Result of FASTA (ccds) for
pFN21AB8196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8196, 458 aa
1>>>pF1KB8196 458 - 458 aa - 458 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5151+/-0.000754; mu= 12.9258+/- 0.046
mean_var=99.2538+/-20.138, 0's: 0 Z-trim(111.6): 14 B-trim: 0 in 0/51
Lambda= 0.128736
statistics sampled from 12461 (12469) to 12461 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.383), width: 16
Scan time: 2.930
The best scores are: opt bits E(32554)
CCDS1951.1 HTRA2 gene_id:27429|Hs108|chr2 ( 458) 2982 563.9 1.2e-160
CCDS1952.1 HTRA2 gene_id:27429|Hs108|chr2 ( 361) 1569 301.4 9.8e-82
CCDS3400.1 HTRA3 gene_id:94031|Hs108|chr4 ( 453) 1133 220.5 2.8e-57
CCDS7630.1 HTRA1 gene_id:5654|Hs108|chr10 ( 480) 1107 215.7 8.4e-56
CCDS6110.1 HTRA4 gene_id:203100|Hs108|chr8 ( 476) 1001 196.0 7.1e-50
CCDS75105.1 HTRA3 gene_id:94031|Hs108|chr4 ( 357) 884 174.2 1.9e-43
>>CCDS1951.1 HTRA2 gene_id:27429|Hs108|chr2 (458 aa)
initn: 2982 init1: 2982 opt: 2982 Z-score: 2997.6 bits: 563.9 E(32554): 1.2e-160
Smith-Waterman score: 2982; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
370 380 390 400 410 420
430 440 450
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::
CCDS19 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
430 440 450
>>CCDS1952.1 HTRA2 gene_id:27429|Hs108|chr2 (361 aa)
initn: 2325 init1: 1567 opt: 1569 Z-score: 1580.9 bits: 301.4 E(32554): 9.8e-82
Smith-Waterman score: 2139; 78.8% identity (78.8% similar) in 458 aa overlap (1-458:1-361)
10 20 30 40 50 60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTK---
190 200 210 220 230
250 260 270 280 290 300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
CCDS19 ------------------------------------------------------------
310 320 330 340 350 360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 --FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
::::::::::: :::::::::::::::::
CCDS19 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
300 310 320
430 440 450
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
::::::::::::::::::::::::::::::::::::::
CCDS19 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
330 340 350 360
>>CCDS3400.1 HTRA3 gene_id:94031|Hs108|chr4 (453 aa)
initn: 885 init1: 634 opt: 1133 Z-score: 1141.8 bits: 220.5 E(32554): 2.8e-57
Smith-Waterman score: 1138; 45.2% identity (71.6% similar) in 454 aa overlap (19-456:10-451)
10 20 30 40 50
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
::... .:.: .: .: .:: : .:.:
CCDS34 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
: ...: . : : : .: .. : : : : . :: .... : :: :..
CCDS34 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
CCDS34 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
CCDS34 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
CCDS34 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
CCDS34 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
. :. :. ..:.::. : :..::.. ::. .:.::.:. :. ...: .::..:.
CCDS34 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
350 360 370 380 390 400
410 420 430 440 450
pF1KB8 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
:.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::
CCDS34 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
410 420 430 440 450
>>CCDS7630.1 HTRA1 gene_id:5654|Hs108|chr10 (480 aa)
initn: 1103 init1: 869 opt: 1107 Z-score: 1115.3 bits: 215.7 E(32554): 8.4e-56
Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (140-455:162-476)
110 120 130 140 150 160
pF1KB8 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
: : : .:::::::::: :::::.::.. .
CCDS76 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
140 150 160 170 180 190
170 180 190 200 210 220
pF1KB8 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
:: ::::...::::.:. :::::::::::....::.:.: .: :::: . :: :::
CCDS76 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
200 210 220 230 240 250
230 240 250 260 270 280
pF1KB8 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
: ..:. . ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
CCDS76 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
260 270 280 290 300 310
290 300 310 320 330 340
pF1KB8 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
CCDS76 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
320 330 340 350 360 370
350 360 370 380 390 400
pF1KB8 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP
.. : . ....:::. :..:. : ::. :. .:::: :. : .:: .::. .::.
CCDS76 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
380 390 400 410 420 430
410 420 430 440 450
pF1KB8 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
.:::..:. : : .:.:: .... .: : . .::: : . . : ::
CCDS76 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
440 450 460 470 480
>>CCDS6110.1 HTRA4 gene_id:203100|Hs108|chr8 (476 aa)
initn: 926 init1: 769 opt: 1001 Z-score: 1008.9 bits: 196.0 E(32554): 7.1e-50
Smith-Waterman score: 1002; 44.1% identity (71.2% similar) in 392 aa overlap (71-455:94-473)
50 60 70 80 90
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
:: :: : .. : ::
CCDS61 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
. ...:: : :: :: . ::. : .. .: : : .::::: :
CCDS61 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
130 140 150 160 170
160 170 180 190 200 210
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
:::.::.::.... : .: ::. .::::.:. ::::.:::::: ... ..: : .:
CCDS61 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
::::: .: :.:...:... ::.: ::::.:.: ::::::.::::.:::: :.:
CCDS61 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
:::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
CCDS61 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB8 PSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLI
::::.:.:: . .... .: . :...:.:..::.:. . ::... :.::::. :: .
CCDS61 PSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYV
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB8 HKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVT
::. :. :. .::: :::. :. . . .. :: .:. ..: :.. . ::...: : :
CCDS61 CKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVI
420 430 440 450 460 470
pF1KB8 PEVTE
::
CCDS61 PETIN
>>CCDS75105.1 HTRA3 gene_id:94031|Hs108|chr4 (357 aa)
initn: 678 init1: 634 opt: 884 Z-score: 893.4 bits: 174.2 E(32554): 1.9e-43
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)
10 20 30 40 50
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
::... .:.: .: .: .:: : .:.:
CCDS75 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
: ...: . : : : .: .. : : : : . :: .... : :: :..
CCDS75 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
60 70 80 90 100
120 130 140 150 160 170
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
: : : : : : .::: ..::::::::: :::::.::.. :::
CCDS75 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
110 120 130 140 150 160
180 190 200 210 220
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
..::.::.:.::::... :::.::::::.. :....:.: .::.:::.. .:
CCDS75 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
.::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
CCDS75 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
:: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: .
CCDS75 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
. :
CCDS75 QDKQIKAPSLAVH
350
458 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:26:33 2016 done: Fri Nov 4 10:26:34 2016
Total Scan time: 2.930 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]