Result of FASTA (omim) for
pFN21AB9340
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9340, 766 aa
1>>>pF1KB9340 766 - 766 aa - 766 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0742+/-0.00043; mu= 12.7859+/- 0.027
mean_var=139.0844+/-29.448, 0's: 0 Z-trim(114.4): 514 B-trim: 317 in 1/56
Lambda= 0.108751
statistics sampled from 23698 (24247) to 23698 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.284), width: 16
Scan time: 11.580
The best scores are: opt bits E(85289)
XP_011518857 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 5085 810.2 0
NP_640334 (OMIM: 609311,611104) FYVE, RhoGEF and P ( 766) 5085 810.2 0
XP_011518858 (OMIM: 609311,611104) PREDICTED: FYVE ( 766) 5085 810.2 0
NP_001291410 (OMIM: 609311,611104) FYVE, RhoGEF an ( 851) 5085 810.3 0
XP_011518856 (OMIM: 609311,611104) PREDICTED: FYVE ( 864) 5085 810.3 0
NP_001291409 (OMIM: 609311,611104) FYVE, RhoGEF an ( 878) 5085 810.3 0
XP_005253361 (OMIM: 609311,611104) PREDICTED: FYVE ( 930) 5085 810.3 0
XP_016874292 (OMIM: 609311,611104) PREDICTED: FYVE ( 914) 4888 779.4 0
NP_001317302 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 4478 715.0 2.6e-205
XP_005253366 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 4478 715.0 2.6e-205
XP_005253365 (OMIM: 609311,611104) PREDICTED: FYVE ( 673) 4478 715.0 2.6e-205
NP_001317303 (OMIM: 609311,611104) FYVE, RhoGEF an ( 673) 4478 715.0 2.6e-205
XP_016874294 (OMIM: 609311,611104) PREDICTED: FYVE ( 582) 3791 607.1 6.5e-173
XP_011518859 (OMIM: 609311,611104) PREDICTED: FYVE ( 582) 3791 607.1 6.5e-173
XP_011518860 (OMIM: 609311,611104) PREDICTED: FYVE ( 567) 3781 605.6 1.9e-172
XP_005253367 (OMIM: 609311,611104) PREDICTED: FYVE ( 518) 3474 557.4 5.6e-158
XP_011518861 (OMIM: 609311,611104) PREDICTED: FYVE ( 511) 3295 529.3 1.6e-149
NP_001291412 (OMIM: 609311,611104) FYVE, RhoGEF an ( 471) 2903 467.7 4.8e-131
NP_001291413 (OMIM: 609311,611104) FYVE, RhoGEF an ( 422) 2842 458.1 3.4e-128
NP_775829 (OMIM: 605091) FYVE, RhoGEF and PH domai ( 655) 2026 330.3 1.6e-89
NP_004454 (OMIM: 300546,305400) FYVE, RhoGEF and P ( 961) 1809 296.3 3.9e-79
XP_016865918 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 662) 1514 249.9 2.5e-65
XP_011512675 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 398) 1057 178.1 6.5e-44
NP_060821 (OMIM: 613520) FYVE, RhoGEF and PH domai (1430) 975 165.6 1.3e-39
XP_011512674 (OMIM: 605091) PREDICTED: FYVE, RhoGE ( 401) 910 155.0 5.8e-37
XP_011531725 (OMIM: 614788) PREDICTED: FYVE, RhoGE (1421) 630 111.5 2.6e-23
XP_011531724 (OMIM: 614788) PREDICTED: FYVE, RhoGE (1464) 630 111.5 2.6e-23
NP_001307205 (OMIM: 614788) FYVE, RhoGEF and PH do (1419) 628 111.2 3.2e-23
NP_689749 (OMIM: 614788) FYVE, RhoGEF and PH domai (1462) 628 111.2 3.3e-23
XP_016875801 (OMIM: 602654) PREDICTED: FERM, RhoGE (1045) 480 87.8 2.5e-16
NP_005757 (OMIM: 602654) FERM, RhoGEF and pleckstr (1045) 480 87.8 2.5e-16
NP_060568 (OMIM: 600586) protein ECT2 isoform b [H ( 883) 364 69.6 6.5e-11
NP_001245245 (OMIM: 600586) protein ECT2 isoform b ( 883) 364 69.6 6.5e-11
XP_006713587 (OMIM: 600586) PREDICTED: protein ECT ( 889) 364 69.6 6.5e-11
XP_016861323 (OMIM: 600586) PREDICTED: protein ECT ( 914) 364 69.6 6.7e-11
XP_016861325 (OMIM: 600586) PREDICTED: protein ECT ( 914) 364 69.6 6.7e-11
XP_016861324 (OMIM: 600586) PREDICTED: protein ECT ( 914) 364 69.6 6.7e-11
NP_001245244 (OMIM: 600586) protein ECT2 isoform a ( 914) 364 69.6 6.7e-11
XP_005247233 (OMIM: 600586) PREDICTED: protein ECT ( 927) 364 69.6 6.7e-11
XP_016861322 (OMIM: 600586) PREDICTED: protein ECT ( 927) 364 69.6 6.7e-11
XP_011510818 (OMIM: 600586) PREDICTED: protein ECT ( 927) 364 69.6 6.7e-11
XP_016861321 (OMIM: 600586) PREDICTED: protein ECT ( 927) 364 69.6 6.7e-11
XP_011510816 (OMIM: 600586) PREDICTED: protein ECT ( 958) 364 69.6 6.9e-11
XP_006713586 (OMIM: 600586) PREDICTED: protein ECT ( 958) 364 69.6 6.9e-11
XP_016861319 (OMIM: 600586) PREDICTED: protein ECT ( 958) 364 69.6 6.9e-11
XP_011510817 (OMIM: 600586) PREDICTED: protein ECT ( 958) 364 69.6 6.9e-11
NP_065871 (OMIM: 606905) phosphatidylinositol 3,4, (1659) 367 70.3 7.6e-11
XP_016861327 (OMIM: 600586) PREDICTED: protein ECT ( 854) 361 69.1 8.8e-11
XP_016861326 (OMIM: 600586) PREDICTED: protein ECT ( 854) 361 69.1 8.8e-11
XP_016861320 (OMIM: 600586) PREDICTED: protein ECT ( 929) 361 69.1 9.4e-11
>>XP_011518857 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (766 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.9 bits: 810.2 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)
10 20 30 40 50 60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
670 680 690 700 710 720
730 740 750 760
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
730 740 750 760
>>NP_640334 (OMIM: 609311,611104) FYVE, RhoGEF and PH do (766 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.9 bits: 810.2 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)
10 20 30 40 50 60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
670 680 690 700 710 720
730 740 750 760
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
::::::::::::::::::::::::::::::::::::::::::::::
NP_640 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
730 740 750 760
>>XP_011518858 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (766 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.9 bits: 810.2 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:1-766)
10 20 30 40 50 60
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
670 680 690 700 710 720
730 740 750 760
pF1KB9 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
730 740 750 760
>>NP_001291410 (OMIM: 609311,611104) FYVE, RhoGEF and PH (851 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.2 bits: 810.3 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:86-851)
10 20 30
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGG
::::::::::::::::::::::::::::::
NP_001 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
60 70 80 90 100 110
40 50 60 70 80 90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
120 130 140 150 160 170
100 110 120 130 140 150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
180 190 200 210 220 230
160 170 180 190 200 210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
360 370 380 390 400 410
340 350 360 370 380 390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
420 430 440 450 460 470
400 410 420 430 440 450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
480 490 500 510 520 530
460 470 480 490 500 510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
540 550 560 570 580 590
520 530 540 550 560 570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
600 610 620 630 640 650
580 590 600 610 620 630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
660 670 680 690 700 710
640 650 660 670 680 690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
720 730 740 750 760 770
700 710 720 730 740 750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
780 790 800 810 820 830
760
pF1KB9 PATLDDHPEPKKKSEC
::::::::::::::::
NP_001 PATLDDHPEPKKKSEC
840 850
>>XP_011518856 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (864 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.1 bits: 810.3 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:99-864)
10 20 30
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGG
::::::::::::::::::::::::::::::
XP_011 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
70 80 90 100 110 120
40 50 60 70 80 90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
130 140 150 160 170 180
100 110 120 130 140 150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
190 200 210 220 230 240
160 170 180 190 200 210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
250 260 270 280 290 300
220 230 240 250 260 270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
310 320 330 340 350 360
280 290 300 310 320 330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
430 440 450 460 470 480
400 410 420 430 440 450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
490 500 510 520 530 540
460 470 480 490 500 510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
550 560 570 580 590 600
520 530 540 550 560 570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
610 620 630 640 650 660
580 590 600 610 620 630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
670 680 690 700 710 720
640 650 660 670 680 690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
730 740 750 760 770 780
700 710 720 730 740 750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
790 800 810 820 830 840
760
pF1KB9 PATLDDHPEPKKKSEC
::::::::::::::::
XP_011 PATLDDHPEPKKKSEC
850 860
>>NP_001291409 (OMIM: 609311,611104) FYVE, RhoGEF and PH (878 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4320.0 bits: 810.3 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:113-878)
10 20 30
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGG
::::::::::::::::::::::::::::::
NP_001 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
90 100 110 120 130 140
40 50 60 70 80 90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
150 160 170 180 190 200
100 110 120 130 140 150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
210 220 230 240 250 260
160 170 180 190 200 210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
270 280 290 300 310 320
220 230 240 250 260 270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
330 340 350 360 370 380
280 290 300 310 320 330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
390 400 410 420 430 440
340 350 360 370 380 390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
450 460 470 480 490 500
400 410 420 430 440 450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
510 520 530 540 550 560
460 470 480 490 500 510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
570 580 590 600 610 620
520 530 540 550 560 570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
630 640 650 660 670 680
580 590 600 610 620 630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
690 700 710 720 730 740
640 650 660 670 680 690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
750 760 770 780 790 800
700 710 720 730 740 750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
810 820 830 840 850 860
760
pF1KB9 PATLDDHPEPKKKSEC
::::::::::::::::
NP_001 PATLDDHPEPKKKSEC
870
>>XP_005253361 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (930 aa)
initn: 5085 init1: 5085 opt: 5085 Z-score: 4319.7 bits: 810.3 E(85289): 0
Smith-Waterman score: 5085; 100.0% identity (100.0% similar) in 766 aa overlap (1-766:165-930)
10 20 30
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGG
::::::::::::::::::::::::::::::
XP_005 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
140 150 160 170 180 190
40 50 60 70 80 90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
200 210 220 230 240 250
100 110 120 130 140 150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
260 270 280 290 300 310
160 170 180 190 200 210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
320 330 340 350 360 370
220 230 240 250 260 270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
380 390 400 410 420 430
280 290 300 310 320 330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
440 450 460 470 480 490
340 350 360 370 380 390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
500 510 520 530 540 550
400 410 420 430 440 450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
560 570 580 590 600 610
460 470 480 490 500 510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
620 630 640 650 660 670
520 530 540 550 560 570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
680 690 700 710 720 730
580 590 600 610 620 630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
740 750 760 770 780 790
640 650 660 670 680 690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
800 810 820 830 840 850
700 710 720 730 740 750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
860 870 880 890 900 910
760
pF1KB9 PATLDDHPEPKKKSEC
::::::::::::::::
XP_005 PATLDDHPEPKKKSEC
920 930
>>XP_016874292 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (914 aa)
initn: 4888 init1: 4888 opt: 4888 Z-score: 4152.8 bits: 779.4 E(85289): 0
Smith-Waterman score: 4888; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:165-904)
10 20 30
pF1KB9 MEEIKPASASCVSKEKPSKVSDLISRFEGG
::::::::::::::::::::::::::::::
XP_016 PPKPLHLQNSPSSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGG
140 150 160 170 180 190
40 50 60 70 80 90
pF1KB9 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLSNYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVA
200 210 220 230 240 250
100 110 120 130 140 150
pF1KB9 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGVMAAQNQMECEEEKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDGN
260 270 280 290 300 310
160 170 180 190 200 210
pF1KB9 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKI
320 330 340 350 360 370
220 230 240 250 260 270
pF1KB9 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLP
380 390 400 410 420 430
280 290 300 310 320 330
pF1KB9 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI
440 450 460 470 480 490
340 350 360 370 380 390
pF1KB9 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHS
500 510 520 530 540 550
400 410 420 430 440 450
pF1KB9 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNM
560 570 580 590 600 610
460 470 480 490 500 510
pF1KB9 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKE
620 630 640 650 660 670
520 530 540 550 560 570
pF1KB9 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWIKALQETIDAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKE
680 690 700 710 720 730
580 590 600 610 620 630
pF1KB9 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRK
740 750 760 770 780 790
640 650 660 670 680 690
pF1KB9 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIP
800 810 820 830 840 850
700 710 720 730 740 750
pF1KB9 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEH
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTERAERNKIRN
860 870 880 890 900 910
760
pF1KB9 PATLDDHPEPKKKSEC
>>NP_001317302 (OMIM: 609311,611104) FYVE, RhoGEF and PH (673 aa)
initn: 4478 init1: 4478 opt: 4478 Z-score: 3806.9 bits: 715.0 E(85289): 2.6e-205
Smith-Waterman score: 4478; 100.0% identity (100.0% similar) in 673 aa overlap (94-766:1-673)
70 80 90 100 110 120
pF1KB9 QKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLL
::::::::::::::::::::::::::::::
NP_001 MAAQNQMECEEEKAATLSSDTSIQASEPLL
10 20 30
130 140 150 160 170 180
pF1KB9 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB9 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB9 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB9 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB9 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB9 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB9 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB9 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB9 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
520 530 540 550 560 570
670 680 690 700 710 720
pF1KB9 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
580 590 600 610 620 630
730 740 750 760
pF1KB9 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
:::::::::::::::::::::::::::::::::::::::::::
NP_001 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
640 650 660 670
>>XP_005253366 (OMIM: 609311,611104) PREDICTED: FYVE, Rh (673 aa)
initn: 4478 init1: 4478 opt: 4478 Z-score: 3806.9 bits: 715.0 E(85289): 2.6e-205
Smith-Waterman score: 4478; 100.0% identity (100.0% similar) in 673 aa overlap (94-766:1-673)
70 80 90 100 110 120
pF1KB9 QKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLL
::::::::::::::::::::::::::::::
XP_005 MAAQNQMECEEEKAATLSSDTSIQASEPLL
10 20 30
130 140 150 160 170 180
pF1KB9 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQEREN
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB9 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB9 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYV
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB9 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYL
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB9 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNEL
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB9 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQN
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB9 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDIHSE
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB9 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYD
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB9 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAW
520 530 540 550 560 570
670 680 690 700 710 720
pF1KB9 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAAD
580 590 600 610 620 630
730 740 750 760
pF1KB9 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
:::::::::::::::::::::::::::::::::::::::::::
XP_005 SEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
640 650 660 670
766 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 23:10:22 2016 done: Thu Nov 3 23:10:23 2016
Total Scan time: 11.580 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]