Result of FASTA (omim) for
pFN21AB8357
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8357, 263 aa
1>>>pF1KB8357 263 - 263 aa - 263 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2125+/-0.000318; mu= 3.5159+/- 0.020
mean_var=197.5668+/-41.612, 0's: 0 Z-trim(122.6): 6 B-trim: 1235 in 1/57
Lambda= 0.091247
statistics sampled from 41022 (41028) to 41022 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.79), E-opt: 0.2 (0.481), width: 16
Scan time: 5.700
The best scores are: opt bits E(85289)
NP_060560 (OMIM: 611624) adaptin ear-binding coat- ( 263) 1821 251.2 1.4e-66
NP_001138750 (OMIM: 611624) adaptin ear-binding co ( 237) 1604 222.6 5.2e-58
NP_001138749 (OMIM: 611624) adaptin ear-binding co ( 273) 1532 213.2 4.1e-55
XP_011540069 (OMIM: 611624) PREDICTED: adaptin ear ( 220) 1159 164.0 2.1e-40
XP_016857210 (OMIM: 611624) PREDICTED: adaptin ear ( 185) 1118 158.5 7.9e-39
NP_056324 (OMIM: 611623,615833) adaptin ear-bindin ( 275) 1082 153.9 2.8e-37
>>NP_060560 (OMIM: 611624) adaptin ear-binding coat-asso (263 aa)
initn: 1821 init1: 1821 opt: 1821 Z-score: 1316.2 bits: 251.2 E(85289): 1.4e-66
Smith-Waterman score: 1821; 100.0% identity (100.0% similar) in 263 aa overlap (1-263:1-263)
10 20 30 40 50 60
pF1KB8 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIW
190 200 210 220 230 240
250 260
pF1KB8 GDFTKSTGSTSSQTQPGTGWVQF
:::::::::::::::::::::::
NP_060 GDFTKSTGSTSSQTQPGTGWVQF
250 260
>>NP_001138750 (OMIM: 611624) adaptin ear-binding coat-a (237 aa)
initn: 1622 init1: 1604 opt: 1604 Z-score: 1162.4 bits: 222.6 E(85289): 5.2e-58
Smith-Waterman score: 1604; 100.0% identity (100.0% similar) in 232 aa overlap (32-263:6-237)
10 20 30 40 50 60
pF1KB8 EESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLED
::::::::::::::::::::::::::::::
NP_001 MEESGAAEWQLDQPSWSGRLRITAKGQMAYIKLED
10 20 30
70 80 90 100 110 120
pF1KB8 RTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 LQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPAS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 TGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIWG
160 170 180 190 200 210
250 260
pF1KB8 DFTKSTGSTSSQTQPGTGWVQF
::::::::::::::::::::::
NP_001 DFTKSTGSTSSQTQPGTGWVQF
220 230
>>NP_001138749 (OMIM: 611624) adaptin ear-binding coat-a (273 aa)
initn: 1515 init1: 1515 opt: 1532 Z-score: 1110.4 bits: 213.2 E(85289): 4.1e-55
Smith-Waterman score: 1532; 88.8% identity (92.3% similar) in 260 aa overlap (1-259:1-257)
10 20 30 40 50 60
pF1KB8 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIW
:::::::::::::::::::::::::::::::::::::::::: :. .:. : :
NP_001 STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSDQLPA---RPSQAQAGSS
190 200 210 220 230
250 260
pF1KB8 GDFTKSTGS-TSSQTQPGTGWVQF
.:.. ::... : :
NP_001 SDLSTVFPHVTSGKALPHLGQRKEDEALLSWPVFGA
240 250 260 270
>>XP_011540069 (OMIM: 611624) PREDICTED: adaptin ear-bin (220 aa)
initn: 1142 init1: 1142 opt: 1159 Z-score: 846.3 bits: 164.0 E(85289): 2.1e-40
Smith-Waterman score: 1159; 86.0% identity (90.3% similar) in 207 aa overlap (54-259:1-204)
30 40 50 60 70 80
pF1KB8 RATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVES
::::::::::::::::::::::::::::::
XP_011 MAYIKLEDRTSGELFAQAPVDQFPGTAVES
10 20 30
90 100 110 120 130 140
pF1KB8 VTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPD
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 QGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPASTGGLSLLPPPPGGKTSTLIPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPASTGGLSLLPPPPGGKTSTLIPPP
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB8 GEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIWGDFTKSTGS-TSSQTQPGTGWVQ
::::::::::::::::::: :. .:. : : .:.. ::... : :
XP_011 GEQLAVGGSLVQPAVAPSSDQLPA---RPSQAQAGSSSDLSTVFPHVTSGKALPHLGQRK
160 170 180 190 200
pF1KB8 F
XP_011 EDEALLSWPVFGA
210 220
>>XP_016857210 (OMIM: 611624) PREDICTED: adaptin ear-bin (185 aa)
initn: 1118 init1: 1118 opt: 1118 Z-score: 818.1 bits: 158.5 E(85289): 7.9e-39
Smith-Waterman score: 1118; 100.0% identity (100.0% similar) in 163 aa overlap (1-163:1-163)
10 20 30 40 50 60
pF1KB8 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPA
:::::::::::::::::::::::::::::::::::::::::::
XP_016 ALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIAVGLGNINRRCSCTLATA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 STGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIW
XP_016 QSCHC
>>NP_056324 (OMIM: 611623,615833) adaptin ear-binding co (275 aa)
initn: 1185 init1: 928 opt: 1082 Z-score: 790.2 bits: 153.9 E(85289): 2.8e-37
Smith-Waterman score: 1160; 62.3% identity (82.8% similar) in 273 aa overlap (6-263:7-275)
10 20 30 40 50
pF1KB8 MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKL
::::::::::: ::::::::.::::::..:.::::.:.::::::.::. :::::
NP_056 MATELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKTAYIKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 EDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFN
::..::::::::::.:.:: :::.::::::::::::.::.:: ::::::: :::::::::
NP_056 EDKVSGELFAQAPVEQYPGIAVETVTDSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 VALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRP
:.::::::::::. :..:..:. : ::::::::::::::: :.:. .:.:.:..::.
NP_056 VSLQDHFKWVKQESEISKESQEMDARPKLDLGFKEGQTIKLCIGNITNKKGGASKPRT--
130 140 150 160 170
180 190 200 210 220
pF1KB8 ASTGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGG-------------AP
: :::::::::::::.. ::::. ..:... .. : . :. : ::
NP_056 ARGGGLSLLPPPPGGKVT--IPPPSSSVAISNHVTPPPIPKSNHGGSDADILLDLDSPAP
180 190 200 210 220 230
230 240 250 260
pF1KB8 VPWPQPNPATA--DIWGDFTKSTGSTSSQTQPGTGWVQF
: : :.:... :.::::. ...:. .:. ..::::
NP_056 VTTPAPTPVSVSNDLWGDFSTASSSVPNQAPQPSNWVQF
240 250 260 270
263 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:04:27 2016 done: Fri Nov 4 12:04:28 2016
Total Scan time: 5.700 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]