Result of FASTA (omim) for
pFN21AB8363
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8363, 503 aa
1>>>pF1KB8363 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1007+/-0.000444; mu= 19.2995+/- 0.027
mean_var=68.1099+/-14.460, 0's: 0 Z-trim(109.7): 150 B-trim: 1059 in 1/48
Lambda= 0.155406
statistics sampled from 17776 (17950) to 17776 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.557), E-opt: 0.2 (0.21), width: 16
Scan time: 8.070
The best scores are: opt bits E(85289)
NP_112503 (OMIM: 107910,139300,613546) aromatase [ ( 503) 3319 753.7 2.8e-217
NP_000094 (OMIM: 107910,139300,613546) aromatase [ ( 503) 3319 753.7 2.8e-217
XP_005254248 (OMIM: 107910,139300,613546) PREDICTE ( 503) 3319 753.7 2.8e-217
XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 348 87.6 9.3e-17
XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 348 87.6 9.3e-17
XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514) 348 87.6 9.3e-17
NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvita ( 514) 348 87.6 9.3e-17
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 335 84.6 5.7e-16
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 335 84.7 7.1e-16
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 325 82.5 3.4e-15
XP_011534666 (OMIM: 604087) PREDICTED: cholesterol ( 490) 321 81.6 5.9e-15
XP_016876422 (OMIM: 604087) PREDICTED: cholesterol ( 462) 307 78.4 5e-14
NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500) 307 78.4 5.3e-14
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 303 77.4 8.2e-14
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 303 77.5 9.9e-14
XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 293 75.2 3.6e-13
XP_016868033 (OMIM: 606534) PREDICTED: cytochrome ( 360) 293 75.2 3.6e-13
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 293 75.2 3.9e-13
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 293 75.2 3.9e-13
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 293 75.3 4.7e-13
NP_001139624 (OMIM: 601637) lanosterol 14-alpha de ( 404) 289 74.3 7.4e-13
XP_011534667 (OMIM: 604087) PREDICTED: cholesterol ( 347) 286 73.6 1e-12
XP_005267331 (OMIM: 604087) PREDICTED: cholesterol ( 355) 286 73.6 1.1e-12
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 286 73.7 1.4e-12
NP_000764 (OMIM: 124040) cytochrome P450 2E1 precu ( 493) 285 73.5 1.6e-12
NP_085079 (OMIM: 608054) cytochrome P450 2A7 isofo ( 443) 283 73.0 2e-12
NP_001185783 (OMIM: 601129) cytochrome P450 2C8 is ( 388) 282 72.7 2.1e-12
NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494) 283 73.0 2.2e-12
NP_001185784 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 282 72.8 2.3e-12
NP_001185782 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 282 72.8 2.3e-12
NP_000761 (OMIM: 601129) cytochrome P450 2C8 isofo ( 490) 282 72.8 2.5e-12
NP_898898 (OMIM: 610670,615030) cytochrome P450 2U ( 544) 281 72.6 3.2e-12
XP_005262774 (OMIM: 610670,615030) PREDICTED: cyto ( 562) 281 72.6 3.3e-12
XP_016872682 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_016872683 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_011518197 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_011518200 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_016872680 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_016872681 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_016872684 (OMIM: 600081,608713) PREDICTED: vita ( 386) 279 72.1 3.4e-12
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 278 71.8 3.4e-12
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 280 72.4 3.5e-12
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 280 72.4 3.5e-12
XP_016872679 (OMIM: 600081,608713) PREDICTED: vita ( 446) 279 72.1 3.8e-12
XP_005252846 (OMIM: 600081,608713) PREDICTED: vita ( 447) 279 72.1 3.8e-12
XP_005252845 (OMIM: 600081,608713) PREDICTED: vita ( 453) 279 72.1 3.8e-12
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 278 71.8 3.9e-12
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 278 71.8 3.9e-12
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 278 71.8 3.9e-12
NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501) 279 72.1 4.1e-12
>>NP_112503 (OMIM: 107910,139300,613546) aromatase [Homo (503 aa)
initn: 3319 init1: 3319 opt: 3319 Z-score: 4022.0 bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
:::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
NP_112 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_112 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_112 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
430 440 450 460 470 480
490 500
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
:::::::::::::::::::::::
NP_112 PDETKNMLEMIFTPRNSDRCLEH
490 500
>>NP_000094 (OMIM: 107910,139300,613546) aromatase [Homo (503 aa)
initn: 3319 init1: 3319 opt: 3319 Z-score: 4022.0 bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
:::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
NP_000 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_000 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_000 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
430 440 450 460 470 480
490 500
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
:::::::::::::::::::::::
NP_000 PDETKNMLEMIFTPRNSDRCLEH
490 500
>>XP_005254248 (OMIM: 107910,139300,613546) PREDICTED: a (503 aa)
initn: 3319 init1: 3319 opt: 3319 Z-score: 4022.0 bits: 753.7 E(85289): 2.8e-217
Smith-Waterman score: 3319; 99.4% identity (99.4% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KB8 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEGTLIISKSSSMFHIMKHNHYSSRFGSKL
:::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
XP_005 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 ESGYVDVLTLLRRVMLDTSNTLFLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_005 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSLH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
XP_005 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
430 440 450 460 470 480
490 500
pF1KB8 PDETKNMLEMIFTPRNSDRCLEH
:::::::::::::::::::::::
XP_005 PDETKNMLEMIFTPRNSDRCLEH
490 500
>>XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25-dih (514 aa)
initn: 258 init1: 98 opt: 348 Z-score: 421.9 bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)
20 30 40 50 60 70
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
......::: .: :. ..:: : :
XP_016 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
30 40 50 60 70
80 90 100 110 120
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
.. :.. ::...:. ... .. ... . ... .. : .:. :
XP_016 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
....: .. . : :. .: :.: : :: : .. . : : . :..:. .: :
XP_016 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
140 150 160 170 180 190
190 200 210 220 230
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
.: :. . : . :. . :. . . ::.. ... :. ..... ... :
XP_016 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
. : . ... . . . .... : .. .. : . . :: . : ..: :
XP_016 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
..... . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_016 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
320 330 340 350 360 370
360 370 380 390 400
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
... .. . :::: : : .. : . :. : . ::: ..:: . : :
XP_016 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
..: :.. : :. .. ::: : : : :. .: .... : ..:.. ... ..
XP_016 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
440 450 460 470 480 490
470 480 490 500
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
: .. .:...: :.. : . : :
XP_016 ---EPVEMLHSGTLVPSRE---LPIAFCQR
500 510
>>XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25-dih (514 aa)
initn: 258 init1: 98 opt: 348 Z-score: 421.9 bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)
20 30 40 50 60 70
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
......::: .: :. ..:: : :
XP_005 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
30 40 50 60 70
80 90 100 110 120
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
.. :.. ::...:. ... .. ... . ... .. : .:. :
XP_005 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
....: .. . : :. .: :.: : :: : .. . : : . :..:. .: :
XP_005 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
140 150 160 170 180 190
190 200 210 220 230
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
.: :. . : . :. . :. . . ::.. ... :. ..... ... :
XP_005 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
. : . ... . . . .... : .. .. : . . :: . : ..: :
XP_005 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
..... . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_005 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
320 330 340 350 360 370
360 370 380 390 400
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
... .. . :::: : : .. : . :. : . ::: ..:: . : :
XP_005 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
..: :.. : :. .. ::: : : : :. .: .... : ..:.. ... ..
XP_005 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
440 450 460 470 480 490
470 480 490 500
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
: .. .:...: :.. : . : :
XP_005 ---EPVEMLHSGTLVPSRE---LPIAFCQR
500 510
>>XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25-dih (514 aa)
initn: 258 init1: 98 opt: 348 Z-score: 421.9 bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)
20 30 40 50 60 70
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
......::: .: :. ..:: : :
XP_016 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
30 40 50 60 70
80 90 100 110 120
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
.. :.. ::...:. ... .. ... . ... .. : .:. :
XP_016 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
....: .. . : :. .: :.: : :: : .. . : : . :..:. .: :
XP_016 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
140 150 160 170 180 190
190 200 210 220 230
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
.: :. . : . :. . :. . . ::.. ... :. ..... ... :
XP_016 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
. : . ... . . . .... : .. .. : . . :: . : ..: :
XP_016 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
..... . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
XP_016 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
320 330 340 350 360 370
360 370 380 390 400
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
... .. . :::: : : .. : . :. : . ::: ..:: . : :
XP_016 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
..: :.. : :. .. ::: : : : :. .: .... : ..:.. ... ..
XP_016 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
440 450 460 470 480 490
470 480 490 500
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
: .. .:...: :.. : . : :
XP_016 ---EPVEMLHSGTLVPSRE---LPIAFCQR
500 510
>>NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvitamin (514 aa)
initn: 258 init1: 98 opt: 348 Z-score: 421.9 bits: 87.6 E(85289): 9.3e-17
Smith-Waterman score: 364; 21.2% identity (56.9% similar) in 480 aa overlap (42-495:53-514)
20 30 40 50 60 70
pF1KB8 NITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIG
......::: .: :. ..:: : :
NP_000 QPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLL---QILWKG-G
30 40 50 60 70
80 90 100 110 120
pF1KB8 SACNY-----YNRVYGEFMRVWISGEGTLIISKSSSMFHIMK-HNHYSSRFGSKLGLQCI
.. :.. ::...:. ... .. ... . ... .. : .:. :
NP_000 LKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYR
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB8 GMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLV-RMVTVCAESLKTHLDRLEEVTNESG
....: .. . : :. .: :.: : :: : .. . : : . :..:. .: :
NP_000 DYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERG
140 150 160 170 180 190
190 200 210 220 230
pF1KB8 YV-DVLTLLRR--------VMLDTSNTLFLRISLDESA-IVVKIQGYFDAWQALLIKPDI
.: :. . : . :. . :. . . ::.. ... :. ..... ... :
NP_000 HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVE
200 210 220 230 240 250
240 250 260 270 280 290
pF1KB8 FFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL
. : . ... . . . .... : .. .. : . . :: . : ..: :
NP_000 LHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPS----ADFLCD-IYHQNR--L
260 270 280 290 300 310
300 310 320 330 340 350
pF1KB8 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDI
..... . :. .:: .: . ::...:. ....:.:.. ..::::.:. : .. . .:.
NP_000 SKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDL
320 330 340 350 360 370
360 370 380 390 400
pF1KB8 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPK
... .. . :::: : : .. : . :. : . ::: ..:: . : :
NP_000 RNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFED
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB8 PNEFT----LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG
..: :.. : :. .. ::: : : : :. .: .... : ..:.. ... ..
NP_000 SSQFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDN
440 450 460 470 480 490
470 480 490 500
pF1KB8 QCVESIQKIHDSSLHPDETKNMLEMIFTPRNSDRCLEH
: .. .:...: :.. : . : :
NP_000 ---EPVEMLHSGTLVPSRE---LPIAFCQR
500 510
>>XP_016863526 (OMIM: 210370,608614) PREDICTED: cytochro (393 aa)
initn: 199 init1: 105 opt: 335 Z-score: 407.8 bits: 84.6 E(85289): 5.7e-16
Smith-Waterman score: 343; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:114-362)
210 220 230 240 250 260
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
..:: .: .:: :.. :. . .:::.
XP_016 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
90 100 110 120 130 140
270 280 290 300
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
.....: : . .:. : ... .:. :..:.. . . ... .
XP_016 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
150 160 170 180 190
310 320 330 340 350 360
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
:: .... . :.:....:.:.. . .:.. :.:. : ..:..::. .: : :..:
XP_016 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
200 210 220 230 240 250
370 380 390 400 410 420
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
: : : :.. :: . :: : :::. .. .:: ..::.:.:: : : .:.
XP_016 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
260 270 280 290 300 310
430 440 450 460 470
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
:: : ::. :::.: :. .:.. :.:: .::.: ... :
XP_016 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
320 330 340 350 360 370
480 490 500
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
XP_016 SNGIWIKLKRRNADER
380 390
>>NP_997235 (OMIM: 210370,608614) cytochrome P450 4V2 [H (525 aa)
initn: 227 init1: 105 opt: 335 Z-score: 406.0 bits: 84.7 E(85289): 7.1e-16
Smith-Waterman score: 343; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:246-494)
210 220 230 240 250 260
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
..:: .: .:: :.. :. . .:::.
NP_997 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
220 230 240 250 260 270
270 280 290 300
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
.....: : . .:. : ... .:. :..:.. . . ... .
NP_997 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
280 290 300 310 320 330
310 320 330 340 350 360
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
:: .... . :.:....:.:.. . .:.. :.:. : ..:..::. .: : :..:
NP_997 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
340 350 360 370 380 390
370 380 390 400 410 420
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
: : : :.. :: . :: : :::. .. .:: ..::.:.:: : : .:.
NP_997 LFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
400 410 420 430 440 450
430 440 450 460 470
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
:: : ::. :::.: :. .:.. :.:: .::.: ... :
NP_997 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
460 470 480 490 500
480 490 500
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
NP_997 SNGIWIKLKRRNADER
510 520
>>XP_005262992 (OMIM: 210370,608614) PREDICTED: cytochro (524 aa)
initn: 186 init1: 105 opt: 325 Z-score: 393.9 bits: 82.5 E(85289): 3.4e-15
Smith-Waterman score: 333; 29.0% identity (62.4% similar) in 255 aa overlap (233-464:246-493)
210 220 230 240 250 260
pF1KB8 FLRISLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK
..:: .: .:: :.. :. . .:::.
XP_005 DSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK---SLQILHTFTNSVIAER
220 230 240 250 260 270
270 280 290 300
pF1KB8 RRRISTEE--------------KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA
.....: : . .:. : ... .:. :..:.. . . ... .
XP_005 ANEMNANEDCRGDGRGSAPSKNKRRAFLDLL--LSVTDDEGNRLSHEDIREEVDTFMFEG
280 290 300 310 320 330
310 320 330 340 350 360
pF1KB8 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD--IKIDDIQKLKVMENFIYESMR
:: .... . :.:....:.:.. . .:.. :.:. : ..:..::. .: : :..:
XP_005 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR
340 350 360 370 380 390
370 380 390 400 410 420
pF1KB8 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF-AKNV-
: : : :.. :: . :: : :::. .. .:: ..::.:.:: : : .:.
XP_005 LFPSVPLFARSVSEDCEV-GYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ
400 410 420 430 440
430 440 450 460 470
pF1KB8 ---PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDSSL
:: : ::. :::.: :. .:.. :.:: .::.: ... :
XP_005 GRHPYAYV-PFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP
450 460 470 480 490 500
480 490 500
pF1KB8 HPDETKNMLEMIFTPRNSDRCLEH
XP_005 SNGIWIKLKRRNADER
510 520
503 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:15:17 2016 done: Fri Nov 4 12:15:19 2016
Total Scan time: 8.070 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]