Result of FASTA (omim) for
pFN21AB9581
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9581, 354 aa
1>>>pF1KB9581 354 - 354 aa - 354 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3733+/-0.000314; mu= 6.1964+/- 0.020
mean_var=224.2021+/-46.580, 0's: 0 Z-trim(124.6): 49 B-trim: 3989 in 2/59
Lambda= 0.085655
statistics sampled from 46433 (46491) to 46433 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.816), E-opt: 0.2 (0.545), width: 16
Scan time: 10.110
The best scores are: opt bits E(85289)
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 2412 309.9 5.6e-84
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 259 43.5 0.00038
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 262 44.1 0.00044
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 256 43.2 0.00057
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 249 42.6 0.0016
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 245 41.9 0.0016
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 245 41.9 0.0016
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 247 42.3 0.0019
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 246 42.2 0.002
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 242 41.5 0.0022
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 232 40.5 0.0074
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 2412 init1: 2412 opt: 2412 Z-score: 1628.6 bits: 309.9 E(85289): 5.6e-84
Smith-Waterman score: 2412; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354)
10 20 30 40 50 60
pF1KB9 MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS
250 260 270 280 290 300
310 320 330 340 350
pF1KB9 ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
310 320 330 340 350
>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom (152 aa)
initn: 279 init1: 258 opt: 259 Z-score: 195.5 bits: 43.5 E(85289): 0.00038
Smith-Waterman score: 259; 71.9% identity (91.2% similar) in 57 aa overlap (159-215:40-96)
130 140 150 160 170 180
pF1KB9 CKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPS
.:::::::::::::.::: :::.:: :.:.
NP_660 PAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQ
10 20 30 40 50 60
190 200 210 220 230 240
pF1KB9 FNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGA
...::::::::::::: :: ::...:
NP_660 WGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKL
70 80 90 100 110 120
>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens] (272 aa)
initn: 288 init1: 209 opt: 262 Z-score: 194.2 bits: 44.1 E(85289): 0.00044
Smith-Waterman score: 276; 35.9% identity (55.8% similar) in 217 aa overlap (84-282:24-225)
60 70 80 90 100
pF1KB9 SLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGA-----SEAAAPRDEVDGRGELVRR
:: :.: : : ..: : . .::
NP_076 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARR
10 20 30 40 50
110 120 130 140 150
pF1KB9 SSGGASSSKSPGPVKVREQLCKLKG--GVVVDELGC----SRQRAPS-----SKQVNGVQ
. :. ... . : : . . :. :.: : : :: :: : .. :. ..
NP_076 QRGAEAGQGARGGVAAGAEGCRPARLLGLVHD---CKRRPSRARAVSRGAKTAETVQRIK
60 70 80 90 100 110
160 170 180 190 200 210
pF1KB9 KQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQT
: ::: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: ::.: :.
NP_076 KTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRL
120 130 140 150 160 170
220 230 240 250 260 270
pF1KB9 PS--GGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTR
. :: : : : . : . .: :..: ..:: : :. :: :
NP_076 ADHCGGGGGGLPGA--------LFSEAVLLSPGG---ASAALSSSGDSPSPASTWSC-TN
180 190 200 210
280 290 300 310 320 330
pF1KB9 FSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSH
::.:.
NP_076 SPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI
220 230 240 250 260 270
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 262 init1: 219 opt: 256 Z-score: 192.3 bits: 43.2 E(85289): 0.00057
Smith-Waterman score: 256; 37.6% identity (59.2% similar) in 157 aa overlap (115-265:29-177)
90 100 110 120 130 140
pF1KB9 PELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSR
: .::: .. : . . ... : .:
NP_803 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAK-GLRSRPARAAARAPGEGR
10 20 30 40 50
150 160 170 180 190 200
pF1KB9 QRAPSSKQVNGVQK---QRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETL
.: :. . .: . :::: .: :::.::: ::.::. ::.::: :::::: :::
NP_803 RRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETL
60 70 80 90 100 110
210 220 230 240 250
pF1KB9 QMAQIYINALSELLQTPSGGEQPP---PPPASCKSDHHHLRTAASYEGGAGNATAAGAQQ
.:. ::..:. . : :... : : : ..: . . ::: .:: : :
NP_803 TLAKNYIKSLTATILTMSSSRLPGLEGPGPKL----YQHYQQQQQVAGGALGATEA---Q
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB9 ASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGS
.: ::
NP_803 PQGHLQRYSTQIHSFREGT
180
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 251 init1: 225 opt: 249 Z-score: 184.3 bits: 42.6 E(85289): 0.0016
Smith-Waterman score: 249; 41.9% identity (67.5% similar) in 117 aa overlap (112-224:45-156)
90 100 110 120 130 140
pF1KB9 LHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELG
: : ...:: .:. . . :: :
NP_073 SQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEE--EEEDREEEDENG
20 30 40 50 60 70
150 160 170 180 190
pF1KB9 CSRQRAPSSKQVNGVQ----KQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSK
:.:. .:... .. : :: :::::: :::::: :.:.::.:.: ... .::::
NP_073 LPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSK
80 90 100 110 120 130
200 210 220 230 240 250
pF1KB9 YETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQ
:::..:. :: ::::.:. :..:
NP_073 IETLRLAKNYIWALSEILRI---GKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFL
140 150 160 170 180
>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap (214 aa)
initn: 261 init1: 214 opt: 245 Z-score: 184.2 bits: 41.9 E(85289): 0.0016
Smith-Waterman score: 254; 30.3% identity (52.2% similar) in 228 aa overlap (61-283:3-206)
40 50 60 70 80 90
pF1KB9 PPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGAS
:. :::.: . .. : . .
NP_066 MTPQPSGAPTVQ-VTRETERSFPRASEDEVTC
10 20 30
100 110 120 130 140 150
pF1KB9 EAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSS
..:: . . ::. .. :: .. : :.: . .:: :.: :
NP_066 PTSAPPSPTRTRGNCAEAEEGGCRGA----PRKLRAR----RGG---------RSRPKSE
40 50 60 70
160 170 180 190 200 210
pF1KB9 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINA
.. ...:: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: :
NP_066 LALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWA
80 90 100 110 120 130
220 230 240 250 260
pF1KB9 LSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTP--
:.. :. . . ::: : .: :. :. . . ...:: :.
NP_066 LTQTLRIADHSLYALEPPAP------HCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASL
140 150 160 170 180
270 280 290 300 310 320
pF1KB9 ---PGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQE
:: . ::: : :
NP_066 EERPGLLGATFSACLSPGSLAFSDFL
190 200 210
>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen (214 aa)
initn: 261 init1: 214 opt: 245 Z-score: 184.2 bits: 41.9 E(85289): 0.0016
Smith-Waterman score: 254; 30.3% identity (52.2% similar) in 228 aa overlap (61-283:3-206)
40 50 60 70 80 90
pF1KB9 PPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGAS
:. :::.: . .. : . .
XP_016 MTPQPSGAPTVQ-VTRETERSFPRASEDEVTC
10 20 30
100 110 120 130 140 150
pF1KB9 EAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSS
..:: . . ::. .. :: .. : :.: . .:: :.: :
XP_016 PTSAPPSPTRTRGNCAEAEEGGCRGA----PRKLRAR----RGG---------RSRPKSE
40 50 60 70
160 170 180 190 200 210
pF1KB9 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINA
.. ...:: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: :
XP_016 LALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWA
80 90 100 110 120 130
220 230 240 250 260
pF1KB9 LSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTP--
:.. :. . . ::: : .: :. :. . . ...:: :.
XP_016 LTQTLRIADHSLYALEPPAP------HCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASL
140 150 160 170 180
270 280 290 300 310 320
pF1KB9 ---PGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQE
:: . ::: : :
XP_016 EERPGLLGATFSACLSPGSLAFSDFL
190 200 210
>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa)
initn: 263 init1: 233 opt: 247 Z-score: 182.7 bits: 42.3 E(85289): 0.0019
Smith-Waterman score: 247; 48.2% identity (80.0% similar) in 85 aa overlap (144-224:82-163)
120 130 140 150 160
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQ----KQRRLAANARER
..:.:..:... .. : ::. ::::::
NP_002 SLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARER
60 70 80 90 100 110
170 180 190 200 210 220
pF1KB9 RRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPA
:::::: :.:.::.:.: ... .:::: :::..:. :: ::::.:.. :..:
NP_002 NRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRS---GKSPDLVSF
120 130 140 150 160
230 240 250 260 270 280
pF1KB9 SCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQL
NP_002 VQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPS
170 180 190 200 210 220
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 275 init1: 231 opt: 246 Z-score: 182.4 bits: 42.2 E(85289): 0.002
Smith-Waterman score: 246; 50.0% identity (77.4% similar) in 84 aa overlap (144-220:68-151)
120 130 140 150 160
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQ----KQRRLAANARER
..:.:..:... .. . ::. ::::::
NP_067 PGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARER
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB9 RRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELL---QTPSGGEQPPP
:::::: :.:.:: :.: ... .:::: :::..:. :: ::::.: ::: :
NP_067 TRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEM
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB9 PPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYS
NP_067 LCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHM
160 170 180 190 200 210
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 258 init1: 211 opt: 242 Z-score: 181.6 bits: 41.5 E(85289): 0.0022
Smith-Waterman score: 252; 38.6% identity (60.0% similar) in 145 aa overlap (144-269:77-215)
120 130 140 150 160 170
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMH
: :. : .......::. :: ::: :::
NP_006 PARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMH
50 60 70 80 90 100
180 190 200 210 220
pF1KB9 GLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQT-----PSGGEQ----P
.:: :.: ::.:.::: .: ::.: :::..: :: ::.: :. :.:: . :
NP_006 NLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLP
110 120 130 140 150 160
230 240 250 260 270
pF1KB9 P------PPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQ----RPTPPGSCRT
: : : : :: : :. .::. :. . .. ..:. :: :
NP_006 PQCVPCLPGPPSPASD------AESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFP
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB9 RFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRS
NP_006 SLPKDLLHTTPCFIPYH
230
354 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 17:29:06 2016 done: Fri Nov 4 17:29:07 2016
Total Scan time: 10.110 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]