Result of FASTA (omim) for
pFN21AB7272
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7272, 442 aa
1>>>pF1KB7272 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1183+/-0.000321; mu= 14.4978+/- 0.020
mean_var=110.2892+/-22.045, 0's: 0 Z-trim(118.8): 81 B-trim: 0 in 0/55
Lambda= 0.122126
statistics sampled from 32077 (32172) to 32077 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.377), width: 16
Scan time: 8.970
The best scores are: opt bits E(85289)
NP_004589 (OMIM: 602264) testican-1 precursor [Hom ( 439) 3140 563.9 2.9e-160
XP_011530320 (OMIM: 607989) PREDICTED: testican-3 ( 436) 1679 306.5 8.8e-83
NP_058646 (OMIM: 607989) testican-3 isoform 2 prec ( 436) 1679 306.5 8.8e-83
XP_016863747 (OMIM: 607989) PREDICTED: testican-3 ( 433) 1646 300.7 4.9e-81
NP_001035249 (OMIM: 607989) testican-3 isoform 1 p ( 433) 1646 300.7 4.9e-81
XP_016863746 (OMIM: 607989) PREDICTED: testican-3 ( 445) 1646 300.7 5e-81
NP_001191281 (OMIM: 607989) testican-3 isoform 3 [ ( 385) 1471 269.8 8.7e-72
NP_055582 (OMIM: 607988) testican-2 isoform 2 prec ( 424) 1350 248.5 2.4e-65
NP_001231879 (OMIM: 607988) testican-2 isoform 2 p ( 424) 1350 248.5 2.4e-65
XP_011538706 (OMIM: 607988) PREDICTED: testican-2 ( 421) 1317 242.7 1.4e-63
NP_001191283 (OMIM: 607989) testican-3 isoform 5 [ ( 344) 1288 237.5 4e-62
NP_001191287 (OMIM: 607989) testican-3 isoform 9 p ( 313) 1265 233.4 6.3e-61
NP_001191282 (OMIM: 607989) testican-3 isoform 4 [ ( 316) 1163 215.5 1.6e-55
NP_001191284 (OMIM: 607989) testican-3 isoform 6 [ ( 340) 1163 215.5 1.7e-55
NP_001238896 (OMIM: 607989) testican-3 isoform 11 ( 338) 1021 190.5 5.8e-48
NP_001191285 (OMIM: 607989) testican-3 isoform 7 p ( 393) 814 154.1 6.2e-37
XP_016865578 (OMIM: 142790) PREDICTED: HLA class I ( 321) 207 47.0 8.3e-05
NP_001020330 (OMIM: 142790) HLA class II histocomp ( 296) 206 46.8 8.8e-05
NP_071420 (OMIM: 206920,608488) SPARC-related modu ( 434) 208 47.3 9.2e-05
NP_001030024 (OMIM: 206920,608488) SPARC-related m ( 435) 208 47.3 9.2e-05
XP_011542497 (OMIM: 131390) PREDICTED: nidogen-1 i (1205) 203 46.8 0.00036
NP_002499 (OMIM: 131390) nidogen-1 precursor [Homo (1247) 203 46.8 0.00037
NP_001013416 (OMIM: 146732) insulin-like growth fa ( 297) 194 44.7 0.00038
NP_000589 (OMIM: 146732) insulin-like growth facto ( 291) 191 44.2 0.00054
XP_016867641 (OMIM: 146732) PREDICTED: insulin-lik ( 291) 191 44.2 0.00054
NP_002169 (OMIM: 146735) insulin-like growth facto ( 240) 182 42.5 0.0014
NP_000590 (OMIM: 146734) insulin-like growth facto ( 272) 175 41.4 0.0037
XP_005268053 (OMIM: 206920,608488) PREDICTED: SPAR ( 445) 176 41.7 0.0047
XP_005268052 (OMIM: 206920,608488) PREDICTED: SPAR ( 446) 176 41.7 0.0047
NP_071421 (OMIM: 125400,607223) SPARC-related modu ( 457) 174 41.4 0.0061
XP_011534367 (OMIM: 125400,607223) PREDICTED: SPAR ( 475) 174 41.4 0.0063
XP_005267464 (OMIM: 605399) PREDICTED: nidogen-2 i (1327) 180 42.8 0.0065
XP_005267463 (OMIM: 605399) PREDICTED: nidogen-2 i (1354) 180 42.8 0.0066
NP_031387 (OMIM: 605399) nidogen-2 precursor [Homo (1375) 180 42.8 0.0067
XP_005267462 (OMIM: 605399) PREDICTED: nidogen-2 i (1402) 180 42.8 0.0068
NP_001159884 (OMIM: 125400,607223) SPARC-related m ( 446) 172 41.0 0.0076
XP_011534368 (OMIM: 125400,607223) PREDICTED: SPAR ( 464) 172 41.0 0.0079
>>NP_004589 (OMIM: 602264) testican-1 precursor [Homo sa (439 aa)
initn: 2719 init1: 2719 opt: 3140 Z-score: 2998.3 bits: 563.9 E(85289): 2.9e-160
Smith-Waterman score: 3140; 99.3% identity (99.3% similar) in 442 aa overlap (1-442:1-439)
10 20 30 40 50 60
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDKYWNRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 RDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQ
:: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RD---DDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQ
70 80 90 100 110
130 140 150 160 170 180
pF1KB7 KKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB7 GPCPCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GPCPCLPEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQGRF
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB7 DTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB7 NNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWC
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB7 VDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHT
360 370 380 390 400 410
430 440
pF1KB7 RAVTEDDEDEDDDKEDEVGYIW
::::::::::::::::::::::
NP_004 RAVTEDDEDEDDDKEDEVGYIW
420 430
>>XP_011530320 (OMIM: 607989) PREDICTED: testican-3 isof (436 aa)
initn: 1523 init1: 1113 opt: 1679 Z-score: 1607.2 bits: 306.5 E(85289): 8.8e-83
Smith-Waterman score: 1687; 54.4% identity (75.6% similar) in 434 aa overlap (5-435:6-427)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
::: . ::::: .. . : ::: . . :::::. :::.:.::::.. ::
XP_011 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
.:::::::::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:
XP_011 KFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
:.:...: ...: :: : :: :::. . :::::::.:. .::::..:: ::....
XP_011 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
:.: ::: : .: . . . ::.: :.:..:.::.::: ::::.... : :
XP_011 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
XP_011 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
. .::::::::::. :::.:.. ::: . :.::: .:: :.:.:::: ::::::.:
XP_011 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
::::::.::::. ::: .:...: . : ::::.:: :: . : .. . :
XP_011 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
360 370 380 390 400 410
420 430 440
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW
. .::::: :: .
XP_011 ------IEDDDEDEGDDDDGGDDHDVYI
420 430
>>NP_058646 (OMIM: 607989) testican-3 isoform 2 precurso (436 aa)
initn: 1523 init1: 1113 opt: 1679 Z-score: 1607.2 bits: 306.5 E(85289): 8.8e-83
Smith-Waterman score: 1687; 54.4% identity (75.6% similar) in 434 aa overlap (5-435:6-427)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
::: . ::::: .. . : ::: . . :::::. :::.:.::::.. ::
NP_058 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
.:::::::::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:
NP_058 KFRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
:.:...: ...: :: : :: :::. . :::::::.:. .::::..:: ::....
NP_058 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
:.: ::: : .: . . . ::.: :.:..:.::.::: ::::.... : :
NP_058 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
NP_058 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
. .::::::::::. :::.:.. ::: . :.::: .:: :.:.:::: ::::::.:
NP_058 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
::::::.::::. ::: .:...: . : ::::.:: :: . : .. . :
NP_058 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
360 370 380 390 400 410
420 430 440
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW
. .::::: :: .
NP_058 ------IEDDDEDEGDDDDGGDDHDVYI
420 430
>>XP_016863747 (OMIM: 607989) PREDICTED: testican-3 isof (433 aa)
initn: 1581 init1: 1008 opt: 1646 Z-score: 1575.8 bits: 300.7 E(85289): 4.9e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:6-424)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
::: . ::::: .. . : ::: . . :::::. :::.:.::::.. ::
XP_016 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
.::: :::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:
XP_016 KFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
:.:...: ...: :: : :: :::. . :::::::.:. .::::..:: ::....
XP_016 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
:.: ::: : .: . . . ::.: :.:..:.::.::: ::::.... : :
XP_016 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
XP_016 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
. .::::::::::. :::.:.. ::: . :.::: .:: :.:.:::: ::::::.:
XP_016 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
::::::.::::. ::: .:...: . : ::::.:: :: . : .. . :
XP_016 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
360 370 380 390 400 410
420 430 440
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW
. .::::: :: .
XP_016 ------IEDDDEDEGDDDDGGDDHDVYI
420 430
>>NP_001035249 (OMIM: 607989) testican-3 isoform 1 precu (433 aa)
initn: 1581 init1: 1008 opt: 1646 Z-score: 1575.8 bits: 300.7 E(85289): 4.9e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:6-424)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD-KYWN
::: . ::::: .. . : ::: . . :::::. :::.:.::::.. ::
NP_001 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTTISQYDKEVGQWN
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 RFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLP
.::: :::::.:.:.:::::::::.::::::.::: ::::..:: :::.:.:...:
NP_001 KFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 RQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATL
:.:...: ...: :: : :: :::. . :::::::.:. .::::..:: ::....
NP_001 RMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 CDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTA
:.: ::: : .: . . . ::.: :.:..:.::.::: ::::.... : :
NP_001 CEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 QGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKD
..:::::::::::::::::::.:: ::::::: ::. .::::: : : : .:::::..::
NP_001 RSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 GKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTG
. .::::::::::. :::.:.. ::: . :.::: .:: :.:.:::: ::::::.:
NP_001 SLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVG
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 QCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKL
::::::.::::. ::: .:...: . : ::::.:: :: . : .. . :
NP_001 QCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---
360 370 380 390 400 410
420 430 440
pF1KB7 RVHTRAVTEDDEDEDDDKEDEVGYIW
. .::::: :: .
NP_001 ------IEDDDEDEGDDDDGGDDHDVYI
420 430
>>XP_016863746 (OMIM: 607989) PREDICTED: testican-3 isof (445 aa)
initn: 1581 init1: 1008 opt: 1646 Z-score: 1575.6 bits: 300.7 E(85289): 5e-81
Smith-Waterman score: 1654; 53.7% identity (74.9% similar) in 434 aa overlap (5-435:18-436)
10 20 30 40
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLST
::: . ::::: .. . : ::: . . :::::. :::.:
XP_016 MPPHPPLCLLSQMLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRS-DGGNFLDDKQWLTT
10 20 30 40 50
50 60 70 80 90 100
pF1KB7 VSQYDRD-KYWNRFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQ
.::::.. ::.::: :::::.:.:.:::::::::.::::::.::: ::::..:: :
XP_016 ISQYDKEVGQWNKFRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB7 TALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEF
::.:.:...: :.:...: ...: :: : :: :::. . :::::::.:. .::::.
XP_016 TAVCISHRRLTHRMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB7 HACSTGKSLATLCDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRLKDWFGALHEDAN
.:: ::.... :.: ::: : .: . . . ::.: :.:..:.::.::: ::::...
XP_016 QACVLGKQISVKCEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB7 RVIKP-TSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCI
. : : ..:::::::::::::::::::.:: ::::::: ::. .::::: : :
XP_016 QNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCT
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB7 KPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEG
: .:::::..::. .::::::::::. :::.:.. ::: . :.::: .:: :.:.:
XP_016 KAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB7 YYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYE
::: ::::::.:::::::.::::. ::: .:...: . : ::::.:: :: . :
XP_016 YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDE
360 370 380 390 400 410
410 420 430 440
pF1KB7 RELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW
.. . : . .::::: :: .
XP_016 DDIMNDEDE---------IEDDDEDEGDDDDGGDDHDVYI
420 430 440
>>NP_001191281 (OMIM: 607989) testican-3 isoform 3 [Homo (385 aa)
initn: 1401 init1: 1003 opt: 1471 Z-score: 1409.8 bits: 269.8 E(85289): 8.7e-72
Smith-Waterman score: 1479; 54.4% identity (76.1% similar) in 373 aa overlap (65-435:15-376)
40 50 60 70 80 90
pF1KB7 HGNFLDNDQWLSTVSQYDRDKYWNRFRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKC
.:::::.:.:.:::::::::.::::::.::
NP_001 MITQDHIHMSSGLSQDDYFRTWSPGKPFDQALDPAKDPCLKMKC
10 20 30 40
100 110 120 130 140 150
pF1KB7 SPHKVCVTQDYQTALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSD
: ::::..:: :::.:.:...: :.:...: ...: :: : :: :::. . :::::
NP_001 SRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPI-LSTCKQCPVVYPSPVCGSD
50 60 70 80 90 100
160 170 180 190 200 210
pF1KB7 GHSYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPK-HKAERSACTDKELRNLASRL
::.:. .::::..:: ::.... :.: ::: : .: . . . ::.: :.:..:.::
NP_001 GHTYSFQCKLEYQACVLGKQISVKCEGHCPC-PSDKPTSTSRNVKRACSDLEFREVANRL
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB7 KDWFGALHEDANRVIKP-TSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEI
.::: ::::.... : : ..:::::::::::::::::::.:: ::::::: ::.
NP_001 RDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSEL
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB7 NAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSL
.::::: : : : .:::::..::. .::::::::::. :::.:.. ::: . :.:
NP_001 RSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKL
230 240 250 260 270 280
340 350 360 370 380 390
pF1KB7 LGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSG
:: .:: :.:.:::: ::::::.:::::::.::::. ::: .:...: . : ::::.::
NP_001 LGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASG
290 300 310 320 330 340
400 410 420 430 440
pF1KB7 GSVVLLDDLEYERELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW
:: . : .. . : . .::::: :: .
NP_001 DFHEWTDDEDDEDDIMNDEDE---------IEDDDEDEGDDDDGGDDHDVYI
350 360 370 380
>>NP_055582 (OMIM: 607988) testican-2 isoform 2 precurso (424 aa)
initn: 868 init1: 427 opt: 1350 Z-score: 1294.0 bits: 248.5 E(85289): 2.4e-65
Smith-Waterman score: 1366; 47.3% identity (71.1% similar) in 425 aa overlap (25-442:25-424)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
:: . : . :::....::::..:::. . :.:::
NP_055 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
:::::::::...:. :. :.::: .:::: ::::: ::::..: :: :.:.:::.: :
NP_055 FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
:. .: . : : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
NP_055 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
130 140 150 160 170
180 190 200 210 220 230
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
.::::: : . :. . .:: ..: .:..::.::: :::.... . .:
NP_055 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
. .: :. ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
NP_055 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
..:. :::.:: .:: :: :..::: .:. : ::: :.:.:::. :: :.
NP_055 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
:.:::::. : ::.:.: .:. .:.. ::::::: .: .:.: :
NP_055 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
360 370 380 390
420 430 440
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
.:. . :. :.:. . . :. ::::
NP_055 ---ETEEAGEEAEEEEGEAGEADDGGYIW
400 410 420
>>NP_001231879 (OMIM: 607988) testican-2 isoform 2 precu (424 aa)
initn: 868 init1: 427 opt: 1350 Z-score: 1294.0 bits: 248.5 E(85289): 2.4e-65
Smith-Waterman score: 1366; 47.3% identity (71.1% similar) in 425 aa overlap (25-442:25-424)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
:: . : . :::....::::..:::. . :.:::
NP_001 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
:::::::::...:. :. :.::: .:::: ::::: ::::..: :: :.:.:::.: :
NP_001 FRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
:. .: . : : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
NP_001 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
130 140 150 160 170
180 190 200 210 220 230
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
.::::: : . :. . .:: ..: .:..::.::: :::.... . .:
NP_001 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
. .: :. ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
NP_001 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
..:. :::.:: .:: :: :..::: .:. : ::: :.:.:::. :: :.
NP_001 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
:.:::::. : ::.:.: .:. .:.. ::::::: .: .:.: :
NP_001 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
360 370 380 390
420 430 440
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
.:. . :. :.:. . . :. ::::
NP_001 ---ETEEAGEEAEEEEGEAGEADDGGYIW
400 410 420
>>XP_011538706 (OMIM: 607988) PREDICTED: testican-2 isof (421 aa)
initn: 793 init1: 427 opt: 1317 Z-score: 1262.7 bits: 242.7 E(85289): 1.4e-63
Smith-Waterman score: 1333; 46.6% identity (70.4% similar) in 425 aa overlap (25-442:25-421)
10 20 30 40 50
pF1KB7 MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYD-RDKYWNR
:: . : . :::....::::..:::. . :.:::
XP_011 MRAPGCGRLVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 FRDEVEDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPR
::: :::...:. :. :.::: .:::: ::::: ::::..: :: :.:.:::.: :
XP_011 FRD---DDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHR
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 QKKGNVAQKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLC
:. .: . : : .. . :::: .:: : :::::::.:.: :::: .:: ..:.::. :
XP_011 IKQPTV-KLH--GNKDSI-CKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 DGPCPCLPEPEPPKHKAERS--ACTDKELRNLASRLKDWFGALHEDANRVIKPTSSNTAQ
.::::: : . :. . .:: ..: .:..::.::: :::.... . .:
XP_011 EGPCPC-PTEQAATSTADGKPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 GRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDG
. .: :. ::::.::::.::: . ::.:: .:. :: ::::: ::.:.:::::..:::
XP_011 SGLDKSLGASCKDSIGWMFSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 KLSNNEWCYCF--QKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGST
..:. :::.:: .:: :: :..::: .:. : ::: :.:.:::. :: :.
XP_011 RVSTAEWCFCFWREKP---PCLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSS
300 310 320 330 340
360 370 380 390 400 410
pF1KB7 GQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGK
:.:::::. : ::.:.: .:. .:.. ::::::: .: .:.: :
XP_011 GDCWCVDQLGLELTGTRTHGSPDCDDIVGFSGDFGSG--------------VGWEDEEEK
350 360 370 380 390
420 430 440
pF1KB7 LRVHTRAVTEDDEDEDDD--KEDEVGYIW
.:. . :. :.:. . . :. ::::
XP_011 ---ETEEAGEEAEEEEGEAGEADDGGYIW
400 410 420
442 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:32:26 2016 done: Fri Nov 4 06:32:27 2016
Total Scan time: 8.970 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]