Result of FASTA (omim) for
pFN21AB9177
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9177, 1138 aa
1>>>pF1KB9177 1138 - 1138 aa - 1138 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4872+/-0.000661; mu= -11.2530+/- 0.040
mean_var=784.6081+/-169.857, 0's: 0 Z-trim(118.7): 756 B-trim: 718 in 1/54
Lambda= 0.045788
statistics sampled from 31077 (31907) to 31077 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.374), width: 16
Scan time: 16.910
The best scores are: opt bits E(85289)
NP_005415 (OMIM: 600222) tyrosine-protein kinase r (1138) 7895 539.0 6.1e-152
NP_001240286 (OMIM: 600222) tyrosine-protein kinas (1093) 7580 518.2 1.1e-145
XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-pr ( 830) 5656 390.9 1.7e-107
XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-pr (1095) 5566 385.1 1.2e-105
XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-pr ( 783) 5269 365.3 8.1e-100
NP_001277007 (OMIM: 600195,600221) angiopoietin-1 ( 976) 1949 146.1 9.6e-34
XP_005251620 (OMIM: 600195,600221) PREDICTED: angi (1080) 1949 146.2 1e-33
NP_001277006 (OMIM: 600195,600221) angiopoietin-1 (1081) 1949 146.2 1e-33
XP_005251618 (OMIM: 600195,600221) PREDICTED: angi (1123) 1949 146.2 1e-33
NP_000450 (OMIM: 600195,600221) angiopoietin-1 rec (1124) 1949 146.2 1e-33
XP_016868719 (OMIM: 101600,123150,136350,147950,16 ( 498) 850 73.1 4.7e-12
NP_075254 (OMIM: 100800,109800,114500,134934,14600 ( 694) 852 73.5 5.1e-12
NP_000133 (OMIM: 100800,109800,114500,134934,14600 ( 806) 852 73.6 5.6e-12
XP_006713935 (OMIM: 100800,109800,114500,134934,14 ( 807) 852 73.6 5.6e-12
NP_001156685 (OMIM: 100800,109800,114500,134934,14 ( 808) 852 73.6 5.6e-12
XP_006713932 (OMIM: 100800,109800,114500,134934,14 ( 810) 852 73.6 5.6e-12
XP_016868717 (OMIM: 101600,123150,136350,147950,16 ( 729) 850 73.4 5.8e-12
NP_075594 (OMIM: 101600,123150,136350,147950,16625 ( 731) 850 73.4 5.8e-12
NP_001167537 (OMIM: 101600,123150,136350,147950,16 ( 733) 850 73.4 5.8e-12
NP_075593 (OMIM: 101600,123150,136350,147950,16625 ( 733) 850 73.4 5.8e-12
XP_006713936 (OMIM: 100800,109800,114500,134934,14 ( 807) 851 73.5 5.9e-12
XP_011511724 (OMIM: 100800,109800,114500,134934,14 ( 808) 851 73.5 5.9e-12
XP_011511722 (OMIM: 100800,109800,114500,134934,14 ( 809) 851 73.5 5.9e-12
XP_006713934 (OMIM: 100800,109800,114500,134934,14 ( 809) 851 73.5 5.9e-12
XP_006713933 (OMIM: 100800,109800,114500,134934,14 ( 810) 851 73.5 5.9e-12
XP_006713931 (OMIM: 100800,109800,114500,134934,14 ( 811) 851 73.5 5.9e-12
XP_016868716 (OMIM: 101600,123150,136350,147950,16 ( 762) 850 73.4 6e-12
XP_016868715 (OMIM: 101600,123150,136350,147950,16 ( 764) 850 73.4 6e-12
XP_011542752 (OMIM: 101600,123150,136350,147950,16 ( 764) 850 73.4 6e-12
NP_001167535 (OMIM: 101600,123150,136350,147950,16 ( 812) 850 73.4 6.2e-12
XP_016868713 (OMIM: 101600,123150,136350,147950,16 ( 818) 850 73.4 6.2e-12
XP_016868714 (OMIM: 101600,123150,136350,147950,16 ( 818) 850 73.4 6.2e-12
NP_001167536 (OMIM: 101600,123150,136350,147950,16 ( 820) 850 73.4 6.2e-12
NP_001167534 (OMIM: 101600,123150,136350,147950,16 ( 820) 850 73.4 6.2e-12
NP_056934 (OMIM: 101600,123150,136350,147950,16625 ( 820) 850 73.4 6.2e-12
NP_075598 (OMIM: 101600,123150,136350,147950,16625 ( 822) 850 73.4 6.2e-12
XP_016868709 (OMIM: 101600,123150,136350,147950,16 ( 851) 850 73.5 6.3e-12
NP_001167538 (OMIM: 101600,123150,136350,147950,16 ( 853) 850 73.5 6.3e-12
XP_011542749 (OMIM: 101600,123150,136350,147950,16 ( 853) 850 73.5 6.3e-12
XP_011542748 (OMIM: 101600,123150,136350,147950,16 ( 855) 850 73.5 6.4e-12
XP_016868718 (OMIM: 101600,123150,136350,147950,16 ( 508) 838 72.4 8.2e-12
XP_011542753 (OMIM: 101600,123150,136350,147950,16 ( 735) 838 72.6 1e-11
XP_006716377 (OMIM: 101600,123150,136350,147950,16 ( 741) 838 72.6 1e-11
XP_006716376 (OMIM: 101600,123150,136350,147950,16 ( 741) 838 72.6 1e-11
XP_006716373 (OMIM: 101600,123150,136350,147950,16 ( 743) 838 72.6 1e-11
XP_006716375 (OMIM: 101600,123150,136350,147950,16 ( 743) 838 72.6 1e-11
XP_006716374 (OMIM: 101600,123150,136350,147950,16 ( 743) 838 72.6 1e-11
XP_011542751 (OMIM: 101600,123150,136350,147950,16 ( 774) 838 72.6 1e-11
XP_011542750 (OMIM: 101600,123150,136350,147950,16 ( 776) 838 72.6 1e-11
XP_006716372 (OMIM: 101600,123150,136350,147950,16 ( 824) 838 72.7 1.1e-11
>>NP_005415 (OMIM: 600222) tyrosine-protein kinase recep (1138 aa)
initn: 7895 init1: 7895 opt: 7895 Z-score: 2848.9 bits: 539.0 E(85289): 6.1e-152
Smith-Waterman score: 7895; 100.0% identity (100.0% similar) in 1138 aa overlap (1-1138:1-1138)
10 20 30 40 50 60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB9 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130
pF1KB9 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
1090 1100 1110 1120 1130
>>NP_001240286 (OMIM: 600222) tyrosine-protein kinase re (1093 aa)
initn: 7580 init1: 7580 opt: 7580 Z-score: 2736.6 bits: 518.2 E(85289): 1.1e-145
Smith-Waterman score: 7580; 100.0% identity (100.0% similar) in 1091 aa overlap (48-1138:3-1093)
20 30 40 50 60 70
pF1KB9 HVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPP
::::::::::::::::::::::::::::::
NP_001 MWAGAGRGSDAWGPPLLLEKDDRIVRTPPGPP
10 20 30
80 90 100 110 120 130
pF1KB9 LRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVN
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB9 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATY
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB9 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB9 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRL
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB9 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGN
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB9 PFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSR
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB9 RFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIV
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB9 VDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVE
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB9 GTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQ
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB9 LDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKY
580 590 600 610 620 630
680 690 700 710 720 730
pF1KB9 VVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTL
640 650 660 670 680 690
740 750 760 770 780 790
pF1KB9 GNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTF
700 710 720 730 740 750
800 810 820 830 840 850
pF1KB9 TYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAM
760 770 780 790 800 810
860 870 880 890 900 910
pF1KB9 IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAI
820 830 840 850 860 870
920 930 940 950 960 970
pF1KB9 EYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIH
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KB9 RDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW
940 950 960 970 980 990
1040 1050 1060 1070 1080 1090
pF1KB9 SFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYER
1000 1010 1020 1030 1040 1050
1100 1110 1120 1130
pF1KB9 PPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
:::::::::::::::::::::::::::::::::::::::::
NP_001 PPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
1060 1070 1080 1090
>>XP_016857696 (OMIM: 600222) PREDICTED: tyrosine-protei (830 aa)
initn: 5656 init1: 5656 opt: 5656 Z-score: 2050.9 bits: 390.9 E(85289): 1.7e-107
Smith-Waterman score: 5656; 100.0% identity (100.0% similar) in 803 aa overlap (1-803:1-803)
10 20 30 40 50 60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
:::::::::::::::::::::::
XP_016 LTLVCIRRSCLHRRRTFTYQSGSAFLGSGASLCLHTSLADVLSPAVATCQ
790 800 810 820 830
>>XP_005271220 (OMIM: 600222) PREDICTED: tyrosine-protei (1095 aa)
initn: 5324 init1: 5324 opt: 5566 Z-score: 2017.6 bits: 385.1 E(85289): 1.2e-105
Smith-Waterman score: 7438; 96.2% identity (96.2% similar) in 1138 aa overlap (1-1138:1-1095)
10 20 30 40 50 60
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
:::: :::::::::::::
XP_005 QCQE-------------------------------------------DRIPQILNMASEL
310
370 380 390 400 410 420
pF1KB9 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB9 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB9 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB9 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB9 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB9 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB9 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB9 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
740 750 760 770 780 790
850 860 870 880 890 900
pF1KB9 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
800 810 820 830 840 850
910 920 930 940 950 960
pF1KB9 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KB9 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KB9 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
980 990 1000 1010 1020 1030
1090 1100 1110 1120 1130
pF1KB9 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
1040 1050 1060 1070 1080 1090
>>XP_006710932 (OMIM: 600222) PREDICTED: tyrosine-protei (783 aa)
initn: 5269 init1: 5269 opt: 5269 Z-score: 1913.0 bits: 365.3 E(85289): 8.1e-100
Smith-Waterman score: 5269; 100.0% identity (100.0% similar) in 783 aa overlap (356-1138:1-783)
330 340 350 360 370 380
pF1KB9 TCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSI
::::::::::::::::::::::::::::::
XP_006 MASELEFNLETMPRINCAAAGNPFPVRGSI
10 20 30
390 400 410 420 430 440
pF1KB9 ELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKV
40 50 60 70 80 90
450 460 470 480 490 500
pF1KB9 PPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVT
100 110 120 130 140 150
510 520 530 540 550 560
pF1KB9 LMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVS
160 170 180 190 200 210
570 580 590 600 610 620
pF1KB9 WSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHC
220 230 240 250 260 270
630 640 650 660 670 680
pF1KB9 TLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAG
280 290 300 310 320 330
690 700 710 720 730 740
pF1KB9 GAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEG
340 350 360 370 380 390
750 760 770 780 790 800
pF1KB9 PVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGE
400 410 420 430 440 450
810 820 830 840 850 860
pF1KB9 ETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKM
460 470 480 490 500 510
870 880 890 900 910 920
pF1KB9 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL
520 530 540 550 560 570
930 940 950 960 970 980
pF1KB9 LDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNV
580 590 600 610 620 630
990 1000 1010 1020 1030 1040
pF1KB9 LVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWE
640 650 660 670 680 690
1050 1060 1070 1080 1090 1100
pF1KB9 IVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL
700 710 720 730 740 750
1110 1120 1130
pF1KB9 QLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
:::::::::::::::::::::::::::::::::
XP_006 QLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
760 770 780
>>NP_001277007 (OMIM: 600195,600221) angiopoietin-1 rece (976 aa)
initn: 2804 init1: 1843 opt: 1949 Z-score: 726.8 bits: 146.1 E(85289): 9.6e-34
Smith-Waterman score: 2951; 47.7% identity (70.0% similar) in 1022 aa overlap (125-1138:18-975)
100 110 120 130 140 150
pF1KB9 KPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQT
: .:: .: ::.:::.. .: . :.
NP_001 MDSLASLVLCGVSLLLSASFLPATLTMTVDKGDNVNISFKKVLIKEE
10 20 30 40
160 170 180 190 200 210
pF1KB9 DVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRG
:.. .:::..... ::. : . ..::..:: ..:.::: :. .. . ::: :::::
NP_001 DAVIYKNGSFIHSVPRHEVPDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRR
50 60 70 80 90 100
220 230 240 250 260 270
pF1KB9 CGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPG
: : .::: :.. : .:...::::. :::.::::: : ::.::. ::..:.:.: :
NP_001 CEAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSG
110 120 130 140 150 160
280 290 300 310 320 330
pF1KB9 ISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCV
::.. .:::::::::::..::.: ::.:. : :..
NP_001 QEGCKSYVFCLPDPYGCSCATGWKGLQCNEG-IP--------------------RMT---
170 180 190 200
340 350 360 370 380 390
pF1KB9 CPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTV
:.:... ...: : . : : :.: :.:. . : ::::::
NP_001 ----------------PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTV
210 220 230 240
400 410 420 430 440 450
pF1KB9 LLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPR
: . ..: : . :.. ::: : : :.: .:. . :...::: : :: ::
NP_001 LHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPN
250 260 270 280 290 300
460 470 480 490 500 510
pF1KB9 LL-TKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKT
.. : .. .. . :::::.. .: :.: . :. : : .: ::: :.:.:
NP_001 VIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRT
310 320 330 340 350 360
520 530 540 550 560 570
pF1KB9 GYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLV
: . ::: : :::::: :: .:: . : .: .. .. : ..:. :.
NP_001 EYELCVQLVRRGEGGEGHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIF
370 380 390 400 410 420
580 590 600 610 620 630
pF1KB9 PGPLVGDGFLLRLWDGTRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGP
:. : : ... . . ..:.. : :. ::..: : .: . ... . :
NP_001 PSSE--DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGE
430 440 450 460 470
640 650 660 670 680
pF1KB9 ASPPAHV-LLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAG
: . : :: :.... . .. : ..: : : ::. ... .: :
NP_001 WSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNE
480 490 500 510 520 530
690 700 710 720 730 740
pF1KB9 DPLWIDVDRPEETSTI--IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGP
: .:: . : : ..::. : : . : ...:. :: . : . ....:
NP_001 DQH-VDVKIKNATITQYQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP
540 550 560 570 580 590
750 760 770 780 790 800
pF1KB9 VQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEE
:. : ..:..:..::.. ::::.: :.: .. ..:. ..:: . ..:. ::
NP_001 ------ADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EE
600 610 620 630 640
810 820 830 840 850 860
pF1KB9 TILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMN
.::.::::.:.:. : .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.
NP_001 PAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMD
650 660 670 680 690 700
870 880 890 900 910 920
pF1KB9 AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLL
:::: .:::::..::::::::::::::::::::::::::::..:::::.::::::.::::
NP_001 AAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLL
710 720 730 740 750 760
930 940 950 960 970 980
pF1KB9 DFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVL
:::::::::::::::: ..:::::::.:::.::.:.: ::.:::.::::::::::::.:
NP_001 DFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNIL
770 780 790 800 810 820
990 1000 1010 1020 1030 1040
pF1KB9 VGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEI
:::: ..::::::::::.::::::::::::::::::::::::::::.:::::.:::::::
NP_001 VGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
830 840 850 860 870 880
1050 1060 1070 1080 1090 1100
pF1KB9 VSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ
:::::::::::::::::::::::::.:.: :::::::.:::::::..::::: :::: ..
NP_001 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
890 900 910 920 930 940
1110 1120 1130
pF1KB9 LGRMLEARKAYVNMSLFENFTYAGIDATAEEA
:.:::: ::.::: .:.:.::::::: .::::
NP_001 LNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
950 960 970
>>XP_005251620 (OMIM: 600195,600221) PREDICTED: angiopoi (1080 aa)
initn: 2804 init1: 1843 opt: 1949 Z-score: 726.3 bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3025; 45.0% identity (68.4% similar) in 1140 aa overlap (13-1138:14-1079)
10 20 30 40 50
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
:.:.. : .:.:: :. .: :.. . :::... .: :
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
:. . .: . . . ::... :. ...:. . : : . :.. : : . ..
XP_005 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
XP_005 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
180 190 200 210 220
240 250 260 270 280 290
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
XP_005 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQI
..::.: ::.:. .: :.. :.:
XP_005 ATGWKGLQCNEG-----------IQ----------RMT-------------------PKI
290 300
360 370 380 390 400 410
pF1KB9 LNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEV
... ...: : . : : :.: :.:. . : ::::::: . ..: : .
XP_005 VDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTI
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB9 PRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFS
:.. ::: : : :.: .:. . :...::: : :: :: .. : .. .. .
XP_005 HRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYF
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB9 GDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAW
:::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : ::::::
XP_005 GDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHP
430 440 450 460 470 480
540 550 560 570 580 590
pF1KB9 GPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRG
:: .:: . : .: .. .. : ..:. :. :. : : ... .
XP_005 GPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQ
490 500 510 520 530 540
600 610 620 630 640
pF1KB9 QERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPR
. ..:.. : :. ::..: : .: . ... . : : . : :: :.
XP_005 KSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPE
550 560 570 580 590 600
650 660 670 680 690 700
pF1KB9 HLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--I
... . .. : ..: : : ::. ... .: : : .:: . : : .
XP_005 NIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQL
610 620 630 640 650
710 720 730 740 750 760
pF1KB9 RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAV
.::. : : . : ...:. :: . : . ....: :. : ..:..:.
XP_005 KGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAI
660 670 680 690 700
770 780 790 800 810 820
pF1KB9 VGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQ
.::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:. : .
XP_005 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EEPAVQFNSGTLALNRKVKNN
710 720 730 740 750 760
830 840 850 860 870 880
pF1KB9 PEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFA
:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..::::::
XP_005 PDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA
770 780 790 800 810 820
890 900 910 920 930 940
pF1KB9 GELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH
::::::::::::::::::::::..:::::.::::::.:::::::::::::::::::: .
XP_005 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN
830 840 850 860 870 880
950 960 970 980 990 1000
pF1KB9 GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE
.:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..::::::::::.:
XP_005 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE
890 900 910 920 930 940
1010 1020 1030 1040 1050 1060
pF1KB9 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEK
:::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::::
XP_005 VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK
950 960 970 980 990 1000
1070 1080 1090 1100 1110 1120
pF1KB9 LPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFEN
::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:.:.
XP_005 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEK
1010 1020 1030 1040 1050 1060
1130
pF1KB9 FTYAGIDATAEEA
::::::: .::::
XP_005 FTYAGIDCSAEEAA
1070 1080
>>NP_001277006 (OMIM: 600195,600221) angiopoietin-1 rece (1081 aa)
initn: 2804 init1: 1843 opt: 1949 Z-score: 726.3 bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3025; 45.0% identity (68.3% similar) in 1140 aa overlap (13-1138:14-1080)
10 20 30 40 50
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
:.:.. : .:.:: :. .: :.. . :::... .: :
NP_001 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
:. . .: . . . ::... :. ...:. . : : . :.. : : . ..
NP_001 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
NP_001 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_001 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
180 190 200 210 220
240 250 260 270 280 290
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
NP_001 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQI
..::.: ::.:. : :.. :.:
NP_001 ATGWKGLQCNEG-IP--------------------RMT-------------------PKI
290 300
360 370 380 390 400 410
pF1KB9 LNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEV
... ...: : . : : :.: :.:. . : ::::::: . ..: : .
NP_001 VDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTI
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB9 PRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLVSFS
:.. ::: : : :.: .:. . :...::: : :: :: .. : .. .. .
NP_001 HRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYF
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB9 GDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAW
:::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : ::::::
NP_001 GDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHP
430 440 450 460 470 480
540 550 560 570 580 590
pF1KB9 GPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRG
:: .:: . : .: .. .. : ..:. :. :. : : ... .
NP_001 GPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERRSVQ
490 500 510 520 530 540
600 610 620 630 640
pF1KB9 QERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPPAPR
. ..:.. : :. ::..: : .: . ... . : : . : :: :.
NP_001 KSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPPQPE
550 560 570 580 590 600
650 660 670 680 690 700
pF1KB9 HLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--I
... . .. : ..: : : ::. ... .: : : .:: . : : .
NP_001 NIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQYQL
610 620 630 640 650
710 720 730 740 750 760
pF1KB9 RGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAV
.::. : : . : ...:. :: . : . ....: :. : ..:..:.
NP_001 KGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAI
660 670 680 690 700
770 780 790 800 810 820
pF1KB9 VGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQ
.::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:. : .
NP_001 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-VREEPAVQFNSGTLALNRKVKNN
710 720 730 740 750 760
830 840 850 860 870 880
pF1KB9 PEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFA
:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..::::::
NP_001 PDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA
770 780 790 800 810 820
890 900 910 920 930 940
pF1KB9 GELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH
::::::::::::::::::::::..:::::.::::::.:::::::::::::::::::: .
NP_001 GELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN
830 840 850 860 870 880
950 960 970 980 990 1000
pF1KB9 GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEE
.:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..::::::::::.:
NP_001 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE
890 900 910 920 930 940
1010 1020 1030 1040 1050 1060
pF1KB9 VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEK
:::::::::::::::::::::::::::.:::::.::::::::::::::::::::::::::
NP_001 VYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK
950 960 970 980 990 1000
1070 1080 1090 1100 1110 1120
pF1KB9 LPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFEN
::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:.:.
NP_001 LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEK
1010 1020 1030 1040 1050 1060
1130
pF1KB9 FTYAGIDATAEEA
::::::: .::::
NP_001 FTYAGIDCSAEEAA
1070 1080
>>XP_005251618 (OMIM: 600195,600221) PREDICTED: angiopoi (1123 aa)
initn: 3040 init1: 1843 opt: 1949 Z-score: 726.2 bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3335; 46.9% identity (71.0% similar) in 1143 aa overlap (13-1138:14-1122)
10 20 30 40 50
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
:.:.. : .:.:: :. .: :.. . :::... .: :
XP_005 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
:. . .: . . . ::... :. ...:. . : : . :.. : : . ..
XP_005 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
XP_005 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
XP_005 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
180 190 200 210 220
240 250 260 270 280 290
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
XP_005 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
..::.: ::.::: :: .: ::.:.:.:.:: ::::.::.: ::.:..::. .:.
XP_005 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB9 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
XP_005 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
350 360 370 380 390 400
420 430 440 450 460
pF1KB9 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
XP_005 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
410 420 430 440 450 460
470 480 490 500 510 520
pF1KB9 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
XP_005 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB9 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
: :: .:: . : .: .. .. : ..:. :. :. : : ...
XP_005 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB9 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
XP_005 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB9 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
:.... . .. : ..: : : ::. ... .: : : .:: . : :
XP_005 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
650 660 670 680 690
710 720 730 740 750 760
pF1KB9 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
..::. : : . : ...:. :: . : . ....: :. : ..:.
XP_005 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
700 710 720 730 740
770 780 790 800 810 820
pF1KB9 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
.:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:.
XP_005 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR--EEPAVQFNSGTLALNRKV
750 760 770 780 790 800
830 840 850 860 870 880
pF1KB9 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
: .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
XP_005 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
810 820 830 840 850 860
890 900 910 920 930 940
pF1KB9 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
:::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
XP_005 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
870 880 890 900 910 920
950 960 970 980 990 1000
pF1KB9 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
XP_005 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
930 940 950 960 970 980
1010 1020 1030 1040 1050 1060
pF1KB9 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
:.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
XP_005 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
990 1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KB9 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
:::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
XP_005 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
1050 1060 1070 1080 1090 1100
1130
pF1KB9 FENFTYAGIDATAEEA
.:.::::::: .::::
XP_005 YEKFTYAGIDCSAEEAA
1110 1120
>>NP_000450 (OMIM: 600195,600221) angiopoietin-1 recepto (1124 aa)
initn: 3040 init1: 1843 opt: 1949 Z-score: 726.2 bits: 146.2 E(85289): 1e-33
Smith-Waterman score: 3334; 46.9% identity (71.0% similar) in 1143 aa overlap (13-1138:14-1123)
10 20 30 40 50
pF1KB9 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
:.:.. : .:.:: :. .: :.. . :::... .: :
NP_000 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 --PLLLEKDDRIVRTPPGPPLRLA----RNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
:. . .: . . . ::... :. ...:. . : : . :.. : : . ..
NP_000 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
NP_000 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
NP_000 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
180 190 200 210 220
240 250 260 270 280 290
pF1KB9 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
NP_000 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
230 240 250 260 270 280
300 310 320 330 340 350
pF1KB9 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD--RI-
..::.: ::.::: :: .: ::.:.:.:.:: ::::.::.: ::.:..::. :.
NP_000 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KB9 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
NP_000 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
350 360 370 380 390 400
420 430 440 450 460
pF1KB9 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
NP_000 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
410 420 430 440 450 460
470 480 490 500 510 520
pF1KB9 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
NP_000 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB9 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
: :: .:: . : .: .. .. : ..:. :. :. : : ...
NP_000 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB9 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
NP_000 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB9 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETSTI
:.... . .. : ..: : : ::. ... .: : : .:: . : :
NP_000 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
650 660 670 680 690
710 720 730 740 750 760
pF1KB9 --IRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
..::. : : . : ...:. :: . : . ....: :. : ..:.
NP_000 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
700 710 720 730 740
770 780 790 800 810 820
pF1KB9 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
.:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:.
NP_000 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-VREEPAVQFNSGTLALNRKV
750 760 770 780 790 800
830 840 850 860 870 880
pF1KB9 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
: .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
NP_000 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
810 820 830 840 850 860
890 900 910 920 930 940
pF1KB9 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
:::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
NP_000 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
870 880 890 900 910 920
950 960 970 980 990 1000
pF1KB9 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
NP_000 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
930 940 950 960 970 980
1010 1020 1030 1040 1050 1060
pF1KB9 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
:.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
NP_000 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
990 1000 1010 1020 1030 1040
1070 1080 1090 1100 1110 1120
pF1KB9 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
:::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
NP_000 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
1050 1060 1070 1080 1090 1100
1130
pF1KB9 FENFTYAGIDATAEEA
.:.::::::: .::::
NP_000 YEKFTYAGIDCSAEEAA
1110 1120
1138 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 23:05:52 2016 done: Thu Nov 3 23:05:54 2016
Total Scan time: 16.910 Total Display time: 0.500
Function used was FASTA [36.3.4 Apr, 2011]