Result of FASTA (omim) for
pFN21AB9027
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9027, 239 aa
1>>>pF1KB9027 239 - 239 aa - 239 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8463+/-0.000348; mu= 17.0258+/- 0.022
mean_var=65.4331+/-13.775, 0's: 0 Z-trim(114.2): 46 B-trim: 1296 in 1/53
Lambda= 0.158553
statistics sampled from 23906 (23952) to 23906 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.281), width: 16
Scan time: 6.390
The best scores are: opt bits E(85289)
NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo ( 239) 1640 383.6 1.6e-106
NP_001291706 (OMIM: 610304) derlin-2 isoform b [Ho ( 238) 1621 379.3 3.2e-105
NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Ho ( 235) 1272 299.5 3.4e-81
XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 is ( 234) 1253 295.1 6.9e-80
XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 is ( 233) 1160 273.8 1.8e-73
NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo ( 205) 1158 273.3 2.2e-73
NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Ho ( 239) 1158 273.4 2.5e-73
XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 is ( 249) 987 234.3 1.5e-61
XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 is ( 165) 755 181.1 1e-45
XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 is ( 299) 627 152.0 1.1e-36
XP_016884568 (OMIM: 610305) PREDICTED: derlin-3 is ( 298) 608 147.7 2.2e-35
NP_077271 (OMIM: 608813) derlin-1 isoform a [Homo ( 251) 487 119.9 4.1e-27
NP_001128143 (OMIM: 608813) derlin-1 isoform b [Ho ( 231) 416 103.6 3e-22
XP_016884569 (OMIM: 610305) PREDICTED: derlin-3 is ( 279) 375 94.3 2.3e-19
NP_001291708 (OMIM: 610304) derlin-2 isoform c [Ho ( 74) 355 89.3 2e-18
XP_006716720 (OMIM: 608813) PREDICTED: derlin-1 is ( 151) 250 65.5 5.8e-11
NP_001317530 (OMIM: 608813) derlin-1 isoform c [Ho ( 151) 250 65.5 5.8e-11
NP_001035546 (OMIM: 615203) rhomboid domain-contai ( 364) 137 40.0 0.0068
>>NP_057125 (OMIM: 610304) derlin-2 isoform a [Homo sapi (239 aa)
initn: 1640 init1: 1640 opt: 1640 Z-score: 2033.5 bits: 383.6 E(85289): 1.6e-106
Smith-Waterman score: 1640; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
190 200 210 220 230
>>NP_001291706 (OMIM: 610304) derlin-2 isoform b [Homo s (238 aa)
initn: 1450 init1: 1450 opt: 1621 Z-score: 2010.0 bits: 379.3 E(85289): 3.2e-105
Smith-Waterman score: 1621; 99.6% identity (99.6% similar) in 239 aa overlap (1-239:1-238)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAV-LELITPFQLYFNPELIFKHFQIWRLITN
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
120 130 140 150 160 170
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
180 190 200 210 220 230
>>NP_001002862 (OMIM: 610305) derlin-3 isoform 2 [Homo s (235 aa)
initn: 1272 init1: 1272 opt: 1272 Z-score: 1578.6 bits: 299.5 E(85289): 3.4e-81
Smith-Waterman score: 1272; 78.0% identity (94.3% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
::.:::::::::::: :.:.::..:: ..:.: ::::: :::::.::
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
190 200 210 220 230
>>XP_011528807 (OMIM: 610305) PREDICTED: derlin-3 isofor (234 aa)
initn: 1138 init1: 1138 opt: 1253 Z-score: 1555.2 bits: 295.1 E(85289): 6.9e-80
Smith-Waterman score: 1253; 77.5% identity (93.8% similar) in 227 aa overlap (1-227:1-226)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.::::::::: :::..::::::::.:.:..::.:::.::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAV-LELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
120 130 140 150 160 170
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
::.:::::::::::: :.:.::..:: ..:.: ::::: :::::.::
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
180 190 200 210 220 230
>>XP_011528808 (OMIM: 610305) PREDICTED: derlin-3 isofor (233 aa)
initn: 1187 init1: 1160 opt: 1160 Z-score: 1440.2 bits: 273.8 E(85289): 1.8e-73
Smith-Waterman score: 1160; 78.7% identity (94.7% similar) in 207 aa overlap (1-207:1-207)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
XP_011 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
XP_011 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
XP_011 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
::.:::::::::::: :.:.::..: :
XP_011 IYYFLEDVFPNQPGGKRLLQTPGFLLATAQQCPHRTGPSAGDFRAARPQLAVA
190 200 210 220 230
>>NP_940842 (OMIM: 610305) derlin-3 isoform 3 [Homo sapi (205 aa)
initn: 1185 init1: 1158 opt: 1158 Z-score: 1438.5 bits: 273.3 E(85289): 2.2e-73
Smith-Waterman score: 1158; 79.0% identity (95.1% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
NP_940 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_940 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_940 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
::.:::::::::::: :.:.::..:
NP_940 IYYFLEDVFPNQPGGKRLLQTPGFL
190 200
>>NP_001129223 (OMIM: 610305) derlin-3 isoform 1 [Homo s (239 aa)
initn: 1158 init1: 1158 opt: 1158 Z-score: 1437.6 bits: 273.4 E(85289): 2.5e-73
Smith-Waterman score: 1158; 79.0% identity (95.1% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
NP_001 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
NP_001 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::::::::
NP_001 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGH
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
::.:::::::::::: :.:.::..:
NP_001 IYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQSQGGPGTAGELAAPS
190 200 210 220 230
>>XP_016884570 (OMIM: 610305) PREDICTED: derlin-3 isofor (249 aa)
initn: 985 init1: 985 opt: 987 Z-score: 1226.0 bits: 234.3 E(85289): 1.5e-61
Smith-Waterman score: 987; 66.8% identity (83.2% similar) in 220 aa overlap (1-220:1-219)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: ::::.::. :: ::
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
:::. :::::::::.: ::.::::::.::::::::.::::::::::::.::::: :
XP_016 GQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGEPPGT
130 140 150 160 170 180
190 200 210 220 230
pF1KB9 IYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG
:.. . .: :: ... :: : . :
XP_016 SSPPQAGHSPQDTLLMPWGPSP-ILAGVLLTPGSIPIFLPSQLLCSYSPSSQPAHIICIV
190 200 210 220 230
XP_016 RTDLLMLARS
240
>>XP_016884571 (OMIM: 610305) PREDICTED: derlin-3 isofor (165 aa)
initn: 755 init1: 755 opt: 755 Z-score: 941.6 bits: 181.1 E(85289): 1e-45
Smith-Waterman score: 755; 82.4% identity (94.7% similar) in 131 aa overlap (75-205:1-131)
50 60 70 80 90 100
pF1KB9 PELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFG
:.:..:::::::::::::::::::::::::
XP_016 MLFVFRYCRMLEEGSFRGRTADFVFMFLFG
10 20 30
110 120 130 140 150 160
pF1KB9 GFLMTLFGLFVSLVFLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLL
: ::::.::. :: :::::. :::::::::.: ::.::::::.::::::::.:::::::
XP_016 GVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB9 LGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGIRILKTPSILKAIFDTPDEDPNYNPLPEE
:::::.::::::::::::.:::::::::::: :.:.::..:
XP_016 LGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLGLQSSKAPAGSSLTIWTQQ
100 110 120 130 140 150
230
pF1KB9 RPGGFAWGEGQRLGG
XP_016 SQGGPGTAGELAAPS
160
>>XP_016884567 (OMIM: 610305) PREDICTED: derlin-3 isofor (299 aa)
initn: 747 init1: 627 opt: 627 Z-score: 779.8 bits: 152.0 E(85289): 1.1e-36
Smith-Waterman score: 627; 77.3% identity (96.4% similar) in 110 aa overlap (1-110:1-110)
10 20 30 40 50 60
pF1KB9 MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQLYFNPELIFKHFQIWRLITN
::.:.: :.::.: :.::::.:::::::::::::..::::::::.:.:..::.:::.::
XP_016 MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FLFFGPVGFNFLFNMIFLYRYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLVFL
::::::.::.:.:::.:..:::::::::::::::::::::::::: :::.
XP_016 FLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTVSFPQALEPRA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 GQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIIVDLLGIAVGH
XP_016 RAPRRPACVGPGANTAMPERDTVAVSSLVCVEGPLCAQLQGSGLDLQCCMQNTKPCTKEP
130 140 150 160 170 180
239 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 22:58:05 2016 done: Thu Nov 3 22:58:06 2016
Total Scan time: 6.390 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]