Result of FASTA (omim) for
pFN21AB9348
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9348, 273 aa
1>>>pF1KB9348 273 - 273 aa - 273 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4409+/-0.000295; mu= 5.7242+/- 0.019
mean_var=120.3386+/-23.081, 0's: 0 Z-trim(121.0): 50 B-trim: 29 in 1/57
Lambda= 0.116915
statistics sampled from 36945 (36998) to 36945 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.434), width: 16
Scan time: 8.520
The best scores are: opt bits E(85289)
NP_001138870 (OMIM: 188595) thyrotroph embryonic f ( 273) 1784 311.1 1.4e-84
NP_003207 (OMIM: 188595) thyrotroph embryonic fact ( 303) 1668 291.6 1.2e-78
NP_002117 (OMIM: 142385) hepatic leukemia factor i ( 295) 1002 179.2 7.6e-45
XP_005257326 (OMIM: 142385) PREDICTED: hepatic leu ( 296) 990 177.2 3.1e-44
NP_001317304 (OMIM: 142385) hepatic leukemia facto ( 210) 815 147.6 1.8e-35
XP_011523007 (OMIM: 142385) PREDICTED: hepatic leu ( 211) 803 145.6 7.2e-35
NP_001343 (OMIM: 124097) D site-binding protein [H ( 325) 753 137.3 3.6e-32
XP_016881877 (OMIM: 124097) PREDICTED: D site-bind ( 182) 647 119.3 5.3e-27
XP_016870233 (OMIM: 605327) PREDICTED: nuclear fac ( 462) 194 43.0 0.0012
NP_005375 (OMIM: 605327) nuclear factor interleuki ( 462) 194 43.0 0.0012
NP_001276928 (OMIM: 605327) nuclear factor interle ( 462) 194 43.0 0.0012
NP_001276929 (OMIM: 605327) nuclear factor interle ( 462) 194 43.0 0.0012
XP_016870232 (OMIM: 605327) PREDICTED: nuclear fac ( 462) 194 43.0 0.0012
>>NP_001138870 (OMIM: 188595) thyrotroph embryonic facto (273 aa)
initn: 1784 init1: 1784 opt: 1784 Z-score: 1639.5 bits: 311.1 E(85289): 1.4e-84
Smith-Waterman score: 1784; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273)
10 20 30 40 50 60
pF1KB9 MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 GESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 PSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEK
190 200 210 220 230 240
250 260 270
pF1KB9 ENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
:::::::::::::::::::::::::::::::::
NP_001 ENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
250 260 270
>>NP_003207 (OMIM: 188595) thyrotroph embryonic factor i (303 aa)
initn: 1641 init1: 1641 opt: 1668 Z-score: 1533.1 bits: 291.6 E(85289): 1.2e-78
Smith-Waterman score: 1668; 96.3% identity (97.4% similar) in 270 aa overlap (4-273:36-303)
10 20 30
pF1KB9 MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEE
: :::.:.:. : : : :::::::::::
NP_003 GGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMEN--PPREARLDKEKGKEKLEE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB9 DEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB9 PVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNF
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB9 NPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKN
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 NVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
250 260 270 280 290 300
>>NP_002117 (OMIM: 142385) hepatic leukemia factor isofo (295 aa)
initn: 978 init1: 732 opt: 1002 Z-score: 926.1 bits: 179.2 E(85289): 7.6e-45
Smith-Waterman score: 1002; 56.8% identity (79.1% similar) in 278 aa overlap (6-273:21-295)
10 20 30 40
pF1KB9 MDMPEVLKSLLEHSLPWPEKRTD---KEKGKEKLEEDEAAAASTM
::.::::. : : .. : :.: ::: .::. . :.
NP_002 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSP-TV
10 20 30 40 50
50 60 70 80 90 100
pF1KB9 AVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKE
:: : : .::::.::::..:.::::::.::: ::::: ::.. :. : :.
NP_002 PQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPP--GLQPAS
60 70 80 90 100 110
110 120 130 140 150
pF1KB9 SASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDVNFNP
::. :. . : ..: ..:. . .: : .:.:::::::. ..: :...:
NP_002 SAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB9 DPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNV
:::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:::.::.:::.
NP_002 DPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNM
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB9 AAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:::
NP_002 AAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
240 250 260 270 280 290
>>XP_005257326 (OMIM: 142385) PREDICTED: hepatic leukemi (296 aa)
initn: 660 init1: 390 opt: 990 Z-score: 915.2 bits: 177.2 E(85289): 3.1e-44
Smith-Waterman score: 990; 56.6% identity (78.9% similar) in 279 aa overlap (6-273:21-296)
10 20 30 40
pF1KB9 MDMPEVLKSLLEHSLPWPEKRTD---KEKGKEKLEEDEAAAASTM
::.::::. : : .. : :.: ::: .::. . :.
XP_005 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSP-TV
10 20 30 40 50
50 60 70 80 90 100
pF1KB9 AVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKE
:: : : .::::.::::..:.::::::.::: ::::: ::.. :. : :.
XP_005 PQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPP--GLQPAS
60 70 80 90 100 110
110 120 130 140 150
pF1KB9 SASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDVNFNP
::. :. . : ..: ..:. . .: : .:.:::::::. ..: :...:
XP_005 SAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB9 DPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQK-DEKYWTRRKKNN
:::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. : :.:::.::.:::
XP_005 DPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB9 VAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:::
XP_005 MAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
240 250 260 270 280 290
>>NP_001317304 (OMIM: 142385) hepatic leukemia factor is (210 aa)
initn: 809 init1: 732 opt: 815 Z-score: 758.0 bits: 147.6 E(85289): 1.8e-35
Smith-Waterman score: 815; 59.0% identity (81.6% similar) in 212 aa overlap (69-273:1-210)
40 50 60 70 80 90
pF1KB9 ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL
:::.::: ::::: ::.. :. : :
NP_001 MDLEEFLSENGIPPSPSQHDHSPHPP--GL
10 20
100 110 120 130 140 150
pF1KB9 EGKESASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDV
. ::. :. . : ..: ..:. . .: : .:.:::::::. ..: :
NP_001 QPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPV
30 40 50 60 70 80
160 170 180 190 200 210
pF1KB9 NFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRK
...::::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:::.::.
NP_001 GYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRR
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB9 KNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYG
:::.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:
NP_001 KNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHG
150 160 170 180 190 200
pF1KB9 PL
::
NP_001 PL
210
>>XP_011523007 (OMIM: 142385) PREDICTED: hepatic leukemi (211 aa)
initn: 521 init1: 390 opt: 803 Z-score: 747.0 bits: 145.6 E(85289): 7.2e-35
Smith-Waterman score: 803; 58.7% identity (81.2% similar) in 213 aa overlap (69-273:1-211)
40 50 60 70 80 90
pF1KB9 ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL
:::.::: ::::: ::.. :. : :
XP_011 MDLEEFLSENGIPPSPSQHDHSPHPP--GL
10 20
100 110 120 130 140 150
pF1KB9 EGKESASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDV
. ::. :. . : ..: ..:. . .: : .:.:::::::. ..: :
XP_011 QPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPV
30 40 50 60 70 80
160 170 180 190 200 210
pF1KB9 NFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQK-DEKYWTRR
...::::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. : :.:::.::
XP_011 GYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARR
90 100 110 120 130 140
220 230 240 250 260 270
pF1KB9 KKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKY
.:::.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...
XP_011 RKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARH
150 160 170 180 190 200
pF1KB9 GPL
:::
XP_011 GPL
210
>>NP_001343 (OMIM: 124097) D site-binding protein [Homo (325 aa)
initn: 738 init1: 638 opt: 753 Z-score: 698.5 bits: 137.3 E(85289): 3.6e-32
Smith-Waterman score: 753; 51.3% identity (76.3% similar) in 232 aa overlap (48-273:100-325)
20 30 40 50 60 70
pF1KB9 PEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLE
: : .:..:.:. :. .::.::: ::::
NP_001 TAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPF-GD---VEYVDLDAFLLE
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB9 NGIPASPTHLAHNLLLPVAELEGKES---ASSSTASPPSSSTAIFQPSETVSSTESSLEK
.:.: :: . : : .: ..::: :: :.... .: :. .
NP_001 HGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPG--HAPARAALGTASGHRA
130 140 150 160 170 180
140 150 160 170 180 190
pF1KB9 ---ERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKK
:.::::.::. ::: ..:.::::::.:::.:: : :.::.:.:.::.:::::..::
NP_001 GLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKK
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB9 AKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAE
:.:. ::.::::::::.:: ::: ::::::::::::::::..:::::::::. :: ::.
NP_001 ARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVA
250 260 270 280 290 300
260 270
pF1KB9 LRKEVGKCKTIVSKYETKYGPL
.:.:... ....:.:....: :
NP_001 VRQELSHYRAVLSRYQAQHGAL
310 320
>>XP_016881877 (OMIM: 124097) PREDICTED: D site-binding (182 aa)
initn: 689 init1: 638 opt: 647 Z-score: 605.8 bits: 119.3 E(85289): 5.3e-27
Smith-Waterman score: 647; 64.5% identity (91.3% similar) in 138 aa overlap (136-273:45-182)
110 120 130 140 150 160
pF1KB9 SSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSV
:.::::.::. ::: ..:.::::::.:::.
XP_016 GARGRCPPRVCWRHCCGSARCRSAMWSLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSI
20 30 40 50 60 70
170 180 190 200 210 220
pF1KB9 PGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARR
:: : :.::.:.:.::.:::::..:::.:. ::.::::::::.:: ::: ::::::::::
XP_016 PGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARR
80 90 100 110 120 130
230 240 250 260 270
pF1KB9 LKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
::::::..:::::::::. :: ::. .:.:... ....:.:....: :
XP_016 LKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL
140 150 160 170 180
>>XP_016870233 (OMIM: 605327) PREDICTED: nuclear factor (462 aa)
initn: 175 init1: 175 opt: 194 Z-score: 186.5 bits: 43.0 E(85289): 0.0012
Smith-Waterman score: 194; 43.3% identity (71.6% similar) in 67 aa overlap (191-257:61-127)
170 180 190 200 210 220
pF1KB9 VLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRS
. :. :.:::.:: :: .:.::: :::::
XP_016 ALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRS
40 50 60 70 80 90
230 240 250 260 270
pF1KB9 RDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
:. :::.. . . : .::..:..:. :. . :
XP_016 REKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQ
100 110 120 130 140 150
XP_016 DYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRS
160 170 180 190 200 210
>>NP_005375 (OMIM: 605327) nuclear factor interleukin-3- (462 aa)
initn: 175 init1: 175 opt: 194 Z-score: 186.5 bits: 43.0 E(85289): 0.0012
Smith-Waterman score: 194; 43.3% identity (71.6% similar) in 67 aa overlap (191-257:61-127)
170 180 190 200 210 220
pF1KB9 VLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRS
. :. :.:::.:: :: .:.::: :::::
NP_005 ALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRS
40 50 60 70 80 90
230 240 250 260 270
pF1KB9 RDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
:. :::.. . . : .::..:..:. :. . :
NP_005 REKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQ
100 110 120 130 140 150
NP_005 DYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRS
160 170 180 190 200 210
273 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:22:14 2016 done: Thu Nov 3 18:22:15 2016
Total Scan time: 8.520 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]