Result of FASTA (omim) for
pFN21AB7545
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7545, 184 aa
1>>>pF1KB7545 184 - 184 aa - 184 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5397+/-0.000309; mu= 6.5522+/- 0.020
mean_var=230.7048+/-46.418, 0's: 0 Z-trim(124.1): 166 B-trim: 0 in 0/59
Lambda= 0.084440
statistics sampled from 44803 (45038) to 44803 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.528), width: 16
Scan time: 5.980
The best scores are: opt bits E(85289)
NP_644811 (OMIM: 300446) rhox homeobox family memb ( 184) 1279 167.0 1.5e-41
XP_011529583 (OMIM: 300446) PREDICTED: rhox homeob ( 212) 1279 167.1 1.7e-41
NP_703149 (OMIM: 300154) homeobox protein ESX1 [Ho ( 406) 317 50.2 4.8e-06
NP_115887 (OMIM: 300447) rhox homeobox family memb ( 288) 273 44.7 0.00016
NP_001157150 (OMIM: 602504) short stature homeobox ( 319) 260 43.2 0.0005
NP_006875 (OMIM: 602504) short stature homeobox pr ( 331) 260 43.2 0.00052
NP_115485 (OMIM: 604529) homeobox protein orthoped ( 325) 253 42.3 0.00092
XP_016862543 (OMIM: 602504) PREDICTED: short statu ( 204) 238 40.3 0.0024
XP_016862542 (OMIM: 602504) PREDICTED: short statu ( 204) 238 40.3 0.0024
XP_016862544 (OMIM: 602504) PREDICTED: short statu ( 190) 236 40.0 0.0028
XP_006713791 (OMIM: 602504) PREDICTED: short statu ( 190) 236 40.0 0.0028
XP_006713790 (OMIM: 602504) PREDICTED: short statu ( 343) 238 40.5 0.0034
NP_003021 (OMIM: 602504) short stature homeobox pr ( 355) 238 40.6 0.0035
NP_005020 (OMIM: 107250,602669,610623) pituitary h ( 302) 236 40.2 0.0037
NP_068745 (OMIM: 605420,609597,613451,615529) home ( 411) 235 40.3 0.0049
NP_006874 (OMIM: 312865,400020) short stature home ( 225) 229 39.2 0.0055
NP_001191326 (OMIM: 137600,180500,180550,601542,60 ( 317) 230 39.5 0.0063
NP_001191327 (OMIM: 137600,180500,180550,601542,60 ( 317) 230 39.5 0.0063
NP_700475 (OMIM: 137600,180500,180550,601542,60422 ( 317) 230 39.5 0.0063
NP_057391 (OMIM: 604675) paired mesoderm homeobox ( 253) 228 39.2 0.0065
NP_000442 (OMIM: 312865,400020) short stature home ( 292) 229 39.4 0.0065
NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 226 39.0 0.0085
NP_005160 (OMIM: 602078,602753) paired mesoderm ho ( 284) 224 38.7 0.0098
>>NP_644811 (OMIM: 300446) rhox homeobox family member 1 (184 aa)
initn: 1279 init1: 1279 opt: 1279 Z-score: 866.8 bits: 167.0 E(85289): 1.5e-41
Smith-Waterman score: 1279; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184)
10 20 30 40 50 60
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_644 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 NRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_644 NRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_644 VFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVY
130 140 150 160 170 180
pF1KB7 IVVD
::::
NP_644 IVVD
>>XP_011529583 (OMIM: 300446) PREDICTED: rhox homeobox f (212 aa)
initn: 1279 init1: 1279 opt: 1279 Z-score: 866.1 bits: 167.1 E(85289): 1.7e-41
Smith-Waterman score: 1279; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:29-212)
10 20 30
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASS
::::::::::::::::::::::::::::::::
XP_011 MLRITMKTRAISLAADATEFVQGRSAPAMARSLVHDTVFYCLSVYQVKISPTPQLGAASS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB7 AEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 MEGPQPENMQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGPQPENMQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFK
130 140 150 160 170 180
160 170 180
pF1KB7 NKRARCRRHQRELMLANELRADPDDCVYIVVD
::::::::::::::::::::::::::::::::
XP_011 NKRARCRRHQRELMLANELRADPDDCVYIVVD
190 200 210
>>NP_703149 (OMIM: 300154) homeobox protein ESX1 [Homo s (406 aa)
initn: 263 init1: 263 opt: 317 Z-score: 229.6 bits: 50.2 E(85289): 4.8e-06
Smith-Waterman score: 356; 43.5% identity (64.0% similar) in 161 aa overlap (50-174:51-210)
20 30 40 50 60 70
pF1KB7 KISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIP------EGGGG
:: :.. ::... .:. .: :::::
NP_703 EDIEEVNDEKLTVTSLMARGGEDEENTRSKPEYGTEAENNVGTEGS-VPSDDQDREGGGG
30 40 50 60 70
80 90 100
pF1KB7 N-----QE------PRQQPQPPP--------EEPAQAAMEGPQP-------ENMQP----
. :: :.:: . :: ::: :...::::: :. ::
NP_703 HEPEQQQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEGPQPAEGPQTAEGPQPPERK
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB7 RTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQR
: ::: :: .:..:::. : ..::::: .:..:: :..:::.:.:::.:.::. .:.::
NP_703 RRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQR
140 150 160 170 180 190
170 180
pF1KB7 ELMLANELRADPDDCVYIVVD
::: : ::
NP_703 VLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMV
200 210 220 230 240 250
>>NP_115887 (OMIM: 300447) rhox homeobox family member 2 (288 aa)
initn: 250 init1: 213 opt: 273 Z-score: 202.3 bits: 44.7 E(85289): 0.00016
Smith-Waterman score: 275; 36.9% identity (61.2% similar) in 160 aa overlap (23-171:48-202)
10 20 30 40 50
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEG
: :. :.:.. : . :: : :. . :
NP_115 AVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAG-EKLKSAGAQG--GEEKDGG
20 30 40 50 60 70
60 70 80 90 100
pF1KB7 GVNHENGMNRDGGMIPEG-------GGGNQEPRQQPQPPPEEP---AQAAMEGPQPEN-M
: ....: : . :: . :: : .: . : . :.:. : .: : .
NP_115 GEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQ
80 90 100 110 120 130
110 120 130 140 150 160
pF1KB7 QPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRH
:: .. :: ::..::: .:.. :.:. ::.::....::: :..::.:.::. :::
NP_115 QPNVH--AFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRH
140 150 160 170 180 190
170 180
pF1KB7 QRELMLANELRADPDDCVYIVVD
:: :: : :
NP_115 QRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPP
200 210 220 230 240 250
>>NP_001157150 (OMIM: 602504) short stature homeobox pro (319 aa)
initn: 266 init1: 236 opt: 260 Z-score: 193.2 bits: 43.2 E(85289): 0.0005
Smith-Waterman score: 271; 36.1% identity (60.0% similar) in 155 aa overlap (24-165:53-202)
10 20 30 40 50
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGG
.: . ::... : : :. : :. ::
NP_001 ITYREVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGG
30 40 50 60 70 80
60 70 80 90 100
pF1KB7 VNHENGMNRDGGMIP--EGGGGNQEPRQQPQPP------PE-----EPAQAAMEGPQPEN
. : . :: : : : : ..: : :: : :.. :: .
NP_001 A----GGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKG-MEDEGQTK
90 100 110 120 130
110 120 130 140 150 160
pF1KB7 MQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRR
.. : ::.::: :..::: .: .:.:::. :.::.. ::..: .:.:::.:.::.::.
NP_001 IKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRK
140 150 160 170 180 190
170 180
pF1KB7 HQRELMLANELRADPDDCVYIVVD
.. .:
NP_001 QENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQVQAQLQLDSAVAHAHHHLHPHLA
200 210 220 230 240 250
>>NP_006875 (OMIM: 602504) short stature homeobox protei (331 aa)
initn: 266 init1: 236 opt: 260 Z-score: 193.0 bits: 43.2 E(85289): 0.00052
Smith-Waterman score: 271; 36.1% identity (60.0% similar) in 155 aa overlap (24-165:53-202)
10 20 30 40 50
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGG
.: . ::... : : :. : :. ::
NP_006 ITYREVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGG
30 40 50 60 70 80
60 70 80 90 100
pF1KB7 VNHENGMNRDGGMIP--EGGGGNQEPRQQPQPP------PE-----EPAQAAMEGPQPEN
. : . :: : : : : ..: : :: : :.. :: .
NP_006 A----GGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKG-MEDEGQTK
90 100 110 120 130
110 120 130 140 150 160
pF1KB7 MQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRR
.. : ::.::: :..::: .: .:.:::. :.::.. ::..: .:.:::.:.::.::.
NP_006 IKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRK
140 150 160 170 180 190
170 180
pF1KB7 HQRELMLANELRADPDDCVYIVVD
.. .:
NP_006 QENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAV
200 210 220 230 240 250
>>NP_115485 (OMIM: 604529) homeobox protein orthopedia [ (325 aa)
initn: 241 init1: 219 opt: 253 Z-score: 188.5 bits: 42.3 E(85289): 0.00092
Smith-Waterman score: 253; 35.2% identity (64.8% similar) in 142 aa overlap (26-163:30-164)
10 20 30 40 50
pF1KB7 MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEG-HVGQGAPGLMGNMNPEGGVN
.::...: : : :. :: : .: :..
NP_115 MLSHADLLDARLGMKDAAELLGHREAVKCRLGVGGSDPGGHPGDLAP----NSDPVEGAT
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 HENGMN-RDGGMIPEGGG-GNQEPRQQPQPPP-EEPAQAAMEGPQPENMQPRTRRTKFTL
: . : : . . . ..: .:: : .:.:: : : ... . .::.::
NP_115 LLPGEDITTVGSTPASLAVSAKDPDKQPGPQGGPNPSQA---GQQQGQQKQKRHRTRFTP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 LQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELR
:..::: : .:.:::. :.::: .:.::..:.:::.:.::. .....
NP_115 AQLNELERSFAKTHYPDIFMREELALRIGLTESRVQVWFQNRRAKWKKRKKTTNVFRAPG
120 130 140 150 160 170
180
pF1KB7 ADPDDCVYIVVD
NP_115 TLLPTPGLPQFPSAAAAAAAAMGDSLCSFHANDTRWAAAAMPGVSQLPLPPALGRQQAMA
180 190 200 210 220 230
>>XP_016862543 (OMIM: 602504) PREDICTED: short stature h (204 aa)
initn: 236 init1: 236 opt: 238 Z-score: 181.0 bits: 40.3 E(85289): 0.0024
Smith-Waterman score: 238; 40.0% identity (72.9% similar) in 85 aa overlap (81-165:3-87)
60 70 80 90 100 110
pF1KB7 EGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKF
:. .. .:: ... : ::.:
XP_016 MSPELKDRKEDAKGMEDEGQTKIKQRRSRTNF
10 20 30
120 130 140 150 160 170
pF1KB7 TLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANE
:: :..::: .: .:.:::. :.::.. ::..: .:.:::.:.::.::... .:
XP_016 TLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVL
40 50 60 70 80 90
180
pF1KB7 LRADPDDCVYIVVD
XP_016 IGAASQFEACRVAPYVNVGALRMPFQQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPA
100 110 120 130 140 150
>>XP_016862542 (OMIM: 602504) PREDICTED: short stature h (204 aa)
initn: 236 init1: 236 opt: 238 Z-score: 181.0 bits: 40.3 E(85289): 0.0024
Smith-Waterman score: 238; 40.0% identity (72.9% similar) in 85 aa overlap (81-165:3-87)
60 70 80 90 100 110
pF1KB7 EGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKF
:. .. .:: ... : ::.:
XP_016 MSPELKDRKEDAKGMEDEGQTKIKQRRSRTNF
10 20 30
120 130 140 150 160 170
pF1KB7 TLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANE
:: :..::: .: .:.:::. :.::.. ::..: .:.:::.:.::.::... .:
XP_016 TLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVL
40 50 60 70 80 90
180
pF1KB7 LRADPDDCVYIVVD
XP_016 IGAASQFEACRVAPYVNVGALRMPFQQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPA
100 110 120 130 140 150
>>XP_016862544 (OMIM: 602504) PREDICTED: short stature h (190 aa)
initn: 236 init1: 236 opt: 236 Z-score: 180.0 bits: 40.0 E(85289): 0.0028
Smith-Waterman score: 236; 45.2% identity (78.1% similar) in 73 aa overlap (93-165:1-73)
70 80 90 100 110 120
pF1KB7 DGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELESVF
:: ... : ::.::: :..::: .:
XP_016 MEDEGQTKIKQRRSRTNFTLEQLNELERLF
10 20 30
130 140 150 160 170 180
pF1KB7 RHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVYIV
.:.:::. :.::.. ::..: .:.:::.:.::.::... .:
XP_016 DETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRV
40 50 60 70 80 90
pF1KB7 VD
XP_016 APYVNVGALRMPFQQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAA
100 110 120 130 140 150
184 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 08:36:44 2016 done: Fri Nov 4 08:36:45 2016
Total Scan time: 5.980 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]