Result of FASTA (ccds) for
pFN21AA0259
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0259, 1522 aa
1>>>pF1KA0259 1522 - 1522 aa - 1522 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5725+/-0.00112; mu= 11.7448+/- 0.067
mean_var=99.3735+/-19.744, 0's: 0 Z-trim(104.9): 25 B-trim: 0 in 0/50
Lambda= 0.128659
statistics sampled from 8134 (8147) to 8134 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.25), width: 16
Scan time: 5.990
The best scores are: opt bits E(32554)
CCDS46919.1 TOPBP1 gene_id:11073|Hs108|chr3 (1522) 10112 1888.4 0
CCDS3220.1 ECT2 gene_id:1894|Hs108|chr3 ( 883) 462 97.2 2.4e-19
CCDS58860.1 ECT2 gene_id:1894|Hs108|chr3 ( 914) 455 95.9 6e-19
>>CCDS46919.1 TOPBP1 gene_id:11073|Hs108|chr3 (1522 aa)
initn: 10112 init1: 10112 opt: 10112 Z-score: 10137.2 bits: 1888.4 E(32554): 0
Smith-Waterman score: 10112; 99.9% identity (100.0% similar) in 1522 aa overlap (1-1522:1-1522)
10 20 30 40 50 60
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHQPESKAALLKKKNSSFSKKDFAPS
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
CCDS46 VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KA0 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KA0 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KA0 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KA0 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KA0 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KA0 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KA0 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KA0 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KA0 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KA0 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KA0 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KA0 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
1450 1460 1470 1480 1490 1500
1510 1520
pF1KA0 TGLSQKRKAPTEKNKIKRPRVH
::::::::::::::::::::::
CCDS46 TGLSQKRKAPTEKNKIKRPRVH
1510 1520
>>CCDS3220.1 ECT2 gene_id:1894|Hs108|chr3 (883 aa)
initn: 393 init1: 249 opt: 462 Z-score: 460.9 bits: 97.2 E(32554): 2.4e-19
Smith-Waterman score: 462; 30.3% identity (60.7% similar) in 300 aa overlap (11-301:53-345)
10 20 30 40
pF1KA0 MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQ
: ... . ... ..:::..:: . ..
CCDS32 DSKVTEISKENLLIGSTSYVEEEMPQIETRVILVQEAGKQEELIKALKDIKV--GFVKME
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 IITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHP
. : :.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .:
CCDS32 SVEEFEGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCRP
90 100 110 120 130
110 120 130 140 150
pF1KA0 VYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLV
.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:. :
CCDS32 LYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFRV
140 150 160 170 180 190
160 170 180 190 200 210
pF1KA0 AANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEV
:..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. ..
CCDS32 AVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTNM
200 210 220 230 240 250
220 230 240 250 260 270
pF1KA0 QQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGFC
...: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
CCDS32 EEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDAR
260 270 280 290 300 310
280 290 300 310 320 330
pF1KA0 QDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESICN
:..: : :: : .: . .::.:
CCDS32 AGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRPS
320 330 340 350 360 370
>>CCDS58860.1 ECT2 gene_id:1894|Hs108|chr3 (914 aa)
initn: 393 init1: 249 opt: 455 Z-score: 453.7 bits: 95.9 E(32554): 6e-19
Smith-Waterman score: 456; 31.2% identity (58.1% similar) in 301 aa overlap (12-301:93-376)
10 20 30
pF1KA0 MSRNDKEPFFVKFLKSSDNS--KCFFKALESIKEFQSEEYL
:..:: : : : .::..::
CCDS58 EELIKALKTIKIMEVPVIKIKESCPGKSDEKLIKSVINMDIKVGFVKMESVEEF------
70 80 90 100 110
40 50 60 70 80 90
pF1KA0 QIITEEEALKIKENDRSLYICDPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEH
:.: : . . . : :. ::. : : ::..:: ::. : .. . .: . .
CCDS58 ------EGLDSPEFENVFVVTD-FQDSVFNDLYKADCRVIGPPVVLNCSQKGEPLPFSCR
120 130 140 150 160
100 110 120 130 140 150
pF1KA0 PVYNMVMSDVTISCTSLEKEKREEVH--KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYL
:.: : .... : . ..:.: :. :. ::: . .:.: .::::.:. . ..:.
CCDS58 PLYCTSMMNLVL-CFTGFRKKEELVRLVTLVHHMGGVIRKDFNSKVTHLVANCTQGEKFR
170 180 190 200 210 220
160 170 180 190 200 210
pF1KA0 VAANLKKPILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKE
::..: ::. : :: ::. .:. . .: ..:: : : ::. :. .. .
CCDS58 VAVSLGTPIMKPEWIYKAWERRNEQDFYAAVDDFRNEFKVPPFQDCILSFLGFSDEEKTN
230 240 250 260 270 280
220 230 240 250 260 270
pF1KA0 VQQLTVKHGGQYMGQLKMNECTHLIVQEP--KGQKYECAKRWNVHCVTTQWFFDSIEKGF
....: .::.:. : ..::::.:.: : .: .:. .. : .::. ::.
CCDS58 MEEMTEMQGGKYL-PLGDERCTHLVVEENIVKDLPFEPSKK--LYVVKQEWFWGSIQMDA
290 300 310 320 330 340
280 290 300 310 320 330
pF1KA0 CQDESIYKTEP--RPEAK---TMPNSSTPTSQINTIDSRTLSDVSNISNINASCVSESIC
:..: : :: : .: . .::.:
CCDS58 RAGETMYLYEKANTPELKKSVSMLSLNTPNSNRKRRRLKETLAQLSRETDVSPFPPRKRP
350 360 370 380 390 400
340 350 360 370 380 390
pF1KA0 NSLNSKLEPTLENLENLDVSAFQAPEDLLDGCRIYLCGFSGRKLDKLRRLINSGGGVRFN
CCDS58 SAEHSLSIGSLLDISNTPESSINYGDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTES
410 420 430 440 450 460
1522 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:37:19 2016 done: Thu Nov 3 19:37:20 2016
Total Scan time: 5.990 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]