Result of FASTA (omim) for
pFN21AB5642
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5642, 350 aa
1>>>pF1KB5642 350 - 350 aa - 350 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6634+/-0.000308; mu= 7.0255+/- 0.019
mean_var=161.8662+/-32.482, 0's: 0 Z-trim(121.6): 33 B-trim: 0 in 0/55
Lambda= 0.100808
statistics sampled from 38477 (38512) to 38477 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.452), width: 16
Scan time: 9.630
The best scores are: opt bits E(85289)
NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 2292 344.7 1.8e-94
NP_877495 (OMIM: 159552) induced myeloid leukemia ( 271) 1507 230.4 3.5e-60
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 1052 164.1 2.3e-40
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 201 40.3 0.0037
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 201 40.4 0.004
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 196 39.7 0.0072
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 196 39.7 0.0072
>>NP_068779 (OMIM: 159552) induced myeloid leukemia cell (350 aa)
initn: 2292 init1: 2292 opt: 2292 Z-score: 1816.9 bits: 344.7 E(85289): 1.8e-94
Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350)
10 20 30 40 50 60
pF1KB5 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
310 320 330 340 350
>>NP_877495 (OMIM: 159552) induced myeloid leukemia cell (271 aa)
initn: 1507 init1: 1507 opt: 1507 Z-score: 1201.4 bits: 230.4 E(85289): 3.5e-60
Smith-Waterman score: 1507; 100.0% identity (100.0% similar) in 230 aa overlap (1-230:1-230)
10 20 30 40 50 60
pF1KB5 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGWVCGVLPCRG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
NP_877 PRRWHQECAAGFCRCCWSRSWFGISNKIALL
250 260 270
>>NP_001184249 (OMIM: 159552) induced myeloid leukemia c (197 aa)
initn: 1050 init1: 1050 opt: 1052 Z-score: 845.7 bits: 164.1 E(85289): 2.3e-40
Smith-Waterman score: 1052; 98.8% identity (98.8% similar) in 164 aa overlap (187-350:34-197)
160 170 180 190 200 210
pF1KB5 DGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRV
: :::::::::::::::::::::::::::
NP_001 LKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATGAKDTKPMGRSGATSRKALETLRRV
10 20 30 40 50 60
220 230 240 250 260 270
pF1KB5 GDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAK
70 80 90 100 110 120
280 290 300 310 320 330
pF1KB5 HLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFA
130 140 150 160 170 180
340 350
pF1KB5 GVAGVGAGLAYLIR
::::::::::::::
NP_001 GVAGVGAGLAYLIR
190
>--
initn: 228 init1: 228 opt: 228 Z-score: 198.1 bits: 44.3 E(85289): 0.00027
Smith-Waterman score: 228; 100.0% identity (100.0% similar) in 33 aa overlap (1-33:1-33)
10 20 30 40 50 60
pF1KB5 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
:::::::::::::::::::::::::::::::::
NP_001 MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATGAKDTKPMGRSGATSRKALETL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
NP_001 RRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAF
70 80 90 100 110 120
>>XP_016882566 (OMIM: 600040) PREDICTED: apoptosis regul (173 aa)
initn: 156 init1: 138 opt: 201 Z-score: 177.6 bits: 40.3 E(85289): 0.0037
Smith-Waterman score: 201; 35.0% identity (58.1% similar) in 117 aa overlap (204-319:35-146)
180 190 200 210 220 230
pF1KB5 LYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLR
:...: : :.:.:: .. : : .: :.
XP_016 ALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNME--LQRMIA
10 20 30 40 50 60
240 250 260 270 280 290
pF1KB5 KLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGA-FVAKHLKTINQESCIEPLAE
.: . .: . :: .:::: ::::.:.:. :.. .: : : : : :. .
XP_016 AVDTDSPREV--FFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPE-LIRTIMG
70 80 90 100 110
300 310 320 330 340 350
pF1KB5 SITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
: : . :. : ::::.. .:
XP_016 WTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
120 130 140 150 160 170
>>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo (192 aa)
initn: 179 init1: 138 opt: 201 Z-score: 177.0 bits: 40.4 E(85289): 0.004
Smith-Waterman score: 201; 35.0% identity (58.1% similar) in 117 aa overlap (204-319:54-165)
180 190 200 210 220 230
pF1KB5 LYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLR
:...: : :.:.:: .. : : .: :.
NP_620 ALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNME--LQRMIA
30 40 50 60 70 80
240 250 260 270 280 290
pF1KB5 KLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGA-FVAKHLKTINQESCIEPLAE
.: . .: . :: .:::: ::::.:.:. :.. .: : : : : :. .
NP_620 AVDTDSPREV--FFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPE-LIRTIMG
90 100 110 120 130
300 310 320 330 340 350
pF1KB5 SITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
: : . :. : ::::.. .:
NP_620 WTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
140 150 160 170 180 190
>>NP_001179 (OMIM: 600516) bcl-2 homologous antagonist/k (211 aa)
initn: 152 init1: 86 opt: 196 Z-score: 172.5 bits: 39.7 E(85289): 0.0072
Smith-Waterman score: 196; 26.3% identity (58.8% similar) in 194 aa overlap (161-342:17-201)
140 150 160 170 180
pF1KB5 PEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEE----EDELYRQSLEIISRYL
:. : .::. .:..:. .. :.
NP_001 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRS--YVFYRHQ
10 20 30 40
190 200 210 220 230
pF1KB5 REQ-ATGAKD-------TKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIK
.:: : :. : :. : .: .. . : .:: ..: ... :: ::..:.
NP_001 QEQEAEGVAAPADPEMVTLPLQPS-STMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT
50 60 70 80 90 100
240 250 260 270 280 290
pF1KB5 NEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVL
:. . .... .: .:. ::::.:.:..:: .: :. . . . ... ..: .
NP_001 AENAYEYFTKIATSLFESGI-NWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFM
110 120 130 140 150 160
300 310 320 330 340 350
pF1KB5 VRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
.. . ::: :.: ... . : : :::... ::. .:
NP_001 LHHCIARWIAQRG--GWVAALNLGN--GPILNVLVVL-GVVLLGQFVVRRFFKS
170 180 190 200 210
>>XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homologou (211 aa)
initn: 152 init1: 86 opt: 196 Z-score: 172.5 bits: 39.7 E(85289): 0.0072
Smith-Waterman score: 196; 26.3% identity (58.8% similar) in 194 aa overlap (161-342:17-201)
140 150 160 170 180
pF1KB5 PEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEE----EDELYRQSLEIISRYL
:. : .::. .:..:. .. :.
XP_011 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRS--YVFYRHQ
10 20 30 40
190 200 210 220 230
pF1KB5 REQ-ATGAKD-------TKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIK
.:: : :. : :. : .: .. . : .:: ..: ... :: ::..:.
XP_011 QEQEAEGVAAPADPEMVTLPLQPS-STMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPT
50 60 70 80 90 100
240 250 260 270 280 290
pF1KB5 NEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVL
:. . .... .: .:. ::::.:.:..:: .: :. . . . ... ..: .
XP_011 AENAYEYFTKIATSLFESGI-NWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFM
110 120 130 140 150 160
300 310 320 330 340 350
pF1KB5 VRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
.. . ::: :.: ... . : : :::... ::. .:
XP_011 LHHCIARWIAQRG--GWVAALNLGN--GPILNVLVVL-GVVLLGQFVVRRFFKS
170 180 190 200 210
350 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:50:20 2016 done: Thu Nov 3 17:50:21 2016
Total Scan time: 9.630 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]