Result of FASTA (omim) for
pFN21AB5154
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5154, 628 aa
1>>>pF1KB5154 628 - 628 aa - 628 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1623+/-0.000343; mu= 12.3325+/- 0.021
mean_var=154.6786+/-32.009, 0's: 0 Z-trim(119.1): 36 B-trim: 0 in 0/56
Lambda= 0.103124
statistics sampled from 32736 (32772) to 32736 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.384), width: 16
Scan time: 12.070
The best scores are: opt bits E(85289)
NP_004665 (OMIM: 604782) set1/Ash2 histone methylt ( 628) 4339 657.6 3.6e-188
XP_005273739 (OMIM: 604782) PREDICTED: set1/Ash2 h ( 634) 4317 654.4 3.5e-187
NP_001098684 (OMIM: 604782) set1/Ash2 histone meth ( 534) 3733 567.4 4.4e-161
XP_006716476 (OMIM: 604782) PREDICTED: set1/Ash2 h ( 595) 3718 565.2 2.2e-160
XP_005273740 (OMIM: 604782) PREDICTED: set1/Ash2 h ( 540) 3711 564.2 4.3e-160
XP_006716475 (OMIM: 604782) PREDICTED: set1/Ash2 h ( 601) 3698 562.3 1.8e-159
NP_001269201 (OMIM: 604782) set1/Ash2 histone meth ( 489) 3416 520.2 6.5e-147
NP_001248761 (OMIM: 604782) set1/Ash2 histone meth ( 501) 3112 475.0 2.7e-133
>>NP_004665 (OMIM: 604782) set1/Ash2 histone methyltrans (628 aa)
initn: 4339 init1: 4339 opt: 4339 Z-score: 3499.2 bits: 657.6 E(85289): 3.6e-188
Smith-Waterman score: 4339; 100.0% identity (100.0% similar) in 628 aa overlap (1-628:1-628)
10 20 30 40 50 60
pF1KB5 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 DCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 GQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 IIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWG
550 560 570 580 590 600
610 620
pF1KB5 AVVEHTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::::::
NP_004 AVVEHTLADVLYHVETEVDGRRSPPWEP
610 620
>>XP_005273739 (OMIM: 604782) PREDICTED: set1/Ash2 histo (634 aa)
initn: 2402 init1: 2402 opt: 4317 Z-score: 3481.5 bits: 654.4 E(85289): 3.5e-187
Smith-Waterman score: 4317; 99.1% identity (99.1% similar) in 634 aa overlap (1-628:1-634)
10 20 30 40 50 60
pF1KB5 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
190 200 210 220 230 240
250 260 270 280 290
pF1KB5 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGG------IAAGSSGK
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_005 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGATFGGGIAAGSSGK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 GRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 PEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 GVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGK
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB5 HYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB5 QTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPM
550 560 570 580 590 600
600 610 620
pF1KB5 SDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::::::::::::
XP_005 SDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
610 620 630
>>NP_001098684 (OMIM: 604782) set1/Ash2 histone methyltr (534 aa)
initn: 3733 init1: 3733 opt: 3733 Z-score: 3012.9 bits: 567.4 E(85289): 4.4e-161
Smith-Waterman score: 3733; 100.0% identity (100.0% similar) in 534 aa overlap (95-628:1-534)
70 80 90 100 110 120
pF1KB5 ANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF
::::::::::::::::::::::::::::::
NP_001 MDTQAGSVDEENGRQLGEVELQCGICTKWF
10 20 30
130 140 150 160 170 180
pF1KB5 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB5 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB5 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQD
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB5 GGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWA
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB5 GKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFE
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB5 ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGD
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB5 VLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFY
400 410 420 430 440 450
550 560 570 580 590 600
pF1KB5 KNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVE
460 470 480 490 500 510
610 620
pF1KB5 HTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::
NP_001 HTLADVLYHVETEVDGRRSPPWEP
520 530
>>XP_006716476 (OMIM: 604782) PREDICTED: set1/Ash2 histo (595 aa)
initn: 3795 init1: 3717 opt: 3718 Z-score: 3000.2 bits: 565.2 E(85289): 2.2e-160
Smith-Waterman score: 4042; 94.7% identity (94.7% similar) in 628 aa overlap (1-628:1-595)
10 20 30 40 50 60
pF1KB5 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 DCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 GQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 IIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWG
:::::::::::::::::::::::::::
XP_006 ---------------------------------VSINFGPCFKYPPKDLTYRPMSDMGWG
550 560
610 620
pF1KB5 AVVEHTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::::::
XP_006 AVVEHTLADVLYHVETEVDGRRSPPWEP
570 580 590
>>XP_005273740 (OMIM: 604782) PREDICTED: set1/Ash2 histo (540 aa)
initn: 2402 init1: 2402 opt: 3711 Z-score: 2995.2 bits: 564.2 E(85289): 4.3e-160
Smith-Waterman score: 3711; 98.9% identity (98.9% similar) in 540 aa overlap (95-628:1-540)
70 80 90 100 110 120
pF1KB5 ANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF
::::::::::::::::::::::::::::::
XP_005 MDTQAGSVDEENGRQLGEVELQCGICTKWF
10 20 30
130 140 150 160 170 180
pF1KB5 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB5 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
100 110 120 130 140 150
250 260 270 280 290
pF1KB5 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGG------IAAGSSGKGRGA
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_005 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGATFGGGIAAGSSGKGRGA
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB5 KRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKL
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB5 ELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRK
280 290 300 310 320 330
420 430 440 450 460 470
pF1KB5 GAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSS
340 350 360 370 380 390
480 490 500 510 520 530
pF1KB5 GYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPH
400 410 420 430 440 450
540 550 560 570 580 590
pF1KB5 SEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMG
460 470 480 490 500 510
600 610 620
pF1KB5 WGAVVEHTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::::::::
XP_005 WGAVVEHTLADVLYHVETEVDGRRSPPWEP
520 530 540
>>XP_006716475 (OMIM: 604782) PREDICTED: set1/Ash2 histo (601 aa)
initn: 4114 init1: 1962 opt: 3698 Z-score: 2984.1 bits: 562.3 E(85289): 1.8e-159
Smith-Waterman score: 4020; 93.8% identity (93.8% similar) in 634 aa overlap (1-628:1-601)
10 20 30 40 50 60
pF1KB5 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGIC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHP
190 200 210 220 230 240
250 260 270 280 290
pF1KB5 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGG------IAAGSSGK
:::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_006 DPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGATFGGGIAAGSSGK
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 GRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 PEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 GVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGK
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB5 HYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB5 QTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPM
:::::: :::::::::::::::::::::
XP_006 QTPHSE---------------------------------VSINFGPCFKYPPKDLTYRPM
550 560
600 610 620
pF1KB5 SDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::::::::::::
XP_006 SDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
570 580 590 600
>>NP_001269201 (OMIM: 604782) set1/Ash2 histone methyltr (489 aa)
initn: 3416 init1: 3416 opt: 3416 Z-score: 2758.5 bits: 520.2 E(85289): 6.5e-147
Smith-Waterman score: 3416; 100.0% identity (100.0% similar) in 489 aa overlap (140-628:1-489)
110 120 130 140 150 160
pF1KB5 LGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMC
::::::::::::::::::::::::::::::
NP_001 MTNYSFHCNVCHHSGNTYFLRKQANLKEMC
10 20 30
170 180 190 200 210 220
pF1KB5 LSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSK
40 50 60 70 80 90
230 240 250 260 270 280
pF1KB5 ERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAA
100 110 120 130 140 150
290 300 310 320 330 340
pF1KB5 GSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPD
160 170 180 190 200 210
350 360 370 380 390 400
pF1KB5 PHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSM
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB5 VRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFH
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB5 QSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKA
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB5 EKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDL
400 410 420 430 440 450
590 600 610 620
pF1KB5 TYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
:::::::::::::::::::::::::::::::::::::::
NP_001 TYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
460 470 480
>>NP_001248761 (OMIM: 604782) set1/Ash2 histone methyltr (501 aa)
initn: 3148 init1: 3111 opt: 3112 Z-score: 2514.0 bits: 475.0 E(85289): 2.7e-133
Smith-Waterman score: 3436; 93.8% identity (93.8% similar) in 534 aa overlap (95-628:1-501)
70 80 90 100 110 120
pF1KB5 ANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF
::::::::::::::::::::::::::::::
NP_001 MDTQAGSVDEENGRQLGEVELQCGICTKWF
10 20 30
130 140 150 160 170 180
pF1KB5 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQD
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB5 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGS
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB5 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQD
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB5 GGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWA
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB5 GKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFE
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB5 ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGD
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB5 VLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSE----
400 410 420 430 440
550 560 570 580 590 600
pF1KB5 KNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVE
:::::::::::::::::::::::::::::::
NP_001 -----------------------------VSINFGPCFKYPPKDLTYRPMSDMGWGAVVE
450 460 470
610 620
pF1KB5 HTLADVLYHVETEVDGRRSPPWEP
::::::::::::::::::::::::
NP_001 HTLADVLYHVETEVDGRRSPPWEP
480 490 500
628 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 16:13:05 2016 done: Thu Nov 3 16:13:06 2016
Total Scan time: 12.070 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]