Result of FASTA (omim) for
pFN21AA1534
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1534, 811 aa
1>>>pF1KA1534 811 - 811 aa - 811 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8455+/-0.000315; mu= 9.7183+/- 0.020
mean_var=145.2781+/-29.087, 0's: 0 Z-trim(120.5): 146 B-trim: 0 in 0/55
Lambda= 0.106408
statistics sampled from 35590 (35741) to 35590 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.419), width: 16
Scan time: 14.950
The best scores are: opt bits E(85289)
NP_001137535 (OMIM: 606733) oxysterol-binding prot ( 811) 5485 853.9 0
NP_663613 (OMIM: 606733) oxysterol-binding protein ( 811) 5485 853.9 0
XP_016872652 (OMIM: 606733) PREDICTED: oxysterol-b ( 879) 4599 717.9 4.8e-206
XP_011518175 (OMIM: 606733) PREDICTED: oxysterol-b ( 879) 4599 717.9 4.8e-206
NP_065947 (OMIM: 606733) oxysterol-binding protein ( 879) 4599 717.9 4.8e-206
XP_016872653 (OMIM: 606733) PREDICTED: oxysterol-b ( 509) 3476 545.4 2.4e-154
NP_001003712 (OMIM: 606736) oxysterol-binding prot ( 847) 2055 327.3 1.7e-88
NP_001306581 (OMIM: 606736) oxysterol-binding prot ( 847) 2055 327.3 1.7e-88
XP_006719287 (OMIM: 606736) PREDICTED: oxysterol-b ( 847) 2055 327.3 1.7e-88
NP_001306584 (OMIM: 606736) oxysterol-binding prot ( 864) 2055 327.3 1.7e-88
NP_001306582 (OMIM: 606736) oxysterol-binding prot ( 886) 2055 327.3 1.8e-88
XP_016874258 (OMIM: 606736) PREDICTED: oxysterol-b ( 886) 2055 327.3 1.8e-88
NP_065892 (OMIM: 606736) oxysterol-binding protein ( 889) 2055 327.3 1.8e-88
XP_005268678 (OMIM: 606736) PREDICTED: oxysterol-b ( 889) 2055 327.3 1.8e-88
XP_011536157 (OMIM: 606736) PREDICTED: oxysterol-b ( 899) 2055 327.4 1.8e-88
XP_011536159 (OMIM: 606736) PREDICTED: oxysterol-b ( 902) 2055 327.4 1.8e-88
XP_011536158 (OMIM: 606736) PREDICTED: oxysterol-b ( 902) 2055 327.4 1.8e-88
XP_016874257 (OMIM: 606736) PREDICTED: oxysterol-b ( 912) 2055 327.4 1.8e-88
XP_016861158 (OMIM: 606738) PREDICTED: oxysterol-b ( 596) 541 94.8 1.2e-18
XP_011531628 (OMIM: 606738) PREDICTED: oxysterol-b ( 632) 541 94.8 1.2e-18
XP_016861156 (OMIM: 606738) PREDICTED: oxysterol-b ( 632) 541 94.8 1.2e-18
XP_016861157 (OMIM: 606738) PREDICTED: oxysterol-b ( 632) 541 94.8 1.2e-18
NP_060254 (OMIM: 606738) oxysterol-binding protein ( 764) 541 94.9 1.4e-18
XP_005264900 (OMIM: 606738) PREDICTED: oxysterol-b ( 769) 541 94.9 1.4e-18
XP_016861159 (OMIM: 606738) PREDICTED: oxysterol-b ( 551) 528 92.8 4.4e-18
NP_001167531 (OMIM: 606738) oxysterol-binding prot ( 700) 528 92.9 5.3e-18
XP_005264901 (OMIM: 606738) PREDICTED: oxysterol-b ( 705) 528 92.9 5.4e-18
XP_005264902 (OMIM: 606738) PREDICTED: oxysterol-b ( 428) 510 90.0 2.4e-17
NP_073613 (OMIM: 606739) oxysterol-binding protein ( 747) 511 90.3 3.4e-17
XP_016881022 (OMIM: 606730) PREDICTED: oxysterol-b ( 437) 434 78.3 7.9e-14
NP_060500 (OMIM: 606730) oxysterol-binding protein ( 437) 434 78.3 7.9e-14
XP_016881023 (OMIM: 606730) PREDICTED: oxysterol-b ( 437) 434 78.3 7.9e-14
NP_001229437 (OMIM: 606730) oxysterol-binding prot ( 568) 434 78.4 9.9e-14
XP_006722443 (OMIM: 606730) PREDICTED: oxysterol-b ( 925) 434 78.5 1.5e-13
NP_542164 (OMIM: 606730) oxysterol-binding protein ( 950) 434 78.5 1.5e-13
XP_016881019 (OMIM: 606730) PREDICTED: oxysterol-b ( 968) 434 78.5 1.5e-13
XP_016883657 (OMIM: 606731,616340) PREDICTED: oxys ( 370) 424 76.8 2e-13
NP_653081 (OMIM: 606731,616340) oxysterol-binding ( 480) 424 76.8 2.5e-13
XP_016883654 (OMIM: 606731,616340) PREDICTED: oxys ( 480) 424 76.8 2.5e-13
XP_016883653 (OMIM: 606731,616340) PREDICTED: oxys ( 516) 424 76.8 2.6e-13
XP_016883652 (OMIM: 606731,616340) PREDICTED: oxys ( 516) 424 76.8 2.6e-13
NP_055650 (OMIM: 606731,616340) oxysterol-binding ( 468) 421 76.4 3.4e-13
XP_016858762 (OMIM: 606734) PREDICTED: oxysterol-b ( 872) 416 75.7 9.6e-13
NP_001188410 (OMIM: 606734) oxysterol-binding prot ( 903) 416 75.7 9.9e-13
XP_016858759 (OMIM: 606734) PREDICTED: oxysterol-b ( 903) 416 75.7 9.9e-13
XP_011508841 (OMIM: 606734) PREDICTED: oxysterol-b ( 928) 416 75.7 1e-12
NP_115912 (OMIM: 606734) oxysterol-binding protein ( 934) 416 75.8 1e-12
NP_665682 (OMIM: 606734) oxysterol-binding protein ( 938) 416 75.8 1e-12
NP_001188409 (OMIM: 606734) oxysterol-binding prot ( 959) 416 75.8 1e-12
XP_016858756 (OMIM: 606734) PREDICTED: oxysterol-b ( 959) 416 75.8 1e-12
>>NP_001137535 (OMIM: 606733) oxysterol-binding protein- (811 aa)
initn: 5485 init1: 5485 opt: 5485 Z-score: 4555.8 bits: 853.9 E(85289): 0
Smith-Waterman score: 5485; 100.0% identity (100.0% similar) in 811 aa overlap (1-811:1-811)
10 20 30 40 50 60
pF1KA1 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LTDPSVVIMADSLKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTDPSVVIMADSLKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 RLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSEREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSEREN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 PEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 SLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 IKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPEL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 SDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQ
730 740 750 760 770 780
790 800 810
pF1KA1 APTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::
NP_001 APTPGLLQSPRSWFLLCVFLACQLFINHILK
790 800 810
>>NP_663613 (OMIM: 606733) oxysterol-binding protein-rel (811 aa)
initn: 5485 init1: 5485 opt: 5485 Z-score: 4555.8 bits: 853.9 E(85289): 0
Smith-Waterman score: 5485; 100.0% identity (100.0% similar) in 811 aa overlap (1-811:1-811)
10 20 30 40 50 60
pF1KA1 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LTDPSVVIMADSLKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 LTDPSVVIMADSLKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 RLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSEREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 RLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSEREN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 PEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 PEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 SLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 SLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 VLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 NRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 NRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 LELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 LELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 IKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 IKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 EKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 ILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPEL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 SDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_663 SDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQ
730 740 750 760 770 780
790 800 810
pF1KA1 APTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::
NP_663 APTPGLLQSPRSWFLLCVFLACQLFINHILK
790 800 810
>>XP_016872652 (OMIM: 606733) PREDICTED: oxysterol-bindi (879 aa)
initn: 4599 init1: 4599 opt: 4599 Z-score: 3820.2 bits: 717.9 E(85289): 4.8e-206
Smith-Waterman score: 5098; 91.9% identity (91.9% similar) in 843 aa overlap (37-811:37-879)
10 20 30 40 50 60
pF1KA1 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
::::::::::::::::::::::::::::::
XP_016 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
70 80 90 100 110 120
130
pF1KA1 VIMADSLK----------------------------------------------------
::::::::
XP_016 VIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGF
130 140 150 160 170 180
140 150 160 170
pF1KA1 ----------------GPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
190 200 210 220 230 240
180 190 200 210 220 230
pF1KA1 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
250 260 270 280 290 300
240 250 260 270 280 290
pF1KA1 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
310 320 330 340 350 360
300 310 320 330 340 350
pF1KA1 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
370 380 390 400 410 420
360 370 380 390 400 410
pF1KA1 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
430 440 450 460 470 480
420 430 440 450 460 470
pF1KA1 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
490 500 510 520 530 540
480 490 500 510 520 530
pF1KA1 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
550 560 570 580 590 600
540 550 560 570 580 590
pF1KA1 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
610 620 630 640 650 660
600 610 620 630 640 650
pF1KA1 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
670 680 690 700 710 720
660 670 680 690 700 710
pF1KA1 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
730 740 750 760 770 780
720 730 740 750 760 770
pF1KA1 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
790 800 810 820 830 840
780 790 800 810
pF1KA1 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::::
XP_016 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
850 860 870
>--
initn: 241 init1: 241 opt: 241 Z-score: 204.5 bits: 48.9 E(85289): 0.00012
Smith-Waterman score: 241; 100.0% identity (100.0% similar) in 36 aa overlap (1-36:1-36)
10 20 30 40 50 60
pF1KA1 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
::::::::::::::::::::::::::::::::::::
XP_016 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
XP_016 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
70 80 90 100 110 120
>>XP_011518175 (OMIM: 606733) PREDICTED: oxysterol-bindi (879 aa)
initn: 4599 init1: 4599 opt: 4599 Z-score: 3820.2 bits: 717.9 E(85289): 4.8e-206
Smith-Waterman score: 5098; 91.9% identity (91.9% similar) in 843 aa overlap (37-811:37-879)
10 20 30 40 50 60
pF1KA1 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
::::::::::::::::::::::::::::::
XP_011 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
70 80 90 100 110 120
130
pF1KA1 VIMADSLK----------------------------------------------------
::::::::
XP_011 VIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGF
130 140 150 160 170 180
140 150 160 170
pF1KA1 ----------------GPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
190 200 210 220 230 240
180 190 200 210 220 230
pF1KA1 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
250 260 270 280 290 300
240 250 260 270 280 290
pF1KA1 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
310 320 330 340 350 360
300 310 320 330 340 350
pF1KA1 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
370 380 390 400 410 420
360 370 380 390 400 410
pF1KA1 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
430 440 450 460 470 480
420 430 440 450 460 470
pF1KA1 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
490 500 510 520 530 540
480 490 500 510 520 530
pF1KA1 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
550 560 570 580 590 600
540 550 560 570 580 590
pF1KA1 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
610 620 630 640 650 660
600 610 620 630 640 650
pF1KA1 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
670 680 690 700 710 720
660 670 680 690 700 710
pF1KA1 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
730 740 750 760 770 780
720 730 740 750 760 770
pF1KA1 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
790 800 810 820 830 840
780 790 800 810
pF1KA1 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::::
XP_011 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
850 860 870
>--
initn: 241 init1: 241 opt: 241 Z-score: 204.5 bits: 48.9 E(85289): 0.00012
Smith-Waterman score: 241; 100.0% identity (100.0% similar) in 36 aa overlap (1-36:1-36)
10 20 30 40 50 60
pF1KA1 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
::::::::::::::::::::::::::::::::::::
XP_011 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
XP_011 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
70 80 90 100 110 120
>>NP_065947 (OMIM: 606733) oxysterol-binding protein-rel (879 aa)
initn: 4599 init1: 4599 opt: 4599 Z-score: 3820.2 bits: 717.9 E(85289): 4.8e-206
Smith-Waterman score: 5098; 91.9% identity (91.9% similar) in 843 aa overlap (37-811:37-879)
10 20 30 40 50 60
pF1KA1 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
::::::::::::::::::::::::::::::
NP_065 LRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSV
70 80 90 100 110 120
130
pF1KA1 VIMADSLK----------------------------------------------------
::::::::
NP_065 VIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGF
130 140 150 160 170 180
140 150 160 170
pF1KA1 ----------------GPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
::::::::::::::::::::::::::::::::::::::::::::
NP_065 CFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSS
190 200 210 220 230 240
180 190 200 210 220 230
pF1KA1 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSER
250 260 270 280 290 300
240 250 260 270 280 290
pF1KA1 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEE
310 320 330 340 350 360
300 310 320 330 340 350
pF1KA1 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRM
370 380 390 400 410 420
360 370 380 390 400 410
pF1KA1 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFH
430 440 450 460 470 480
420 430 440 450 460 470
pF1KA1 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGT
490 500 510 520 530 540
480 490 500 510 520 530
pF1KA1 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRD
550 560 570 580 590 600
540 550 560 570 580 590
pF1KA1 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRA
610 620 630 640 650 660
600 610 620 630 640 650
pF1KA1 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQ
670 680 690 700 710 720
660 670 680 690 700 710
pF1KA1 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCP
730 740 750 760 770 780
720 730 740 750 760 770
pF1KA1 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARA
790 800 810 820 830 840
780 790 800 810
pF1KA1 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::::
NP_065 AQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
850 860 870
>--
initn: 241 init1: 241 opt: 241 Z-score: 204.5 bits: 48.9 E(85289): 0.00012
Smith-Waterman score: 241; 100.0% identity (100.0% similar) in 36 aa overlap (1-36:1-36)
10 20 30 40 50 60
pF1KA1 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
::::::::::::::::::::::::::::::::::::
NP_065 MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
NP_065 GPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSA
70 80 90 100 110 120
>>XP_016872653 (OMIM: 606733) PREDICTED: oxysterol-bindi (509 aa)
initn: 3476 init1: 3476 opt: 3476 Z-score: 2892.0 bits: 545.4 E(85289): 2.4e-154
Smith-Waterman score: 3476; 100.0% identity (100.0% similar) in 509 aa overlap (303-811:1-509)
280 290 300 310 320 330
pF1KA1 TTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFL
::::::::::::::::::::::::::::::
XP_016 MWTLLKQLRPGMDLSRVVLPTFVLEPRSFL
10 20 30
340 350 360 370 380 390
pF1KA1 NKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCW
40 50 60 70 80 90
400 410 420 430 440 450
pF1KA1 FHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKAT
100 110 120 130 140 150
460 470 480 490 500 510
pF1KA1 LTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGST
160 170 180 190 200 210
520 530 540 550 560 570
pF1KA1 SINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLE
220 230 240 250 260 270
580 590 600 610 620 630
pF1KA1 EQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDP
280 290 300 310 320 330
640 650 660 670 680 690
pF1KA1 ITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQR
340 350 360 370 380 390
700 710 720 730 740 750
pF1KA1 LRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHE
400 410 420 430 440 450
760 770 780 790 800 810
pF1KA1 AILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
460 470 480 490 500
>>NP_001003712 (OMIM: 606736) oxysterol-binding protein- (847 aa)
initn: 2265 init1: 1944 opt: 2055 Z-score: 1709.8 bits: 327.3 E(85289): 1.7e-88
Smith-Waterman score: 2511; 50.0% identity (72.5% similar) in 822 aa overlap (74-811:55-847)
50 60 70 80 90 100
pF1KA1 SPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQK
.: .: :::.:. : ....::::.::.::
NP_001 ASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDS-STSSKLTKKESLKVQK
30 40 50 60 70 80
110 120 130
pF1KA1 ENYRQEKKRATRQLLSALTDPSVVIMAD--------------------------------
.:::.::::::..:::..:::::..:::
NP_001 KNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNG
90 100 110 120 130 140
140 150
pF1KA1 ------------------------------------SLKGPKGESVGSITQPLPSSYLIF
..::::::.::::::::::::::.
NP_001 QWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLII
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 RAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHP
::.::::::::.:::::::.:::::. . :.. . ..: :.. .. :: . ..:
NP_001 RATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHS
210 220 230 240 250 260
220 230 240 250 260
pF1KA1 DQDLFPLNGSSLE------NDAFSDKSERENPEESD-TETQDHSRKTESGSDQSET----
: : :: : .: .: .::::..:: .: : .... ... :: .: ::
NP_001 G-DNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDS
270 280 290 300 310 320
270 280 290 300 310
pF1KA1 -----PGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV
: :... :::.:: .::::: :::::.::::::::::.::::::.:::::::.:
NP_001 YIEPEPVEPLKE-TTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKV
330 340 350 360 370 380
320 330 340 350 360 370
pF1KA1 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKP
:::::.:::::::.::::::::::.::.::.::. : :.: :..::::::::::::.:::
NP_001 VLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKP
390 400 410 420 430 440
380 390 400 410 420 430
pF1KA1 YNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFY
::::::::::: :.::.:.:.:::::::::::::.:::.:::::::::.:::: :::.::
NP_001 YNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFY
450 460 470 480 490 500
440 450 460 470 480 490
pF1KA1 GNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQ
::::::.:.:.: ::::::.:::..::::::::::::::::::::: :.: : :....:
NP_001 GNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAI
510 520 530 540 550 560
500 510 520 530 540 550
pF1KA1 LEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEV
::::::::.:.: .::::::. :.::::.: :::: .::: .. . .: .::.:. ..
NP_001 LEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDI
570 580 590 600 610 620
560 570 580 590 600 610
pF1KA1 RRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQES
.. :: .::: .::: ..:::.:::.:::::. :: .:::::..::::::: ::.:. .
NP_001 KQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTK
630 640 650 660 670 680
620 630 640 650 660 670
pF1KA1 LMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGS
:. .::.:::.: ::::.. : :::::.:. :::.::...: : ..: ...
NP_001 NEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQT----KVKHRTPMVSV
690 700 710 720 730
680 690 700 710 720 730
pF1KA1 PGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPR
: .:. . .... :. ..: : .:::: .: .: :
NP_001 PKMKHKPTRQQKKVAKGYSSPEPDIQ--DSSGSEAQSV-----------------KPSTR
740 750 760 770
740 750 760 770 780 790
pF1KA1 CRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVF
::.. .: .. .: ::...:.:..:.. :. . . .. : : .::. ...:.. ..
NP_001 -RKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPA-TDYFLQQ-KDYFIIFLL
780 790 800 810 820 830
800 810
pF1KA1 LACQLFINHILK
. :..:: ..:
NP_001 ILLQVIINFMFK
840
>>NP_001306581 (OMIM: 606736) oxysterol-binding protein- (847 aa)
initn: 2265 init1: 1944 opt: 2055 Z-score: 1709.8 bits: 327.3 E(85289): 1.7e-88
Smith-Waterman score: 2511; 50.0% identity (72.5% similar) in 822 aa overlap (74-811:55-847)
50 60 70 80 90 100
pF1KA1 SPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQK
.: .: :::.:. : ....::::.::.::
NP_001 ASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDS-STSSKLTKKESLKVQK
30 40 50 60 70 80
110 120 130
pF1KA1 ENYRQEKKRATRQLLSALTDPSVVIMAD--------------------------------
.:::.::::::..:::..:::::..:::
NP_001 KNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNG
90 100 110 120 130 140
140 150
pF1KA1 ------------------------------------SLKGPKGESVGSITQPLPSSYLIF
..::::::.::::::::::::::.
NP_001 QWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLII
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 RAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHP
::.::::::::.:::::::.:::::. . :.. . ..: :.. .. :: . ..:
NP_001 RATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHS
210 220 230 240 250 260
220 230 240 250 260
pF1KA1 DQDLFPLNGSSLE------NDAFSDKSERENPEESD-TETQDHSRKTESGSDQSET----
: : :: : .: .: .::::..:: .: : .... ... :: .: ::
NP_001 G-DNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDS
270 280 290 300 310 320
270 280 290 300 310
pF1KA1 -----PGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV
: :... :::.:: .::::: :::::.::::::::::.::::::.:::::::.:
NP_001 YIEPEPVEPLKE-TTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKV
330 340 350 360 370 380
320 330 340 350 360 370
pF1KA1 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKP
:::::.:::::::.::::::::::.::.::.::. : :.: :..::::::::::::.:::
NP_001 VLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKP
390 400 410 420 430 440
380 390 400 410 420 430
pF1KA1 YNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFY
::::::::::: :.::.:.:.:::::::::::::.:::.:::::::::.:::: :::.::
NP_001 YNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFY
450 460 470 480 490 500
440 450 460 470 480 490
pF1KA1 GNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQ
::::::.:.:.: ::::::.:::..::::::::::::::::::::: :.: : :....:
NP_001 GNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAI
510 520 530 540 550 560
500 510 520 530 540 550
pF1KA1 LEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEV
::::::::.:.: .::::::. :.::::.: :::: .::: .. . .: .::.:. ..
NP_001 LEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDI
570 580 590 600 610 620
560 570 580 590 600 610
pF1KA1 RRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQES
.. :: .::: .::: ..:::.:::.:::::. :: .:::::..::::::: ::.:. .
NP_001 KQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTK
630 640 650 660 670 680
620 630 640 650 660 670
pF1KA1 LMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGS
:. .::.:::.: ::::.. : :::::.:. :::.::...: : ..: ...
NP_001 NEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQT----KVKHRTPMVSV
690 700 710 720 730
680 690 700 710 720 730
pF1KA1 PGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPR
: .:. . .... :. ..: : .:::: .: .: :
NP_001 PKMKHKPTRQQKKVAKGYSSPEPDIQ--DSSGSEAQSV-----------------KPSTR
740 750 760 770
740 750 760 770 780 790
pF1KA1 CRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVF
::.. .: .. .: ::...:.:..:.. :. . . .. : : .::. ...:.. ..
NP_001 -RKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPA-TDYFLQQ-KDYFIIFLL
780 790 800 810 820 830
800 810
pF1KA1 LACQLFINHILK
. :..:: ..:
NP_001 ILLQVIINFMFK
840
>>XP_006719287 (OMIM: 606736) PREDICTED: oxysterol-bindi (847 aa)
initn: 2265 init1: 1944 opt: 2055 Z-score: 1709.8 bits: 327.3 E(85289): 1.7e-88
Smith-Waterman score: 2511; 50.0% identity (72.5% similar) in 822 aa overlap (74-811:55-847)
50 60 70 80 90 100
pF1KA1 SPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQK
.: .: :::.:. : ....::::.::.::
XP_006 ASPHSQGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDS-STSSKLTKKESLKVQK
30 40 50 60 70 80
110 120 130
pF1KA1 ENYRQEKKRATRQLLSALTDPSVVIMAD--------------------------------
.:::.::::::..:::..:::::..:::
XP_006 KNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNG
90 100 110 120 130 140
140 150
pF1KA1 ------------------------------------SLKGPKGESVGSITQPLPSSYLIF
..::::::.::::::::::::::.
XP_006 QWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLII
150 160 170 180 190 200
160 170 180 190 200 210
pF1KA1 RAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHP
::.::::::::.:::::::.:::::. . :.. . ..: :.. .. :: . ..:
XP_006 RATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHS
210 220 230 240 250 260
220 230 240 250 260
pF1KA1 DQDLFPLNGSSLE------NDAFSDKSERENPEESD-TETQDHSRKTESGSDQSET----
: : :: : .: .: .::::..:: .: : .... ... :: .: ::
XP_006 G-DNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDS
270 280 290 300 310 320
270 280 290 300 310
pF1KA1 -----PGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV
: :... :::.:: .::::: :::::.::::::::::.::::::.:::::::.:
XP_006 YIEPEPVEPLKE-TTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKV
330 340 350 360 370 380
320 330 340 350 360 370
pF1KA1 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKP
:::::.:::::::.::::::::::.::.::.::. : :.: :..::::::::::::.:::
XP_006 VLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKP
390 400 410 420 430 440
380 390 400 410 420 430
pF1KA1 YNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFY
::::::::::: :.::.:.:.:::::::::::::.:::.:::::::::.:::: :::.::
XP_006 YNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFY
450 460 470 480 490 500
440 450 460 470 480 490
pF1KA1 GNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQ
::::::.:.:.: ::::::.:::..::::::::::::::::::::: :.: : :....:
XP_006 GNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAI
510 520 530 540 550 560
500 510 520 530 540 550
pF1KA1 LEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEV
::::::::.:.: .::::::. :.::::.: :::: .::: .. . .: .::.:. ..
XP_006 LEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDI
570 580 590 600 610 620
560 570 580 590 600 610
pF1KA1 RRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQES
.. :: .::: .::: ..:::.:::.:::::. :: .:::::..::::::: ::.:. .
XP_006 KQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTK
630 640 650 660 670 680
620 630 640 650 660 670
pF1KA1 LMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGS
:. .::.:::.: ::::.. : :::::.:. :::.::...: : ..: ...
XP_006 NEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQT----KVKHRTPMVSV
690 700 710 720 730
680 690 700 710 720 730
pF1KA1 PGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPR
: .:. . .... :. ..: : .:::: .: .: :
XP_006 PKMKHKPTRQQKKVAKGYSSPEPDIQ--DSSGSEAQSV-----------------KPSTR
740 750 760 770
740 750 760 770 780 790
pF1KA1 CRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVF
::.. .: .. .: ::...:.:..:.. :. . . .. : : .::. ...:.. ..
XP_006 -RKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPA-TDYFLQQ-KDYFIIFLL
780 790 800 810 820 830
800 810
pF1KA1 LACQLFINHILK
. :..:: ..:
XP_006 ILLQVIINFMFK
840
>>NP_001306584 (OMIM: 606736) oxysterol-binding protein- (864 aa)
initn: 2350 init1: 1944 opt: 2055 Z-score: 1709.7 bits: 327.3 E(85289): 1.7e-88
Smith-Waterman score: 2511; 50.0% identity (72.5% similar) in 822 aa overlap (74-811:72-864)
50 60 70 80 90 100
pF1KA1 SPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQK
.: .: :::.:. : ....::::.::.::
NP_001 LSPSLPGFERGKEDISQNKDESSLSMSKSKSESKLYNGSEKDS-STSSKLTKKESLKVQK
50 60 70 80 90 100
110 120 130
pF1KA1 ENYRQEKKRATRQLLSALTDPSVVIMAD--------------------------------
.:::.::::::..:::..:::::..:::
NP_001 KNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQKNG
110 120 130 140 150 160
140 150
pF1KA1 ------------------------------------SLKGPKGESVGSITQPLPSSYLIF
..::::::.::::::::::::::.
NP_001 QWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLII
170 180 190 200 210 220
160 170 180 190 200 210
pF1KA1 RAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHP
::.::::::::.:::::::.:::::. . :.. . ..: :.. .. :: . ..:
NP_001 RATSESDGRCWMDALELALKCSSLLKRTMIREGKEHDLSVSSDSTHVTFYGLLRANNLHS
230 240 250 260 270 280
220 230 240 250 260
pF1KA1 DQDLFPLNGSSLE------NDAFSDKSERENPEESD-TETQDHSRKTESGSDQSET----
: : :: : .: .: .::::..:: .: : .... ... :: .: ::
NP_001 G-DNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNEVMGKSEESDTDTSERQDDS
290 300 310 320 330
270 280 290 300 310
pF1KA1 -----PGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV
: :... :::.:: .::::: :::::.::::::::::.::::::.:::::::.:
NP_001 YIEPEPVEPLKE-TTYTEQSHEELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKV
340 350 360 370 380 390
320 330 340 350 360 370
pF1KA1 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKP
:::::.:::::::.::::::::::.::.::.::. : :.: :..::::::::::::.:::
NP_001 VLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKP
400 410 420 430 440 450
380 390 400 410 420 430
pF1KA1 YNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFY
::::::::::: :.::.:.:.:::::::::::::.:::.:::::::::.:::: :::.::
NP_001 YNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFY
460 470 480 490 500 510
440 450 460 470 480 490
pF1KA1 GNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQ
::::::.:.:.: ::::::.:::..::::::::::::::::::::: :.: : :....:
NP_001 GNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAI
520 530 540 550 560 570
500 510 520 530 540 550
pF1KA1 LEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEV
::::::::.:.: .::::::. :.::::.: :::: .::: .. . .: .::.:. ..
NP_001 LEFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDI
580 590 600 610 620 630
560 570 580 590 600 610
pF1KA1 RRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQES
.. :: .::: .::: ..:::.:::.:::::. :: .:::::..::::::: ::.:. .
NP_001 KQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTK
640 650 660 670 680 690
620 630 640 650 660 670
pF1KA1 LMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGS
:. .::.:::.: ::::.. : :::::.:. :::.::...: : ..: ...
NP_001 NEEWSCKLFELDPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQT----KVKHRTPMVSV
700 710 720 730 740 750
680 690 700 710 720 730
pF1KA1 PGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPR
: .:. . .... :. ..: : .:::: .: .: :
NP_001 PKMKHKPTRQQKKVAKGYSSPEPDIQ--DSSGSEAQSV-----------------KPSTR
760 770 780 790
740 750 760 770 780 790
pF1KA1 CRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVF
::.. .: .. .: ::...:.:..:.. :. . . .. : : .::. ...:.. ..
NP_001 -RKKGIELGDIQSSIESIKQTQEEIKRNIMALRNHLVSSTPA-TDYFLQQ-KDYFIIFLL
800 810 820 830 840 850
800 810
pF1KA1 LACQLFINHILK
. :..:: ..:
NP_001 ILLQVIINFMFK
860
811 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:36:32 2016 done: Fri Nov 4 01:36:34 2016
Total Scan time: 14.950 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]