Result of FASTA (omim) for
pFN21AB7094
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7094, 186 aa
1>>>pF1KB7094 186 - 186 aa - 186 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0366+/-0.000346; mu= 14.0394+/- 0.021
mean_var=60.8626+/-12.102, 0's: 0 Z-trim(113.5): 20 B-trim: 20 in 1/50
Lambda= 0.164399
statistics sampled from 22805 (22825) to 22805 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.268), width: 16
Scan time: 5.840
The best scores are: opt bits E(85289)
XP_011525982 (OMIM: 615869) PREDICTED: tumor necro ( 186) 1202 293.3 1.5e-79
XP_005259544 (OMIM: 615869) PREDICTED: tumor necro ( 186) 1202 293.3 1.5e-79
NP_689575 (OMIM: 615869) tumor necrosis factor alp ( 186) 1202 293.3 1.5e-79
NP_001161414 (OMIM: 615869) tumor necrosis factor ( 186) 1202 293.3 1.5e-79
NP_001071122 (OMIM: 612111) tumor necrosis factor ( 188) 754 187.1 1.4e-47
NP_001273742 (OMIM: 612111) tumor necrosis factor ( 198) 754 187.1 1.5e-47
NP_055165 (OMIM: 612111) tumor necrosis factor alp ( 198) 754 187.1 1.5e-47
XP_016864816 (OMIM: 612111) PREDICTED: tumor necro ( 201) 754 187.1 1.5e-47
NP_001273743 (OMIM: 612111) tumor necrosis factor ( 210) 754 187.1 1.6e-47
XP_016877657 (OMIM: 616438) PREDICTED: tumor necro ( 203) 694 172.9 3e-43
NP_001298104 (OMIM: 616438) tumor necrosis factor ( 204) 694 172.9 3e-43
XP_011519847 (OMIM: 616438) PREDICTED: tumor necro ( 218) 694 172.9 3.1e-43
NP_997264 (OMIM: 616438) tumor necrosis factor alp ( 292) 694 173.0 4e-43
NP_078851 (OMIM: 612112) tumor necrosis factor alp ( 184) 678 169.0 3.8e-42
NP_001273746 (OMIM: 612111) tumor necrosis factor ( 166) 673 167.8 7.9e-42
NP_001273744 (OMIM: 612111) tumor necrosis factor ( 166) 673 167.8 7.9e-42
XP_016864817 (OMIM: 612111) PREDICTED: tumor necro ( 166) 673 167.8 7.9e-42
XP_016877658 (OMIM: 616438) PREDICTED: tumor necro ( 158) 574 144.3 8.9e-35
>>XP_011525982 (OMIM: 615869) PREDICTED: tumor necrosis (186 aa)
initn: 1202 init1: 1202 opt: 1202 Z-score: 1549.3 bits: 293.3 E(85289): 1.5e-79
Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186)
10 20 30 40 50 60
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
pF1KB7 LDEGSL
::::::
XP_011 LDEGSL
>>XP_005259544 (OMIM: 615869) PREDICTED: tumor necrosis (186 aa)
initn: 1202 init1: 1202 opt: 1202 Z-score: 1549.3 bits: 293.3 E(85289): 1.5e-79
Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186)
10 20 30 40 50 60
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
pF1KB7 LDEGSL
::::::
XP_005 LDEGSL
>>NP_689575 (OMIM: 615869) tumor necrosis factor alpha-i (186 aa)
initn: 1202 init1: 1202 opt: 1202 Z-score: 1549.3 bits: 293.3 E(85289): 1.5e-79
Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186)
10 20 30 40 50 60
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
pF1KB7 LDEGSL
::::::
NP_689 LDEGSL
>>NP_001161414 (OMIM: 615869) tumor necrosis factor alph (186 aa)
initn: 1202 init1: 1202 opt: 1202 Z-score: 1549.3 bits: 293.3 E(85289): 1.5e-79
Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186)
10 20 30 40 50 60
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
pF1KB7 LDEGSL
::::::
NP_001 LDEGSL
>>NP_001071122 (OMIM: 612111) tumor necrosis factor alph (188 aa)
initn: 754 init1: 754 opt: 754 Z-score: 975.0 bits: 187.1 E(85289): 1.4e-47
Smith-Waterman score: 754; 57.7% identity (91.8% similar) in 182 aa overlap (2-183:4-185)
10 20 30 40 50
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQK
:.:..:.::.:::::.:.::.::.....:.:::::::::::::.:::.:...:::.:
NP_001 MATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 MLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAA
..:::.:...::..: :..:.. .::::...:..... ::::.:::::::.:::: ::.
NP_001 IIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 GLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLG
: :::..::: . :::::::::.:.:: :..::.::::::.: .. ::...:.:..
NP_001 LLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGIN
130 140 150 160 170 180
180
pF1KB7 RMLDEGSL
.::::
NP_001 KMLDEENI
>>NP_001273742 (OMIM: 612111) tumor necrosis factor alph (198 aa)
initn: 754 init1: 754 opt: 754 Z-score: 974.6 bits: 187.1 E(85289): 1.5e-47
Smith-Waterman score: 754; 57.7% identity (91.8% similar) in 182 aa overlap (2-183:14-195)
10 20 30 40
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATRE
:.:..:.::.:::::.:.::.::.....:.:::::::::::::.:::
NP_001 MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 FTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVD
.:...:::.:..:::.:...::..: :..:.. .::::...:..... ::::.:::::::
NP_001 YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 FTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRS
.:::: ::. : :::..::: . :::::::::.:.:: :..::.::::::.: ..
NP_001 YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
130 140 150 160 170 180
170 180
pF1KB7 HLRRICEGLGRMLDEGSL
::...:.:...::::
NP_001 HLQKLCDGINKMLDEENI
190
>>NP_055165 (OMIM: 612111) tumor necrosis factor alpha-i (198 aa)
initn: 754 init1: 754 opt: 754 Z-score: 974.6 bits: 187.1 E(85289): 1.5e-47
Smith-Waterman score: 754; 57.7% identity (91.8% similar) in 182 aa overlap (2-183:14-195)
10 20 30 40
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATRE
:.:..:.::.:::::.:.::.::.....:.:::::::::::::.:::
NP_055 MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 FTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVD
.:...:::.:..:::.:...::..: :..:.. .::::...:..... ::::.:::::::
NP_055 YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 FTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRS
.:::: ::. : :::..::: . :::::::::.:.:: :..::.::::::.: ..
NP_055 YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
130 140 150 160 170 180
170 180
pF1KB7 HLRRICEGLGRMLDEGSL
::...:.:...::::
NP_055 HLQKLCDGINKMLDEENI
190
>>XP_016864816 (OMIM: 612111) PREDICTED: tumor necrosis (201 aa)
initn: 754 init1: 754 opt: 754 Z-score: 974.5 bits: 187.1 E(85289): 1.5e-47
Smith-Waterman score: 754; 57.7% identity (91.8% similar) in 182 aa overlap (2-183:17-198)
10 20 30 40
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRA
:.:..:.::.:::::.:.::.::.....:.:::::::::::::.
XP_016 MAKGGDTETEREGVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 TREFTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFH
:::.:...:::.:..:::.:...::..: :..:.. .::::...:..... ::::.::::
XP_016 TREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFH
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 QVDFTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEP
:::.:::: ::. : :::..::: . :::::::::.:.:: :..::.::::::.:
XP_016 QVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGN
130 140 150 160 170 180
170 180
pF1KB7 YRSHLRRICEGLGRMLDEGSL
.. ::...:.:...::::
XP_016 FKPHLQKLCDGINKMLDEENI
190 200
>>NP_001273743 (OMIM: 612111) tumor necrosis factor alph (210 aa)
initn: 754 init1: 754 opt: 754 Z-score: 974.2 bits: 187.1 E(85289): 1.6e-47
Smith-Waterman score: 754; 57.7% identity (91.8% similar) in 182 aa overlap (2-183:26-207)
10 20 30
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSS
:.:..:.::.:::::.:.::.::.....:.:::::
NP_001 MTLPRYCEVVLLIAHGEKMLKLVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSS
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB7 EVLDELYRATREFTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARC
::::::::.:::.:...:::.:..:::.:...::..: :..:.. .::::...:.....
NP_001 EVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQ
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 LAMTAVSFHQVDFTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFL
::::.:::::::.:::: ::. : :::..::: . :::::::::.:.:: :..::.::
NP_001 LAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFL
130 140 150 160 170 180
160 170 180
pF1KB7 AALYGPAEPYRSHLRRICEGLGRMLDEGSL
::::.: .. ::...:.:...::::
NP_001 AALYNPFGNFKPHLQKLCDGINKMLDEENI
190 200 210
>>XP_016877657 (OMIM: 616438) PREDICTED: tumor necrosis (203 aa)
initn: 686 init1: 686 opt: 694 Z-score: 897.6 bits: 172.9 E(85289): 3e-43
Smith-Waterman score: 694; 55.1% identity (85.9% similar) in 185 aa overlap (2-186:19-203)
10 20 30 40
pF1KB7 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELY
:.::.::::::::::.:::.:::.:. .:.::::::..::::
XP_016 MIHPPVASQVSASVSSGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDELY
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 RATREFTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVS
..:.: :...:::.:..:.:.:::.:.:.: :..:.. :::.....::.. ::: ::
XP_016 KVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 FHQVDFTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPA
:..:..:::: ::. : ::.::.:. : ::: ..::::::::.:.:: .::..::.
XP_016 FYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLD
130 140 150 160 170 180
170 180
pF1KB7 EPYRSHLRRICEGLGRMLDEGSL
: .:.:::::....::: :
XP_016 GDCRPNLKRICEGINKLLDEKVL
190 200
186 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 04:39:28 2016 done: Fri Nov 4 04:39:29 2016
Total Scan time: 5.840 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]