Result of FASTA (omim) for
pFN21ASDA0975
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0975, 1504 aa
1>>>pF1KSDA0975 1504 - 1504 aa - 1504 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.9935+/-0.0005; mu= -0.6245+/- 0.031
mean_var=373.3203+/-79.737, 0's: 0 Z-trim(119.9): 39 B-trim: 2978 in 2/56
Lambda= 0.066379
statistics sampled from 34520 (34579) to 34520 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.405), width: 16
Scan time: 21.360
The best scores are: opt bits E(85289)
NP_009115 (OMIM: 615507) nischarin isoform 1 [Homo (1504) 9994 972.7 0
XP_005264896 (OMIM: 615507) PREDICTED: nischarin i (1113) 7472 731.0 1.2e-209
XP_016861132 (OMIM: 615507) PREDICTED: nischarin i (1113) 7472 731.0 1.2e-209
XP_006713018 (OMIM: 615507) PREDICTED: nischarin i ( 998) 6717 658.7 6.6e-188
NP_001263223 (OMIM: 615507) nischarin isoform 3 [H ( 515) 3293 330.5 2.1e-89
NP_001263222 (OMIM: 615507) nischarin isoform 2 [H ( 583) 3285 329.8 3.9e-89
XP_011508831 (OMIM: 607172) PREDICTED: serine/thre ( 704) 319 45.9 0.0014
XP_011508829 (OMIM: 607172) PREDICTED: serine/thre (1041) 319 46.0 0.0019
XP_011508828 (OMIM: 607172) PREDICTED: serine/thre (1066) 319 46.0 0.0019
NP_443134 (OMIM: 607172) serine/threonine-protein (1088) 319 46.0 0.0019
>>NP_009115 (OMIM: 615507) nischarin isoform 1 [Homo sap (1504 aa)
initn: 9994 init1: 9994 opt: 9994 Z-score: 5188.2 bits: 972.7 E(85289): 0
Smith-Waterman score: 9994; 99.9% identity (99.9% similar) in 1504 aa overlap (1-1504:1-1504)
10 20 30 40 50 60
pF1KSD MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD DVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD SIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD VLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLT
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 FYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD VKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD QPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 QPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD GSAQGSFADGQPAERRASNDQRPQEVPAEALAPAPVEVPAPAPAAASASGPAKTPAPAEA
:: ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_009 GSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD STSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 STSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD AIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 AIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD EPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 EPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTR
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD DSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD SEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 SEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEI
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD FLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 FLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGH
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD DLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPV
1450 1460 1470 1480 1490 1500
pF1KSD ELTG
::::
NP_009 ELTG
>>XP_005264896 (OMIM: 615507) PREDICTED: nischarin isofo (1113 aa)
initn: 7472 init1: 7472 opt: 7472 Z-score: 3884.6 bits: 731.0 E(85289): 1.2e-209
Smith-Waterman score: 7472; 99.8% identity (99.9% similar) in 1113 aa overlap (392-1504:1-1113)
370 380 390 400 410 420
pF1KSD LAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYR
::::::::::::::::::::::::::::::
XP_005 MEEVRSIGSLPCLEHVSLLNNPLSIIPDYR
10 20 30
430 440 450 460 470 480
pF1KSD TKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSA
40 50 60 70 80 90
490 500 510 520 530 540
pF1KSD APCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCS
100 110 120 130 140 150
550 560 570 580 590 600
pF1KSD DSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQD
160 170 180 190 200 210
610 620 630 640 650 660
pF1KSD FIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPPD
220 230 240 250 260 270
670 680 690 700 710 720
pF1KSD VEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGS
280 290 300 310 320 330
730 740 750 760 770 780
pF1KSD IRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLV
340 350 360 370 380 390
790 800 810 820 830 840
pF1KSD LKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTF
400 410 420 430 440 450
850 860 870 880 890 900
pF1KSD YKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAV
460 470 480 490 500 510
910 920 930 940 950 960
pF1KSD KSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQ
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KSD PRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTGG
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KSD SAQGSFADGQPAERRASNDQRPQEVPAEALAPAPVEVPAPAPAAASASGPAKTPAPAEAS
: ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_005 SPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEAS
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KSD TSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSA
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KSD IIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSE
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KSD PLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRD
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KSD SYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPS
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KSD EEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIF
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KSD LLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHD
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KSD LMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVE
1060 1070 1080 1090 1100 1110
pF1KSD LTG
:::
XP_005 LTG
>>XP_016861132 (OMIM: 615507) PREDICTED: nischarin isofo (1113 aa)
initn: 7472 init1: 7472 opt: 7472 Z-score: 3884.6 bits: 731.0 E(85289): 1.2e-209
Smith-Waterman score: 7472; 99.8% identity (99.9% similar) in 1113 aa overlap (392-1504:1-1113)
370 380 390 400 410 420
pF1KSD LAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYR
::::::::::::::::::::::::::::::
XP_016 MEEVRSIGSLPCLEHVSLLNNPLSIIPDYR
10 20 30
430 440 450 460 470 480
pF1KSD TKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSA
40 50 60 70 80 90
490 500 510 520 530 540
pF1KSD APCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCS
100 110 120 130 140 150
550 560 570 580 590 600
pF1KSD DSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQD
160 170 180 190 200 210
610 620 630 640 650 660
pF1KSD FIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPPD
220 230 240 250 260 270
670 680 690 700 710 720
pF1KSD VEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGS
280 290 300 310 320 330
730 740 750 760 770 780
pF1KSD IRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLV
340 350 360 370 380 390
790 800 810 820 830 840
pF1KSD LKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTF
400 410 420 430 440 450
850 860 870 880 890 900
pF1KSD YKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAV
460 470 480 490 500 510
910 920 930 940 950 960
pF1KSD KSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQ
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KSD PRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTGG
580 590 600 610 620 630
1030 1040 1050 1060 1070 1080
pF1KSD SAQGSFADGQPAERRASNDQRPQEVPAEALAPAPVEVPAPAPAAASASGPAKTPAPAEAS
: ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_016 SPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEAS
640 650 660 670 680 690
1090 1100 1110 1120 1130 1140
pF1KSD TSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSA
700 710 720 730 740 750
1150 1160 1170 1180 1190 1200
pF1KSD IIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFSE
760 770 780 790 800 810
1210 1220 1230 1240 1250 1260
pF1KSD PLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTRD
820 830 840 850 860 870
1270 1280 1290 1300 1310 1320
pF1KSD SYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYPS
880 890 900 910 920 930
1330 1340 1350 1360 1370 1380
pF1KSD EEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEIF
940 950 960 970 980 990
1390 1400 1410 1420 1430 1440
pF1KSD LLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGHD
1000 1010 1020 1030 1040 1050
1450 1460 1470 1480 1490 1500
pF1KSD LMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVE
1060 1070 1080 1090 1100 1110
pF1KSD LTG
:::
XP_016 LTG
>>XP_006713018 (OMIM: 615507) PREDICTED: nischarin isofo (998 aa)
initn: 6717 init1: 6717 opt: 6717 Z-score: 3494.5 bits: 658.7 E(85289): 6.6e-188
Smith-Waterman score: 6717; 99.8% identity (99.9% similar) in 995 aa overlap (510-1504:4-998)
480 490 500 510 520 530
pF1KSD SAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQG
::::::::::::::::::::::::::::::
XP_006 MKCGIMFVQEEALASSLSSTDSLTPEHQPIAQG
10 20 30
540 550 560 570 580 590
pF1KSD CSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATN
40 50 60 70 80 90
600 610 620 630 640 650
pF1KSD QDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QDFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGP
100 110 120 130 140 150
660 670 680 690 700 710
pF1KSD PDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQ
160 170 180 190 200 210
720 730 740 750 760 770
pF1KSD GSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELC
220 230 240 250 260 270
780 790 800 810 820 830
pF1KSD LVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLL
280 290 300 310 320 330
840 850 860 870 880 890
pF1KSD TFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TFYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSE
340 350 360 370 380 390
900 910 920 930 940 950
pF1KSD AVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSC
400 410 420 430 440 450
960 970 980 990 1000 1010
pF1KSD TQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGT
460 470 480 490 500 510
1020 1030 1040 1050 1060 1070
pF1KSD GGSAQGSFADGQPAERRASNDQRPQEVPAEALAPAPVEVPAPAPAAASASGPAKTPAPAE
::: ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
XP_006 GGSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAE
520 530 540 550 560 570
1080 1090 1100 1110 1120 1130
pF1KSD ASTSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASTSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRG
580 590 600 610 620 630
1140 1150 1160 1170 1180 1190
pF1KSD SAIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYF
640 650 660 670 680 690
1200 1210 1220 1230 1240 1250
pF1KSD SEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLT
700 710 720 730 740 750
1260 1270 1280 1290 1300 1310
pF1KSD RDSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RDSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTY
760 770 780 790 800 810
1320 1330 1340 1350 1360 1370
pF1KSD PSEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSE
820 830 840 850 860 870
1380 1390 1400 1410 1420 1430
pF1KSD IFLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQG
880 890 900 910 920 930
1440 1450 1460 1470 1480 1490
pF1KSD HDLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HDLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELP
940 950 960 970 980 990
1500
pF1KSD VELTG
:::::
XP_006 VELTG
>>NP_001263223 (OMIM: 615507) nischarin isoform 3 [Homo (515 aa)
initn: 3391 init1: 3293 opt: 3293 Z-score: 1726.2 bits: 330.5 E(85289): 2.1e-89
Smith-Waterman score: 3293; 99.8% identity (100.0% similar) in 512 aa overlap (1-512:1-512)
10 20 30 40 50 60
pF1KSD MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC
:::::::::::::::::::::::::::::::.
NP_001 AAPCIRPSSSPPTVAPASASLPQPILSNQGILGDE
490 500 510
550 560 570 580 590 600
pF1KSD SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ
>>NP_001263222 (OMIM: 615507) nischarin isoform 2 [Homo (583 aa)
initn: 3285 init1: 3285 opt: 3285 Z-score: 1721.3 bits: 329.8 E(85289): 3.9e-89
Smith-Waterman score: 3285; 100.0% identity (100.0% similar) in 510 aa overlap (1-510:1-510)
10 20 30 40 50 60
pF1KSD MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC
::::::::::::::::::::::::::::::
NP_001 AAPCIRPSSSPPTVAPASASLPQPILSNQGNRVCILLLVEPHSPAWAPWLGWGWGRGAST
490 500 510 520 530 540
>>XP_011508831 (OMIM: 607172) PREDICTED: serine/threonin (704 aa)
initn: 369 init1: 168 opt: 319 Z-score: 185.2 bits: 45.9 E(85289): 0.0014
Smith-Waterman score: 377; 26.8% identity (51.2% similar) in 615 aa overlap (180-777:81-636)
150 160 170 180 190 200
pF1KSD GPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLL
.:. : :: ..:.: :: :
XP_011 PWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGP-GPTG---------
60 70 80 90 100
210 220 230 240 250 260
pF1KSD PFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEWE
:. . ::::...:. . ..:: . : :: : ...:.: ...:
XP_011 PIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDF----
110 120 130 140 150
270 280 290 300 310 320
pF1KSD PEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-L
...: : :: . ..:.:... .: :..:. ..::.:::: . .. :
XP_011 ----------CSALP-WLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFL
160 170 180 190 200
330 340 350 360 370 380
pF1KSD QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNR
. : .: :::.:::.: . . . . . .: : :: :.:: ::..: .: .::: :
XP_011 MDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNL
210 220 230 240 250 260
390 400 410 420 430 440
pF1KSD IEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVC----LDDTVTTE
.: .:. . : :... : .::: . :..:. . .. :: .. :: : .
XP_011 LEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSL
270 280 290 300 310 320
450 460 470 480 490 500
pF1KSD KELDTVEVLKAIQKAKEVKSKL-SNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQ
...: : . . . :.:: .:: : :: . :: .:. :
XP_011 TDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPD--LSDS-----LSSGGVVT-------Q
330 340 350 360 370
510 520 530 540 550 560
pF1KSD PILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSD-SLESIPAGQAASDDLRDVPG
:.: . ..: : :.:: :: . . . . ... : . :. .:. :
XP_011 PLLHKVKSRVRVRRASISEPSDTD---PEPRTLNPSPAGWFVQQHPELELMSS-FRERFG
380 390 400 410 420
570 580 590 600 610 620
pF1KSD AVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWI
: :: ::. :: : .:. :. .. : :
XP_011 RNWLQYRSHLEP-------SGNP--LPAT----PTTSAPSAPPASSQGPDTAPRPSPPQE
430 440 450 460 470
630 640 650 660 670 680
pF1KSD EAANQREEGQ--GEQGEEEDEEEEEEEDVAENRYFEMGPPDVEEEEGGGQGEEEEEEEED
:: . .: : .:. . : .:::::.. :.. : : . :: .:. ::::.....
XP_011 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK--EEGEMVEQGEEEAGEEEEEEQDQKE
480 490 500 510 520 530
690 700 710 720 730 740
pF1KSD EEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFE
::: : : : . : .. .:.: :..:. . . : : .. : .:
XP_011 VEAELCRPLLVCPLEGPEGVRGREC-FLRVTSAHLFEVELQAARTLERLELQSLEAAEIE
540 550 560 570 580 590
750 760 770 780 790
pF1KSD IPHQESRG---SSQHILS-----SLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLF
: .:. ... .: :::: . : .: .. : :.
XP_011 PEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPV
600 610 620 630 640 650
800 810 820 830 840 850
pF1KSD IISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGCQERS
XP_011 TNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTDTT
660 670 680 690 700
>>XP_011508829 (OMIM: 607172) PREDICTED: serine/threonin (1041 aa)
initn: 446 init1: 168 opt: 319 Z-score: 182.9 bits: 46.0 E(85289): 0.0019
Smith-Waterman score: 377; 26.8% identity (51.2% similar) in 615 aa overlap (180-777:81-636)
150 160 170 180 190 200
pF1KSD GPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLL
.:. : :: ..:.: :: :
XP_011 PWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGP-GPTG---------
60 70 80 90 100
210 220 230 240 250 260
pF1KSD PFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEWE
:. . ::::...:. . ..:: . : :: : ...:.: ...:
XP_011 PIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDF----
110 120 130 140 150
270 280 290 300 310 320
pF1KSD PEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-L
...: : :: . ..:.:... .: :..:. ..::.:::: . .. :
XP_011 ----------CSALP-WLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFL
160 170 180 190 200
330 340 350 360 370 380
pF1KSD QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNR
. : .: :::.:::.: . . . . . .: : :: :.:: ::..: .: .::: :
XP_011 MDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNL
210 220 230 240 250 260
390 400 410 420 430 440
pF1KSD IEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVC----LDDTVTTE
.: .:. . : :... : .::: . :..:. . .. :: .. :: : .
XP_011 LEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSL
270 280 290 300 310 320
450 460 470 480 490 500
pF1KSD KELDTVEVLKAIQKAKEVKSKL-SNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQ
...: : . . . :.:: .:: : :: . :: .:. :
XP_011 TDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPD--LSDS-----LSSGGVVT-------Q
330 340 350 360 370
510 520 530 540 550 560
pF1KSD PILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSD-SLESIPAGQAASDDLRDVPG
:.: . ..: : :.:: :: . . . . ... : . :. .:. :
XP_011 PLLHKVKSRVRVRRASISEPSDTD---PEPRTLNPSPAGWFVQQHPELELMSS-FRERFG
380 390 400 410 420
570 580 590 600 610 620
pF1KSD AVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWI
: :: ::. :: : .:. :. .. : :
XP_011 RNWLQYRSHLEP-------SGNP--LPAT----PTTSAPSAPPASSQGPDTAPRPSPPQE
430 440 450 460 470
630 640 650 660 670 680
pF1KSD EAANQREEGQ--GEQGEEEDEEEEEEEDVAENRYFEMGPPDVEEEEGGGQGEEEEEEEED
:: . .: : .:. . : .:::::.. :.. : : . :: .:. ::::.....
XP_011 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK--EEGEMVEQGEEEAGEEEEEEQDQKE
480 490 500 510 520 530
690 700 710 720 730 740
pF1KSD EEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFE
::: : : : . : .. .:.: :..:. . . : : .. : .:
XP_011 VEAELCRPLLVCPLEGPEGVRGREC-FLRVTSAHLFEVELQAARTLERLELQSLEAAEIE
540 550 560 570 580 590
750 760 770 780 790
pF1KSD IPHQESRG---SSQHILS-----SLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLF
: .:. ... .: :::: . : .: .. : :.
XP_011 PEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPV
600 610 620 630 640 650
800 810 820 830 840 850
pF1KSD IISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGCQERS
XP_011 TNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCG
660 670 680 690 700 710
>>XP_011508828 (OMIM: 607172) PREDICTED: serine/threonin (1066 aa)
initn: 446 init1: 168 opt: 319 Z-score: 182.8 bits: 46.0 E(85289): 0.0019
Smith-Waterman score: 377; 26.8% identity (51.2% similar) in 615 aa overlap (180-777:81-636)
150 160 170 180 190 200
pF1KSD GPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLL
.:. : :: ..:.: :: :
XP_011 PWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGP-GPTG---------
60 70 80 90 100
210 220 230 240 250 260
pF1KSD PFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEWE
:. . ::::...:. . ..:: . : :: : ...:.: ...:
XP_011 PIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDF----
110 120 130 140 150
270 280 290 300 310 320
pF1KSD PEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-L
...: : :: . ..:.:... .: :..:. ..::.:::: . .. :
XP_011 ----------CSALP-WLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFL
160 170 180 190 200
330 340 350 360 370 380
pF1KSD QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNR
. : .: :::.:::.: . . . . . .: : :: :.:: ::..: .: .::: :
XP_011 MDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNL
210 220 230 240 250 260
390 400 410 420 430 440
pF1KSD IEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVC----LDDTVTTE
.: .:. . : :... : .::: . :..:. . .. :: .. :: : .
XP_011 LEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSL
270 280 290 300 310 320
450 460 470 480 490 500
pF1KSD KELDTVEVLKAIQKAKEVKSKL-SNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQ
...: : . . . :.:: .:: : :: . :: .:. :
XP_011 TDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPD--LSDS-----LSSGGVVT-------Q
330 340 350 360 370
510 520 530 540 550 560
pF1KSD PILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSD-SLESIPAGQAASDDLRDVPG
:.: . ..: : :.:: :: . . . . ... : . :. .:. :
XP_011 PLLHKVKSRVRVRRASISEPSDTD---PEPRTLNPSPAGWFVQQHPELELMSS-FRERFG
380 390 400 410 420
570 580 590 600 610 620
pF1KSD AVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWI
: :: ::. :: : .:. :. .. : :
XP_011 RNWLQYRSHLEP-------SGNP--LPAT----PTTSAPSAPPASSQGPDTAPRPSPPQE
430 440 450 460 470
630 640 650 660 670 680
pF1KSD EAANQREEGQ--GEQGEEEDEEEEEEEDVAENRYFEMGPPDVEEEEGGGQGEEEEEEEED
:: . .: : .:. . : .:::::.. :.. : : . :: .:. ::::.....
XP_011 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK--EEGEMVEQGEEEAGEEEEEEQDQKE
480 490 500 510 520 530
690 700 710 720 730 740
pF1KSD EEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFE
::: : : : . : .. .:.: :..:. . . : : .. : .:
XP_011 VEAELCRPLLVCPLEGPEGVRGREC-FLRVTSAHLFEVELQAARTLERLELQSLEAAEIE
540 550 560 570 580 590
750 760 770 780 790
pF1KSD IPHQESRG---SSQHILS-----SLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLF
: .:. ... .: :::: . : .: .. : :.
XP_011 PEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPV
600 610 620 630 640 650
800 810 820 830 840 850
pF1KSD IISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGCQERS
XP_011 TNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCG
660 670 680 690 700 710
>>NP_443134 (OMIM: 607172) serine/threonine-protein kina (1088 aa)
initn: 446 init1: 168 opt: 319 Z-score: 182.7 bits: 46.0 E(85289): 0.0019
Smith-Waterman score: 377; 26.8% identity (51.2% similar) in 615 aa overlap (180-777:81-636)
150 160 170 180 190 200
pF1KSD GPLQLYAVTEQLQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEGPFGTSNIQEQLL
.:. : :: ..:.: :: :
NP_443 PWGPGQTGFVALPSHPADSPVILQLQFLFDVLQKTLSLKLVHVAGP-GPTG---------
60 70 80 90 100
210 220 230 240 250 260
pF1KSD PFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEWE
:. . ::::...:. . ..:: . : :: : ...:.: ...:
NP_443 PIKIFPFKSLRHLELRGVPLHCLHGLRGIYSQLETLICSRSLQALEELLSACGGDF----
110 120 130 140 150
270 280 290 300 310 320
pF1KSD PEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-L
...: : :: . ..:.:... .: :..:. ..::.:::: . .. :
NP_443 ----------CSALP-WLALLSANFSYNALTALDSSLRLLSALRFLNLSHNQVQDCQGFL
160 170 180 190 200
330 340 350 360 370 380
pF1KSD QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNR
. : .: :::.:::.: . . . . . .: : :: :.:: ::..: .: .::: :
NP_443 MDLCELHHLDISYNRLHLVPRMGPSGAALGVLILRGNELRSLHGLEQLRNLRHLDLAYNL
210 220 230 240 250 260
390 400 410 420 430 440
pF1KSD IEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVC----LDDTVTTE
.: .:. . : :... : .::: . :..:. . .. :: .. :: : .
NP_443 LEGHRELSPLWLLAELRKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSL
270 280 290 300 310 320
450 460 470 480 490 500
pF1KSD KELDTVEVLKAIQKAKEVKSKL-SNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQ
...: : . . . :.:: .:: : :: . :: .:. :
NP_443 TDFQTHTSLGLSPMGPPLPWPVGSTPETSGGPD--LSDS-----LSSGGVVT-------Q
330 340 350 360 370
510 520 530 540 550 560
pF1KSD PILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSD-SLESIPAGQAASDDLRDVPG
:.: . ..: : :.:: :: . . . . ... : . :. .:. :
NP_443 PLLHKVKSRVRVRRASISEPSDTD---PEPRTLNPSPAGWFVQQHPELELMSS-FRERFG
380 390 400 410 420
570 580 590 600 610 620
pF1KSD AVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQDFIQRLSTLIRQAIERQLPAWI
: :: ::. :: : .:. :. .. : :
NP_443 RNWLQYRSHLEP-------SGNP--LPAT----PTTSAPSAPPASSQGPDTAPRPSPPQE
430 440 450 460 470
630 640 650 660 670 680
pF1KSD EAANQREEGQ--GEQGEEEDEEEEEEEDVAENRYFEMGPPDVEEEEGGGQGEEEEEEEED
:: . .: : .:. . : .:::::.. :.. : : . :: .:. ::::.....
NP_443 EARGPQESPQKMSEEVRAEPQEEEEEKEGKEEK--EEGEMVEQGEEEAGEEEEEEQDQKE
480 490 500 510 520 530
690 700 710 720 730 740
pF1KSD EEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSIRQFAACLVLTDFGIAVFE
::: : : : . : .. .:.: :..:. . . : : .. : .:
NP_443 VEAELCRPLLVCPLEGPEGVRGREC-FLRVTSAHLFEVELQAARTLERLELQSLEAAEIE
540 550 560 570 580 590
750 760 770 780 790
pF1KSD IPHQESRG---SSQHILS-----SLRFVFCFPHGDLTEFGFLMPELCLVLKVRHSENTLF
: .:. ... .: :::: . : .: .. : :.
NP_443 PEAQAQRSPRPTGSDLLPGAPILSLRFSYICPDRQLRRYLVLEPDAHAAVQELLAVLTPV
600 610 620 630 640 650
800 810 820 830 840 850
pF1KSD IISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFYKVAGGCQERS
NP_443 TNVAREQLGEARDLLLGRFQCLRCGHEFKPEEPRMGLDSEEGWRPLFQKTESPAVCPNCG
660 670 680 690 700 710
1504 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:54:23 2016 done: Thu Nov 3 18:54:26 2016
Total Scan time: 21.360 Total Display time: 0.420
Function used was FASTA [36.3.4 Apr, 2011]