Result of FASTA (omim) for
pFN21AA1343
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1343, 495 aa
1>>>pF1KA1343 495 - 495 aa - 495 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.8855+/-0.000443; mu= -21.0178+/- 0.028
mean_var=495.8669+/-101.354, 0's: 0 Z-trim(123.0): 47 B-trim: 0 in 0/60
Lambda= 0.057596
statistics sampled from 41944 (41991) to 41944 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.492), width: 16
Scan time: 11.560
The best scores are: opt bits E(85289)
NP_775858 (OMIM: 616019) REST corepressor 2 [Homo ( 523) 1674 153.5 1.4e-36
XP_005273989 (OMIM: 616019) PREDICTED: REST corepr ( 477) 1280 120.7 9.4e-27
NP_055971 (OMIM: 607675) REST corepressor 1 [Homo ( 485) 909 89.9 1.8e-17
>>NP_775858 (OMIM: 616019) REST corepressor 2 [Homo sapi (523 aa)
initn: 1570 init1: 756 opt: 1674 Z-score: 777.7 bits: 153.5 E(85289): 1.4e-36
Smith-Waterman score: 1898; 60.3% identity (80.2% similar) in 491 aa overlap (1-485:46-513)
10 20
pF1KA1 MRVGAEYQARIPEFDP-GATKYTDKDNGGM
.:::..::: ::: : . ..:..:. ::
NP_775 SRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGM
20 30 40 50 60 70
30 40 50 60 70 80
pF1KA1 LVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEW
::::: : . :::::.:::.::::::::.:::::::.::::..::::::: :::::::::
NP_775 LVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEW
80 90 100 110 120 130
90 100 110 120 130 140
pF1KA1 TVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLAN
::::::::::::.:::: :.::::::::: : :::::::::::::::::.::::::.:..
NP_775 TVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGG
140 150 160 170 180 190
150 160 170 180 190 200
pF1KA1 RHNQGDSDDDVEETHPMDGNDSDYDPKK-EAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
:... :::. .:: . :. :. .: . :.: .:.. .. : :..: : :.::
NP_775 RKDKEDSDE-LEEGR---GGVSEGEPDPADPKREPLPSRPLN-ARPGPGKKEVQVSQYRH
200 210 220 230 240 250
210 220 230 240 250 260
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
: :.. ::::::::. : ..::: ::. :: :: :: .:::::::::. ::.::.:.:
NP_775 HPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQ
260 270 280 290 300 310
270 280 290 300 310 320
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
.::::. ..:::.: :.:.::::.:::::::..:.::::: :::.::::::. :::.::
NP_775 ALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFF
320 330 340 350 360 370
330 340 350 360 370 380
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQ----T
:.:::::::::::::::::: ... : : . ::.. .. .:. . .:..:.: .
NP_775 VSYRRRFNLEEVLQEWEAEQ--DGAPG-APVPMEEARRGAPLPA-PALEEDDEVQITSVS
380 390 400 410 420
390 400 410 420 430 440
pF1KA1 PQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQP
..::.. :.:: : : :: .:.:::::::: ::.::.: :::::::: .::.::
NP_775 TSVPRSVPPAPPPP---PPPT----SLSQPPPLLRPPLPTAPTLLRQPPPLQQ-GRFLQP
430 440 450 460 470
450 460 470 480 490
pF1KA1 RPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH
: . ::::::::::: . : : . :: : : ::.:::
NP_775 RLAPNQPPPPLIRPALAAP-RHSARP-----GPQPPPTLIGTPLEPPAPSL
480 490 500 510 520
>>XP_005273989 (OMIM: 616019) PREDICTED: REST corepresso (477 aa)
initn: 1363 init1: 756 opt: 1280 Z-score: 601.3 bits: 120.7 E(85289): 9.4e-27
Smith-Waterman score: 1337; 49.2% identity (69.5% similar) in 465 aa overlap (1-459:46-465)
10 20
pF1KA1 MRVGAEYQARIPEFDP-GATKYTDKDNGGM
.:::..::: ::: : . ..:..:. ::
XP_005 SRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGM
20 30 40 50 60 70
30 40 50 60 70 80
pF1KA1 LVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEW
::::: : . :::::.:::.::::::::.:::::::.::::..::::::: :::::::::
XP_005 LVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEW
80 90 100 110 120 130
90 100 110 120 130 140
pF1KA1 TVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLAN
::::::::::::.:::: :.::::::::: : :::::::::::::::::.::::::.:..
XP_005 TVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGG
140 150 160 170 180 190
150 160 170 180 190 200
pF1KA1 RHNQGDSDDDVEETHPMDGNDSDYDPKK-EAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
:... :::. .:: . :. :. .: . :.: .:.. .. : :..: : :.::
XP_005 RKDKEDSDE-LEEGR---GGVSEGEPDPADPKREPLPSRPLN-ARPGPGKKEVQVSQYRH
200 210 220 230 240 250
210 220 230 240 250 260
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
: :.. ::::::::. : ..::: ::. :: :: :: .:::::::::. ::.::.:.:
XP_005 HPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQ
260 270 280 290 300 310
270 280 290 300 310 320
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
.::::. ..:::.: :.:.::::.:::::::: : :: .. . ..
XP_005 ALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQG-----------PDYIGLHVRAPIS---
320 330 340 350
330 340 350 360 370 380
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQA-
. :.. ..: : .. .:....: . ..: :
XP_005 --------------------APCATTPSTSHL-----AVPATPAAEATFAHGSHSAPTAT
360 370 380 390
390 400 410 420 430 440
pF1KA1 PRTLGPSPPAPSST-PTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRP
: . :: ::::.. :.::: . :: :: :.::. : .. ..:
XP_005 PTAAGPLPPAPAGPQPAPTASHPPRSGCPPPQRPPWPSAPTHPDWNPSGAPSTLTLSP-D
400 410 420 430 440 450
450 460 470 480 490
pF1KA1 TLNQP--PPPLIRPANSMPPRLNPRPVLSTVGGQQPPSLIGIQTDSQSSLH
.:.:: : :: :.
XP_005 VLHQPRAPGPLCWPSPGISGVTEDRRD
460 470
>>NP_055971 (OMIM: 607675) REST corepressor 1 [Homo sapi (485 aa)
initn: 1567 init1: 759 opt: 909 Z-score: 434.6 bits: 89.9 E(85289): 1.8e-17
Smith-Waterman score: 1616; 64.6% identity (84.4% similar) in 384 aa overlap (1-382:105-474)
10 20
pF1KA1 MRVGAEYQARIPEFDPG--ATKYTDKDNGG
:::: .::: .:.:::. : . ..:: :
NP_055 AAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLG
80 90 100 110 120 130
30 40 50 60 70 80
pF1KA1 MLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDE
:::::: ... .:::::::::::::::::.::::::::::::::::::::::::::::::
NP_055 MLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDE
140 150 160 170 180 190
90 100 110 120 130 140
pF1KA1 WTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLA
::::::::::::::::::.:::::::::::.::::::.::::::::..::.:::.:::
NP_055 WTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARK--
200 210 220 230 240 250
150 160 170 180 190 200
pF1KA1 NRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRH
..... .:.:..::.. . : . : .::.::: :..: . ..: .: : ..
NP_055 QKREREESEDELEEANGNNPIDIEVDQNKESKKE---VPPTET--VPQVKKEKHSTQAKN
260 270 280 290 300
210 220 230 240 250 260
pF1KA1 HSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQ
:.: .:::::.:.:::: ::: . .::.:.::::::::.:.:::.:: ::.:::::.
NP_055 ---RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKE
310 320 330 340 350 360
270 280 290 300 310 320
pF1KA1 KMEGGIEEFKPPESNQKINARWTTEEQLLAVQGVRKYGKDFQAIADVIGNKTVGQVKNFF
:..:::: .. :: :: ::::::::::::::..::::.:::::.::::::.: ::::::
NP_055 KLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFF
370 380 390 400 410 420
330 340 350 360 370 380
pF1KA1 VNYRRRFNLEEVLQEWEAEQGTQASNGDASTLGEETKSASNVPSGKSTDEEEEAQTPQAP
::::::::..:::::::::.: . .:: .. . .:: .: : : .::.::
NP_055 VNYRRRFNIDEVLQEWEAEHGKEETNGPSNQ--KPVKSPDN--SIKMPEEEDEAPVLDVR
430 440 450 460 470 480
390 400 410 420 430 440
pF1KA1 RTLGPSPPAPSSTPTPTAPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTL
NP_055 YASAS
495 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:29:21 2016 done: Fri Nov 4 01:29:23 2016
Total Scan time: 11.560 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]