Result of FASTA (omim) for
pFN21AB8959
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8959, 338 aa
1>>>pF1KB8959 338 - 338 aa - 338 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2221+/-0.000402; mu= 13.6023+/- 0.025
mean_var=143.4455+/-28.976, 0's: 0 Z-trim(116.0): 119 B-trim: 76 in 2/50
Lambda= 0.107086
statistics sampled from 26763 (26887) to 26763 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.315), width: 16
Scan time: 8.190
The best scores are: opt bits E(85289)
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 2257 360.3 3.4e-99
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 1208 198.3 2.4e-50
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 996 165.6 1.7e-40
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 522 92.4 2e-18
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 512 90.9 6.3e-18
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 508 90.2 9e-18
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 496 88.3 2.8e-17
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 492 87.6 4.3e-17
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 492 87.7 4.6e-17
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 492 87.7 4.6e-17
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 492 87.7 4.6e-17
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 492 87.7 4.9e-17
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 492 87.7 4.9e-17
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 492 87.7 4.9e-17
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 492 87.7 4.9e-17
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 479 85.5 1.5e-16
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 478 85.4 1.8e-16
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 450 81.5 5.8e-15
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 450 81.5 6e-15
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 450 81.5 6.3e-15
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 450 81.5 6.3e-15
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 450 81.5 6.4e-15
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 450 81.5 6.4e-15
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 444 80.2 7.3e-15
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 434 78.5 1.7e-14
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 430 78.1 3.3e-14
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 381 70.8 9.3e-12
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 335 63.1 5.6e-10
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 335 63.1 5.6e-10
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 334 63.4 1.1e-09
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 334 63.4 1.2e-09
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 334 63.4 1.2e-09
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 334 63.4 1.3e-09
XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 334 63.5 1.3e-09
XP_016882384 (OMIM: 164176) PREDICTED: POU domain, ( 602) 334 63.5 1.3e-09
XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 334 63.5 1.3e-09
XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 334 63.5 1.4e-09
XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 334 63.6 1.5e-09
XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 334 63.6 1.5e-09
XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 334 63.6 1.5e-09
XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 334 63.6 1.5e-09
XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 334 63.6 1.5e-09
XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 334 63.6 1.5e-09
XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 334 63.6 1.5e-09
XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 334 63.6 1.5e-09
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 325 61.9 2.7e-09
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 325 62.0 3e-09
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 325 62.0 3.1e-09
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 325 62.1 3.5e-09
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 325 62.1 3.6e-09
>>NP_002691 (OMIM: 602459,602460) POU domain, class 4, t (338 aa)
initn: 2257 init1: 2257 opt: 2257 Z-score: 1901.9 bits: 360.3 E(85289): 3.4e-99
Smith-Waterman score: 2257; 100.0% identity (100.0% similar) in 338 aa overlap (1-338:1-338)
10 20 30 40 50 60
pF1KB8 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 AAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 MIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPS
250 260 270 280 290 300
310 320 330
pF1KB8 SEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
::::::::::::::::::::::::::::::::::::::
NP_002 SEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
310 320 330
>>NP_004566 (OMIM: 113725) POU domain, class 4, transcri (409 aa)
initn: 1377 init1: 979 opt: 1208 Z-score: 1025.0 bits: 198.3 E(85289): 2.4e-50
Smith-Waterman score: 1506; 70.7% identity (86.3% similar) in 335 aa overlap (22-336:78-407)
10 20 30 40 50
pF1KB8 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDE
:: .:::::::.:::.: .::::..::
NP_004 SSSSNAGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDE
50 60 70 80 90 100
60 70 80 90 100
pF1KB8 SLLARAEALAAVDIVSHGKNH--------PFKPDATYHTMSSVPCTS--TSSTVPISHPA
::::::::::::::::..:.: :::::::::::...:::: .::.::::::.
NP_004 SLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPS
110 120 130 140 150 160
110 120 130 140 150
pF1KB8 ALTS---------HPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAM
::.. : :: ::.:::.::::.:: :.......:. .:. . : :...:
NP_004 ALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATM
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB8 GHLHQA-MGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAA
. .::: ..:.: : . : . :.:::..:::.:::::::::::::::::::::::.:
NP_004 NPMHQAALSMAHAHGLPSHMG---CMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSA
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB8 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNG
:::::::::::::::::::::::::::::::::::.::::::::: ..::: .:::::::
NP_004 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNG
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB8 SERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
.:.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR
350 360 370 380 390 400
pF1KB8 MKYSAVH
:::::
NP_004 MKYSAGI
>>NP_006228 (OMIM: 601632) POU domain, class 4, transcri (419 aa)
initn: 1451 init1: 945 opt: 996 Z-score: 847.9 bits: 165.6 E(85289): 1.7e-40
Smith-Waterman score: 1223; 59.6% identity (69.4% similar) in 376 aa overlap (49-338:50-419)
20 30 40 50 60 70
pF1KB8 PKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDI-VSHGKNHPFKPD
.::.::::::::::::: ::.::.::::::
NP_006 HKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPD
20 30 40 50 60 70
80 90 100 110 120
pF1KB8 ATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLE-GDLLEHIS-PTLSV------
::::::.:::::::: :::..: : :: ::.:: ::::.::: :.:..
NP_006 ATYHTMNSVPCTSTS-TVPLAH-----HHHHHHHHQALEPGDLLDHISSPSLALMAGAGG
80 90 100 110 120 130
130 140
pF1KB8 ---------------------------------------SGLGAPEHSVMPAQIHPH-HL
.: :.: ... .. ::: :.
NP_006 AGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHM
140 150 160 170 180 190
150 160 170
pF1KB8 GAMGHL-HQAM--------GMSHPHTVAP---HSAMPAC---------------------
..::: : : :. :: :: :.: :
NP_006 HSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAA
200 210 220 230 240 250
180 190 200 210 220 230
pF1KB8 ----LSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFE
. : ..:::::::::::::::::::::::::::.::::::::::::::::::::::
NP_006 GLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFE
260 270 280 290 300 310
240 250 260 270 280 290
pF1KB8 SLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAY
::::::::::::::.:::::::::.: ::: .:::::::.:.::::::::::::::::::
NP_006 SLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAY
320 330 340 350 360 370
300 310 320 330
pF1KB8 FAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
::.::::::::::::::::::::::::::::::::::::::.::..
NP_006 FAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
380 390 400 410
>--
initn: 215 init1: 172 opt: 225 Z-score: 204.1 bits: 46.5 E(85289): 0.00012
Smith-Waterman score: 225; 67.3% identity (89.8% similar) in 49 aa overlap (1-48:1-49)
10 20 30 40 50
pF1KB8 MMAMNSKQP-FGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEA
::.:::::: :.:::.: : :. ::::.:::.::.:::.: ::.:.:.:
NP_006 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 LAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDL
NP_006 LAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHI
70 80 90 100 110 120
>>NP_005595 (OMIM: 600494) POU domain, class 3, transcri (443 aa)
initn: 535 init1: 364 opt: 522 Z-score: 451.8 bits: 92.4 E(85289): 2e-18
Smith-Waterman score: 537; 43.2% identity (66.9% similar) in 236 aa overlap (117-332:186-412)
90 100 110 120 130
pF1KB8 PCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGL----GAP----EHS
: :: . .:...:.:. : : .:.
NP_005 HHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLL-YSQPSFTVNGMLGAGGQPAGLHHHG
160 170 180 190 200 210
140 150 160 170 180
pF1KB8 VMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHS-------AMPACLSDVESD---PR--E
. :. .::: : : :::: : . :. : .:: : .
NP_005 LRDAHDEPHHADHHPHPH-----SHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDD
220 230 240 250 260
190 200 210 220 230 240
pF1KB8 LEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKP
:: ::..::::::::: :::::: ::..: : . .::.::::::.: :: .:: :::
NP_005 LEQFAKQFKQRRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSFKNMCKLKP
270 280 290 300 310 320
250 260 270 280 290 300
pF1KB8 VLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAA
.:. :::::... .: .. .....::::: . : .::..: :.::...:..
NP_005 LLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITS
330 340 350 360 370 380
310 320 330
pF1KB8 IAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
.:..:.:.:.::::::::.:::.:::
NP_005 LADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
390 400 410 420 430 440
>>NP_006227 (OMIM: 602480) POU domain, class 3, transcri (500 aa)
initn: 542 init1: 362 opt: 512 Z-score: 442.8 bits: 90.9 E(85289): 6.3e-18
Smith-Waterman score: 540; 37.0% identity (61.0% similar) in 305 aa overlap (37-332:176-464)
10 20 30 40 50 60
pF1KB8 KQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNI--FGSFDESLLARAEALAAVD
: : ::. .:. . : : : ::.
NP_006 GPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAH
150 160 170 180 190 200
70 80 90 100 110 120
pF1KB8 IVSHGKNHPFKPDATYHTMS---SVPCTSTSSTVPISHPAALTSHPHHAVHQGL-EGDLL
. : . .. :.. ... .: .. : . .. . . :: :: .::
NP_006 LPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGD--
210 220 230 240 250 260
130 140 150 160 170
pF1KB8 EHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHP--HTVAPHSAMPACLS
.: :. .: . : :::: . : . : . : .. ::: . :
NP_006 ---TPELAEHH-HHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTS
270 280 290 300 310
180 190 200 210 220 230
pF1KB8 DVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSL-SQSTICRFESLTLS
: .:: ::..::::::::: :::::: ::..: :.. ::.::::::.: ::
NP_006 D------DLEQFAKQFKQRRIKLGFTQADVGLALGTL----YGNVFSQTTICRFEALQLS
320 330 340 350 360
240 250 260 270 280 290
pF1KB8 HNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQP
.:: :::.:. :::::... .: .. .....::::: . : .::..: :
NP_006 FKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCP
370 380 390 400 410 420
300 310 320 330
pF1KB8 RPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH
.::...:. .:..:.:.:.::::::::.:::.:::
NP_006 KPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTP
430 440 450 460 470 480
NP_006 PPHHGLQTSVQ
490 500
>>NP_002690 (OMIM: 602479) POU domain, class 3, transcri (451 aa)
initn: 550 init1: 352 opt: 508 Z-score: 440.0 bits: 90.2 E(85289): 9e-18
Smith-Waterman score: 523; 44.0% identity (67.1% similar) in 234 aa overlap (108-336:188-401)
80 90 100 110 120 130
pF1KB8 ATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQ-GLEGDLLEHISPTLSVSGLGAPE
:::.:. : :..: : : ::
NP_002 LYAQAAYPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQLEPSPPPHL-----GAHG
160 170 180 190 200 210
140 150 160 170 180 190
pF1KB8 HSVMPAQIHPHHLG---AMGHLHQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAER
: :. : : : : .::: . : . .:. :: : :: .:: ::..
NP_002 H----AHGHAHAGGLHAAAAHLHPGAG-GGGSSVGEHSDEDAPSSD------DLEQFAKQ
220 230 240 250 260
200 210 220 230 240 250
pF1KB8 FKQRRIKLGVTQADVGAALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPVLQAWL
::::::::: :::::: ::..: :.. ::.::::::.: :: .:: :::.:. ::
NP_002 FKQRRIKLGFTQADVGLALGTL----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWL
270 280 290 300 310
260 270 280 290 300 310
pF1KB8 EEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLD
::.... .. .. .....::::: . : .::..: :.::...:...:..:.
NP_002 EETDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQ
320 330 340 350 360 370
320 330
pF1KB8 LKKNVVRVWFCNQRQKQKRMKYSAVH
:.:.::::::::.:::.::: .:
NP_002 LEKEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAA
380 390 400 410 420 430
>>NP_000298 (OMIM: 300039,304400) POU domain, class 3, t (361 aa)
initn: 519 init1: 357 opt: 496 Z-score: 431.2 bits: 88.3 E(85289): 2.8e-17
Smith-Waterman score: 511; 39.2% identity (62.7% similar) in 268 aa overlap (66-332:101-336)
40 50 60 70 80 90
pF1KB8 LPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTV
:.: . : .:.: : .: : .:.
NP_000 LATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAW--GASPAPNPSITSS-
80 90 100 110 120
100 110 120 130 140 150
pF1KB8 PISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHL
..: . :.: .: . .::: . :. .: .:. :. .: : .:
NP_000 --GQPLNVYSQPGFTV-----SGMLEHGG--LTPPPAAASAQSLHPVLREPPDHGELGS-
130 140 150 160 170
160 170 180 190 200 210
pF1KB8 HQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANL
: :: . :: ::: ::..::::::::: :::::: ::..:
NP_000 ---------HHCQDHSDEETPTSD------ELEQFAKQFKQRRIKLGFTQADVGLALGTL
180 190 200 210 220
220 230 240 250 260 270
pF1KB8 KIPGVGSL-SQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSER
:.. ::.::::::.: :: .:: :::.:. :::::... .: .. ...
NP_000 ----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRK
230 240 250 260 270
280 290 300 310 320 330
pF1KB8 KRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKY
..::::: . : ::..: :.:....:...:..:.:.:.::::::::.:::.:::
NP_000 RKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTP
280 290 300 310 320 330
pF1KB8 SAVH
NP_000 PGDQQPHEVYSHTVKTDTSCHDL
340 350 360
>>XP_016872976 (OMIM: 607394) PREDICTED: POU domain, cla (356 aa)
initn: 489 init1: 216 opt: 492 Z-score: 427.9 bits: 87.6 E(85289): 4.3e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:80-339)
60 70 80 90 100
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
... :: . .: :... :. : : .
XP_016 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
. .:::. .:: : . ::: :. . :. : : : . .
XP_016 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
: .:. . .: :: .::: ::. ::::::::: ::.::: :.. :. : ..
XP_016 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
170 180 190 200 210 220
230 240 250 260 270
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
.::.:: :::.:.:: .:: :::.:. ::..::.. . . : : : . ::::
XP_016 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
:::: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_016 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
290 300 310 320 330 340
pF1KB8 VH
XP_016 ATPIKPPVYNSRL
350
>>XP_011541044 (OMIM: 607394) PREDICTED: POU domain, cla (403 aa)
initn: 489 init1: 216 opt: 492 Z-score: 427.3 bits: 87.7 E(85289): 4.6e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:47-306)
60 70 80 90 100
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
... :: . .: :... :. : : .
XP_011 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
20 30 40 50 60 70
110 120 130 140 150 160
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
. .:::. .:: : . ::: :. . :. : : : . .
XP_011 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
80 90 100 110 120 130
170 180 190 200 210 220
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
: .:. . .: :: .::: ::. ::::::::: ::.::: :.. :. : ..
XP_011 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
140 150 160 170 180 190
230 240 250 260 270
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
.::.:: :::.:.:: .:: :::.:. ::..::.. . . : : : . ::::
XP_011 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
:::: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_011 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
260 270 280 290 300 310
pF1KB8 VH
XP_011 ATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSP
320 330 340 350 360 370
>>XP_011541045 (OMIM: 607394) PREDICTED: POU domain, cla (403 aa)
initn: 489 init1: 216 opt: 492 Z-score: 427.3 bits: 87.7 E(85289): 4.6e-17
Smith-Waterman score: 500; 39.8% identity (62.8% similar) in 266 aa overlap (83-332:47-306)
60 70 80 90 100
pF1KB8 LLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISH----PAALTSHPH
... :: . .: :... :. : : .
XP_011 LSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQ
20 30 40 50 60 70
110 120 130 140 150 160
pF1KB8 HAV------HQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMS
. .:::. .:: : . ::: :. . :. : : : . .
XP_011 FLLSQTQPGQQGLQPNLLPF--PQQQ-SGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEA
80 90 100 110 120 130
170 180 190 200 210 220
pF1KB8 HPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGS
: .:. . .: :: .::: ::. ::::::::: ::.::: :.. :. : ..
XP_011 SQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-ND
140 150 160 170 180 190
230 240 250 260 270
pF1KB8 LSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKN-----SKPELFNGSERKRK
.::.:: :::.:.:: .:: :::.:. ::..::.. . . : : : . ::::
XP_011 FSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRK
200 210 220 230 240 250
280 290 300 310 320 330
pF1KB8 -RTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSA
:::: . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::.
XP_011 KRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPV
260 270 280 290 300 310
pF1KB8 VH
XP_011 ATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSP
320 330 340 350 360 370
338 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:41:27 2016 done: Fri Nov 4 16:41:28 2016
Total Scan time: 8.190 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]