Result of FASTA (omim) for
pFN21AA0259
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0259, 1522 aa
1>>>pF1KA0259 1522 - 1522 aa - 1522 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1173+/-0.000463; mu= 14.7792+/- 0.029
mean_var=108.9508+/-22.104, 0's: 0 Z-trim(112.1): 52 B-trim: 496 in 1/52
Lambda= 0.122874
statistics sampled from 20829 (20881) to 20829 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.245), width: 16
Scan time: 15.860
The best scores are: opt bits E(85289)
NP_008958 (OMIM: 607760) DNA topoisomerase 2-bindi (1522) 10112 1804.7 0
XP_016861125 (OMIM: 607760) PREDICTED: DNA topoiso (1522) 10112 1804.7 0
XP_005247133 (OMIM: 607760) PREDICTED: DNA topoiso (1517) 10059 1795.3 0
XP_011510659 (OMIM: 607760) PREDICTED: DNA topoiso (1126) 7409 1325.5 0
XP_016861126 (OMIM: 607760) PREDICTED: DNA topoiso (1087) 7141 1278.0 0
XP_016861326 (OMIM: 600586) PREDICTED: protein ECT ( 854) 462 93.9 5.9e-18
XP_016861327 (OMIM: 600586) PREDICTED: protein ECT ( 854) 462 93.9 5.9e-18
NP_001245245 (OMIM: 600586) protein ECT2 isoform b ( 883) 462 93.9 6e-18
NP_060568 (OMIM: 600586) protein ECT2 isoform b [H ( 883) 462 93.9 6e-18
XP_016861321 (OMIM: 600586) PREDICTED: protein ECT ( 927) 462 93.9 6.3e-18
XP_011510818 (OMIM: 600586) PREDICTED: protein ECT ( 927) 462 93.9 6.3e-18
XP_005247233 (OMIM: 600586) PREDICTED: protein ECT ( 927) 462 93.9 6.3e-18
XP_016861322 (OMIM: 600586) PREDICTED: protein ECT ( 927) 462 93.9 6.3e-18
XP_006713587 (OMIM: 600586) PREDICTED: protein ECT ( 889) 455 92.7 1.4e-17
NP_001245244 (OMIM: 600586) protein ECT2 isoform a ( 914) 455 92.7 1.5e-17
XP_016861324 (OMIM: 600586) PREDICTED: protein ECT ( 914) 455 92.7 1.5e-17
XP_016861325 (OMIM: 600586) PREDICTED: protein ECT ( 914) 455 92.7 1.5e-17
XP_016861323 (OMIM: 600586) PREDICTED: protein ECT ( 914) 455 92.7 1.5e-17
XP_016861320 (OMIM: 600586) PREDICTED: protein ECT ( 929) 455 92.7 1.5e-17
XP_016861319 (OMIM: 600586) PREDICTED: protein ECT ( 958) 455 92.7 1.5e-17
XP_011510816 (OMIM: 600586) PREDICTED: protein ECT ( 958) 455 92.7 1.5e-17
XP_011510817 (OMIM: 600586) PREDICTED: protein ECT ( 958) 455 92.7 1.5e-17
XP_006713586 (OMIM: 600586) PREDICTED: protein ECT ( 958) 455 92.7 1.5e-17
XP_011514285 (OMIM: 104300,608254) PREDICTED: PAX- (1022) 270 59.9 1.2e-07
XP_016867370 (OMIM: 104300,608254) PREDICTED: PAX- (1035) 270 59.9 1.2e-07
XP_005249596 (OMIM: 104300,608254) PREDICTED: PAX- (1035) 270 59.9 1.2e-07
XP_011514284 (OMIM: 104300,608254) PREDICTED: PAX- (1043) 270 59.9 1.2e-07
NP_031375 (OMIM: 104300,608254) PAX-interacting pr (1069) 270 59.9 1.3e-07
>>NP_008958 (OMIM: 607760) DNA topoisomerase 2-binding p (1522 aa)
initn: 10112 init1: 10112 opt: 10112 Z-score: 9684.6 bits: 1804.7 E(85289): 0
Smith-Waterman score: 10112; 99.9% identity (100.0% similar) in 1522 aa overlap (1-1522:1-1522)
10 20 30 40 50 60
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
NP_008 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
1450 1460 1470 1480 1490 1500
1510 1520
pF1KA0 TGLSQKRKAPTEKNKIKRPRVH
::::::::::::::::::::::
NP_008 TGLSQKRKAPTEKNKIKRPRVH
1510 1520
>>XP_016861125 (OMIM: 607760) PREDICTED: DNA topoisomera (1522 aa)
initn: 10112 init1: 10112 opt: 10112 Z-score: 9684.6 bits: 1804.7 E(85289): 0
Smith-Waterman score: 10112; 99.9% identity (100.0% similar) in 1522 aa overlap (1-1522:1-1522)
10 20 30 40 50 60
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_016 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
1450 1460 1470 1480 1490 1500
1510 1520
pF1KA0 TGLSQKRKAPTEKNKIKRPRVH
::::::::::::::::::::::
XP_016 TGLSQKRKAPTEKNKIKRPRVH
1510 1520
>>XP_005247133 (OMIM: 607760) PREDICTED: DNA topoisomera (1517 aa)
initn: 7980 init1: 7980 opt: 10059 Z-score: 9633.8 bits: 1795.3 E(85289): 0
Smith-Waterman score: 10059; 99.5% identity (99.7% similar) in 1522 aa overlap (1-1522:1-1517)
10 20 30 40 50 60
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
::::::: .:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQINTID-----NVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
310 320 330 340 350
370 380 390 400 410 420
pF1KA0 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA0 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_005 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA0 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA0 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA0 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA0 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA0 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
720 730 740 750 760 770
790 800 810 820 830 840
pF1KA0 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
780 790 800 810 820 830
850 860 870 880 890 900
pF1KA0 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
840 850 860 870 880 890
910 920 930 940 950 960
pF1KA0 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KA0 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KA0 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KA0 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KA0 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250 1260
pF1KA0 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
1200 1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KA0 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KA0 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KA0 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KA0 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
1440 1450 1460 1470 1480 1490
1510 1520
pF1KA0 TGLSQKRKAPTEKNKIKRPRVH
::::::::::::::::::::::
XP_005 TGLSQKRKAPTEKNKIKRPRVH
1500 1510
>>XP_011510659 (OMIM: 607760) PREDICTED: DNA topoisomera (1126 aa)
initn: 7409 init1: 7409 opt: 7409 Z-score: 7097.0 bits: 1325.5 E(85289): 0
Smith-Waterman score: 7409; 99.9% identity (100.0% similar) in 1123 aa overlap (1-1123:1-1123)
10 20 30 40 50 60
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_011 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
:::::::::::::::::::::::::::::::::::::::::::
XP_011 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALSCL
1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KA0 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
>>XP_016861126 (OMIM: 607760) PREDICTED: DNA topoisomera (1087 aa)
initn: 7141 init1: 7141 opt: 7141 Z-score: 6840.5 bits: 1278.0 E(85289): 0
Smith-Waterman score: 7141; 99.9% identity (100.0% similar) in 1087 aa overlap (436-1522:1-1087)
410 420 430 440 450 460
pF1KA0 DELKQFWNKSAHRPHVVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALL
:::::::::::::::::::::.::::::::
XP_016 MLSEEPYIHANYQPVEIPVSHKPESKAALL
10 20 30
470 480 490 500 510 520
pF1KA0 KKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKKNSSFSKKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDST
40 50 60 70 80 90
530 540 550 560 570 580
pF1KA0 HISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HISLQEENQSSVSHCVPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSL
100 110 120 130 140 150
590 600 610 620 630 640
pF1KA0 LSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSRTVADYAVVPLLGCEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTP
160 170 180 190 200 210
650 660 670 680 690 700
pF1KA0 LEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKY
220 230 240 250 260 270
710 720 730 740 750 760
pF1KA0 EAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEH
280 290 300 310 320 330
770 780 790 800 810 820
pF1KA0 PGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGTRLQTHRKTVVTPLDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSK
340 350 360 370 380 390
830 840 850 860 870 880
pF1KA0 FLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLSKDKLFKPSFDVKDALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVAL
400 410 420 430 440 450
890 900 910 920 930 940
pF1KA0 SASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHF
460 470 480 490 500 510
950 960 970 980 990 1000
pF1KA0 IYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQ
520 530 540 550 560 570
1010 1020 1030 1040 1050 1060
pF1KA0 DGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTL
580 590 600 610 620 630
1070 1080 1090 1100 1110 1120
pF1KA0 EMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQ
640 650 660 670 680 690
1130 1140 1150 1160 1170 1180
pF1KA0 SRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPF
700 710 720 730 740 750
1190 1200 1210 1220 1230 1240
pF1KA0 QKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPP
760 770 780 790 800 810
1250 1260 1270 1280 1290 1300
pF1KA0 VAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAPHPREKIITIEETHEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCT
820 830 840 850 860 870
1310 1320 1330 1340 1350 1360
pF1KA0 HIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HIVVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINV
880 890 900 910 920 930
1370 1380 1390 1400 1410 1420
pF1KA0 QQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQRRLALAAMRWRKKIQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPG
940 950 960 970 980 990
1430 1440 1450 1460 1470 1480
pF1KA0 HSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSVPLFKEATHLFSDLNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYC
1000 1010 1020 1030 1040 1050
1490 1500 1510 1520
pF1KA0 LPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH
:::::::::::::::::::::::::::::::::::::
XP_016 LPEAISFIQNNKELGTGLSQKRKAPTEKNKIKRPRVH
1060 1070 1080
>>XP_016861326 (OMIM: 600586) PREDICTED: protein ECT2 is (854 aa)
initn: 393 init1: 249 opt: 462 Z-score: 443.4 bits: 93.9 E(85289): 5.9e-18
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
XP_016 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
XP_016 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
XP_016 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
XP_016 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
XP_016 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
XP_016 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPHTPKS
320 330 340 350 360 370
>>XP_016861327 (OMIM: 600586) PREDICTED: protein ECT2 is (854 aa)
initn: 393 init1: 249 opt: 462 Z-score: 443.4 bits: 93.9 E(85289): 5.9e-18
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
XP_016 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
XP_016 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
XP_016 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
XP_016 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
XP_016 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
XP_016 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPHTPKS
320 330 340 350 360 370
>>NP_001245245 (OMIM: 600586) protein ECT2 isoform b [Ho (883 aa)
initn: 393 init1: 249 opt: 462 Z-score: 443.2 bits: 93.9 E(85289): 6e-18
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
NP_001 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
NP_001 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
NP_001 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
NP_001 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
NP_001 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
NP_001 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRPS
320 330 340 350 360 370
>>NP_060568 (OMIM: 600586) protein ECT2 isoform b [Homo (883 aa)
initn: 393 init1: 249 opt: 462 Z-score: 443.2 bits: 93.9 E(85289): 6e-18
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
NP_060 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
NP_060 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
NP_060 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
NP_060 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
NP_060 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
NP_060 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRPS
320 330 340 350 360 370
>>XP_016861321 (OMIM: 600586) PREDICTED: protein ECT2 is (927 aa)
initn: 393 init1: 249 opt: 462 Z-score: 442.8 bits: 93.9 E(85289): 6.3e-18
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
XP_016 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
XP_016 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
XP_016 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
XP_016 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
XP_016 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
XP_016 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRPS
320 330 340 350 360 370
1522 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:37:20 2016 done: Thu Nov 3 19:37:22 2016
Total Scan time: 15.860 Total Display time: 0.510
Function used was FASTA [36.3.4 Apr, 2011]