Result of FASTA (omim) for
pFN21AB9625
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9625, 133 aa
1>>>pF1KB9625 133 - 133 aa - 133 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5667+/-0.000267; mu= 8.9107+/- 0.017
mean_var=173.7233+/-34.763, 0's: 0 Z-trim(125.6): 54 B-trim: 2653 in 1/54
Lambda= 0.097307
statistics sampled from 49778 (49841) to 49778 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.867), E-opt: 0.2 (0.584), width: 16
Scan time: 5.410
The best scores are: opt bits E(85289)
NP_005589 (OMIM: 162360) helix-loop-helix protein ( 133) 903 136.7 1e-32
NP_001104531 (OMIM: 162361) helix-loop-helix prote ( 135) 487 78.3 4e-15
NP_005590 (OMIM: 162361) helix-loop-helix protein ( 135) 487 78.3 4e-15
NP_001277335 (OMIM: 187040,613065) T-cell acute ly ( 172) 202 38.5 0.0052
XP_016857682 (OMIM: 187040,613065) PREDICTED: T-ce ( 172) 202 38.5 0.0052
XP_005268588 (OMIM: 602406) PREDICTED: heart- and ( 214) 202 38.6 0.006
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 202 38.6 0.006
XP_005259969 (OMIM: 151440) PREDICTED: protein lyl ( 206) 200 38.3 0.0071
NP_001277334 (OMIM: 187040,613065) T-cell acute ly ( 331) 202 38.8 0.0079
NP_001277333 (OMIM: 187040,613065) T-cell acute ly ( 331) 202 38.8 0.0079
XP_016857677 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
XP_016857679 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
NP_003180 (OMIM: 187040,613065) T-cell acute lymph ( 331) 202 38.8 0.0079
XP_016857678 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
XP_005271217 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
XP_016857680 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
XP_016857676 (OMIM: 187040,613065) PREDICTED: T-ce ( 331) 202 38.8 0.0079
NP_001274276 (OMIM: 187040,613065) T-cell acute ly ( 331) 202 38.8 0.0079
NP_001277332 (OMIM: 187040,613065) T-cell acute ly ( 331) 202 38.8 0.0079
NP_005412 (OMIM: 186855,613065) T-cell acute lymph ( 108) 194 37.1 0.0084
NP_005089 (OMIM: 603628) musculin [Homo sapiens] ( 206) 198 38.0 0.0086
NP_005574 (OMIM: 151440) protein lyl-1 [Homo sapie ( 280) 200 38.4 0.0086
XP_016882306 (OMIM: 151440) PREDICTED: protein lyl ( 302) 200 38.5 0.009
XP_016882305 (OMIM: 151440) PREDICTED: protein lyl ( 351) 200 38.5 0.01
>>NP_005589 (OMIM: 162360) helix-loop-helix protein 1 [H (133 aa)
initn: 903 init1: 903 opt: 903 Z-score: 708.2 bits: 136.7 E(85289): 1e-32
Smith-Waterman score: 903; 100.0% identity (100.0% similar) in 133 aa overlap (1-133:1-133)
10 20 30 40 50 60
pF1KB9 MMLNSDTMELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MMLNSDTMELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLA
70 80 90 100 110 120
130
pF1KB9 ICYISYLNHVLDV
:::::::::::::
NP_005 ICYISYLNHVLDV
130
>>NP_001104531 (OMIM: 162361) helix-loop-helix protein 2 (135 aa)
initn: 478 init1: 461 opt: 487 Z-score: 392.5 bits: 78.3 E(85289): 4e-15
Smith-Waterman score: 487; 64.3% identity (75.5% similar) in 143 aa overlap (1-133:1-135)
10 20 30 40 50
pF1KB9 MMLNSD-TMELDLPPT-HSETES-GFSDCG--GGAG---P--DGAGPGGPGGGQARGPEP
:::. : . . : : . ::. :: : .: :... : .. : : :. : :.:
NP_001 MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 GEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKK
:.:::::.:::::::::::.::::::::::::::::::::::::::::::::
NP_001 --------QQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKK
70 80 90 100 110
120 130
pF1KB9 LSKIEILRLAICYISYLNHVLDV
:::::::::::::::::::::::
NP_001 LSKIEILRLAICYISYLNHVLDV
120 130
>>NP_005590 (OMIM: 162361) helix-loop-helix protein 2 [H (135 aa)
initn: 478 init1: 461 opt: 487 Z-score: 392.5 bits: 78.3 E(85289): 4e-15
Smith-Waterman score: 487; 64.3% identity (75.5% similar) in 143 aa overlap (1-133:1-135)
10 20 30 40 50
pF1KB9 MMLNSD-TMELDLPPT-HSETES-GFSDCG--GGAG---P--DGAGPGGPGGGQARGPEP
:::. : . . : : . ::. :: : .: :... : .. : : :. : :.:
NP_005 MMLSPDQAADSDHPSSAHSDPESLGGTDTKVLGSVSDLEPVEEAEGDGKGGSRAALYPHP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 GEPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKK
:.:::::.:::::::::::.::::::::::::::::::::::::::::::::
NP_005 --------QQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTLPPDKK
70 80 90 100 110
120 130
pF1KB9 LSKIEILRLAICYISYLNHVLDV
:::::::::::::::::::::::
NP_005 LSKIEILRLAICYISYLNHVLDV
120 130
>>NP_001277335 (OMIM: 187040,613065) T-cell acute lympho (172 aa)
initn: 200 init1: 200 opt: 202 Z-score: 175.0 bits: 38.5 E(85289): 0.0052
Smith-Waterman score: 202; 64.7% identity (82.4% similar) in 51 aa overlap (82-132:35-85)
60 70 80 90 100 110
pF1KB9 EPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKL
.::: : . : ::::::::.:: ::::::
NP_001 NNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKL
10 20 30 40 50 60
120 130
pF1KB9 SKIEILRLAICYISYLNHVLDV
:: ::::::. ::..: ..:.
NP_001 SKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQD
70 80 90 100 110 120
>>XP_016857682 (OMIM: 187040,613065) PREDICTED: T-cell a (172 aa)
initn: 200 init1: 200 opt: 202 Z-score: 175.0 bits: 38.5 E(85289): 0.0052
Smith-Waterman score: 202; 64.7% identity (82.4% similar) in 51 aa overlap (82-132:35-85)
60 70 80 90 100 110
pF1KB9 EPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKL
.::: : . : ::::::::.:: ::::::
XP_016 NNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKL
10 20 30 40 50 60
120 130
pF1KB9 SKIEILRLAICYISYLNHVLDV
:: ::::::. ::..: ..:.
XP_016 SKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQD
70 80 90 100 110 120
>>XP_005268588 (OMIM: 602406) PREDICTED: heart- and neur (214 aa)
initn: 197 init1: 175 opt: 202 Z-score: 174.0 bits: 38.6 E(85289): 0.006
Smith-Waterman score: 211; 43.1% identity (65.1% similar) in 109 aa overlap (30-131:52-150)
10 20 30 40 50
pF1KB9 MMLNSDTMELDLPPTHSETESGFSDCGGGAGPD----GAGPGGPGGGQARGPE--PGE-
:.:: : :.. ... : ::. ::.
XP_005 MLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQS
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB9 PGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLS
::: :. :. : ::.... .:: :.:..: ::::::. .:..: : :::
XP_005 PGR--LEALGG--RLGRRKGSG------PKKERRRTESINSAFAELRECIPNVPADTKLS
90 100 110 120 130
120 130
pF1KB9 KIEILRLAICYISYLNHVLDV
::. :::: ::.:: ::
XP_005 KIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQHEGFPPALG
140 150 160 170 180 190
>>NP_004812 (OMIM: 602406) heart- and neural crest deriv (215 aa)
initn: 197 init1: 175 opt: 202 Z-score: 173.9 bits: 38.6 E(85289): 0.006
Smith-Waterman score: 211; 43.1% identity (65.1% similar) in 109 aa overlap (30-131:52-150)
10 20 30 40 50
pF1KB9 MMLNSDTMELDLPPTHSETESGFSDCGGGAGPD----GAGPGGPGGGQARGPE--PGE-
:.:: : :.. ... : ::. ::.
NP_004 MLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQS
30 40 50 60 70 80
60 70 80 90 100 110
pF1KB9 PGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLS
::: :. :. : ::.... .:: :.:..: ::::::. .:..: : :::
NP_004 PGR--LEALGG--RLGRRKGSG------PKKERRRTESINSAFAELRECIPNVPADTKLS
90 100 110 120 130
120 130
pF1KB9 KIEILRLAICYISYLNHVLDV
::. :::: ::.:: ::
NP_004 KIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPAL
140 150 160 170 180 190
>>XP_005259969 (OMIM: 151440) PREDICTED: protein lyl-1 i (206 aa)
initn: 216 init1: 194 opt: 200 Z-score: 172.6 bits: 38.3 E(85289): 0.0071
Smith-Waterman score: 200; 43.0% identity (65.6% similar) in 93 aa overlap (39-131:42-132)
10 20 30 40 50 60
pF1KB9 ELDLPPTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGRKDLQHLSREERRR
::.: . : : . .:. : ..
XP_005 PLLQLSTLGTAPPTLALHYHPHPFLNSVYIGPAGPFSIFPSSRLKRRPSHCELDLAEGHQ
20 30 40 50 60 70
70 80 90 100 110 120
pF1KB9 RRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLN
.... . : .::: : . : ::::::::::: :::.:::: :.::::. ::..:
XP_005 PQKVARRVFTN--SRERWRQQNVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFLV
80 90 100 110 120
130
pF1KB9 HVLDV
..:
XP_005 RLLRDQAAALAAGPTPPGPRKRPVHRVPDDGARRGSGRRAEAAARSQPAPPADPDGSPGG
130 140 150 160 170 180
>>NP_001277334 (OMIM: 187040,613065) T-cell acute lympho (331 aa)
initn: 277 init1: 200 opt: 202 Z-score: 171.8 bits: 38.8 E(85289): 0.0079
Smith-Waterman score: 202; 64.7% identity (82.4% similar) in 51 aa overlap (82-132:194-244)
60 70 80 90 100 110
pF1KB9 EPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKL
.::: : . : ::::::::.:: ::::::
NP_001 NNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKL
170 180 190 200 210 220
120 130
pF1KB9 SKIEILRLAICYISYLNHVLDV
:: ::::::. ::..: ..:.
NP_001 SKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQD
230 240 250 260 270 280
>>NP_001277333 (OMIM: 187040,613065) T-cell acute lympho (331 aa)
initn: 277 init1: 200 opt: 202 Z-score: 171.8 bits: 38.8 E(85289): 0.0079
Smith-Waterman score: 202; 64.7% identity (82.4% similar) in 51 aa overlap (82-132:194-244)
60 70 80 90 100 110
pF1KB9 EPGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKL
.::: : . : ::::::::.:: ::::::
NP_001 NNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKL
170 180 190 200 210 220
120 130
pF1KB9 SKIEILRLAICYISYLNHVLDV
:: ::::::. ::..: ..:.
NP_001 SKNEILRLAMKYINFLAKLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQD
230 240 250 260 270 280
133 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:47:28 2016 done: Fri Nov 4 17:47:29 2016
Total Scan time: 5.410 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]