Result of FASTA (omim) for
pFN21AB8880
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8880, 175 aa
1>>>pF1KB8880 175 - 175 aa - 175 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8759+/-0.00033; mu= 14.3319+/- 0.020
mean_var=55.9055+/-11.079, 0's: 0 Z-trim(114.7): 46 B-trim: 644 in 1/52
Lambda= 0.171533
statistics sampled from 24691 (24737) to 24691 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.29), width: 16
Scan time: 5.090
The best scores are: opt bits E(85289)
NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 1179 299.5 1.8e-81
NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 935 239.1 2.6e-63
NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 204 58.3 1e-08
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 195 56.0 3.6e-08
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 195 56.0 3.9e-08
XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 194 55.8 5.3e-08
XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 192 55.3 6.7e-08
NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 192 55.3 6.9e-08
NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 183 52.9 2e-07
NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 183 53.0 2.4e-07
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 178 51.8 7.4e-07
NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 175 51.1 1.1e-06
NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 175 51.1 1.2e-06
NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 178 52.0 1.2e-06
NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 175 51.1 1.3e-06
NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 175 51.1 1.4e-06
NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 172 50.4 2.4e-06
XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 172 50.4 2.4e-06
NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 172 50.4 2.4e-06
XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 172 50.4 2.4e-06
NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 166 48.8 5.7e-06
NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 166 48.8 5.7e-06
XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 164 48.3 6.6e-06
NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 163 48.0 7.3e-06
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 164 48.4 8.7e-06
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 164 48.4 8.7e-06
>>NP_004040 (OMIM: 601056) bcl-2-related protein A1 isof (175 aa)
initn: 1179 init1: 1179 opt: 1179 Z-score: 1583.6 bits: 299.5 E(85289): 1.8e-81
Smith-Waterman score: 1179; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175)
10 20 30 40 50 60
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
130 140 150 160 170
>>NP_001108207 (OMIM: 601056) bcl-2-related protein A1 i (163 aa)
initn: 935 init1: 935 opt: 935 Z-score: 1257.8 bits: 239.1 E(85289): 2.6e-63
Smith-Waterman score: 935; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140)
10 20 30 40 50 60
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
70 80 90 100 110 120
130 140 150 160 170
pF1KB8 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
::::::::::::::::::::
NP_001 FVAEFIMNNTGEWIRQNGGWGKWHNHTPMLVESVAHKKRKMAL
130 140 150 160
>>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp (239 aa)
initn: 230 init1: 96 opt: 204 Z-score: 277.6 bits: 58.3 E(85289): 1e-08
Smith-Waterman score: 204; 37.6% identity (70.6% similar) in 85 aa overlap (66-150:125-204)
40 50 60 70 80 90
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
::: : :.:. :.::. ::::::..: :
NP_000 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
:.. . . ....: ::. :. ...:.. . ::..::::. .::. . :
NP_000 GGVMCVESVNREMSPLVDN---IALWMTEYLNRHLHTWIQDNGGWD-AFVELYGPSMRPL
160 170 180 190 200
160 170
pF1KB8 TFLEVTGKICEMLSLLKQYC
NP_000 FDFSWLSLKTLLSLALVGACITLGAYLGHK
210 220 230
>>XP_016882566 (OMIM: 600040) PREDICTED: apoptosis regul (173 aa)
initn: 144 init1: 86 opt: 195 Z-score: 267.7 bits: 56.0 E(85289): 3.6e-08
Smith-Waterman score: 195; 27.6% identity (60.5% similar) in 152 aa overlap (23-173:31-171)
10 20 30 40 50
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNL
.:: .: .: :. :. .. :...:.
XP_016 MKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDAS-TKKLSECLKRIG----DELDSNM
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 KSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDV
. . .:..:. : .: .: : :: .::::.:..: : . :. : : .. :..
XP_016 E-LQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 DTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLL
. : .. .:. . ::...:::. :... : . :.: . :.: . :..
XP_016 --IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIW
120 130 140 150 160
pF1KB8 KQYC
:.
XP_016 KKMG
170
>>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo (192 aa)
initn: 144 init1: 86 opt: 195 Z-score: 267.0 bits: 56.0 E(85289): 3.9e-08
Smith-Waterman score: 195; 27.6% identity (60.5% similar) in 152 aa overlap (23-173:50-190)
10 20 30 40 50
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNL
.:: .: .: :. :. .. :...:.
NP_620 MKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDAS-TKKLSECLKRIG----DELDSNM
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB8 KSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDV
. . .:..:. : .: .: : :: .::::.:..: : . :. : : .. :..
NP_620 E-LQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB8 DTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLL
. : .. .:. . ::...:::. :... : . :.: . :.: . :..
NP_620 --IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIW
140 150 160 170 180
pF1KB8 KQYC
:.
NP_620 KKMG
190
>>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul (224 aa)
initn: 203 init1: 96 opt: 194 Z-score: 264.7 bits: 55.8 E(85289): 5.3e-08
Smith-Waterman score: 194; 38.2% identity (71.1% similar) in 76 aa overlap (66-141:125-196)
40 50 60 70 80 90
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
::: : :.:. :.::. ::::::..: :
XP_011 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
:.. . . ....: ::. :. ...:.. . ::..::::.
XP_011 GGVMCVESVNREMSPLVDN---IALWMTEYLNRHLHTWIQDNGGWDALVLFAGLREFQHG
160 170 180 190 200 210
160 170
pF1KB8 TFLEVTGKICEMLSLLKQYC
XP_011 PGNYFLKRNLNAKF
220
>>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul (198 aa)
initn: 159 init1: 96 opt: 192 Z-score: 262.8 bits: 55.3 E(85289): 6.7e-08
Smith-Waterman score: 192; 38.7% identity (70.7% similar) in 75 aa overlap (66-140:125-195)
40 50 60 70 80 90
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
::: : :.:. :.::. ::::::..: :
XP_016 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
:.. . . ....: :: .:. ...:.. . ::..::::
XP_016 GGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWLYM
160 170 180 190
160 170
pF1KB8 TFLEVTGKICEMLSLLKQYC
>>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet (205 aa)
initn: 159 init1: 96 opt: 192 Z-score: 262.6 bits: 55.3 E(85289): 6.9e-08
Smith-Waterman score: 192; 38.7% identity (70.7% similar) in 75 aa overlap (66-140:125-195)
40 50 60 70 80 90
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
::: : :.:. :.::. ::::::..: :
NP_000 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
:.. . . ....: :: .:. ...:.. . ::..::::
NP_000 GGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWVGALGDVSLG
160 170 180 190 200
160 170
pF1KB8 TFLEVTGKICEMLSLLKQYC
>>NP_001278360 (OMIM: 600040) apoptosis regulator BAX is (114 aa)
initn: 144 init1: 86 opt: 183 Z-score: 254.3 bits: 52.9 E(85289): 2e-07
Smith-Waterman score: 183; 29.3% identity (62.1% similar) in 116 aa overlap (59-173:2-112)
30 40 50 60 70 80
pF1KB8 GPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGR
. .:..:. : .: .: : :: .::::
NP_001 MIAAVDTDSPREVFFRVAADMFSDGNFNWGR
10 20 30
90 100 110 120 130 140
pF1KB8 IVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKF
.:..: : . :. : : .. :.. . : .. .:. . ::...:::. :... :
NP_001 VVALFYFASKLVLKALCTKV-PEL--IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYF
40 50 60 70 80
150 160 170
pF1KB8 EPKSGWMTF-LEVTGKICEMLSLLKQYC
. :.: . :.: . :.. :.
NP_001 GTPT-WQTVTIFVAGVLTASLTIWKKMG
90 100 110
>>NP_620118 (OMIM: 600040) apoptosis regulator BAX isofo (143 aa)
initn: 144 init1: 86 opt: 183 Z-score: 252.9 bits: 53.0 E(85289): 2.4e-07
Smith-Waterman score: 199; 27.2% identity (59.6% similar) in 151 aa overlap (25-173:7-141)
10 20 30 40 50
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQP-GSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNV
:: :.::... ..... :. .: .
NP_620 MDGSGEQPRGGGPTSSEQIMKTGALLLQ-----------GMI
10 20 30
60 70 80 90 100 110
pF1KB8 NVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEIS
.:..:. : .: .: : :: .::::.:..: : . :. : : .. :.. . :
NP_620 AAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL--IRTIM
40 50 60 70 80
120 130 140 150 160 170
pF1KB8 YFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLLKQYC
.. .:. . ::...:::. :... : . :.: . :.: . :.. :.
NP_620 GWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIWKKMG
90 100 110 120 130 140
175 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:18:38 2016 done: Fri Nov 4 16:18:39 2016
Total Scan time: 5.090 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]