Result of FASTA (omim) for
pFN21AB8244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8244, 334 aa
1>>>pF1KB8244 334 - 334 aa - 334 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4090+/-0.000389; mu= 15.4936+/- 0.024
mean_var=61.6539+/-12.415, 0's: 0 Z-trim(111.4): 44 B-trim: 1120 in 2/54
Lambda= 0.163340
statistics sampled from 19962 (20005) to 19962 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.235), width: 16
Scan time: 6.090
The best scores are: opt bits E(85289)
NP_006828 (OMIM: 604850) COP9 signalosome complex ( 334) 2209 529.2 4.8e-150
NP_005796 (OMIM: 607173) 26S proteasome non-ATPase ( 310) 474 120.3 5.3e-27
NP_077308 (OMIM: 300617) lys-63-specific deubiquit ( 316) 157 45.6 0.00017
XP_005274808 (OMIM: 300617) PREDICTED: lys-63-spec ( 317) 157 45.6 0.00017
XP_016885327 (OMIM: 300617) PREDICTED: lys-63-spec ( 291) 153 44.7 0.0003
NP_001018065 (OMIM: 300617) lys-63-specific deubiq ( 291) 153 44.7 0.0003
NP_001229569 (OMIM: 300617) lys-63-specific deubiq ( 292) 153 44.7 0.0003
NP_002802 (OMIM: 157970) 26S proteasome non-ATPase ( 324) 147 43.3 0.00087
>>NP_006828 (OMIM: 604850) COP9 signalosome complex subu (334 aa)
initn: 2209 init1: 2209 opt: 2209 Z-score: 2814.8 bits: 529.2 E(85289): 4.8e-150
Smith-Waterman score: 2209; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334)
10 20 30 40 50 60
pF1KB8 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
250 260 270 280 290 300
310 320 330
pF1KB8 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
::::::::::::::::::::::::::::::::::
NP_006 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
310 320 330
>>NP_005796 (OMIM: 607173) 26S proteasome non-ATPase reg (310 aa)
initn: 414 init1: 236 opt: 474 Z-score: 605.7 bits: 120.3 E(85289): 5.3e-27
Smith-Waterman score: 474; 35.7% identity (66.3% similar) in 252 aa overlap (57-301:33-271)
30 40 50 60 70 80
pF1KB8 EIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGK-V
::.::::::. :.:.: .::::::::. :
NP_005 RLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFV
10 20 30 40 50 60
90 100 110 120 130 140
pF1KB8 DGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGC
: :. ..: ::.: :: :...:. ..: ... ::.:: : ..::::::::.::
NP_005 DDYTVRVIDVFAMPQSGT--GVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
70 80 90 100 110 120
150 160 170 180 190 200
pF1KB8 WLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGY----KPPDEGPS
::::.:..::. . ..: ::::.:: .... ::: . ::: .. . : . :
NP_005 WLSGVDINTQQSFEALSERAVAVVVDPIQSVK-GKVVIDAFRLINANMMVLGHEPRQTTS
130 140 150 160 170
210 220 230 240 250
pF1KB8 EYQTIPLNKIEDFGVH--CKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNA
. . .:. . .: ..::.. ..: :. :..:.: : .: :.. : :
NP_005 NLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGL------TLQ
180 190 200 210 220 230
260 270 280 290 300 310
pF1KB8 DYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLM
::. . .:.. . .:.. .. ..: .:. . ..::
NP_005 DYS--EHCKHNESVVKEMLELAK-NYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVD
240 250 260 270 280
320 330
pF1KB8 SQVIKDKLFNQINIS
NP_005 VLMTSNIVQCLAAMLDTVVFK
290 300 310
>>NP_077308 (OMIM: 300617) lys-63-specific deubiquitinas (316 aa)
initn: 202 init1: 139 opt: 157 Z-score: 201.9 bits: 45.6 E(85289): 0.00017
Smith-Waterman score: 157; 24.6% identity (56.9% similar) in 130 aa overlap (84-205:65-193)
60 70 80 90 100 110
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
:::. .. . : . .. . . .. .
NP_077 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
NP_077 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPD--EGPSEYQTIPLNKIEDFGVHCKQYYALE
. .. ..:.: :.. .. : . .:: .. .
NP_077 SCFIEDKNTKTGRVLYTCFQSI-QAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIE
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB8 VSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSF
NP_077 IPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLC
220 230 240 250 260 270
>>XP_005274808 (OMIM: 300617) PREDICTED: lys-63-specific (317 aa)
initn: 202 init1: 139 opt: 157 Z-score: 201.9 bits: 45.6 E(85289): 0.00017
Smith-Waterman score: 157; 24.6% identity (56.9% similar) in 130 aa overlap (84-205:66-194)
60 70 80 90 100 110
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
:::. .. . : . .. . . .. .
XP_005 GLCIGELNDDTSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
XP_005 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPD--EGPSEYQTIPLNKIEDFGVHCKQYYALE
. .. ..:.: :.. .. : . .:: .. .
XP_005 SCFIEDKNTKTGRVLYTCFQSI-QAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIE
160 170 180 190 200 210
230 240 250 260 270 280
pF1KB8 VSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSF
XP_005 IPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLC
220 230 240 250 260 270
>>XP_016885327 (OMIM: 300617) PREDICTED: lys-63-specific (291 aa)
initn: 202 init1: 139 opt: 153 Z-score: 197.3 bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:65-175)
60 70 80 90 100 110
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
:::. .. . : . .. . . .. .
XP_016 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
XP_016 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
. .. ..:.: :..
XP_016 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
160 170 180 190 200 210
>>NP_001018065 (OMIM: 300617) lys-63-specific deubiquiti (291 aa)
initn: 202 init1: 139 opt: 153 Z-score: 197.3 bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:65-175)
60 70 80 90 100 110
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
:::. .. . : . .. . . .. .
NP_001 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
NP_001 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
. .. ..:.: :..
NP_001 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
160 170 180 190 200 210
>>NP_001229569 (OMIM: 300617) lys-63-specific deubiquiti (292 aa)
initn: 202 init1: 139 opt: 153 Z-score: 197.3 bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:66-176)
60 70 80 90 100 110
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
:::. .. . : . .. . . .. .
NP_001 GLCIGELNDDTSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
. :: : :. .:: ..::::::: : : .:: :: . :.... ::....
NP_001 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
. .. ..:.: :..
NP_001 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
160 170 180 190 200 210
>>NP_002802 (OMIM: 157970) 26S proteasome non-ATPase reg (324 aa)
initn: 97 init1: 97 opt: 147 Z-score: 189.0 bits: 43.3 E(85289): 0.00087
Smith-Waterman score: 154; 23.0% identity (53.3% similar) in 291 aa overlap (57-326:11-283)
30 40 50 60 70 80
pF1KB8 EIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMH----ARSGGNLEVMGLML
. :.::..: : .. :.. .:.:..:
NP_002 MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLL
10 20 30 40
90 100 110 120 130 140
pF1KB8 GKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPG
:. . ... . .:::.: . . .. ..:. . :.:. : .::::. :
NP_002 GSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPK
50 60 70 80 90 100
150 160 170 180 190
pF1KB8 YGCWLSGIDVSTQMLNQQFQEPFVAVVID--------PTRT-ISAGKVNLGAFRTYPKGY
: :.. . : ... : :.:: ::.. ::. .:. . :
NP_002 ----LHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFE
110 120 130 140 150
200 210 220 230 240
pF1KB8 KPPDE-GPSEYQTIP----LNKIEDFGVHC-KQYYALEVSYFKSSLDRKLLELLWNKYWV
. .: : : . . : :.: : .: . .: .:. :. :::.. . ..
NP_002 HVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKG-LNSKLLDI---RSYL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB8 NTLSSSSLLTNAD--YTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATR
. .....: : . : .::.: : . : .:.: :..:... .
NP_002 EKVATGKLPINHQIIYQLQDVFNL---LPDVSLQEFVKAFYL-------KTNDQMVVVYL
220 230 240 250 260
310 320 330
pF1KB8 DSCKTTIEAIHGLMSQVIKDKLFNQINIS
: .. :.:.:... : ..
NP_002 ASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKE
270 280 290 300 310 320
334 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:56:23 2016 done: Fri Nov 4 10:56:24 2016
Total Scan time: 6.090 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]