Result of FASTA (omim) for
pFN21AB4388
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4388, 349 aa
1>>>pF1KB4388 349 - 349 aa - 349 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8084+/-0.00047; mu= 18.8011+/- 0.029
mean_var=92.4311+/-23.323, 0's: 0 Z-trim(110.0): 476 B-trim: 2176 in 2/51
Lambda= 0.133403
statistics sampled from 17595 (18262) to 17595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.214), width: 16
Scan time: 7.430
The best scores are: opt bits E(85289)
NP_005285 (OMIM: 601909) probable G-protein couple ( 349) 2376 468.2 1.2e-131
XP_005251990 (OMIM: 601909) PREDICTED: probable G- ( 349) 2376 468.2 1.2e-131
NP_005675 (OMIM: 604106) probable G-protein couple ( 361) 1595 317.9 2.2e-86
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 348 77.9 3.8e-14
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 348 77.9 3.8e-14
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 348 78.0 4e-14
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 348 78.0 4.2e-14
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 348 78.0 4.2e-14
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 348 78.0 4.2e-14
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 348 78.0 4.2e-14
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 348 78.0 4.2e-14
NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 313 71.2 3.9e-12
NP_000668 (OMIM: 600445) adenosine receptor A3 iso ( 318) 303 69.2 1.4e-11
NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 298 68.3 2.9e-11
NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 290 66.7 7.8e-11
NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 290 66.7 8.5e-11
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 290 66.9 1e-10
NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 288 66.4 1.2e-10
NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 287 66.1 1.3e-10
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 283 65.5 2.4e-10
NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 278 64.4 4.1e-10
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 275 63.8 6.3e-10
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 270 63.0 1.4e-09
XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 270 63.0 1.5e-09
XP_011507677 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_011507678 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_005245113 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_016856351 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_011507679 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_005245114 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
NP_722561 (OMIM: 612250) G-protein coupled recepto ( 529) 266 62.3 2.7e-09
XP_011507680 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
NP_001254539 (OMIM: 612250) G-protein coupled rece ( 529) 266 62.3 2.7e-09
XP_016856349 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
XP_016856350 (OMIM: 612250) PREDICTED: G-protein c ( 529) 266 62.3 2.7e-09
NP_001254540 (OMIM: 612250) G-protein coupled rece ( 546) 266 62.3 2.8e-09
XP_005245112 (OMIM: 612250) PREDICTED: G-protein c ( 549) 266 62.3 2.8e-09
NP_001254538 (OMIM: 612250) G-protein coupled rece ( 549) 266 62.3 2.8e-09
XP_016856348 (OMIM: 612250) PREDICTED: G-protein c ( 549) 266 62.3 2.8e-09
XP_006711314 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
XP_011507673 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
XP_011507672 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
XP_016856347 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
XP_011507674 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
XP_011507675 (OMIM: 612250) PREDICTED: G-protein c ( 552) 266 62.3 2.8e-09
NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 265 62.1 2.9e-09
XP_006711316 (OMIM: 612250) PREDICTED: G-protein c ( 609) 266 62.4 3e-09
XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 265 62.1 3.1e-09
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 259 60.7 5.1e-09
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 259 60.7 5.1e-09
>>NP_005285 (OMIM: 601909) probable G-protein coupled re (349 aa)
initn: 2376 init1: 2376 opt: 2376 Z-score: 2484.5 bits: 468.2 E(85289): 1.2e-131
Smith-Waterman score: 2376; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)
10 20 30 40 50 60
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
250 260 270 280 290 300
310 320 330 340
pF1KB4 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
310 320 330 340
>>XP_005251990 (OMIM: 601909) PREDICTED: probable G-prot (349 aa)
initn: 2376 init1: 2376 opt: 2376 Z-score: 2484.5 bits: 468.2 E(85289): 1.2e-131
Smith-Waterman score: 2376; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)
10 20 30 40 50 60
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
250 260 270 280 290 300
310 320 330 340
pF1KB4 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
310 320 330 340
>>NP_005675 (OMIM: 604106) probable G-protein coupled re (361 aa)
initn: 1591 init1: 1140 opt: 1595 Z-score: 1672.0 bits: 317.9 E(85289): 2.2e-86
Smith-Waterman score: 1595; 67.5% identity (85.8% similar) in 345 aa overlap (8-349:20-361)
10 20 30 40
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNII
: : . : :.::. .:. :..:...::.:: :::.::.
NP_005 MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB4 VIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFV
:::::::::::.:.::::::::::::::::::::.::.:::::. :.::::::.::..
NP_005 VIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB4 VSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHW
.::::::::: :::::.:::.::::::.:: :::: :::.::.:::.:: :.:::::: :
NP_005 ISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGW
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB4 GKPGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISER
::::::::.:.::: :: :..::: ::: .::::::..::::::.::.::.::::.:..:
NP_005 GKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDR
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB4 QARFSSQSGETG-EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASF
.::: :. ... :. ::.::::::::::::::.:::::::::::::: .: ::
NP_005 RARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSF
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB4 LTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSC--ASQTTANDPYTVRSKGPLN
::::::::::::::::::::::::. ::.::: .::::: ... :..: . . :
NP_005 LTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEP---KPRKRAN
310 320 330 340 350
pF1KB4 GCHI
.: :
NP_005 SCSI
360
>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa)
initn: 227 init1: 149 opt: 348 Z-score: 375.0 bits: 77.9 E(85289): 3.8e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
NP_071 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
NP_071 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
NP_071 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
NP_071 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
NP_071 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
NP_071 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
NP_071 REPRQQEEKPLKLQVWSGTEVTAPQGATDR
330 340 350
>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa)
initn: 227 init1: 149 opt: 348 Z-score: 375.0 bits: 77.9 E(85289): 3.8e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
XP_006 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
XP_006 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
XP_006 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
XP_006 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
XP_006 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
XP_006 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
XP_006 REPRQQEEKPLKLQVWSGTEVTAPQGATDRNSS
330 340 350 360
>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa)
initn: 227 init1: 149 opt: 348 Z-score: 374.5 bits: 78.0 E(85289): 4e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
NP_001 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
NP_001 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
NP_001 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
NP_001 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
NP_001 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
NP_001 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
NP_001 REPRQQEEKPLKLQVWSGTEVTAPQGATDRPWLCLPECWSVELTHSFIHLFIHSFANIHP
330 340 350 360 370 380
>>XP_016864915 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 227 init1: 149 opt: 348 Z-score: 374.2 bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
XP_016 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
XP_016 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
XP_016 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
XP_016 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
XP_016 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
XP_016 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
XP_016 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
330 340 350 360 370 380
>>XP_011532850 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 227 init1: 149 opt: 348 Z-score: 374.2 bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
XP_011 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
XP_011 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
XP_011 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
XP_011 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
XP_011 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
XP_011 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
XP_011 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
330 340 350 360 370 380
>>XP_006714927 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 227 init1: 149 opt: 348 Z-score: 374.2 bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
XP_006 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
XP_006 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
XP_006 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
XP_006 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
XP_006 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
XP_006 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
XP_006 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
330 340 350 360 370 380
>>XP_011532851 (OMIM: 142703) PREDICTED: histamine H2 re (422 aa)
initn: 227 init1: 149 opt: 348 Z-score: 374.2 bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)
10 20 30 40 50
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
: .. ::: . . : . . ... . .:: ..::..: .. :
XP_011 MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
10 20 30 40
60 70 80 90 100 110
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
.. :. :: ..: .::..:. :.: .: ... : . :. :.:. . .: ..:
XP_011 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
. .: ::.::: :. :: : .:::: :. . . :::. : :: :: . :..
XP_011 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
: : . . : . .. : . .. .: : ::.:.::. ::.. ..: ..:
XP_011 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
170 180 190 200 210
240 250 260 270 280
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
..:: .. : . ... ...: . ..: : :.::. :. .. : . :. .
XP_011 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
. ::. .:: : ..:. : :. : ..: .: :....
XP_011 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
280 290 300 310 320
pF1KB4 I
XP_011 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
330 340 350 360 370 380
349 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:55:25 2016 done: Thu Nov 3 14:55:27 2016
Total Scan time: 7.430 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]