Result of FASTA (omim) for
pFN21AB7386
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7386, 418 aa
1>>>pF1KB7386 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.1878+/-0.000419; mu= -0.5997+/- 0.026
mean_var=192.8907+/-39.162, 0's: 0 Z-trim(117.8): 46 B-trim: 727 in 3/54
Lambda= 0.092346
statistics sampled from 30052 (30100) to 30052 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.353), width: 16
Scan time: 9.710
The best scores are: opt bits E(85289)
NP_061944 (OMIM: 607493) inhibitor of growth prote ( 418) 2744 378.0 2.4e-104
XP_016867858 (OMIM: 607493) PREDICTED: inhibitor o ( 91) 585 90.0 2.5e-18
NP_938008 (OMIM: 607493) inhibitor of growth prote ( 92) 585 90.0 2.6e-18
NP_937861 (OMIM: 275355,601566) inhibitor of growt ( 210) 408 66.6 6.5e-11
NP_937860 (OMIM: 275355,601566) inhibitor of growt ( 235) 408 66.7 7.1e-11
NP_001254657 (OMIM: 275355,601566) inhibitor of gr ( 262) 408 66.7 7.8e-11
NP_937862 (OMIM: 275355,601566) inhibitor of growt ( 279) 408 66.7 8.2e-11
NP_005528 (OMIM: 275355,601566) inhibitor of growt ( 422) 408 66.8 1.2e-10
XP_005253755 (OMIM: 608524) PREDICTED: inhibitor o ( 200) 386 63.7 4.7e-10
XP_011519267 (OMIM: 608524) PREDICTED: inhibitor o ( 222) 386 63.7 5.2e-10
NP_001121057 (OMIM: 608524) inhibitor of growth pr ( 225) 386 63.7 5.2e-10
NP_001121054 (OMIM: 608524) inhibitor of growth pr ( 249) 386 63.8 5.7e-10
NP_001121055 (OMIM: 608524) inhibitor of growth pr ( 246) 382 63.2 8.2e-10
XP_016874881 (OMIM: 608524) PREDICTED: inhibitor o ( 199) 380 62.9 8.2e-10
XP_011519266 (OMIM: 608524) PREDICTED: inhibitor o ( 224) 380 62.9 9.1e-10
XP_016874882 (OMIM: 608524) PREDICTED: inhibitor o ( 196) 378 62.6 9.7e-10
NP_057246 (OMIM: 608524) inhibitor of growth prote ( 248) 380 63.0 9.9e-10
NP_001121056 (OMIM: 608524) inhibitor of growth pr ( 245) 378 62.7 1.2e-09
NP_115705 (OMIM: 608525) inhibitor of growth prote ( 240) 372 61.9 2e-09
XP_011530229 (OMIM: 604215) PREDICTED: inhibitor o ( 225) 371 61.7 2.1e-09
NP_001278888 (OMIM: 604215) inhibitor of growth pr ( 240) 371 61.7 2.2e-09
XP_016860586 (OMIM: 608525) PREDICTED: inhibitor o ( 300) 372 61.9 2.4e-09
NP_001555 (OMIM: 604215) inhibitor of growth prote ( 280) 371 61.8 2.5e-09
NP_001317091 (OMIM: 608525) inhibitor of growth pr ( 226) 311 53.7 5.4e-07
XP_016860587 (OMIM: 608525) PREDICTED: inhibitor o ( 286) 311 53.8 6.5e-07
XP_016860588 (OMIM: 608525) PREDICTED: inhibitor o ( 286) 311 53.8 6.5e-07
XP_016860591 (OMIM: 608525) PREDICTED: inhibitor o ( 206) 285 50.3 5.5e-06
NP_001121058 (OMIM: 608524) inhibitor of growth pr ( 179) 264 47.4 3.4e-05
XP_016860590 (OMIM: 608525) PREDICTED: inhibitor o ( 207) 251 45.7 0.00013
NP_001317090 (OMIM: 608525) inhibitor of growth pr ( 254) 251 45.8 0.00015
>>NP_061944 (OMIM: 607493) inhibitor of growth protein 3 (418 aa)
initn: 2744 init1: 2744 opt: 2744 Z-score: 1994.4 bits: 378.0 E(85289): 2.4e-104
Smith-Waterman score: 2744; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KB7 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 QMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 QMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 RRSLELDTPSQPVNNHHAHSHTPVEKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RRSLELDTPSQPVNNHHAHSHTPVEKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDAS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 KENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KENTLGCRNNNSTASSNNAYNVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 EGRRTSSLKASYEAFKNNDFQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 EGRRTSSLKASYEAFKNNDFQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 KSKNNNKSSSQQSSSSSSSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 KSKNNNKSSSQQSSSSSSSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEP
310 320 330 340 350 360
370 380 390 400 410
pF1KB7 RYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 RYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
370 380 390 400 410
>>XP_016867858 (OMIM: 607493) PREDICTED: inhibitor of gr (91 aa)
initn: 585 init1: 585 opt: 585 Z-score: 449.9 bits: 90.0 E(85289): 2.5e-18
Smith-Waterman score: 585; 100.0% identity (100.0% similar) in 89 aa overlap (1-89:1-89)
10 20 30 40 50 60
pF1KB7 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 QMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILE
:::::::::::::::::::::::::::::
XP_016 QMASIKKDYYKALEDADEKVQLANQIYDLHF
70 80 90
>>NP_938008 (OMIM: 607493) inhibitor of growth protein 3 (92 aa)
initn: 585 init1: 585 opt: 585 Z-score: 449.9 bits: 90.0 E(85289): 2.6e-18
Smith-Waterman score: 585; 100.0% identity (100.0% similar) in 89 aa overlap (1-89:1-89)
10 20 30 40 50 60
pF1KB7 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 QMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILE
:::::::::::::::::::::::::::::
NP_938 QMASIKKDYYKALEDADEKVQLANQIYDLQHF
70 80 90
>>NP_937861 (OMIM: 275355,601566) inhibitor of growth pr (210 aa)
initn: 448 init1: 379 opt: 408 Z-score: 316.9 bits: 66.6 E(85289): 6.5e-11
Smith-Waterman score: 408; 35.2% identity (69.3% similar) in 179 aa overlap (231-406:18-187)
210 220 230 240 250
pF1KB7 NVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKE--GRRTSSLKASYEAFKNN
. .: ..:: : :: .. . : :. .
NP_937 MLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQ
10 20 30 40
260 270 280 290 300 310
pF1KB7 DFQLGKEFSMARETVGYSSSS-ALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSS
. .:: .:.: :... : :... .:. .:...::.. . .:. .
NP_937 Q-ELG-------DTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDH
50 60 70 80 90
320 330 340 350 360 370
pF1KB7 SSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCD
.... .. . ... ... .... . : .. : .: ::::: ::.:::::::::.:::
NP_937 DDGASGTPKEKKAKTSKKKKRSKAKAEREA-SPADLPIDPNEPTYCLCNQVSYGEMIGCD
100 110 120 130 140 150
380 390 400 410
pF1KB7 NQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:..:::::::..::::.. ::::::::.:
NP_937 NDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
160 170 180 190 200 210
>>NP_937860 (OMIM: 275355,601566) inhibitor of growth pr (235 aa)
initn: 448 init1: 379 opt: 408 Z-score: 316.2 bits: 66.7 E(85289): 7.1e-11
Smith-Waterman score: 408; 35.2% identity (69.3% similar) in 179 aa overlap (231-406:43-212)
210 220 230 240 250
pF1KB7 NVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKE--GRRTSSLKASYEAFKNN
. .: ..:: : :: .. . : :. .
NP_937 RFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQ
20 30 40 50 60 70
260 270 280 290 300 310
pF1KB7 DFQLGKEFSMARETVGYSSSS-ALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSS
. .:: .:.: :... : :... .:. .:...::.. . .:. .
NP_937 Q-ELG-------DTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDH
80 90 100 110 120
320 330 340 350 360 370
pF1KB7 SSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCD
.... .. . ... ... .... . : .. : .: ::::: ::.:::::::::.:::
NP_937 DDGASGTPKEKKAKTSKKKKRSKAKAEREA-SPADLPIDPNEPTYCLCNQVSYGEMIGCD
130 140 150 160 170 180
380 390 400 410
pF1KB7 NQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:..:::::::..::::.. ::::::::.:
NP_937 NDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
190 200 210 220 230
>>NP_001254657 (OMIM: 275355,601566) inhibitor of growth (262 aa)
initn: 448 init1: 379 opt: 408 Z-score: 315.5 bits: 66.7 E(85289): 7.8e-11
Smith-Waterman score: 408; 35.2% identity (69.3% similar) in 179 aa overlap (231-406:70-239)
210 220 230 240 250
pF1KB7 NVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKE--GRRTSSLKASYEAFKNN
. .: ..:: : :: .. . : :. .
NP_001 RFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQ
40 50 60 70 80 90
260 270 280 290 300 310
pF1KB7 DFQLGKEFSMARETVGYSSSS-ALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSS
. .:: .:.: :... : :... .:. .:...::.. . .:. .
NP_001 Q-ELG-------DTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDH
100 110 120 130 140 150
320 330 340 350 360 370
pF1KB7 SSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCD
.... .. . ... ... .... . : .. : .: ::::: ::.:::::::::.:::
NP_001 DDGASGTPKEKKAKTSKKKKRSKAKAEREA-SPADLPIDPNEPTYCLCNQVSYGEMIGCD
160 170 180 190 200 210
380 390 400 410
pF1KB7 NQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:..:::::::..::::.. ::::::::.:
NP_001 NDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
220 230 240 250 260
>>NP_937862 (OMIM: 275355,601566) inhibitor of growth pr (279 aa)
initn: 544 init1: 379 opt: 408 Z-score: 315.1 bits: 66.7 E(85289): 8.2e-11
Smith-Waterman score: 408; 35.2% identity (69.3% similar) in 179 aa overlap (231-406:87-256)
210 220 230 240 250
pF1KB7 NVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKE--GRRTSSLKASYEAFKNN
. .: ..:: : :: .. . : :. .
NP_937 RFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQ
60 70 80 90 100 110
260 270 280 290 300 310
pF1KB7 DFQLGKEFSMARETVGYSSSS-ALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSS
. .:: .:.: :... : :... .:. .:...::.. . .:. .
NP_937 Q-ELG-------DTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDH
120 130 140 150 160
320 330 340 350 360 370
pF1KB7 SSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCD
.... .. . ... ... .... . : .. : .: ::::: ::.:::::::::.:::
NP_937 DDGASGTPKEKKAKTSKKKKRSKAKAEREA-SPADLPIDPNEPTYCLCNQVSYGEMIGCD
170 180 190 200 210 220
380 390 400 410
pF1KB7 NQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:..:::::::..::::.. ::::::::.:
NP_937 NDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
230 240 250 260 270
>>NP_005528 (OMIM: 275355,601566) inhibitor of growth pr (422 aa)
initn: 448 init1: 379 opt: 408 Z-score: 312.3 bits: 66.8 E(85289): 1.2e-10
Smith-Waterman score: 408; 35.2% identity (69.3% similar) in 179 aa overlap (231-406:230-399)
210 220 230 240 250
pF1KB7 NVNSSQPLGSYNIGSLSSGTGAGAITMAAAQAVQATAQMKE--GRRTSSLKASYEAFKNN
. .: ..:: : :: .. . : :. .
NP_005 RFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQ
200 210 220 230 240 250
260 270 280 290 300 310
pF1KB7 DFQLGKEFSMARETVGYSSSS-ALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSS
. .:: .:.: :... : :... .:. .:...::.. . .:. .
NP_005 Q-ELG-------DTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDH
260 270 280 290 300 310
320 330 340 350 360 370
pF1KB7 SSSSLSSCSSSSTVVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCD
.... .. . ... ... .... . : .. : .: ::::: ::.:::::::::.:::
NP_005 DDGASGTPKEKKAKTSKKKKRSKAKAEREA-SPADLPIDPNEPTYCLCNQVSYGEMIGCD
320 330 340 350 360 370
380 390 400 410
pF1KB7 NQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:..:::::::..::::.. ::::::::.:
NP_005 NDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
380 390 400 410 420
>>XP_005253755 (OMIM: 608524) PREDICTED: inhibitor of gr (200 aa)
initn: 499 init1: 357 opt: 386 Z-score: 301.4 bits: 63.7 E(85289): 4.7e-10
Smith-Waterman score: 386; 38.6% identity (73.2% similar) in 127 aa overlap (290-413:74-200)
260 270 280 290 300 310
pF1KB7 FQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSSSS
:::. ...:: .:... . .......:.
XP_005 VDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDE
50 60 70 80 90 100
320 330 340 350 360 370
pF1KB7 SSLSSCSSSSTVVQ---EISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGC
. .. ... .:. : .. ... .. .: ::::: ::.:.:::::::.::
XP_005 EAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGC
110 120 130 140 150 160
380 390 400 410
pF1KB7 DNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:: :: :::::..::::: :.:::.::.:. :..
XP_005 DNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
170 180 190 200
>>XP_011519267 (OMIM: 608524) PREDICTED: inhibitor of gr (222 aa)
initn: 499 init1: 357 opt: 386 Z-score: 300.7 bits: 63.7 E(85289): 5.2e-10
Smith-Waterman score: 386; 38.6% identity (73.2% similar) in 127 aa overlap (290-413:96-222)
260 270 280 290 300 310
pF1KB7 FQLGKEFSMARETVGYSSSSALMTTLTQNASSSAADSRSGRKSKNNNKSSSQQSSSSSSS
:::. ...:: .:... . .......:.
XP_011 VDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDE
70 80 90 100 110 120
320 330 340 350 360 370
pF1KB7 SSLSSCSSSSTVVQ---EISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGC
. .. ... .:. : .. ... .. .: ::::: ::.:.:::::::.::
XP_011 EAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGC
130 140 150 160 170 180
380 390 400 410
pF1KB7 DNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAAMKRRGSRHK
:: :: :::::..::::: :.:::.::.:. :..
XP_011 DNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
190 200 210 220
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 07:06:24 2016 done: Fri Nov 4 07:06:26 2016
Total Scan time: 9.710 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]