Result of FASTA (omim) for
pFN21AB3863
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3863, 801 aa
1>>>pF1KB3863 801 - 801 aa - 801 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.9431+/-0.000373; mu= -7.6857+/- 0.023
mean_var=376.7432+/-76.263, 0's: 0 Z-trim(125.2): 190 B-trim: 947 in 1/61
Lambda= 0.066077
statistics sampled from 48284 (48497) to 48284 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.569), width: 16
Scan time: 15.240
The best scores are: opt bits E(85289)
NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 5299 519.2 2.8e-146
NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 5299 519.2 2.8e-146
NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 4981 488.9 3.5e-137
NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 4462 439.4 2.5e-122
NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 4149 409.6 2.9e-113
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 1971 201.9 8.1e-51
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1971 201.9 8.1e-51
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 1971 201.9 8.1e-51
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 1971 201.9 8.1e-51
NP_055114 (OMIM: 608749) bromodomain-containing pr ( 722) 1101 119.0 7.5e-26
XP_011526158 (OMIM: 608749) PREDICTED: bromodomain ( 722) 1101 119.0 7.5e-26
NP_001317313 (OMIM: 608749) bromodomain-containing ( 794) 1101 119.0 8.1e-26
XP_011526156 (OMIM: 608749) PREDICTED: bromodomain (1362) 1101 119.2 1.2e-25
NP_490597 (OMIM: 608749) bromodomain-containing pr (1362) 1101 119.2 1.2e-25
XP_016870655 (OMIM: 601541) PREDICTED: bromodomain ( 405) 738 84.2 1.2e-15
NP_001229739 (OMIM: 602144) bromodomain testis-spe ( 874) 738 84.4 2.3e-15
NP_001229736 (OMIM: 602144) bromodomain testis-spe ( 901) 738 84.4 2.3e-15
NP_001229737 (OMIM: 602144) bromodomain testis-spe ( 901) 738 84.4 2.3e-15
NP_001229735 (OMIM: 602144) bromodomain testis-spe ( 951) 708 81.6 1.8e-14
NP_001229734 (OMIM: 602144) bromodomain testis-spe ( 947) 701 80.9 2.8e-14
XP_006710918 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_006710920 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_011540335 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_006710916 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_011540334 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_006710919 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
NP_997072 (OMIM: 602144) bromodomain testis-specif ( 947) 701 80.9 2.8e-14
XP_006710917 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
NP_001717 (OMIM: 602144) bromodomain testis-specif ( 947) 701 80.9 2.8e-14
XP_011540338 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_011540336 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
XP_011540337 (OMIM: 602144) PREDICTED: bromodomain ( 947) 701 80.9 2.8e-14
>>NP_005095 (OMIM: 601540) bromodomain-containing protei (801 aa)
initn: 5299 init1: 5299 opt: 5299 Z-score: 2747.3 bits: 519.2 E(85289): 2.8e-146
Smith-Waterman score: 5299; 100.0% identity (100.0% similar) in 801 aa overlap (1-801:1-801)
10 20 30 40 50 60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
730 740 750 760 770 780
790 800
pF1KB3 SDSSSSSSSSSSSDTSDSDSG
:::::::::::::::::::::
NP_005 SDSSSSSSSSSSSDTSDSDSG
790 800
>>NP_001106653 (OMIM: 601540) bromodomain-containing pro (801 aa)
initn: 5299 init1: 5299 opt: 5299 Z-score: 2747.3 bits: 519.2 E(85289): 2.8e-146
Smith-Waterman score: 5299; 100.0% identity (100.0% similar) in 801 aa overlap (1-801:1-801)
10 20 30 40 50 60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
730 740 750 760 770 780
790 800
pF1KB3 SDSSSSSSSSSSSDTSDSDSG
:::::::::::::::::::::
NP_001 SDSSSSSSSSSSSDTSDSDSG
790 800
>>NP_001186385 (OMIM: 601540) bromodomain-containing pro (754 aa)
initn: 4981 init1: 4981 opt: 4981 Z-score: 2583.8 bits: 488.9 E(85289): 3.5e-137
Smith-Waterman score: 4981; 100.0% identity (100.0% similar) in 754 aa overlap (48-801:1-754)
20 30 40 50 60 70
pF1KB3 GLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTN
::::::::::::::::::::::::::::::
NP_001 MASVPALQLTPANPPPPEVSNPKKPGRVTN
10 20 30
80 90 100 110 120 130
pF1KB3 QLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 ASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 KGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSA
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 GPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVD
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 ASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVA
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 MARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEE
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKK
460 470 480 490 500 510
560 570 580 590 600 610
pF1KB3 RKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPK
520 530 540 550 560 570
620 630 640 650 660 670
pF1KB3 KATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLR
580 590 600 610 620 630
680 690 700 710 720 730
pF1KB3 DSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELE
640 650 660 670 680 690
740 750 760 770 780 790
pF1KB3 KRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSD
700 710 720 730 740 750
800
pF1KB3 SDSG
::::
NP_001 SDSG
>>NP_001278915 (OMIM: 601540) bromodomain-containing pro (681 aa)
initn: 4462 init1: 4462 opt: 4462 Z-score: 2317.1 bits: 439.4 E(85289): 2.5e-122
Smith-Waterman score: 4462; 100.0% identity (100.0% similar) in 681 aa overlap (121-801:1-681)
100 110 120 130 140 150
pF1KB3 WKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFT
::::::::::::::::::::::::::::::
NP_001 MDMGTIKRRLENNYYWAASECMQDFNTMFT
10 20 30
160 170 180 190 200 210
pF1KB3 NCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVT
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB3 SAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPA
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB3 QPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKD
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB3 LPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDII
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB3 KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB3 AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESS
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB3 DSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGAD
400 410 420 430 440 450
580 590 600 610 620 630
pF1KB3 EDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTG
460 470 480 490 500 510
640 650 660 670 680 690
pF1KB3 YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFET
520 530 540 550 560 570
700 710 720 730 740 750
pF1KB3 LKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNST
580 590 600 610 620 630
760 770 780 790 800
pF1KB3 KKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
640 650 660 670 680
>>NP_001186384 (OMIM: 601540) bromodomain-containing pro (836 aa)
initn: 4134 init1: 4134 opt: 4149 Z-score: 2154.5 bits: 409.6 E(85289): 2.9e-113
Smith-Waterman score: 5198; 95.8% identity (95.8% similar) in 833 aa overlap (1-798:1-833)
10 20 30 40 50 60
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
550 560 570 580 590 600
610 620
pF1KB3 GPSGFGPSGGSGTKL-----------------------------------PKKATKTAPP
::::::::::::::: ::::::::::
NP_001 GPSGFGPSGGSGTKLQAGVQWRDLGLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KB3 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIE
670 680 690 700 710 720
690 700 710 720 730 740
pF1KB3 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSG
730 740 750 760 770 780
750 760 770 780 790 800
pF1KB3 QLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
790 800 810 820 830
>>XP_016870654 (OMIM: 601541) PREDICTED: bromodomain-con (725 aa)
initn: 2657 init1: 961 opt: 1971 Z-score: 1033.3 bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.6% identity (79.6% similar) in 763 aa overlap (49-799:10-725)
20 30 40 50 60 70
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
:..:: :.::::::::::.:::: :::
XP_016 MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
10 20 30
80 90 100 110 120 130
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_016 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
XP_016 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
: : :. .:: :::::: : . . :: . : . : :. : : :.
XP_016 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
XP_016 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
XP_016 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_016 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
XP_016 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_016 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
460 470 480 490
560 570 580 590 600
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
XP_016 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
500 510 520 530 540
610 620 630 640 650 660
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
.: .: ::. : : ..::::::::. :::::::::::::::.:::::::::::
XP_016 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
550 560 570 580 590
670 680 690 700 710 720
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI-KKPVGKTKE
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.::
XP_016 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSSGKKQAAKSKE
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB3 ELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSS
::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.::
XP_016 ELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGSS
660 670 680 690 700 710
790 800
pF1KB3 SSSSSSSDTSDSDSG
:::.::::.:::.
XP_016 SSSGSSSDSSDSE
720
>>XP_006717354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 2503 init1: 961 opt: 1971 Z-score: 1033.3 bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)
20 30 40 50 60 70
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
:..:: :.::::::::::.:::: :::
XP_006 MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
10 20 30
80 90 100 110 120 130
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_006 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
XP_006 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
: : :. .:: :::::: : . . :: . : . : :. : : :.
XP_006 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
XP_006 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
XP_006 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_006 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
XP_006 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_006 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
460 470 480 490
560 570 580 590 600
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
XP_006 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
500 510 520 530 540
610 620 630 640 650 660
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
.: .: ::. : : ..::::::::. :::::::::::::::.:::::::::::
XP_006 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
550 560 570 580 590
670 680 690 700 710 720
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.:
XP_006 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
:::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.:
XP_006 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
660 670 680 690 700 710
790 800
pF1KB3 SSSSSSSSDTSDSDSG
::::.::::.:::.
XP_006 SSSSGSSSDSSDSE
720
>>XP_011517354 (OMIM: 601541) PREDICTED: bromodomain-con (726 aa)
initn: 2503 init1: 961 opt: 1971 Z-score: 1033.3 bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)
20 30 40 50 60 70
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
:..:: :.::::::::::.:::: :::
XP_011 MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
10 20 30
80 90 100 110 120 130
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
XP_011 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
XP_011 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
: : :. .:: :::::: : . . :: . : . : :. : : :.
XP_011 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
XP_011 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
XP_011 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
XP_011 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
XP_011 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
XP_011 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
460 470 480 490
560 570 580 590 600
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
XP_011 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
500 510 520 530 540
610 620 630 640 650 660
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
.: .: ::. : : ..::::::::. :::::::::::::::.:::::::::::
XP_011 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
550 560 570 580 590
670 680 690 700 710 720
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.:
XP_011 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
:::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.:
XP_011 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
660 670 680 690 700 710
790 800
pF1KB3 SSSSSSSSDTSDSDSG
::::.::::.:::.
XP_011 SSSSGSSSDSSDSE
720
>>NP_031397 (OMIM: 601541) bromodomain-containing protei (726 aa)
initn: 2503 init1: 961 opt: 1971 Z-score: 1033.3 bits: 201.9 E(85289): 8.1e-51
Smith-Waterman score: 2918; 63.5% identity (79.5% similar) in 764 aa overlap (49-799:10-726)
20 30 40 50 60 70
pF1KB3 LLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQ
:..:: :.::::::::::.:::: :::
NP_031 MSTATTVAPAGIPATP-GPVNPPPPEVSNPSKPGRKTNQ
10 20 30
80 90 100 110 120 130
pF1KB3 LQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAA
:::...::.:.:::::::::: :::::.::.:::::::::.::::::::.::::::::.:
NP_031 LQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSA
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB3 SECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKK
:::::::::::::::::::::::::::::.::::::::::.::::: ::. ::.. .:
NP_031 SECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRK
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB3 GAKLAALQGSVTSAHQVPAVSSVSH-TALYTPPPEIPTT--VLNIPHPS----VISSPLL
: : :. .:: :::::: : . . :: . : . : :. : : :.
NP_031 PAAGAQSAGT----QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVP
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB3 KSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAA
. : : ..::. :..::::::::::::::: .:: : : . :: : .:: :
NP_031 PAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLS-DPKQA
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB3 RLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWP
.. :. .:::::::.::: :.. ....:::::::.:..:..::.:.:::::::::::
NP_031 KVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWP
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB3 FYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPP
::::::: :: :::::::::::::::::::::..:.: ::: ::::::::::::::::::
NP_031 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB3 DHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES-SSEESSSESS
::.:::::::::::::.:.:::::::.: ::. .: : ..:.. : :::::::.:.
NP_031 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAA--PMVSKGAESSRSSEESSSDSG
400 410 420 430 440 450
500 510 520 530 540 550
pF1KB3 SEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKRE
: :::::::: :::::::::.:::::::::::.:..:::.:.:
NP_031 S------------------SDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKE
460 470 480 490
560 570 580 590 600
pF1KB3 KKEKKKKRK---AEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGP
::::.::.: ::.. .. :.:. :. :: : . ..::: .. ..:..
NP_031 KKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAP-PAKQAQQKKAPAKKANSTTT-------
500 510 520 530 540
610 620 630 640 650 660
pF1KB3 SGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVH
.: .: ::. : : ..::::::::. :::::::::::::::.:::::::::::
NP_031 ---AGRQL-KKGGKQAS----ASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVH
550 560 570 580 590
670 680 690 700 710 720
pF1KB3 IIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTI--KKPVGKTK
:::.::::::::::.:::::::::::.::::::::: :::.:: :::.. :: ..:.:
NP_031 IIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSK
600 610 620 630 640 650
730 740 750 760 770 780
pF1KB3 EELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSS
:::: :::.:::::::::::::.:.::: .: :: .:: . . :::: :::::.:.:
NP_031 EELAQEKKKELEKRLQDVSGQLSSSKKPARK--EKP--GSAPSGGPSRLS-SSSSSESGS
660 670 680 690 700 710
790 800
pF1KB3 SSSSSSSSDTSDSDSG
::::.::::.:::.
NP_031 SSSSGSSSDSSDSE
720
>>NP_055114 (OMIM: 608749) bromodomain-containing protei (722 aa)
initn: 2481 init1: 898 opt: 1101 Z-score: 585.1 bits: 119.0 E(85289): 7.5e-26
Smith-Waterman score: 2486; 54.8% identity (72.9% similar) in 764 aa overlap (27-754:5-721)
10 20 30 40 50
pF1KB3 MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPAL-QLTPA
..:: :.:. .. .:.:. :... : : ::
NP_055 MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPA
10 20 30
60 70 80 90 100 110
pF1KB3 N-----PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYH
: :::::.:::.:: : ::::::: .::.:.::::::::::.::::::::.::::.
NP_055 NAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYY
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB3 KIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL
:::: ::::::::.:::::::: :.::.:::::::::::::::: :::::::..:::.::
NP_055 KIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFL
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB3 QKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIP
::. .: :: :.... :. . . .. . .:... .. .:. .: :: :. :
NP_055 QKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQ--TPQPN-P
160 170 180 190 200 210
240 250 260 270
pF1KB3 TTVLNIPHPS-------VISSPLLKSLH----SAGPPLLAVTAAPPA-------------
: ::: ....:.. . .. ::. :::
NP_055 PPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPII
220 230 240 250 260 270
280 290 300 310 320
pF1KB3 ----QPLAKKKGVKRKADTTTPTPT-AILAPGSPASPPGSLEPKAARLPPMRRESGRPIK
::. :::::::::::::: : : :. :: :::...: .::::.::.:
NP_055 AATPQPVKTKKGVKRKADTTTPTTIDPIHEP--PSLPP---EPKTTKLG-QRRESSRPVK
280 290 300 310 320
330 340 350 360 370 380
pF1KB3 PPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHD
::.::.:::::. :..:.::::: :.:::::...:::::::::::::::. ::::::
NP_055 PPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHD
330 340 350 360 370 380
390 400 410 420 430 440
pF1KB3 YHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
: ::::::::.::.: :.: :.:::::::.::::::::::::::::::.:::::::::::
NP_055 YCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
390 400 410 420 430 440
450 460 470 480 490 500
pF1KB3 FEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEE
::.:.::::::: :: : :.:: .: . :: .:::.::: .
NP_055 FEMRFAKMPDEPEEPVVAVSSPAVPPP-TKVVAPPSSSDSSSDSSS------------DS
450 460 470 480 490
510 520 530 540 550 560
pF1KB3 ESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRK-REKKEKKKKRKAEKHR
.: ..:::::::.:::::::::.::::::::::: .:::.: ..:::::: :::.
NP_055 DSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKK----EKHK
500 510 520 530 540 550
570 580 590 600 610 620
pF1KB3 GRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAP
: :..: .: .:: :::.:: ..:... . :. : :. :
NP_055 -RKEEVEENKKSKAKEPP-PKKTKKNNSSNSNVSKKEPA---P------------MKSKP
560 570 580 590
630 640 650 660 670 680
pF1KB3 PALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEI
: :: :.::::.. .::::.:::::::::::::::::::::::::.:::::..:::.::
NP_055 P--PT-YESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEI
600 610 620 630 640 650
690 700 710 720 730 740
pF1KB3 EIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVS
::::::::::::::::::: :::::: ::: . : : . .. .. : :. .. :
NP_055 EIDFETLKPSTLRELERYVTSCLRKK-RKPQAEKVDVIAGSSKMKGFSSSESESSSESSS
660 670 680 690 700 710
750 760 770 780 790 800
pF1KB3 GQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
.. .... :
NP_055 SDSEDSETGPA
720
801 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:05:30 2016 done: Thu Nov 3 14:05:32 2016
Total Scan time: 15.240 Total Display time: 0.240
Function used was FASTA [36.3.4 Apr, 2011]