Result of FASTA (omim) for
pFN21AB8186
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8186, 303 aa
1>>>pF1KB8186 303 - 303 aa - 303 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3819+/-0.000348; mu= 15.4001+/- 0.022
mean_var=74.5576+/-14.717, 0's: 0 Z-trim(115.2): 9 B-trim: 83 in 1/53
Lambda= 0.148535
statistics sampled from 25505 (25510) to 25505 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.299), width: 16
Scan time: 6.400
The best scores are: opt bits E(85289)
NP_001668 (OMIM: 145500,182330) sodium/potassium-t ( 303) 2095 458.1 9.8e-129
NP_001669 (OMIM: 182331) sodium/potassium-transpor ( 290) 512 118.9 1.2e-26
NP_000696 (OMIM: 137217) potassium-transporting AT ( 291) 389 92.5 1.1e-18
NP_001670 (OMIM: 601867) sodium/potassium-transpor ( 279) 317 77.1 4.5e-14
NP_001290192 (OMIM: 182331) sodium/potassium-trans ( 208) 257 64.1 2.7e-10
>>NP_001668 (OMIM: 145500,182330) sodium/potassium-trans (303 aa)
initn: 2095 init1: 2095 opt: 2095 Z-score: 2432.2 bits: 458.1 E(85289): 9.8e-129
Smith-Waterman score: 2095; 100.0% identity (100.0% similar) in 303 aa overlap (1-303:1-303)
10 20 30 40 50 60
pF1KB8 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
250 260 270 280 290 300
pF1KB8 VKS
:::
NP_001 VKS
>>NP_001669 (OMIM: 182331) sodium/potassium-transporting (290 aa)
initn: 661 init1: 347 opt: 512 Z-score: 599.2 bits: 118.9 E(85289): 1.2e-26
Smith-Waterman score: 729; 39.5% identity (67.4% similar) in 304 aa overlap (4-301:11-287)
10 20 30 40 50
pF1KB8 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGT
:.. :: ::.:.:: . ..:.:::: :: :::::..::: :...: :
NP_001 MVIQKEKKSCGQVVEE--WKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLT
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 IQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYK
. ::: :.:. : ::::.: ::: :. .. .. .: .:.. .: .. .::: :.
NP_001 MWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYN
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 DS--AQRDDMIFEDC--GDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDET-YG
:: ::..:. : : .: . : .:. . ..:.:. ::::::..: : ::
NP_001 DSIQAQKNDV----CRPGRYYEQP-DNGVLNYPK---RACQFNRTQLGNCSGIGDSTHYG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 YKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVE
:. :.::..::.:::..: :.:.. : :.:::::: ...::
NP_001 YSTGQPCVFIKMNRVINFYAG--ANQSMN-------------VTCAGKRDEDAENLGNFV
180 190 200 210
230 240 250 260 270 280
pF1KB8 YFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYS-E
.: ... . :.:.::::: .. .: :::.::.: :.: ..:. .::. . ::. . :
NP_001 MFPANGN--IDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDE
220 230 240 250 260 270
290 300
pF1KB8 KDRFQGRFDVKIEVKS
.:.: :: :...
NP_001 RDKFAGRVAFKLRINKT
280 290
>>NP_000696 (OMIM: 137217) potassium-transporting ATPase (291 aa)
initn: 477 init1: 194 opt: 389 Z-score: 456.7 bits: 92.5 E(85289): 1.1e-18
Smith-Waterman score: 522; 30.1% identity (61.8% similar) in 306 aa overlap (4-302:11-290)
10 20 30 40 50
pF1KB8 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGT
:. :: .... :: . ..:::: . : : :.:: :: ..:.:
NP_000 MAALQEKKTCGQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 IQVMLLTISEFKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLE
. :.. :.. . : :::.. ::.: :.. . :: . .: ... . .. ::
NP_000 LYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 KYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYK
:. .::.:.. .: . .: .: . :.: . : ::::: : ..:..
NP_000 GYSPAAQEDSI---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFE
120 130 140 150 160 170
180 190 200 210 220
pF1KB8 EGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGN---V
:::::.:::.::.. : :. : .. :.:. :. .. .:. :
NP_000 EGKPCFIIKMNRIVKFLPS---------------NGSAPRVDCAFL-DQPRE-LGQPLQV
180 190 200 210
230 240 250 260 270 280
pF1KB8 EYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE
.:. ... : :.:.::::: ::.: .::.:... :. ..:. : ::...:.. ...
NP_000 KYYPPNGT--FSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNN
220 230 240 250 260 270
290 300
pF1KB8 -KDRFQGRFDVKIEVKS
.: ..:. . :....
NP_000 PHDPYEGKVEFKLKIEK
280 290
>>NP_001670 (OMIM: 601867) sodium/potassium-transporting (279 aa)
initn: 580 init1: 241 opt: 317 Z-score: 373.6 bits: 77.1 E(85289): 4.5e-14
Smith-Waterman score: 603; 36.6% identity (60.4% similar) in 298 aa overlap (12-303:16-279)
10 20 30 40 50
pF1KB8 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQV
:: ::.: ::::::. :: :::::..::: ::..: :. :
NP_001 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 MLLTISEFKPTYQDRVAPPGLTQIPQ-IQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDS
:: :... : :.:.. ::: .:. . : .: .:: :: .:. .. .::. :
NP_001 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 AQRDDMIFEDCGDVPSEPKERGDFNHERGERKV-CRFKLEWLGNCSGLNDETYGYKEGKP
:.. . : : : . ...: : :.: . : :::.:: .::..:.:
NP_001 EQKNLTV---CPD--------GALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNP
130 140 150 160
180 190 200 210 220 230
pF1KB8 CIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGN
::..:.::..:.:: : : ..:..: .:: .:. . :.
NP_001 CILVKMNRIIGLKP--------EGVPR---------IDCVSK-NEDIPNVAVYPHNGM--
170 180 190 200
240 250 260 270 280 290
pF1KB8 SPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDT--EIRIECKAYGE-NI-GYSEKDR
. :.:.::::: :. :::::.::: . .: :. .::: : :. . ...:.
NP_001 ---IDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDK
210 220 230 240 250 260
300
pF1KB8 FQGRFDVKIEVKS
: :: :: ...
NP_001 FLGRVMFKITARA
270
>>NP_001290192 (OMIM: 182331) sodium/potassium-transport (208 aa)
initn: 359 init1: 141 opt: 257 Z-score: 305.9 bits: 64.1 E(85289): 2.7e-10
Smith-Waterman score: 456; 35.8% identity (64.6% similar) in 226 aa overlap (81-301:4-205)
60 70 80 90 100 110
pF1KB8 IGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLE
:. .. .. .: .:.. .: .. .:::
NP_001 MIRPKTENLDVIVNVSDTESWDQHVQKLNKFLE
10 20 30
120 130 140 150 160
pF1KB8 KYKDS--AQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDET-Y
:.:: ::..:. : :.. :. : . ...:.:. ::::::..: : :
NP_001 PYNDSIQAQKNDV----C--RPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHY
40 50 60 70 80
170 180 190 200 210 220
pF1KB8 GYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNV
::. :.::..::.:::..: :.:.. : :.:::::: ...::
NP_001 GYSTGQPCVFIKMNRVINFYAGA--NQSMN-------------VTCAGKRDEDAENLGNF
90 100 110 120 130
230 240 250 260 270 280
pF1KB8 EYFGL-GNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYS
.: :: . :.:.::::: .. .: :::.::.: :.: ..:. .::. . ::. .
NP_001 VMFPANGN---IDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATD
140 150 160 170 180
290 300
pF1KB8 -EKDRFQGRFDVKIEVKS
:.:.: :: :...
NP_001 DERDKFAGRVAFKLRINKT
190 200
303 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:19:28 2016 done: Fri Nov 4 10:19:29 2016
Total Scan time: 6.400 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]