLPGAG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB9 CLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYDQQMLSPSYCSEVTPREACMYS
XP_006 GAGGLVPLPGAPGGRPSPPNPELRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYP
380 390 400 410 420 430
545 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 18:40:23 2016 done: Fri Nov 4 18:40:24 2016
Total Scan time: 10.000 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]