Result of FASTA (omim) for
pFN21AB8716
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8716, 543 aa
1>>>pF1KB8716 543 - 543 aa - 543 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.8032+/-0.000388; mu= -6.0273+/- 0.024
mean_var=309.3684+/-63.241, 0's: 0 Z-trim(122.1): 14 B-trim: 0 in 0/57
Lambda= 0.072918
statistics sampled from 39570 (39584) to 39570 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.464), width: 16
Scan time: 12.450
The best scores are: opt bits E(85289)
NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Hom ( 677) 3642 396.8 1.1e-109
NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [ ( 643) 3339 364.9 4.3e-100
NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] ( 392) 274 42.3 0.0033
>>NP_443071 (OMIM: 608421) pannexin-2 isoform 1 [Homo sa (677 aa)
initn: 3642 init1: 3642 opt: 3642 Z-score: 2090.0 bits: 396.8 E(85289): 1.1e-109
Smith-Waterman score: 3642; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:135-677)
10 20 30
pF1KB8 MYVPALGWEFLASTRLTSELNFLLQEIDNC
::::::::::::::::::::::::::::::
NP_443 DALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNC
110 120 130 140 150 160
40 50 60 70 80 90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
290 300 310 320 330 340
220 230 240 250 260 270
pF1KB8 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
350 360 370 380 390 400
280 290 300 310 320 330
pF1KB8 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
410 420 430 440 450 460
340 350 360 370 380 390
pF1KB8 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
470 480 490 500 510 520
400 410 420 430 440 450
pF1KB8 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
530 540 550 560 570 580
460 470 480 490 500 510
pF1KB8 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
590 600 610 620 630 640
520 530 540
pF1KB8 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
:::::::::::::::::::::::::::::::::
NP_443 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
650 660 670
>>NP_001153772 (OMIM: 608421) pannexin-2 isoform 2 [Homo (643 aa)
initn: 3339 init1: 3339 opt: 3339 Z-score: 1918.1 bits: 364.9 E(85289): 4.3e-100
Smith-Waterman score: 3339; 100.0% identity (100.0% similar) in 497 aa overlap (1-497:135-631)
10 20 30
pF1KB8 MYVPALGWEFLASTRLTSELNFLLQEIDNC
::::::::::::::::::::::::::::::
NP_001 DALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNC
110 120 130 140 150 160
40 50 60 70 80 90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
170 180 190 200 210 220
100 110 120 130 140 150
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCKLPSV
230 240 250 260 270 280
160 170 180 190 200 210
pF1KB8 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDI
290 300 310 320 330 340
220 230 240 250 260 270
pF1KB8 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQT
350 360 370 380 390 400
280 290 300 310 320 330
pF1KB8 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPAR
410 420 430 440 450 460
340 350 360 370 380 390
pF1KB8 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKTATDTLIAPLLDRSAHHYKGGGGDPGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGT
470 480 490 500 510 520
400 410 420 430 440 450
pF1KB8 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPAPIKDAPLPEKEIPYPTEPARAGLP
530 540 550 560 570 580
460 470 480 490 500 510
pF1KB8 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLYEAREEEDGGPRL
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINTLSSSPPSTSRERS
590 600 610 620 630 640
520 530 540
pF1KB8 PQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF
>>NP_443191 (OMIM: 608422) pannexin-3 [Homo sapiens] (392 aa)
initn: 102 init1: 102 opt: 274 Z-score: 178.5 bits: 42.3 E(85289): 0.0033
Smith-Waterman score: 274; 25.4% identity (58.7% similar) in 264 aa overlap (1-255:121-378)
10 20 30
pF1KB8 MYVPALGWEFLASTRLTSELNFLLQEIDNC
::.:.: :.. : :.:.: :...:.:.
NP_443 HKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKS
100 110 120 130 140 150
40 50 60 70 80 90
pF1KB8 YHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRGRSNFLA
:.:. . .. . .:. : . : .:.:.::. : :.:.:: . ::. :.
NP_443 YNRSIRLVQHMLKIRQKSSDPYVFWNE----LEKARKERYFEFPLLERYLACKQRSHSLV
160 170 180 190 200
100 110 120 130 140
pF1KB8 KLYLARHVLILLLSAVPISYLCTYYATQK-QNEFTCALGASPDGAAGAGPAVRVSCKLPS
:: :. :.:..... :: .. :.::.:.. .. . : . ..:.: :
NP_443 ATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNL-ITCRLTS
210 220 230 240 250 260
150 160 170 180 190 200
pF1KB8 VQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNF-IFDKLHKVGIKTRRQWRRSQFC
... .:.. .... .. .:. :: .: . : . ... : . .:.. .
NP_443 LSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLG-CPIN
270 280 290 300 310 320
210 220 230 240 250 260
pF1KB8 DINILAMFCNENRDHIKSLNRLDFITNESDLM-----YDNVVR--QLLAALAQSNHDATP
:.:.. .: : ... :.. :. . .: :.:: :::.: :
NP_443 DLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLT
330 340 350 360 370 380
270 280 290 300 310 320
pF1KB8 TVRDSGVQTVDPSANPAEPDGAAEPPVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENS
NP_443 NSACDEHP
390
543 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 14:51:45 2016 done: Fri Nov 4 14:51:47 2016
Total Scan time: 12.450 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]