Result of FASTA (omim) for
pFN21AB7236
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7236, 311 aa
1>>>pF1KB7236 311 - 311 aa - 311 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1696+/-0.000369; mu= 16.1683+/- 0.023
mean_var=63.9609+/-12.166, 0's: 0 Z-trim(113.7): 142 B-trim: 0 in 0/51
Lambda= 0.160368
statistics sampled from 23006 (23163) to 23006 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.272), width: 16
Scan time: 7.840
The best scores are: opt bits E(85289)
NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [ ( 331) 2024 477.0 2.3e-134
NP_000404 (OMIM: 109684) estradiol 17-beta-dehydro ( 328) 748 181.7 1.7e-45
NP_001317148 (OMIM: 109684) estradiol 17-beta-dehy ( 329) 736 179.0 1.2e-44
XP_011523032 (OMIM: 109684) PREDICTED: estradiol 1 ( 383) 649 158.9 1.5e-38
XP_011523031 (OMIM: 109684) PREDICTED: estradiol 1 ( 384) 644 157.7 3.4e-38
XP_005257349 (OMIM: 109684) PREDICTED: estradiol 1 ( 359) 628 154.0 4.2e-37
XP_006721922 (OMIM: 109684) PREDICTED: estradiol 1 ( 360) 616 151.2 2.9e-36
XP_006721921 (OMIM: 109684) PREDICTED: estradiol 1 ( 414) 529 131.1 3.7e-30
XP_006721920 (OMIM: 109684) PREDICTED: estradiol 1 ( 415) 524 130.0 8.2e-30
NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 356 91.0 3.2e-18
XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325) 356 91.0 3.4e-18
NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325) 356 91.0 3.4e-18
XP_016879914 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 356 91.1 3.8e-18
XP_005256652 (OMIM: 616160) PREDICTED: dehydrogena ( 372) 356 91.1 3.8e-18
XP_011522088 (OMIM: 616160) PREDICTED: dehydrogena ( 334) 351 89.9 7.7e-18
XP_016862498 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 333 85.7 1.3e-16
XP_016862499 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324) 333 85.7 1.3e-16
XP_016862501 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 333 85.7 1.4e-16
XP_016862497 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 333 85.7 1.4e-16
XP_016862500 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330) 333 85.7 1.4e-16
NP_976059 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 333 85.7 1.4e-16
XP_005269409 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 333 85.7 1.4e-16
XP_016862496 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343) 333 85.7 1.4e-16
NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 333 85.7 1.4e-16
NP_976060 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343) 333 85.7 1.4e-16
XP_011511369 (OMIM: 603063) PREDICTED: D-beta-hydr ( 347) 333 85.7 1.4e-16
NP_001207422 (OMIM: 616161) dehydrogenase/reductas ( 312) 324 83.6 5.5e-16
NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 322 83.1 7.1e-16
NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 322 83.2 8.2e-16
XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404) 322 83.2 9.4e-16
NP_001099041 (OMIM: 616161) dehydrogenase/reductas ( 311) 317 82.0 1.7e-15
NP_001186700 (OMIM: 136880,601617) 11-cis retinol ( 318) 299 77.9 3.1e-14
NP_002896 (OMIM: 136880,601617) 11-cis retinol deh ( 318) 299 77.9 3.1e-14
XP_005266734 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 298) 292 76.2 9e-14
NP_002026 (OMIM: 136440) 3-ketodihydrosphingosine ( 332) 292 76.2 9.8e-14
NP_683695 (OMIM: 609769) short-chain dehydrogenase ( 313) 291 76.0 1.1e-13
XP_011523034 (OMIM: 109684) PREDICTED: estradiol 1 ( 180) 284 74.2 2.1e-13
NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319) 281 73.7 5.6e-13
XP_011508777 (OMIM: 612131) PREDICTED: dehydrogena ( 319) 281 73.7 5.6e-13
NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319) 281 73.7 5.6e-13
NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319) 281 73.7 5.6e-13
NP_001276692 (OMIM: 612131) dehydrogenase/reductas ( 379) 281 73.7 6.4e-13
XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 274 72.0 1.5e-12
NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280) 274 72.0 1.5e-12
XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 274 72.0 1.5e-12
NP_878912 (OMIM: 615194) dehydrogenase/reductase S ( 300) 274 72.1 1.6e-12
NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid de ( 300) 267 70.4 5e-12
XP_016881179 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 255) 262 69.2 9.7e-12
NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 261 69.0 1.2e-11
XP_005269265 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317) 259 68.6 1.9e-11
>>NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [Homo (331 aa)
initn: 2024 init1: 2024 opt: 2024 Z-score: 2533.2 bits: 477.0 E(85289): 2.3e-134
Smith-Waterman score: 2024; 100.0% identity (100.0% similar) in 311 aa overlap (1-311:21-331)
10 20 30 40
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMR
::::::::::::::::::::::::::::::::::::::::
NP_056 MNGQSQVLPGGGHESREGINMAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 DLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLE
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 GLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKF
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB7 ALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB7 LPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT
250 260 270 280 290 300
290 300 310
pF1KB7 THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
:::::::::::::::::::::::::::::::
NP_056 THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
310 320 330
>>NP_000404 (OMIM: 109684) estradiol 17-beta-dehydrogena (328 aa)
initn: 727 init1: 402 opt: 748 Z-score: 937.8 bits: 181.7 E(85289): 1.7e-45
Smith-Waterman score: 748; 46.9% identity (73.1% similar) in 286 aa overlap (4-286:2-285)
10 20 30 40 50
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
: .:::.::::::::.:::.:: ::.. ..: ::.::: . : ::: . :
NP_000 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
.: . :::: ...::: . .:.::::: :::.::.::::.:. :. .:.:.: :
NP_000 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
.::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
NP_000 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 IFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQD
. .::.: ::: : : :.:.. . . :: .:.: : . :: :...: ..:::..
NP_000 VHLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 VVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQ
:........ . .: :: :. :. :: .. : ::: :: . :: .:
NP_000 VAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGA
240 250 260 270 280 290
300 310
pF1KB7 CLSCGCLPTRVRPR
NP_000 EAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
300 310 320
>>NP_001317148 (OMIM: 109684) estradiol 17-beta-dehydrog (329 aa)
initn: 695 init1: 364 opt: 736 Z-score: 922.8 bits: 179.0 E(85289): 1.2e-44
Smith-Waterman score: 736; 46.7% identity (72.8% similar) in 287 aa overlap (4-286:2-286)
10 20 30 40 50
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
: .:::.::::::::.:::.:: ::.. ..: ::.::: . : ::: . :
NP_001 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
.: . :::: ...::: . .:.::::: :::.::.::::.:. :. .:.:.: :
NP_001 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
.::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
NP_001 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 IF-ISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQ
. .::.: ::: : : :.:.. . . :: .:.: : . :: :...: ..:::.
NP_001 VHSLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 DVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGL
.:........ . .: :: :. :. :: .. : ::: :: . :: .:
NP_001 EVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAG
240 250 260 270 280 290
300 310
pF1KB7 QCLSCGCLPTRVRPR
NP_001 AEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
300 310 320
>>XP_011523032 (OMIM: 109684) PREDICTED: estradiol 17-be (383 aa)
initn: 648 init1: 402 opt: 649 Z-score: 813.0 bits: 158.9 E(85289): 1.5e-38
Smith-Waterman score: 656; 42.6% identity (68.0% similar) in 303 aa overlap (4-303:2-295)
10 20 30 40 50
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
: .:::.::::::::.:::.:: ::.. ..: ::.::: . : ::: . :
XP_011 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
.: . :::: ...::: . .:.::::: :::.::.::::.:. :. .:.:.: :
XP_011 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
.::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
XP_011 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 IFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQD
. .::.: ::: : : :.:.. . . :: .:.: : . :: :...: ..:::..
XP_011 VHLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 VVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQ
:.. :.. ..: ... . : . . ::. : . .. : . .
XP_011 VAE--VSAGLDSRSGGGASSGAQRWPQLSSRRRRSSSPLCAPRSRPCATSPP-----SAS
240 250 260 270 280
300 310
pF1KB7 CLSCGCLPTRVRPR
: :::
XP_011 CPCCGCAWTTPAAPTTSPPCTGKCSATFRQRPRLGPRLGAGPGLGQRTRPGAVRWGTLSS
290 300 310 320 330 340
>>XP_011523031 (OMIM: 109684) PREDICTED: estradiol 17-be (384 aa)
initn: 616 init1: 364 opt: 644 Z-score: 806.7 bits: 157.7 E(85289): 3.4e-38
Smith-Waterman score: 644; 42.4% identity (67.8% similar) in 304 aa overlap (4-303:2-296)
10 20 30 40 50
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
: .:::.::::::::.:::.:: ::.. ..: ::.::: . : ::: . :
XP_011 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
.: . :::: ...::: . .:.::::: :::.::.::::.:. :. .:.:.: :
XP_011 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
.::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
XP_011 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 IF-ISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQ
. .::.: ::: : : :.:.. . . :: .:.: : . :: :...: ..:::.
XP_011 VHSLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 DVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGL
.:.. :.. ..: ... . : . . ::. : . .. : .
XP_011 EVAE--VSAGLDSRSGGGASSGAQRWPQLSSRRRRSSSPLCAPRSRPCATSPP-----SA
240 250 260 270 280
300 310
pF1KB7 QCLSCGCLPTRVRPR
.: :::
XP_011 SCPCCGCAWTTPAAPTTSPPCTGKCSATFRQRPRLGPRLGAGPGLGQRTRPGAVRWGTLS
290 300 310 320 330 340
>>XP_005257349 (OMIM: 109684) PREDICTED: estradiol 17-be (359 aa)
initn: 686 init1: 402 opt: 628 Z-score: 787.2 bits: 154.0 E(85289): 4.2e-37
Smith-Waterman score: 676; 42.3% identity (65.9% similar) in 317 aa overlap (4-286:2-316)
10 20 30
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
: .:::.::::::::.:::.:: ::.. ..
XP_005 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
10 20 30 40 50
40 50 60 70 80
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
: ::.::: . : ::: . : .: . :::: ...::: . .:.:::
XP_005 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
:: :::.::.::::.:. :. .:.:.: :.::...: :: :::: .:...: .:: ::
XP_005 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFP
.:. ::::: ::::::::. ::::. :: :.. .::.: ::: : : :.:.. . .
XP_005 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEV-LD
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB7 GTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTT
:: .:.: : . :: :...: ..:::..:........ . .: :: :. :. ::
XP_005 RTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLR
240 250 260 270 280 290
270 280 290 300 310
pF1KB7 LKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
.. : ::: :: . :: .:
XP_005 MRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPA
300 310 320 330 340 350
>>XP_006721922 (OMIM: 109684) PREDICTED: estradiol 17-be (360 aa)
initn: 654 init1: 364 opt: 616 Z-score: 772.1 bits: 151.2 E(85289): 2.9e-36
Smith-Waterman score: 664; 42.1% identity (65.7% similar) in 318 aa overlap (4-286:2-317)
10 20 30
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
: .:::.::::::::.:::.:: ::.. ..
XP_006 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
10 20 30 40 50
40 50 60 70 80
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
: ::.::: . : ::: . : .: . :::: ...::: . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
:: :::.::.::::.:. :. .:.:.: :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIF-ISLVEPGPVVTEFEGKLLAQVSMAEF
.:. ::::: ::::::::. ::::. :: :.. .::.: ::: : : :.:.. . .
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIECGPVHTAFMEKVLGSPEEV-L
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB7 PGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLT
:: .:.: : . :: :...: ..:::..:........ . .: :: :. :. ::
XP_006 DRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLL
240 250 260 270 280 290
270 280 290 300 310
pF1KB7 TLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
.. : ::: :: . :: .:
XP_006 RMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPP
300 310 320 330 340 350
>>XP_006721921 (OMIM: 109684) PREDICTED: estradiol 17-be (414 aa)
initn: 607 init1: 402 opt: 529 Z-score: 662.4 bits: 131.1 E(85289): 3.7e-30
Smith-Waterman score: 584; 38.6% identity (61.7% similar) in 334 aa overlap (4-303:2-326)
10 20 30
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
: .:::.::::::::.:::.:: ::.. ..
XP_006 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
10 20 30 40 50
40 50 60 70 80
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
: ::.::: . : ::: . : .: . :::: ...::: . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
:: :::.::.::::.:. :. .:.:.: :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFP
.:. ::::: ::::::::. ::::. :: :.. .::.: ::: : : :.:.. . .
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEV-LD
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB7 GTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTT
:: .:.: : . :: :...: ..:::..:.. :.. ..: ... . : .
XP_006 RTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAE--VSAGLDSRSGGGASSGAQRWPQLS
240 250 260 270 280 290
270 280 290 300 310
pF1KB7 LKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
. ::. : . .. : . .: :::
XP_006 SRRRRSSSPLCAPRSRPCATSPP-----SASCPCCGCAWTTPAAPTTSPPCTGKCSATFR
300 310 320 330 340
XP_006 QRPRLGPRLGAGPGLGQRTRPGAVRWGTLSSAILRPPRSKGFLSRCLPRPSLSPGSVWSL
350 360 370 380 390 400
>>XP_006721920 (OMIM: 109684) PREDICTED: estradiol 17-be (415 aa)
initn: 542 init1: 364 opt: 524 Z-score: 656.2 bits: 130.0 E(85289): 8.2e-30
Smith-Waterman score: 572; 38.5% identity (61.5% similar) in 335 aa overlap (4-303:2-327)
10 20 30
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
: .:::.::::::::.:::.:: ::.. ..
XP_006 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
10 20 30 40 50
40 50 60 70 80
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
: ::.::: . : ::: . : .: . :::: ...::: . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
60 70 80 90 100 110
90 100 110 120 130 140
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
:: :::.::.::::.:. :. .:.:.: :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
120 130 140 150 160 170
150 160 170 180 190 200
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIF-ISLVEPGPVVTEFEGKLLAQVSMAEF
.:. ::::: ::::::::. ::::. :: :.. .::.: ::: : : :.:.. . .
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIECGPVHTAFMEKVLGSPEEV-L
180 190 200 210 220 230
210 220 230 240 250 260
pF1KB7 PGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLT
:: .:.: : . :: :...: ..:::..:.. :.. ..: ... . :
XP_006 DRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAE--VSAGLDSRSGGGASSGAQRWPQL
240 250 260 270 280 290
270 280 290 300 310
pF1KB7 TLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
. . ::. : . .. : . .: :::
XP_006 SSRRRRSSSPLCAPRSRPCATSPP-----SASCPCCGCAWTTPAAPTTSPPCTGKCSATF
300 310 320 330 340
XP_006 RQRPRLGPRLGAGPGLGQRTRPGAVRWGTLSSAILRPPRSKGFLSRCLPRPSLSPGSVWS
350 360 370 380 390 400
>>NP_001317088 (OMIM: 616160) dehydrogenase/reductase SD (310 aa)
initn: 315 init1: 315 opt: 356 Z-score: 448.0 bits: 91.0 E(85289): 3.2e-18
Smith-Waterman score: 356; 33.6% identity (64.3% similar) in 244 aa overlap (8-241:40-275)
10 20 30
pF1KB7 MAAAPRTVLISGCSSGIGLELA-VQLAHDPKKRYQVV
:.:.: .::.: : : : : : .:
NP_001 LPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAK----LV
10 20 30 40 50 60
40 50 60 70 80
pF1KB7 ATMRDLGKKETL--EAAAGEALG-QTLT--VAQLDVCSDESV----AQCLSCIQGEVDVL
:. : : : : .:..: :: .. .:. .. .. :. :.:. : ::.:
NP_001 LCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCF-GYVDIL
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB7 VNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQ
:::::.. : . .. . . :..::.:: : :.::.::.: .:::::::.:::..: .
NP_001 VNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKM
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB7 GVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPG
.. : ..::::: : ..::. : .. :..: .... :: . :.. .. : .. . :
NP_001 SIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNL--SVNAITADGSRYG
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB7 TDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTL
. : :. . ... .. .::.. .::. :
NP_001 VMDTTTAQGRS-PVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRA
250 260 270 280 290 300
270 280 290 300 310
pF1KB7 KTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
NP_001 RKERKSKNS
310
311 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:11:12 2016 done: Fri Nov 4 06:11:13 2016
Total Scan time: 7.840 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]